Phone: 02 6776789
Fax: 02 6421234
E mail: tally@cc.huji.ac.il
Personal Details
Born: September l2, l954, Jerusalem, Israel
Marital Status: Married, mother of 3 children
Address: 35 Beit Haaravah St. Jerusalem, Israel.
Tel. 972-2-6721714
l973 - l975 Army service (officer)
Higher Education
l976 - l978 B.S. Biology, Hebrew University-Hadassah Medical School, Jerusalem.
l979 - l983 Ph.D. in Molecular Biology, Dept. of Cellular Biochemistry Supervisor: Prof. H. Cedar, Hebrew University-Hadassah Medical School, Jerusalem. #13-17
Professional Employment
Since l985 Senior scientist, Minerva Center for Calcium and Bone Metabolism Hadassah University, Hospital, Jerusalem.
Appointments at the Hebrew University
1992 Lecturer in Medicine, Hebrew University Medical School, Jerusalem.
1998 Senior lecturer in Medicine, Hebrew University Medical School, Jerusalem.
Additional Functions
Since 2000 Member in the Research and Development advisory committee to the director of the Hadassah Medical Organization
Services in other Academic and Research institutions
2003–12–11 Nominated member in the American Society for Biochemistry and Molecular Biology (ASBMB)
Other Activities
2001-2002 Co-organizer of the RNA club meetings
2002 Co-organizer of the Minerva German-Israel School on 'Cytoplasmic fate of RNA, Berlin
2003 Organizing committee for the Symposium on post-transcriptional events & RNA fate, Maagan, Israel
Awards
l987 -
(l) Van Recklinghausen Prize of the German Society of Endocrinology for outstanding research work in the field of calcium regulating hormones and bone metabolism by a European research worker under the age of 40.
(2) The Norwich Eaton International Young Investigator Award by the American Society of Bone and Mineral Research.
Services in other Academic and Research institutions
2003–12–11 Nominated member in the American Society for Biochemistry and Molecular Biology (ASBMB)
Other Activities
2001-2002 Co-organizer of the RNA club meetings
2002 Co-organizer of the Minerva German-Israel School on 'Cytoplasmic fate of RNA, Berlin
2003 Organizing committee for the Symposium on post-transcriptional events & RNA fate, Maagan, Israel
Research Grants (T. Naveh-Many)
l985- l989 Israel Cancer Research Fund $60,000
1994-1995 Thyssen Foundation $180,000
1996-1999 Israel Academy of Sciences $150,000 Post-transcriptional regulation of the PTH gene by calcium. # 35,36,37.
1999-2002 US-Israel Binational Science Foundation $110,000/110,000 Protein-RNA Interactions regulating PTH mRNA Stability. (with G, Brewer, Piscataway, NJ) # 40.
1999-2002 Israel Academy of Sciences $155,000. Isolation of a second parathyroid protein which determines the stability of the PTH mRNA. # 39,41.
2000 Hurwitz Foundation. # 38,42. $50,000
2002-2006 Israel Academy of Sciences $160,000. Mechanisms in the regulation of PTH mRNA stability
Co-Investigator on Grants
l985-l987 Israel Cancer Association (with J. Silver) $30,000
l985-l988, 1991 Israel Academy of Sciences (with J. Silver) $100,000
l985-l993 Gesellschaft für Biotechnologische Forschung DM 90,000
l986-l990 U.S.-Israel Binational Science Foundation $90,000
l989-l99l N.I.H. (with J. Silver) $180,000
l990-l992 German-Israel Foundation for Scientific Research and Development (G.I.F.) (with J. Silver) DM 180,000
l99l-l993 U.S.-Israel Binational Science Foundation (with J. Silver) $105,000
From l992 Minerva Center in Calcium and Bone Metabolism (interest on standing endowment) (with J. Silver)
2000 Hadassah Women’s Health Program (with Z. Bar shavit) $12,500/25,000 Parathyroid hormone and bone: synthesis and action
2001 Takeda Pharmaceutical Industries (with J. Silver) $150,000
2003 Hadassah Women’s Health Program (with Z. Bar shavit) $10,000/20,000 Parathyroid hormone and bone: synthesis and action
List of Publications
Doctoral Dissertations
The organization and function of 5-methylcytosine in eukaryotic DNA, supervisor: Prof. Howard Cedar. Awarded 1994. # 1-5
Books
Parathyroid hormone molecular biology. Kluwer Academic Press (New York) 2003). Editor: Tally Naveh-Many. Invited by Landes Bioscience, Georgetown Texas. (expected to be published in December 2003).
