Recent Publications

Neuroimmunology and Autoimmune Diseases

Ben-Menachem, G., Mousa, A., Brenner, T., Pinto, F., Zahringer, U., Rottem, S. (2001) Choline deficiency induced by Mycoplasma fermentans enhances apoptosis of rat astrocytes. FEMS Microbiol Lett 201: 157-62.

Boneva, N., Brenner, T., Argov, Z. (2000) Gabapentin may be hazardous in myasthenia gravis. Muscle Nerve 23: 1204-8.

Brenner, T., Arnon, R., Sela, M., Abramsky, O., Meiner, Z., Riven-Kreitman, R., Tarcik, N., Teitelbaum, D. (2001) Humoral and cellular immune responses to Copolymer 1 in multiple sclerosis patients treated with Copaxone. J Neuroimmunol 115: 152-60.

Brenner, T., Pinto, F., Abramsky, O., Gallily, R. (2001) Inhibition of nitric oxide production for down-regulation of CNS inflammation and demyelination. Prog Brain Res 132: 499-506.

Chapman, J., Vinokurov, S., Achiron, A., Karussis, D.M., Mitosek-Szewczyk, K., Birnbaum, M., Michaelson, D.M., Korczyn, A.D. (2001) APOE genotype is a major predictor of long-term progression of disability in MS. Neurology 56: 312-6.

Chapman, J., Korczyn, A.D., Karussis, D.M., Michaelson, D.M. (2001) The effects of APOE genotype on age at onset and progression of neurodegenerative diseases. Neurology 57: 1482-5.

Cohen, O., Biran, I., Steiner, I. (2000) Cerebrospinal fluid oligoclonal IgG bands in patients with spinal arteriovenous malformation and structural central nervous system lesions. Arch Neurol 57: 553-7.

Cohen, O., Steiner-Birmanns, B., Biran, I., Abramsky, O., Honigman, S., Steiner, I. (2001) Recurrence of acute disseminated encephalomyelitis at the previously affected brain site. Arch Neurol 58: 797-801.

Comi, G., Kappos, L., Clanet, M., Ebers, G., Fassas, A., Fazekas, F., Filippi, M., Hartung, H.P., Hertenstein, B., Karussis, D., Martino, G., Tyndall, A., van der Meche, F.G. (2000) Guidelines for autologous blood and marrow stem cell transplantation in multiple sclerosis: a consensus report written on behalf of the European Group for Blood and Marrow Transplantation and the European Charcot Foundation. BMT-MS Study Group. J Neurol 247: 376-82.

Karussis, D., Abramsky, O., Grigoriadis, N., Chapman, J., Mizrachi-Koll, R., Niv, H., Kloog, Y. (2001) The Ras-pathway inhibitor, S-trans-trans-farnesylthiosalicylic acid, suppresses experimental allergic encephalomyelitis. J Neuroimmunol 120: 1-9.

Katzav, A., Kloog, Y., Korczyn, A.D., Niv, H., Karussis, D.M., Wang, N., Rabinowitz, R., Blank, M., Shoenfeld, Y., Chapman, J. (2001) Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS). Clin Exp Immunol 126: 570-7.

Keynan, S., Hirshberg, B., Levin-Iaina, N., Wexler, I. D., Dahan, R., Reinhartz, E., Ovadia, H., Wollman, Y., Chernihovskey, T., Iaina, A., Raz, I. (2000) Renal nitric oxide production during the early phase of experimental diabetes mellitus. Kidney Int 58: 740-7.

Leker, R.R., Karni, A., Brenner, T., Weidenfeld, J., Abramsky, O. (2000) Effects of sex hormones on experimental autoimmune myasthenia gravis. Eur J Neurol 7: 203-6.

Matoth, I., Pinto, F., Sicsic, C., Brenner, T. (2000) Inhibitory effect of carbamazepine on inflammatory mediators produced by stimulated glial cells. Neurosci Res 38: 209-12.

Pollak, Y., Ovadia, H., Goshen, I., Gurevich, R., Monsa, K., Avitsur, R., Yirmiya, R. (2000) Behavioral aspects of experimental autoimmune encephalomyelitis. J Neuroimmunol 104: 31-6.

Reubinoff, B.E., Itsykson, P., Turetsky, T., Pera, M. F., Reinhartz, E., Itzik, A., Ben-Hur, T. (2001) Neural progenitors from human embryonic stem cells. Nat Biotechnol 19: 1134-40.

