Head of Department: Prof. Tamir Ben-Hur
Tel: 02-6776455
Fax: 02-6437782
E-mail: laros@hadassah.org.il
STAFF
Professor Emeritus
Feldman S., M.D
Abramsky O., M.D., Ph.D., FRCP
Professors
Ben-Hur T., M.D., Ph.D (Head of Department)
Reches A., M.D
Argov Z., M.D
Siegal T., M.D. (Neurooncology)
Brenner T., Ph.D
Associate Professors
Karussis D., M.D., Ph.D
Gabizon R., Ph.D
Ovadia H., Ph.D
Senior lecturers of Neurology
Lossos A., M.D
Leker RR., M.D
Senior research associate
Rosenmann H., Ph.D
Lecturers
Meiner Z., M.D. (Mount Scopus)
Instructors
Levin N., M.D
Linetsky E., M.D
Gotkine M., M.D
Vaknin A., M.D
Raphaeli G., M.D
Ezra Y., M.D
Physicians participating in teaching
Eckstein D., M.D
Liberman A., M.D
Khaitov D., M.D
Khouri S., M.D
Eichel R., M.D
Research and teaching fellows
Newman JP, Ph.D
Gal A., M.Sc
INTRODUCTION
The Department of Neurology has several laboratories involved in research and in clinical services. Neuroimmunology - provides diagnostic services for patients suffering from neurological and muscular diseases, and conduct research on autoimmune mechanisms related to pathological conditions involving the central nervous system (multiple sclerosis), peripheral nerves (Guillain Barre syndrome) and muscles (myasthenia gravis); immunomodulation and immunosuppression of autoimmunity; transplantation of neural stem cells and remyelination.
Neurogenetics - conducts research on prion diseases, Alzheimer’s disease, tauopathies, Parkinson’s disease and inherited neuromuscular diseases. The laboratory holds a DNA bank and acts as a National Registry for Neurological Diseases. Research is conducted to allocate new mutations involved in neurological diseases. A core facility was established to test neuroprotective and neurotoxic compounds on animal models of diseases.
Neurovascular diseases - conducts experimental research on brain ischemia and stroke. The model of stroke provides a tool for the evaluation of new drugs and of novel modalities, such as enhancement of endogenous neural stem cells in order to minimize the damage caused by the insult.
Neurooncology - investigates neoplastic diseases that affect the brain. The laboratory focuses on development of diagnostic tests for specific genetic deletions and MGMT methylation. These are related to the ability of certain tumors to respond efficiently to cytotoxic drugs. The laboratory investigates the relationship between MGMT and NFkB expression in brain tumor cells. Furthermore, the laboratory has a tumor bank. Neuropsychology- provides clinical services as well as engages in research activities in the areas of behavioral neurology and clinical neuropsychology.
Clinical services include intelligence testing, neuropsychological assessment, attention deficit-hyperactivity disorder assessments (including TOVA testing) and personality assessment. Research activities include development of Hebrew-language neuropsychological tests and the investigation of neuropsychological components of neurological diseases.
RESEARCH AREAS
§ Transplantation of stem cells (Ben-Hur, Einstein)
§ Cell migration in CNS (Ben-Hur, Einstein)
§ Remyelination (Ben-Hur, Einstein)
§ Multiple sclerosis (Brenner, Karussis, Ovadia, Abramsky, Ben Hur)
§ Inflammation of the CNS (Brenner, Ovadia, Karussis, Rosenmann)
§ Acetylcholine receptor and acethlcholine esterase (Brenner)
§ Myasthenia gravis (Brenner)
§ Prion diseases (Gabizon)
§ T regulatory cells (Karussis)
§ Stromal stem cells (Karussis)
§ Anti-oxidants and MS (Ovadia, Abramsky)
§ Blood brain barrier (Ovadia, Abramsky, Siegal)
§ Brain tumors (Lavon, Siegal)
§ NFkB and MGMT (Lavon, Siegal)
§ Gene deletions (Lavon, Siegal)
§ Traumatic Brain Injury (Leker, Ovadia)
§ Stroke (Leker, Ovadia)
§ Cerebral hemmorhage (Leker)
§ Neural Stem Cells (Leker)
§ Metabolic neurological diseases (Lossos, Gabizon)
§ Alzheimer's disease (Rosenmann, Abramsky)
§ Tauopathies (Rosenmann, Abramsky)
§ Amyotrophic lateral sclerosis (Rosenmann, Abramsky, Argov)
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