Chapters in Collections
1. Silver J, Epstein A, Almogi G, Naveh-Many T. The effect of sex steroids on calciotropic hormones in vivo. In: Sex Steroids and Bone. Ziegler R, Pfeilschifter J, Bräutigam M (eds). Springer-Verlag (Berlin) 1994. pp 57-71.
2. Naveh-Many T, Silver J. Parathyroid hormone synthesis, secretion and action.In: Coe FL, Favus MJ, Pak C, Parks J, Preminger G (eds). Kidney Stones: Medical and Surgical Management. Raven Press (New York) 1996 pp175-199
3. Naveh-Many T, Silver J. Vitamin D and the parathyroid. In: Vitamin D. Feldman D, Glorieux F, Pike JW (eds). Academic Press (San Diego) 1997 pp 353-368.
4. Naveh-Many T, Silver J. Regulation of parathyroid hormone gene expression and secretion by vitamin D. In: Vitamin D: Molecular Biology, Physiology and Clinical Applications. Holick MF (ed). Humana Press, Totowa, NJ. 1998 pp 217-237.
5. Silver J, Naveh-Many T. Regulation of PTH synthesis and secretion and parathyroid cell proliferation. In: The Spectrum of Renal Osteodystrophy. Drueke T, Salusky I. (eds.). Oxford University Press, Oxford, UK. 1999.
6. Silver J, Naveh-Many T. Parathyroid hormone - synthesis and secretion. In: Favus MJ, Coe FL (eds). Disorders of Bone and Mineral Metabolism. Raven Press (New York) 2000.
7. Silver J, Naveh-Many T. Regulation of PTH synthesis and secretion and parathyroid cell proliferation. In: The Spectrum of Renal Osteodystrophy. Drueke T, Salusky I. (eds.). Oxford University Press, Oxford, UK. 2001 pp 25-52.
8. Silver J, Naveh-Many T, Kronenberg HM. Parathyroid Hormone - Molecular Biology. In: Principles of Bone Biology, second edition. Bilezikian JB, Raisz LG, Rodan GA (eds). Academic Press (San Diego) 2002 pp 407-422.
9. Silver J, Naveh-Many T. Parathyroid hormone - synthesis and secretion. In: Favus MJ, Coe FL (eds). Disorders of Bone and Mineral Metabolism. Raven Press (New York) 2002, pp 74-101.
10. Silver J, Naveh-Many T. Regulation of PTH gene expression by 1,25-dihydroxyvitamin D. In: Parathyroid molecular biology, Naveh-Many T (ed). Kluwer Academic Press (New York) 2003 (in press).
11. Naveh-Many T, Silver J. Regulation of parathyroid hormone (PTH) mRNA stability by calcium and phosphate. In: Parathyroid molecular biology, Naveh-Many T (ed). Kluwer Academic Press (New York) 2003 (in press).
12. Silver J, Naveh-Many T. Vitamin D and the parathyroid. In: Vitamin D, second edition. Feldman D, Glorieux F, Pike JW (eds). Academic Press (San Diego).
13. Bell O, Silver J, Naveh-Many T. Parathyroid hormone from gene to protein. In: Parathyroid molecular biology, Naveh-Many T (ed). Kluwer Academic Press (New York) 2004 (in press).
Articles
14. Naveh-Many, T. Cedar H. (1981). Active gene sequences are under methylated. Proc Natl Acad Sci USA. 78: 4246-4250.
15. Gruenbaum, Y. Naveh-Many, T. Cedar, H. Razin, A. (1981). Sequence specficity of methylation in higher plant DNA. Nature. 292: 860-862.
16. Naveh-Many, T. Cedar, H. (1982) Topographical distribution of 5-Methylcytosine in animal and plant DNA. Molec & Cell Biol. 2: 758-762.
17. Cedar, H. Stein, R. Gruenbaum, Y. Naveh-Many, T. Sziaky-gallili, N. Razin, A. (1983). Effect of DNA methylation on gene expression. Cold Spring Harbor Symposia on quantative Biology. 47: 605-609.
18. Razin, A. Webb, C. Szyf, M. Ysraeli, Y. Rosental, A. Naveh-Many, T. Sziaki-galili, N. Cedar, H. (1984). Variations in DNA methyllation during mouse cell differentiation in vivo and in vitro. Proc Natl Acad Sci USA. 871: 1296-1301.
19. Silver, J. Naveh-Many, T. Mayer, H. Smelzer, HJ. Popovtzer, MM. (l986). Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat. J Clin Invest. 78: l296-l30l.
20. Naveh-Many, T. Silver, J. (l988). Regulation of calcitonin gene transcription by vitamin D metabolites in vivo in the rat. J Clin Invest. 8l: 270-273.
