Updated February 2008
Director
Hadassah Human Embryonic Stem Cell
Research Center,
The Goldyne Savad Institute of Gene Therapy
Sydney Swartz Chair in
Human Embryonic Stem Cell Research
Senior Staff Physician
Dept. of Obstetrics and Gynecology
Hadassah University Medical Center, Jerusalem
Phone: 972-2-677-7495
Fax: 972-2-643-0982
Email: reubinof@md.huji.ac.il
Academic Rank
Associate Professor of Obstetrics & Gynecology
Affiliation
Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Education
1982-1984 B.Sc. in Medical Science, with excellence, (cum laude) Hebrew University - Hadassah Medical School, Jerusalem
1985-1988 Medical training, Hebrew University - Hadassah Medical School, Jerusalem
1985-1990 M.Sc. in Neurobiology, with special distinction (summa cum laude) Hebrew University - Hadassah Medical School, Jerusalem
1988-1989 Internship, Hadassah Medical School, Jerusalem
1989 - M.D. Graduation Hebrew University - Hadassah Medical School, Jerusalem.
1989-1995 Residency in Obstetrics and Gynecology, Hadassah Medical School, Jerusalem
1995 - Israel Boards of Obstetrics and Gynecology
1998-1999 Ph.D. in Developmental Biology at Monash University, Victoria, Australia
Awards
2004 - The ESHRE (European Society of Human Reproduction and Embryology) "Established Scientist Award" for the study: "Human embryonic stem cell-derived neural progenitors correct behavioral deficits in Parkinsonian rats."
2000 - The HWZOA (Hadassah Women Zionist Organization of America) Award for Middle Level Investigators for Excellence in Research.
2000 - The ALPHA (International Forum for Scientists in Reproductive Medicine) Award for Research Work on Human Embryonic Stem Cells.
1998 - Sir J. McNeil Scholarship Prize toward research of Ph.D. thesis.
1997 - Honored to be elected as a Teacher with Special Distinction at the Faculty of Medicine.
1996 - Honored to be included in the Rector's List of Outstanding Teachers
1995 - Israel Fertility Society Award for Most Outstanding Work in Fertility Research.
1994 - Dr. M. Stich . Faculty Prize for Special Distinction in Clinical Work
1990 - Dr. A. Heler Faculty Prize for Special Distinction of M.Sc. Thesis in Neurobiology.
1985 - Korenfeld Scholarship Prize toward research of Master's thesis
1981/2 - Honored to be included in the Dean's List of Students of Special Distinction
1984/5
Research interests
Human embryonic stem cell, cell therapy, reproduction, transplantation
Selected Recent Publications
Turetsky T, Aizenman E, Gil Y, Weinberg N, Shufaro Y, Revel A, Laufer N, Simon A, Abeliovich D, Reubinoff BE. Laser-assisted derivation of human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis. 2007. Hum Reprod 23(1):46-53.
The International Stem Cell Initiative*, Adewumi O, Aflatoonian B, Ahrlund-Richter L, Amit M, Andrews PW, Beighton G, Bello PA, Benvenisty N, Berry LS, Bevan S, Blum B, Brooking J, Chen KG, Choo AB, Churchill GA, Corbel M, Damjanov I, Draper JS, Dvorak P, Emanuelsson K, Fleck RA, Ford A, Gertow K, Gertsenstein M, Gokhale PJ, Hamilton RS, Hampl A, Healy LE, Hovatta O, Hyllner J, Imreh MP, Itskovitz-Eldor J, Jackson J, Johnson JL, Jones M, Kee K, King BL, Knowles BB, Lako M, Lebrin F, Mallon BS, Manning D, Mayshar Y, McKay RD, Michalska AE, Mikkola M, Mileikovsky M, Minger SL, Moore HD, Mummery CL, Nagy A, Nakatsuji N, O'brien CM, Oh SK, Olsson C, Otonkoski T, Park KY, Passier R, Patel H, Patel M, Pedersen R, Pera MF, Piekarczyk MS, Pera RA, Reubinoff BE, Robins AJ, Rossant J, Rugg-Gunn P, Schulz TC, Semb H, Sherrer ES, Siemen H, Stacey GN, Stojkovic M, Suemori H, Szatkiewicz J, Turetsky T, Tuuri T, van den Brink S, Vintersten K, Vuoristo S, Ward D, Weaver TA, Young LA, Zhang W. 2007. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol. 25(7):803-16.
