Basic Research

• Ongoing Research
• New Research Projects

Clinical Research

• Ongoing Research

1. The effect of a novel bi-functional anti-superoxide-nitric-oxide donor on experimental in-stent restenosis
Principal Investigators:
C. Lotan MD, A. Haji-Yehia PhD, R. Jabara MD, G. Golomb PhD, T. Nassar PhD

2. Clinical application of synthetic heparin-mimicking polyanionic compounds in in-stent restenosis
Principal investigators:
Chaim Lotan MD and Shmuel Ben-Sasson PhD

3. Comparison of the effect of different natriuretic peptides (ANP, BNP, CNP, DNP) on cardiac myocytes and further definition of the effect of these peptides on apoptosis and its possible mechanism
Principal Investigator:
Amiram Nir MD

4. Assessment of the relationship between plasma homocysteine, mutations in methylene-tetra-hydrofolate reductase (MTHFR) and other risk factors in the development of vascular disease in women
Principal Investigators:
Chaim Lotan MD, Arthur Pollak MD, Tova Chajek MD, Gideon Friedman MD

5. The presence of the NK2.5 gene mutation in congenital heart disease: A molecular genetic analysis
Principal Investigators: Annick Rothschild MD and Azaria J-J.T. Rein MD

6. Development of a personal automatic defibrillator for out-of-hospital cardiac arrest
Principal Investigators:
A. Teddy Weiss MD, Ioni Katz PhD, Mendel Mandelbaum, Shraga Gorni

1. Cardiac dysfunction post herceptin-therapy in women with breast cancer
Principal Investigators:
Thea Pugatsch PhD, Chaim Lotan MD, Herzl Schwalb PhD

1. PRINCESS: Prevention of Re-Infarction by early treatment with CerivaStatin-Study
Principal Investigators:
Chaim Lotan MD, MD Mark Papoff MD A.Teddy Weiss MD, David Leibowitz MD

2. EPHESUS: Eplerenone in heart failure post acute myocardial infarction
Principal Investigators:
Chaim Lotan MD, Arthur Pollak MD, Bilha Kreisberg RN A.Teddy Weiss MD, David Leibowitz MD

3. RECOVER: Research into Etanercept; CytOkine antagonism in VentriculaR dysfunction
Principal Investigators:
Chaim Lotan MD, Dan AdmonMD, Bilha Kreisberg RN

4. RECOVERS:
Principal Investigator
Chaim Lotan MD

5. ACTION: Nifedipine extended release tablet BAY a 1040 calcium antagonist
Principal Investigators:
Mervin Gotsman MD, Ludmilla Lapidus MD, Yelena Novikov MD, A. Teddy Weiss MD, David Leibowitz MD

6. Evaluation of left ventricular function as a predictor of survival in thalassemic patients
Principal Investigators:
Arthur Pollak MD, Yasmin Shibli

7. The prognostic significance of troponin and echocardiographic left ventricular function in acute pulmonary edema
Principal Investigators:
A.Teddy Weiss MD, David Leibovitz MD, Chaim Lotan MD

8. TROPAMIC: The role of troponin kit in the community for diagnosis of acute myocardial infarction
Principal Investigators:
A. Teddy Weiss MD, David Planner MD, David Leibovitz MD, Menachem Nahir MD, Chaim Lotan MD

9. CAPSID: Development of a computerized automatic pressure sensor and inflator device for coronary angioplasty
Principal Investigators:
A. Teddy Weiss MD, Ioni Katz PhD, Morris Mosseri MD, Hisham Nassar MD, Yoseph Rozenman MD, Mervyn S. Gotsman MD, Chaim Lotan MD

10. Non-invasive assessment of atrial and ventricular electro-mechanical coupling and atrioventricular time intervals:
A tissue velocity Doppler study
Principal Investigators:
Azaria J-J.T. Rein MD, Clare P O'Donnell MD, Steven D Colan, MD, Gerald R Marx, MD.

11. Measuring atrioventricular conduction in the fetus using tissue velocity doppler technique
Principal investigators:
Rein AJJT, Sahn DJ, Geva T, Nir A.

12. The fetal kinetocardiogram: An alternative for the ECG in the fetus
Principal investigator:
Azaria J-J.T. Rein MD

13. Euro-SPAH
Principal Investigator:
Morris Mosseri, MD

14. SPLASH: Sonotherapy Prevention of Late Arterial In-Stent Hyperplasia
Principal Investigator:
Morris Mosseri MD

15. The role of periodontal infections as risk and prognostic factors in ischemic heart disease
Principal Investigators:
Israel Gotsman MD, Chaim Lotan MD, Ayala Stabholz DD

17. A double-blind randomized, multi-center placebo-controlled, dose-ranging study on the efficacy and safety of recombinant P-selectin glycoprotein ligand in patients with acute myocardial infarction assessed by positron emission tomography
Principal Investigators:
Chaim Lotan MD, Morris Mosseri MD

18. Assessment of risk profile in Israeli women with coronary heart disease: Comparison between Arab and Jewish women
Principal Investigators:
Rifat Jabara MD and Chaim Lotan MD

19. MAGIC: Effect of magnesium-sulfate when given IV to patients with suspected acute myocardial infarction
Principal Investigators: Morris Mosseri MD, Arthur Pollak MD, Avraham T. Weiss MD, David Leibovitz MD

20. The BeStar Study
Principal Investigator:
Morris Mosseri MD, Hisham Nassar MD

21. E-SIRIUS: A European multi-center randomized, double blind study of the SIRolimUS - coated BX velocityTM balloon-expandable stent in the treatment of patients with de novo coronary artery lesions
Principal investigator:
Morris Mosseri,MD, Chaim Lotan MD, Rifat Jabara MD, Hisham Nassar, MD

22. Nirflex/Nirtop: NIRFLEXTM vs NIRFLEXTM royal stent systems in the treatment of coronary artery lesions
Principal Investigators:
Chaim Lotan MD, Refat Jabara MD

23. The PRACTICE study: Prospective randomized placebo controlled trial to assess the role of GP Ilb/llla by Integrilin in patients with Troponin increase and non-persistent ST elevation acute coronary syndrome
Principal Investigator:
Morris Mosseri MD

24. Senior PAMI: A prospective randomized multi-centre trial acomparing two perfusion strategies in elderly patients with acute MI:primary percutaneous coronary intervention (PCI) vs intravenous thrombolytic therapy
Principal Investigator:
Morris Mosseri MD

25. Mitsubishi: A phase lla randomized, double blind, placebo controlled clinical study to examine the safety, tolerability and preliminary efficacy of MCC-135 infusion in patients following AMI
Principal Investigator
Dan Gilon MD