Shapira, L., Ayalon, S., Brenner, T. (2002) Effects of Porphyromonas gingivalis on the central nervous system: activation of glial cells and exacerbation of experimental autoimmune encephalomyelitis. J Periodontol 73: 511-6.

Steiner, I., Nisipianu, P., Wirguin, I. (2001) Infection and the etiology and pathogenesis of multiple sclerosis. Curr Neurol Neurosci Rep 1: 271-6.

Steiner, I., Wirguin, I. (2000) Multiple sclerosis--in need of a critical reappraisal. Med Hypotheses 54: 99-106.

Prion Diseases

Keshet, G.I., Bar-Peled, O., Yaffe, D., Nudel, U., Gabizon, R. (2000) The cellular prion protein colocalizes with the dystroglycan complex in the brain. J Neurochem 75: 1889-97.

Rosenmann, H., Talmor, G., Halimi, M., Yanai, A., Gabizon, R., Meiner, Z. (2001) Prion protein with an E200K mutation displays properties similar to those of the cellular isoform PrP(C). J Neurochem 76: 1654-62.

Shaked, G.M., Meiner, Z., Avraham, I., Taraboulos, A., Gabizon, R. (2001) Reconstitution of prion infectivity from solubilized protease-resistant PrP and nonprotein components of prion rods. J Biol Chem 276: 14324-8.

Shaked, G.M., Shaked, Y., Kariv-Inbal, Z., Halimi, M., Avraham, I., Gabizon, R. (2001) A protease-resistant prion protein isoform is present in urine of animals and humans affected with prion diseases. J Biol Chem 276: 31479-82.

Shaked, Y., Rosenmann, H., Hijazi, N., Halimi, M., Gabizon, R. (2001) Copper binding to the PrP isoforms: a putative marker of their conformation and function. J Virol 75: 7872-4.

Shaked, Y., Engelstein, R., Gabizon, R. (2002) The binding of prion proteins to serum components is affected by detergent extraction conditions. J Neurochem 82: 1-5.

Simon, E.S., Kahana, E., Chapman, J., Treves, T.A., Gabizon, R., Rosenmann, H., Zilber, N., Korczyn, A.D. (2000) Creutzfeldt-Jakob disease profile in patients homozygous for the PRNP E200K mutation. Ann Neurol 47: 257-60.

Stroke and Brain Ischemia

Ashkenazi, A., Kaufman, Y., Ben-Hur, T. (2000) Bilateral focal motor status epilepticus with retained consciousness after stroke. Neurology 54: 976-8.

Korn-Lubetzki, I., Gillis, S., Steiner, I. (2001) Mutation in the methylenetetrahydrofolate reductase gene might be a risk factor for cerebrovascular disease in peripartum and under oral contraceptive use. Eur Neurol 45: 171-3.

Karussis, D., Leker, R.R., Abramsky, O. (2000) Cognitive dysfunction following thalamic stroke: a study of 16 cases and review of the literature. J Neurol Sci 172: 25-9.

Lavie, G., Teichner, A., Shohami, E., Ovadia, H., Leker, R.R. (2001) Long term cerebroprotective effects of dexanabinol in a model of focal cerebral ischemia. Brain Res 901: 195-201.

Leker, R.R., Ben-Hur, T. (2000) Prognostic factors in artificially ventilated stroke patients. J Neurol Sci 176: 83-7.

Leker, R.R., Ben-Hur, T. (2001) Re: cost and outcome of mechanical ventilation for life-threatening stroke. Stroke 32: 1443-8.

Leker, R.R., Ovadia, H. (2002) Re: Feasibility and safety of moderate hypothermia after massive hemispheric infarction. Stroke 33: 877-8.

Leker, R.R., Shohami, E. (2002) Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities. Brain Res Rev 39: 55-73.

Leker, R.R., Steiner, I. (2000) Isolated intracranial hypertension as the only sign of cerebral venous thrombosis. Neurology 54: 2030.

Leker, R.R., Teichner, A., Grigoriadis, N., Ovadia, H., Brenneman, D.E., Fridkin, M., Giladi, E., Romano, J., Gozes, I. (2002) NAP, a femtomolar-acting peptide, protects the brain against ischemic injury by reducing apoptotic death. Stroke 33: 1085-92.