21. Naveh-Many, T. Friedlaender, MM. Mayer, H. Silver, J. (l989). Calcium regulates parathyroid hormone messenger ribonucleic acid (mRNA), but not calcitonin mRNA in vivo in the rat. Dominant role of l,25-dihydroxy-vitamin D. Endocrinology. l25: 275-280.
22. Shvil, Y. Naveh-Many, T. Barach, P. Silver, J. (l990) Regulation of parathyroid cell gene expression in experimental uremia. J Amer Soc Nephrol. l: 99-l04.
23. Naveh-Many, T. Silver, J. (l990). Regulation of parathyroid hormone gene expression by hypocalcemia, hypercalcemia and vitamin D in the rat. J Clin Invest. 86: l3l3-l3l9.
24. Naveh-Many, T. Marks, R. Keshet, E. Pike, JW. Silver, J. (l990) Regulation of l,25-dihydroxyvitamin D3 receptor gene expression by l,25-dihydroxyvitamin D3 in the parathyroid in vivo. J Clin Invest. 86: l968-l975.
25. Naveh-Many, T. Raue, F. Grauer, A. Silver, J. (1992) Regulation of calcitonin gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat. J Bone Miner Res. 7:1233-1237.
26. Naveh-Many, T. Almogi, G. Livni, N. Silver, J. (1992). Estrogen receptors and biological response in rat parathyroid tissue and C-cells. J Clin Invest. 90:2434-2438.
27. Grauer, A. Klein, P. Naveh-Many, T. Silver, J. Ziegler, R. Raue, F.(1993). Diminished calcitonin secretion after ovariectomy without apparent reduction in calcitonin content in the rat. Horm metab Res. 25: 389-390.
28. Naveh-Many, T. Silver, J. (1993). Effects of calcitriol, 22-oxacalcitriol and calcipotriol on serum calcium and parathyroid hormone gene expression. Endocrinology. 133:2724-2728.
29. Moallem, E. Silver, J. Naveh-Many, T. (1995) Regulation of parathyroid hormone messenger RNA levels by protein kinase A and C in bovine parathyroid cells. J Bone Miner Res. 10: 447-452.
29. Kilav, R. Silver, J. Biber, J. Murer, H. Naveh-Many, T. (1995). Coordinate Regulation of the Rat Renal Parathyroid Hormone Receptor mRNA and the Na/Pi-cotransport mRNA and Protein. Amer J Physiol. 268: F1017-F1022.
30. Kilav, R. Silver, J. Naveh-Many, T. (1995). Parathyroid hormone gene expression in hypophosphatemic rats. J Clin Invest. 96: 327-333.
31. Naveh-Many, T. Rahamimov, R. Livni, N. Silver, J. (1995). Parathyroid cell proliferation in normal and chronic renal failure rats: the effects of calcium, phosphate and vitamin D. J Clin Invest. 96: 1786-1793.
32. Epstein, E. Silver, J. Almogi, G. Livni, N. Naveh-Many, T. (1996). Parathyroid hormone mRNA levels are increased by progestins and vary during the rat estrus cycle. Am. J. Physiol. 33:E158-E163.
33. Marks, KH. Kilav, R. Berman, E. Naveh-Many, T. Silver, J. (1997). Parathyroid hormone gene expression in Hyp mice fed a low phosphate diet. Nephrol Dialysis Transplantation. 12:1581-1585
34. Cohen, Y. Rahamimov, R. Naveh-Many, T. Silver, J. Rahamimoff, R. (1997). Where is the ‘Inverting Factor’ in hormone secretion from Parathyroid cells? Am. J. Physiol. 36:E630-E637.
34. Moallem, E. Kilav, R. Silver, J. Naveh-Many, T. (1998). RNA-protein binding and post-transcriptional regulation of PTH gene expression by calcium and phosphate. J. Biol. Chem. 273:5253-5259.
35. Sela-Brown, A. Russell, J. Koszewski, NJ. Michalak, M. Naveh-Many, T. Silver, J. (1998). Calreticulin inhibits vitamin D’s action on the PTH gene in vitro and may prevent vitamin D’s effect in vivo in hypocalcemic rats. Molecular Endocrinology 12:1193-1200.
36. Yalcindag, C. Silver, J. Naveh-Many, T. (1999). Mechanism of increased PTH mRNA in experimental uremia: roles of protein RNA binding and RNA degradation.
J Amer Soc Nephrol. 10:2562-2568.
37. Moz, Y. Silver, J. Naveh-Many, T. (1999). Protein-RNA interactions determine the stability of the renal Na/Pi-2 cotransporter mRNA and its translation in hypophosphatemic rats. J Biol Chem. 274:25266-25272.
