Associate Professor
M.D. - Hebrew University-Hadassah Medical School, Jerusalem, 1977.
Professional Societies
1. Israel Medical Association.
2. Israel Endocrine Society.
3. Israel Diabetes Association.
4. European Association for the Study of Diabetes.
Research Interests
1. Biochemistry and pathophysiology of insulin and proinsulin production by the pancreatic b-cell in the diabetic state.
2. Treatment of insulin-dependent diabetes mellitus by immunomodulation and expansion of b-cell mass.
3. Clinical and genetic aspects of endocrine tumors.
Current Research Projects
1. The effect of the novel somatostatin analogue SOM230 on growth and development of medullary thyroid carcinoma.
2. The potential efficiacy of L-amino acid decarboxylase inhibitors for treatment of neuroendocrine tumors.
Recent Representative Publications
1. Gross DJ, Weiss L, Reibstein I, Hedlund G, Dahlén E, Rapoport MJ, Slavin S. The immunomodulator linomide: Role in treatment and prevention of autoimmune diabetes mellitus. International Immunopharmacology 1:1131-9, 2001.
2. Leibowitz G, Üçkaya G, Oprescu AI, Cerasi E, Gross DJ, Kaiser N. Glucose-regulated insulin gene expression is required for adequate insulin production during increased secretory demand. Endocrinology 143:3214-20, 2002.
3.Weiss L, Barak V, Zeira M, Abdul-Hai A, Raibstein I, Reich S, Hirschfeld E, Gross D, Slavin S. Cytokine production in Linomide treated NOD mice and the potential role of th1/th2 shift on autoimmune and anti-inflammatory processes. Cytokine 19:85-93, 2002.
4. Dahlén E, Dawe K, Ohlsson L, Hall H, Hedse K, Annersten K, Aström M, Gross DJ, Hedlund G. Linomide inhibits insulitis and modulates cytokine production in pancreatic islets in the non-obese diabetic mouse. Int Immunopharmacol. 3:17-30, 2003.
5. Gross DJ, Reibstein I, Weiss, L., Slavin S, Dafni H, Neeman M, Pines M, Nagler A. Treatment with halofuginone results in marked growth inhibition of a von Hippel-Lindau pheochromocytoma in-vivo. Clin. Cancer Res. 9:3788-93, 2003.
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