Leker, R.R., Teichner, A., Ovadia, H., Keshet, E., Reinherz, E., Ben-Hur, T. (2001) Expression of endothelial nitric oxide synthase in the ischemic penumbra: relationship to expression of neuronal nitric oxide synthase and vascular endothelial growth factor. Brain Res 909: 1-7.

Linetsky, E., Leker, R.R., Ben-Hur, T. (2001) Headache characteristics in patients after migrainous stroke. Neurology 57: 130-2.

Steiner, I., Biran, I. (2000) Better outcome after stroke with higher serum cholesterol levels. Neurology 55: 1941-2.

Genetics of Neurological Diseases

Anderson, L.V., Harrison, R.M., Pogue, R., Vafiadaki, E., Pollitt, C., Davison, K., Moss, J.A., Keers, S., Pyle, A., Shaw, P.J., Mahjneh, I., Argov, Z., Greenberg, C.R., Wrogemann, K., Bertorini, T., Goebel, H.H., Beckmann, J.S., Bashir, R., Bushby, K. M. (2000) Secondary reduction in calpain 3 expression in patients with limb girdle muscular dystrophy type 2B and Miyoshi myopathy (primary dysferlinopathies). Neuromuscul Disord 10: 553-9.

Argov, Z. (2000) Drug-induced myopathies. Curr Opin Neurol 13: 541-5.

Argov, Z., Arnold, D.L. (2000) MR spectroscopy and imaging in metabolic myopathies. Neurol Clin 18: 35-52.

Argov, Z., Lofberg, M., Arnold, D.L. (2000) Insights into muscle diseases gained by phosphorus magnetic resonance spectroscopy. Muscle Nerve 23: 1316-34.

Argov, Z., Sadeh, M., Mazor, K., Soffer, D., Kahana, E., Eisenberg, I., Mitrani-Rosenbaum, S., Richard, I., Beckmann, J., Keers, S., Bashir, R., Bushby, K., Rosenmann, H. (2000) Muscular dystrophy due to dysferlin deficiency in Libyan Jews. Clinical and genetic features. Brain 123: 1229-37.

Chen, J.T., Taivassalo, T., Argov, Z., Arnold, D.L. (2001) Modeling in vivo recovery of intracellular pH in muscle to provide a novel index of proton handling: application to the diagnosis of mitochondrial myopathy. Magn Reson Med 46: 870-8.

Eisenberg, I., Hochner, H., Shemesh, M., Levi, T., Potikha, T., Sadeh, M., Argov, Z., Jackson, C.L., Mitrani-Rosenbaum, S. (2001) Physical and transcriptional map of the hereditary inclusion body myopathy locus on chromosome 9p12-p13. Eur J Hum Genet 9: 501-9.

Eisenberg, I., Avidan, N., Potikha, T., Hochner, H., Chen, M., Olender, T., Barash, M., Shemesh, M., Sadeh, M., Grabov-Nardini, G., Shmilevich, I., Friedmann, A., Karpati, G., Bradley, W.G., Baumbach, L., Lancet, D., Asher, E.B., Beckmann, J.S., Argov, Z., Mitrani-Rosenbaum, S. (2001) The UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase gene is mutated in recessive hereditary inclusion body myopathy. Nat Genet 29: 83-7.

McNally, E.M., Ly, C.T., Rosenmann, H., Mitrani Rosenbaum, S., Jiang, W., Anderson, L.V., Soffer, D., Argov, Z. (2000) Splicing mutation in dysferlin produces limb-girdle muscular dystrophy with inflammation. Am J Med Genet 91: 305-12.

Meiner, V., Shpitzen, S., Mandel, H., Klar, A., Ben-Neriah, Z., Zlotogora, J., Sagi, M., Lossos, A., Bargal, R., Sury, V., Carmi, R., Leitersdorf, E., Zeigler, M. (2001) Clinical-biochemical correlation in molecularly characterized patients with Niemann-Pick type C. Genet Med 3: 343-8.

Steiner, I., Farcas, P., Wirguin, I. (2000) Tattoo-related brachial plexopathies with adjacent muscle atrophy. Ann Intern Med 133: 158-9.

Tartaglia, M.C., Chen, J.T., Caramanos, Z., Taivassalo, T., Arnold, D.L., Argov, Z. (2000) Muscle phosphorus magnetic resonance spectroscopy oxidative indices correlate with physical activity. Muscle Nerve 23: 175-81.