38. Epstein, E. Sela-Brown, A. Ringel, I. Kilav, R. King, SM. Benashski, S. Yisraeli, JK. Silver, J. Naveh-Many, T. (2000). Dynein light chain (Mr 8000) binds the parathyroid hormone mRNA 3'-untranslated region and mediates its association with microtubules. J Clin Invest. 105:505-512.
39. Sela-Brown, A. Silver, J. Brewer, G. Naveh-Many, T. (2000). Identification of AUF1 as a parathyroid hormone mRNA 3’-untranslated region binding protein that determines parathyroid hormone mRNA stability. J Biol Chem. 275:7424-7429.
40. Kilav, R. Silver, J. Naveh-Many, T. (2001). A conserved cis-acting element in the parathyroid hormone 3’-untranslated region is sufficient for regulation of RNA stability by calcium and phosphate. J Biol Chem. 276:8727-33.
41. Moz, Y. Silver, J. Naveh-Many, T. (2003). Characterization of a cis-acting elment in the renal NaPi-2 co-transporter mRNA that determines mRNA stability. Am J Physiol. 284:F663-670.
42. Kilav, R. Bell, O. Le, SY, Silver J. Naveh-Many, T (2004). The PTH mRNA 3’-UTR AU rich element is an unstructured functional element. J Biol Chem. 279:2109-16
Reviews and Editorials
43. Silver J, Naveh-Many T. (1994). Regulation of the synthesis and secretion of parathyroid hormone. In: Seminars in Nephrology. Kurtzman NA, Slatopolsky E (eds). W.B.Saunders (Philadelphia) 14:175-194.
44. Silver J, Moallem E, Epstein E, Kilav R, Naveh-Many T. (1994). New aspects in the control of parathyroid hormone secretion. Current Opinion in Nephrology and Hypertension 3:379-385.
45. Naveh-Many T, Epstein E, Silver J. (1995). Estrogens and calcium regulatory hormone- potential implications for bone. Current Opinion in Nephrology and Hypertension 4:319-323.
46. Silver J, Epstein E, Naveh-Many T. (1996). Oestrogen deficiency - does it have a role in the genesis of skeletal problems of dialyzed women? Nephrology Dialysis Transplantation 11:565-566.
47. Silver J, Moallem E, Kilav R, Sela A, Naveh-Many T. (1996). New insights into the regulation of parathyroid hormone synthesis and secretion in chronic renal failure. Nephrology Dialysis Transplantation 11 (Suppl 3): 2-5.
48. Marks K.H., Kilav R., Naveh-Many T, Silver J. (1996). Calcium, Phosphate, Vitamin D and the Parathyroid. Pediatr. Nephrol. 10: 364-367.
49. Silver J, Bar Sela S, Naveh-Many T. (1997). Regulation of parathyroid cell proliferation. Current Opinion in Nephrology and Hypertension, 6:321-326.
50. Silver J, Moallem E, Kilav R, Sela A, Naveh-Many T. (1998). Regulation of the parathyroid gene by calcium, phosphate and 1,25-dihydroxyvitamin D. Nephrology Dialysis Transplantation 13 (Suppl 1):40-44.
51. Naveh-Many T, Sela-Brown A, Silver J. (1999). Protein-RNA interactions in the regulation of PTH gene expression by calcium and phosphate. Nephrology Dialysis Transplantation 14:811-813.
52. Silver J, Yalcindag C, Sela-Brown A, Kilav R, Naveh-Many T. (1999). Regulation of the parathyroid hormone gene by vitamin D, calcium and phosphate. Kidney International 56: suppl. 73, S2-S7.
53. Naveh-Many T. (1999). Post-transcriptional regulation of the parathyroid hormone gene by calcium and phosphate. Current Opinion in Nephrology and Hypertension 8:415-419.
54. Silver J, Kilav R, Sela-Brown A, Naveh-Many T. (2000). Molecular mechanisms of secondary hyperparathyroidism. Pediatr. Nephrol. 14:626-628.
55. Silver J, Kilav R, Naveh-Many T. (2002). Mechanisms of secondary hyperparathyroidism. American J of Physiology (Renal) 283:F367-F376.
56. Naveh-Many T, Bell O, Silver J, Kilav R. (2002). Cis and trans acting factors in the regulation of PTH mRNA stability by calcium and phosphate. FEBS Letters 529:60-64.
More in: PubMed
Israeli Patent
Number: 133875
Date of Patent: January 3, 2000
Title: Protein binding parathyroid hormone nucleotide sequences and uses thereof.
Inventors: Justin Silver, Tally Naveh.