Endocrinology and Metabolism Service

Hadassah University Hospital

Ein-Karem, Jerusalem

Phone: (+972)-2-677-6787

Fax: (+972)-2-643-7940

E-mail: nesherr@cc.huji.ac.il

Senior Lecturer, Ph.D. - Ohio State University, Columbus, Ohio, 1975.

Societies  and Awards

The Wolfson Award, Israel Diabetes Association.

The M. Stiech Award, The Hebrew University School  of Medicine.

European Association for the Study of Diabetes.

Israel Diabetes Association.

Israel Endocrine Association.

American Diabetes Association

New York Academy of Sciences

Research Interest

Pancreatic beta-cell signal transduction: the role in modulation of the dynamics of the insulin response.

Animal models of type 2 diabetes mellitus.

Beta cell master developmental genes

List of Publications

Yedovitzky, M., Nesher, R. Vardi, Z., Cerasi, E.  and R. Rahamimoff. (1993). The methodology for studying coordinated calcium  concentration changes in pancreatic b cell line. Reviews in Clinical &  Basic Pharmacology 4:101-122, 1993.

Nesher, R., and Cerasi, E. (1994). Signal modulation  for phasic insulin release in normal and diabetic B-cells. In: Insulin  secretion and pancreatic B-cell research. P.R. Flatt and S. Lenzen eds.  Smith-Gordon Publ, pp. 411-419.

Nesher, R. and Cerasi, E. (1994). The spiny mouse:  In search for an animal model for the pathogenesis of Type 2 Diabetes mellitus.  Israel J. Zool, 40, 185-197.

Cerasi, E., Nesher, R., Gadot, M., Gross, D. and  Kaiser, N. (1995).Insulin secretion in obese and non-obese NIDDM. Diabetes  Res Clin Practice. 28 (suppl), S27-S37.

Kowaluru, A., Seavey, S.E., Li, G., Sorenson, R.L.,  Weinhous, A.J. Nesher, R., Rabaglia, M.E., Vadakekalam, J. and Metz, S.A.  (1996).Glucose- and GTP-dependent stimulation of the carboxyl methylation  ofCDC42 in rodent and human pancreatic islets and pure b-cells. J Clin  Invest, 98,540-555.

Kowaluru, A., Seavey, S.E., Rabaglia, M.E., Nesher,  R. and Metz, S.A.(1996). Carboxyl methylation of the catalytic subunit  of protein phosphatase 2A in insulin-secreting cells: Evidence for functional  consequences on enzyme activity and insulin secretion. Endocrinology,137:2315-2323.

Yedovitzky, M., Mochly-Rosen, D., Johnson, J.A.,  Gray, M.O., Ron, D, Abramovitch, E., Cerasi, E. and Nesher, R. (1997).  Translocation inhibitors define specificity of Protein Kinase C isoenzymes  in cells. -bpancreatic   J Biol Chem, 272:1417-1420.

Nesher, R., Gross, D.J., Donath, M.Y., Cerasi, E.  and Kaiser, N. (1999), Interactions between genetic and dietary factors  -cellbdetermine   function in Psammomys obesus, an animal model of type 2. Diabetes, 48,  731-737.

Nesher, R., Warwar, N., Khan, A., Efendic, S., Cerasi, E. and Kaiser, N.  (2001)..Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 Diabetes.   Diabetes, 50, 308-314.

Leibowitz, G., Yuli, M., Donath, M., Nesher, R., Melloul, D., Cerasi, E., Gross, D., and Kaiser, N.  (2001 ) ß-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes.  Diabetes. Feb;50 Suppl 1:S113-7.

Nesher, R. and Cerasi, E.  (2002). Modeling phasic insulin release: immediate and time-dependent effects of glucose.   Diabetes, 51 (Suppl 1):S53-S59.

Nesher, R., Anteby, E., Yedovitzky, M., Warwar, N., Kaiser, N. and Cerasi, E. (2002). ß-Cell Protein Kinases and the Dynamics of the Insulin Response to Glucose.   Diabetes, 51 (Suppl 1):S68-S73.

Pertusa , J.A.G., Nesher, R., Kaiser, N., Cerasi, E., Henquin, J.C. and Jonas, J.C.  (2002)  Comparison of the functional properties of islets from prediabetic and diabetic Psamommys obesus.    Diabetes, 51:2552–2560.

Kaiser, N., Leibowitz, G., and Nesher R. Glucotoxicity and beta-cell failure in type 2 diabetes mellitus. (2003)   J Pediatr Endocrinol Metab. 2003 Jan;16(1):5-22.