Neuroendocrinology and Neuroimmunomodulation

Barak, O., Goshen, I., Ben-Hur, T., Weidenfeld, J., Taylor, A.N., Yirmiya, R. (2002) Involvement of brain cytokines in the neurobehavioral disturbances induced by HIV-1 glycoprotein120. Brain Res 933: 98-108.

Ben-Hur, T., Cialic, R., Itzik, A., Barak, O., Yirmiya, R., Weidenfeld, J. (2001) A novel permissive role for glucocorticoids in induction of febrile and behavioral signs of experimental herpes simplex virus encephalitis. Neuroscience 108: 119-27

Ben-Hur, T., Cialic, R., Itzik, A., Yirmiya, R., Weidenfeld, J. (2001) Acute effects of purified and UV-inactivated Herpes simplex virus type 1 on the hypothalamo-pituitary-adrenocortical axis. Neuroendocrinology 74: 160-6.

DeKeyser, F.G., Leker, R.R., Weidenfeld, J. (2000) Activation of the adrenocortical axis by surgical stress: involvement of central norepinephrine and interleukin-1. Neuroimmunomodulation 7: 182-8

Feldman, S., Newman, M.E., Weidenfeld, J. (2000) Effects of adrenergic and serotonergic agonists in the amygdala on the hypothalamo-pituitary-adrenocortical axis. Brain Res Bull 52: 531-6.

Feldman, S., Weidenfeld, J. (2001) Electrical stimulation of the dorsal hippocampus caused a long lasting inhibition of ACTH and adrenocortical responses to photic stimuli in freely moving rats. Brain Res 911: 22-6.

Ovadia, H., Abramsky, O., Feldman, S., Weidenfeld, J. (2001) Evaluation of the effect of stress on the blood--brain barrier: critical role of the brain perfusion time. Brain Res 905: 21-5.

Weidenfeld, J., Feldman, S. (2000) Effects of adrenalectomy and corticosterone replacement on the hypothalamic-pituitary response to neural stimuli. Brain Res 877: 73-8.

Weidenfeld, J., Feldman, S., Itzik, A., Van de Kar, L.D., Newman, M.E. (2002) Evidence for a mutual interaction between noradrenergic and serotonergic agonists in stimulation of ACTH and corticosterone secretion in the rat. Brain Res 941: 113-117.

Wohlman, A., Yirmiya, R., Gallily, R., Weidenfeld, J. (2001) Effect of Mycoplasma fermentans on brain PGE(2): role of glucocorticoids and their receptors. Neuroimmunomodulation 9: 141-7

Yirmiya, R., Pollak, Y., Barak, O., Avitsur, R., Ovadia, H., Bette, M., Weihe, E., Weidenfeld, J. (2001) Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents. Neuropsychopharmacology 24: 531-44.

Yirmiya, R., Pollak, Y., Morag, M., Reichenberg, A., Barak, O., Avitsur, R., Shavit, Y., Ovadia, H., Weidenfeld, J., Morag, A., Newman, M.E., Pollmacher, T. (2000) Illness, cytokines, and depression. Ann N Y Acad Sci 917: 478-87

Neuroocology, Brain tumors and Blood Brain Barrier

Bokstein, F., Lossos, A., Lossos, I.S., Siegal, T. (2002) Central nervous system relapse of systemic non-Hodgkin's lymphoma: results of treatment based on high-dose methotrexate combination chemotherapy. Leuk Lymphoma 43: 587-93.

Cohen, Y., Lossos, A., Polliack, A. (2002) Neurotoxicity with leukoencephalopathy after a single intravenous high dose of methotrexate in a patient with lymphoma. Acta Haematol 107: 185-6

Doolittle, N.D., Anderson, C.P., Bleyer, W.A., Cairncross, J.G., Cloughesy, T., Eck, S.L., Guastadisegni, P., Hall, W.A., Muldoon, L.L., Patel, S.J., Peereboom, D., Siegal, T., Neuwelt, E.A. (2001) Importance of dose intensity in neuro-oncology clinical trials: summary report of the Sixth Annual Meeting of the Blood-Brain Barrier Disruption Consortium. Neuro-oncol 3: 46-54.

Doolittle, N.D., Miner, M.E., Hall, W.A., Siegal, T., Jerome, E., Osztie, E., McAllister, L.D., Bubalo, J.S., Kraemer, D.F., Fortin, D., Nixon, R., Muldoon, L.L., Neuwelt, E.A. (2000) Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors. Cancer 88: 637-47.

