Hadassah Medical Center - Prof. Mia Levite

Prof. Mia Levite

Prof. Mia Levite is group leader at the Gene Therapy Institute. Prof. Levite have explored scientifically and clinically related research in Neuroimmunology. Neuroimmunology is the field of bi-directional communications between the nervous system and the immune system.

Her work focuses on, understanding Nerve-Driven Immunity, developing of Novel ‘Personalized Adoptive Neuro-Immunotherapies, studying the expression and function of dopamine receptors and glutamate receptors in human T cells, exploring the role of autoantibodies for Glutamate receptor in Autoimmune Epilepsy, and studying the role of Ion Channels receptor expression in T cells in Immunity. Dr. Levite is an author on 60 papers published in the most prestigious Journals in neuroimmunology.

Prof. Mia Levite

Prof. Mia Levite

Publications

T Cells Plead for Rejuvenation and Amplification; With the Brain's Neurotransmitters and Neuropeptides We Can Make It Happen. Levite M. Front Immunol. 2021 Mar 22; 12:617658

Neurotransmitters and Neuropeptides decrease PD-1 in T cells of healthy subjects and patients with hepatocellular carcinoma (HCC), and increase their proliferation and eradication of HCC cells 2021 May 12; 89:102159

2008 Aug;8(4):460-71 Neurotransmitters activate T-cells and elicit crucial functions via neurotransmitter receptors

Towards neuroimmunotherapy for cancer: the neurotransmitters glutamate, dopamine and GnRH-II augment substantially the ability of T cells of few head and neck cancer patients to perform spontaneous 2014 Aug;121(8):1007-27

The neurotransmitter glutamate and human T cells: glutamate receptors and glutamate-induced direct and potent effects on normal human T cells, cancerous human leukemia and lymphoma T cells, and autoimmune human T cells 2014 Aug;121(8):983-1006

Dopamine and T cells: dopamine receptors and potent effects on T cells, dopamine production in T cells, and abnormalities in the dopaminergic system in T cells in autoimmune, neurological and psychiatric diseases.2016 Ja

Instantaneous depolarization of T cells via dopamine receptors, and inhibition of activated T cells of Psoriasis patients and inflamed human skin, by D1-like receptor agonist: Fenoldopam 2019 Nov;158(3):171-193

Normal human CD4(+) helper T cells express Kv1.1 voltage-gated K(+) channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB non-canonical pathway. 2016 Mar;123(3):137-57

Glutamate receptor antibodies in neurological diseases. 2014 Aug;121(8):1029-75

Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient's glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells 2020 Aug;112:102462