Clinical Research

  • Development of hardware and computer techniques for the measurement of lung function in infants
  • Acoustic analysis of breath sounds for the detection and quantification of wheezing in infants and young children
  • Studies of bronchial reactivity in infants, children and adults with asthma and other types of chronic lung disease
  • Studies of nitric oxide levels in normal adults and children and in patients with lung disease
  • Screening and early detection of lung cancer
  • Pulmonary hypertension, including genetic screening
  • Lung function methodology
  • Mechanisms of lung fibrosis
  • Positron emission tomography (PET) scan in lung cancer

International, Multi-Institutional Clinical Trials, Conducted in Cooperation with Commercial Entities

  • Drug therapy in moderate-to-severe asthma, outpatient and emergency room settings
  • Drug therapy in stable and moderate-to severe COPD, and in acute exacerbation of COPD
  • Drug therapy in pulmonary hypertension
  • Drug therapy in idiopathic pulmonary fibrosis
  • Drug therapy in outpatient pneumonia

Basic Research

  • Cellular and molecular mechanisms of lung fibrosis
  • Cellular and molecular remodeling in asthma
  • Chemokines and asthma
  • Murine model of post-transplant bronchiolitis obliterans
  • Genetic predisposition for lung cancer
  • Development of diagnostic techniques for detecting gastro-esophageal reflux and aspiration in animal models and in young children
  • Predicting diagnosis and disease activity of interstitial lung disease with the aid of positron emission tomography (PET) scan.