Israel, Z.H., Lossos, A., Barak, V., Soffer, D., Siegal, T. (2000) Multifocal demyelinative leukoencephalopathy associated with 5-fluorouracil and levamisole. Acta Oncol 39: 117-20

Lossos, I.S., Breuer, R., Intrator, O., Lossos, A. (2000) Cerebrospinal fluid lactate dehydrogenase isoenzyme analysis for the diagnosis of central nervous system involvement in hematooncologic patients. Cancer 88: 1599-604.

Siegal, T., Rubinstein, R., Bokstein, F., Schwartz, A., Lossos, A., Shalom, E., Chisin, R., Gomori, J.M. (2000) In vivo assessment of the window of barrier opening after osmotic blood-brain barrier disruption in humans. J Neurosurg 92: 599-605.

Siegal, T., Zylber-Katz, E. (2002) Strategies for increasing drug delivery to the brain: focus on brain lymphoma. Clin Pharmacokinet 41: 171-86

Zylber-Katz, E., Gomori, J.M., Schwartz, A., Lossos, A., Bokstein, F., Siegal, T. (2000) Pharmacokinetics of methotrexate in cerebrospinal fluid and serum after osmotic blood-brain barrier disruption in patients with brain lymphoma. Clin Pharmacol Ther 67: 631-41


Ball, M.J., Mathews, R., Steiner, I., Hill, J. M., Wisner, T.W., Murdoch, G.H., Kohama, S., Sexton, G., Nagalla, S. (2001) Latent HSV 1 virus in trigeminal ganglia: the optimal site for linking prevention of Alzheimer's disease to vaccination. Neurobiol Aging 22: 705-9; discussion 717-9.

Ben-Paz, H., Bergman, H., Goldber, J.A., Giladi, N., Hansel, D., Reches, A., Simon, E.S. (2001) Synchrony of rest tremor in multiple limbs in Parkinson's disease: evidence for multiple oscillators. J Neural Transm 108: 287-96

Biran, I., Steiner, I. (2001) The speech disorder of Doc in Walt Disney's "Snow White and the Seven Dwarfs". Neurology 57: 363.

Biran, I., Steiner, I. (2002) Coital headaches induced by amiodarone. Neurology 58: 501-2.

Cohen, R., Reches, A., Steinberg, A., Kedar, H. (2000b) Evaluation of a workshop to teach clinical bioethics in the clinical setting. Med Law 19: 451-61

Diener, H.C., Jansen, J.P., Reches, A., Pascual, J., Pitei, D., Steiner, T.J. (2002) Efficacy, tolerability and safety of oral eletriptan and ergotamine plus caffeine (Cafergot) in the acute treatment of migraine: a multicentre, randomised, double-blind, placebo-controlled comparison. Eur Neurol 47: 99-107

Linetsky, E., Planer, D., Ben-Hur, T. (2000) Echolalia-palilalia as the sole manifestation of nonconvulsive status epilepticus. Neurology 55: 733-4.

Nishino, I., Spinazzola, A., Papadimitriou, A., Hammans, S., Steiner, I., Hahn, C.D., Connolly, A.M., Verloes, A., Guimaraes, J., Maillard, I., Hamano, H., Donati, M.A., Semrad, C.E., Russell, J.A., Andreu, A.L., Hadjigeorgiou, G.M., Vu, T.H., Tadesse, S., Nygaard, T.G., Nonaka, I., Hirano, I., Bonilla, E., Rowland, L.P., DiMauro, S., Hirano, M. (2000) Mitochondrial neurogastrointestinal encephalomyopathy: an autosomal recessive disorder due to thymidine phosphorylase mutations. Ann Neurol 47: 792-800.

Steiner, I., Newman, J.P. (2001) Head size and cognitive ability in nondemented older adults are related. Neurology 57: 2149-50.

Steiner, I., Steiner-Birmanns, B., Levin, N., Hershko, K., Korn-Lubetzki, I., Biran, I. (2001) Spinal cord involvement in uncomplicated herpes zoster. Clin Diagn Lab Immunol 8: 850-1.

Vaknin-Dembinsky, A., Eliakim, R., Steiner, I. (2002) Neurological deficits in patients with celiac disease. Arch Neurol 59: 647-8.