פרופ' עידו בן דב


טלפון משרד: 02-6776881
אימייל: [email protected]
תחום מחקר: גנומיקה

Synopsis
In my research, I hope to continue to study and contribute to both basic understanding of molecular mechanisms of disease and unmet health needs. The research of post-transcriptional regulators of gene expression is lagging behind other fields in molecular biology, despite obvious translational potential. I believe this is due to the complexity of interactions between RNA-binding proteins, non-coding RNA and their targets. I intend to apply and develop sophisticated tools to decipher the targets and function of RNA-binding proteins, with potential to contribute to the health of millions of kidney patients. Specifically, i aim to:

1. decipher basic mechanisms leading to phenotypic variability in ADPKD and follow those with translational potential;
2. reveal the role of specific miRNA in maintaining podocyte viability and function, to contribute to our understanding of, and our ability to manipulate, glomerular disorders;
3. expose small RNA biomarkers useful for the diagnosis and management of patients with kidney diseases.

מלגות ופרסים

  • Israel Science Foundation Physician Scientist grant. “Biochemical and genetic studies of the PKD-related RNA binding protein BICC1“, Iddo Ben-Dov, 50% salary support and 200,000 NIS annually for 3 years (+ 14,000 NIS INCPM supplement granted during 2015).

    Period: 2012-2015
  • German-Israeli Foundation grant. “Utility of microRNA profiling for diagnosis and evaluation of prognosis in patients with pheochromocytoma or paraganglioma“, Iddo Ben-Dov/Graeme Eisenhofer, €136,000/€62,000

    Period: 2014-2016
  • Junior faculty, The Israeli Centers of Research Excellence (I-CORE) program (Center No. 41/11; Gene Regulation in Complex Human Disease), http://www.icore-human-disease.org/faculty/, 1,500,000 NIS over 5 years

    Period: 2013-2018
  • Israel Ministry of Industry, Trade, and Labor – Kamin grant. “Parasite microRNA in the diagnosis of human schistosomiasis”, Eli Schwartz/Iddo Ben-Dov, 331,000/200,000 NIS for the first 12 months

    Period: 2014-2016

מאמרים

פרויקטי מחקר

  • Biomarker discovery through small RNA deep sequencing

  • Biochemical and genetic characterization of BICC1 RNA-binding protein; a protein associated with autosomal dominant polycystic kidney disease progression

  • Role of miRNA in podocyte development and maintenance

  • Characterizing the phenotype and genetics of AFVD

     

פטנטים

  • Matrices with specific molecular recognition sites

    Willner I, Katz E, Doron A, Lahav M, Ben-Dov I and Patolsky F. Application in Israel No. 119345, 2/10/1996

  • Biosensor for cells

    Willner I, Ben-Dov I, Levi S and Zisman E. Application in Israel No. 120445, 13/3/1997