Gropp M, Reubinoff BE. 2007. Lentiviral-RNA-Interference System Mediating Homogenous and Monitored Level of Gene Silencing in Human Embryonic Stem Cells. Cloning Stem Cells 9(3):339-45.
Brokhman I, Gamarnik-Ziegler L, Pomp O, Aharonowiz M, Reubinoff BE, Goldstein RS. 2007. Peripheral sensory neurons differentiate from neural precursors derived from human embryonic stem cells. Differentiation.
Tsafrir A, Simon A, Revel A, Reubinoff B, Lewin A, Laufer N. 2007. Retrospective analysis of 1217 IVF cycles in women aged 40 years and older. Reprod Biomed Online. 14(3):348-55.
Biton S, Gropp M, Itsykson P, Pereg Y, Mittelman L, Johe K, Reubinoff B, Shiloh Y. ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells. 2007. DNA Repair (Amst) 6(1):128-34.
Shin S, Sun Y, Liu Y, Khaner H, Svant S, Cai J, Xu XQ, Davidson BP, Stice SL, Smith AK, Goldman SA, Reubinoff BE, Zhan M, Rao MS, Chesnut JD. 2007. Whole genome analysis of human neural stem cells derived from embryonic stem cells and stem and progenitor cells isolated from fetal tissue. Stem Cells 25(5):1298-306.
Ben-Dor I, Itsykson P, Goldenberg D, Galun E, Reubinoff BE. 2006. Lentiviral vectors harboring a dual-gene system allow high and homogeneous transgene expression in selected polyclonal human embryonic stem cells. Mol Ther 14(2):255-67.
Gropp M, Reubinoff B. 2006. Lentiviral vector-mediated gene delivery into human embryonic stem cells. Methods Enzymol 420:64-81.
Herszfeld D, Wolvetang E, Langton-Bunker E, Chung TL, Filipczyk AA, Houssami S, Jamshidi P, Koh K, Laslett AL, Michalska A, Nguyen L, Reubinoff BE, Tellis I, Auerbach JM, Ording CJ, Looijenga LH, Pera MF. 2006. CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells. Nat Biotechnol 24(3):351-7.
Banin E, Obolensky A, Idelson M, Hemo I, Reinhardtz E, Pikarsky E, Ben-Hur T, Reubinoff B. 2006. Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells. Stem Cells 24(2):246-57.
Banin E, Obolensky A, Idelson M, Hemo I, Reinhardtz E, Pikarsky E, Ben-Hur T, Reubinoff B. 2006. Retinal Incorporation and Differentiation of Neural Precursors Derived from Human Embryonic Stem Cells. Stem Cells 24(2):246-57.
Itsykson P, Ilouz N, Turetsky T, Goldstein RS, Pera MF, Fishbein I, Segal M, Reubinoff BE. Derivation of neural precursors from human embryonic stem cells in the presence of noggin. 2005. Mol Cell Neurosci 30(1):24-36
Pomp O, Brockhman I, Ben-Dor I, Reubinoff BE, Goldstein RS. 2005. Generation of peripheral sensory and sympathetic neurons and neural crest cells from human embryonic stem cells. Stem Cells 23(7):923-30.
Pera MF, Andrade J, Houssami S, Reubinoff BE, Trounson A, Stanley EG, Ward-van Oostwaard D, Mummery C. 2004. Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin. J Cell Sci117:1269-1280.
Shufaro Y, Reubinoff BE. 2004. Therapeutic applications of embryonic stem cells. Best Pract Res Clin Obstet Gynecol 18:909-27.
Ben-Hur T, Idelson M, Khaner H, Pera M, Reinhartz E, Itzik A, Reubinoff BE. 2004. Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats. Stem Cells; 22(7):1246-55.
Gropp M, Itsykson P, Singer O, Ben-Hur T, Reinhartz E, Galun E, and Reubinoff BE. 2003. Stable genetic modification of human embryonic stem cells by lentiviral vectors. Molecular Therapy 7: 281-7.
