Research Laboratories

The Center’s clinical research focuses on the development of new treatment modalities based on innovative biotechnologies for a range of diseases that may be curable by cellular therapy and/or immunological manipulations. New therapeutic regimens that consist of less intensive chemotherapy and more effective immunotherapy are already being clinically applied. They have proved their ability to reduce short- and long-term toxicity and mortality, and are well-tolerated and relatively safe for patients of all ages.

The research activities of the Department are concentrated on the following areas:

  • Improving methods for safer and more effective stem cell transplantation for the treatment of malignant and non-malignant disorders
  • New approaches for cancer immunotherapy
  • Development and clinical application of tumor cell vaccines
  • Gene therapy for cancer and genetic disorders
  • New approaches for the treatment of autoimmune diseases based on stem cell transplantation and immune regulation
  • New approaches for the induction of transplantation tolerance to cellular and organ allografts and xenografts
  • Study of the biology and plasticity of hematopoietic stem cells derived from cord blood, and their clinical application
  • New approaches for the treatment of AIDS and resistant viral infections
  • New approaches for the enhancement of immunological reconstitution
  • Development of new drugs, focusing on small molecules for regulation of the immune system and autoimmunity
  • New immunotherapy protocols and procedures that focus on adoptive allogeneic cell therapy, cytokines, targeted chemotherapy and tumor cell vaccination, are already being clinically applied for resistant acute and chronic leukemias, Hodgkin’s and non-Hodgkin’s lymphoma, multiple myeloma, myelodysplastic syndromes and metastatic solid tumors, as well as adoptive allogeneic cell mediated immunotherapy for hematological malignancies, utilizing naïve, cytokine- and tumor-specific or rather tumor-reactive lymphocytes, and cytokine

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