Cooper S, Bennett W, Andrade J, Reubinoff BE, Thomson J, Pera MF. 2002. Biochemical properties of a keratan sulphate/chondroitin sulphate proteoglycan expressed in primate pluripotent stem cells. J Anat 200(Pt 3):259-65.
Drukker M, Katz G, Urbach A, Schuldiner M, Markel G, Itskovitz-Eldor J, Reubinoff B, Mandelboim O, Benvenisty N. 2002. Characterization of the expression of MHC proteins in human embryonic stem cells. Proc Natl Acad Sci U.S.A 99: 9864-9.
Goldstein RS, Drukker M, Reubinoff BE, Benvenisty N. 2002. Integration and differentiation of human embryonic stem cells transplanted to the chick embryo. Developmental Dynamics 225: 80-6.
Reubinoff BE, Pera M, Vajta G, Trounson AO. 2001. Effective cryopreservation of human embryonic stem cells by the open pulled straw (OPS) vitrification method. Human Reproduction 16: 2187-94.
Reubinoff BE, Itsykson P, Turetsky T, Pera M, Reinhartz E, Itzik A, Ben-Hur T. 2001. Neural progenitors from human embryonic stem cells. Nature Biotechnology 19:1134-40.
Reubinoff BE, Pera MF, Fong CY, Trounson A Bongso A. 2000. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nature Biotechnology 18(4):399-404.
Patents
1. Reubinoff BE, Pera MF, Fong CW, Trounson AO, Bongso A. Embryonic stem cells. U.S. patent application number 09/436/164, International patent application number PCT/AU99/00990, 1999.
2. Reubinoff BE, Pera MF, Ben Hur T. Embryonic stem cells and neural progenitor cells derived there from. International patent application number PCT/AU01/00278, 2001.
Research group
Ben-Dor, Israel, Ph.D. Phone: 677-7908/8273
Ben-Shushan, Etti, Ph.D. Phone: 677-8823/8894
Gropp, Michal, Ph.D. Phone: 677-8785/8274
Idelson, Maria (Ph.D. student) Phone: 677-8881/8273
Ilouz, Nili, Ph.D. Phone: 677-7908/8273
Itsykson, Pavel (Ph.D. student) Phone: 677-7945/8274
Khaner, Hanita, Ph.D. Phone: 677-8535/8273
Mordecai, Talya, B. (M.A. student) Phone: 677-8273
Singer, Orna, M.Sc. Phone: 677-8894
Turetsky, Tikva, , M.Sc. Phone: 677-8785/8274
Aharonovitz, Michal Phone: 677-8887/8274
Zur, Galit (Ph.D. student) Phone: 677-8948/8894
Yechimivitz, Nurit (Post-doc) Phone: 677-8826/8274
Shufaro, Yoel, M.D. Phone: 677-7877
Tannenbaum, Shelly, B.Sc. Phone: 677-7947
(Q & A Manager)
Collaborators
Prof. Eithan Galun – The Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem Israel. Genetic modification of human embryonic stem cells, differentiation of human embryonic stem cells into liver cells
Dr. Jacob Rachmilewitz – The Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem Israel. Immunogenicity of human embryonic stem cells.
Prof. Tamir Ben-Hur, The Agnes Ginges Center for Human Neurogenetics Department of Neurology, Hadassah University Hospital, Jerusalem Israel. Human embryonic stem cell-derived neural cells for transplantation in neurodegenerative disorders.
Dr. Gil Leibowitz, Department of Endocrinology and Metabolism. Hadassah University Hospital, Jerusalem Israel. Differentiation of human ES cells into pancreatic cells.
Prof. Menahem Segal, Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel. The electrophysiological properties of human ES cell-derived neurons.
Prof. Martin Pera, Monash Institute of Reproduction and Development, Monash University, Melbourne Australia. Derivation, characterization and differentiation of human ES cells.
Prof. Ronald S.Goldstein, Gonda Research Center, Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel. Peripheral neurons from human ES cells.
Prof. Yosef Shiloh, The David and Inez Myers Chair in Cancer Genetics and Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv. The expression and function of ATM in human ES cells.
RESEARCH SUMMARY
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