Education

M.D. – Hebrew University-Hadassah Medical School, 1988;

Internal Medicine Residency – Hadassah-Hebrew University Med. Ctr., Jerusalem, 1993;

Endocrinology Fellowship – Hadassah-Hebrew University Med. Ctr., Jerusalem, 1995

2003    Senior Lecturer of Endocrinology

2008 - Associate Professor of Endocrinology

Employment

1995-present   Senior Endocrinologist, Hadassah-Hebrew University Medical Center. 

Clinical Specialty

·         General endocrinology

·         Diabetes Mellitus

·         Pituitary disease

·         Neuroendocrine tumors (Carcinoid, Islet-cell tumors)

·         Thyroid disease

Research Activity (Areas of Research Interest)

·         Cell dyfunction in Type 2 Diabetesb Mellitus

·         Regulation of insulin gene transcription and translation in normal physiology and Type 2 Diabetes Mellitus

·         Cellb Oxidative stress and  apoptosis in Type 2 Diabetes Mellitus

·         Cell differentiation in humanb embryonic stem cells

·         Cell therapy of diabetes

Professional Organizations

·         American Diabetes Association

·         European Association for the Study of Diabetes

·         Israel Diabetes Association

·         Israel Endocrine Society

Recent publications

1. Glaser B, Leibovich G, Nesher R, Hartling S, Binder C and Cerasi E. Improved ß-cell function after intensive insulin treatment in severe non-insulin dependent diabetes. Acta Endocrinologica 1988; 118:365-373.

2. Gadot M, Leibowitz G, Shafrir E, Cerasi E, Gross DJ, and Kaiser N. Hyperproinsulinemia and insulin deficiency in the diabetic Psammomys obesus. Endocrinology 1994; 135:610-616.

3. Leibowitz G, Glaser B, Higazi AA, Salameh M, Cerasi E, Landau H. Hyperinsulinemic hypoglycemia of infancy (nesidioblastosis) in clinical remission: high incidence of diabetes mellitus and persistent ß-cell dysfunction at long-term follow-up. J Clin Endocrinol Metab 1995; 80:386-392.

4. Leibowitz G, Weintrob N, Pikarsky A, Josefsberg Z, Landau H, Glaser B, Hales CN, Cerasi E. Normal proinsulin processing despite ß-cell dysfunction in persistent hyperinsulinaemic hypoglycemia of infancy (nesidioblastosis). Diabetologia 1996; 39:1338-1344. 

5. Gross DJ, Leibowitz G, Cerasi E, Kaiser N. Increased susceptibility of islets from diabetes-prone Psammomys obesus to the deleterious effects of chronic glucose exposure. Endocrinology 1996; 137:5610-5615.

6. Kang DE, Soriano S, Frosch MP, Collins T, Naruse S, Sisodia SS, Leibowitz G, Levine F, Koo EH. Presenilin 1 facilitates the constitutive turnover of beta-catenin-signaling pathway. J Neurosci 1999; 19:4229-4237.

7. Leibowitz G, Beattie GM, Kafri T, Cirulli V, Lopez AD, Hayek A, Levine F. Gene transfer to human pancreatic endocrine cells using viral vectors. Diabetes 1999; 48:745-753.

8.  Beattie GM, Itkin-Ansari P, Cirulli V, Leibowitz G, Lopez AD, Bossie S, Mally M, Levine F, Hayek A. Sustained proliferation of PDX-1+ cells derived from human islets. Diabetes 1999; 48:1013-1019.

9. Halvorsen T, Leibowitz G,  Levine F. Telomerase activity is sufficient to allow transformed cells to escape from crisis. Mol Cell Biol 1999; 19: 1864- 1870.

10. Marshak S, Leibowitz G, Bertuzzi F, Socci C, Kaiser N, Gross DJ, Cerasi E, Melloul D. Impaired ß-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose. Diabetes 1999; 1230- 1236.

11. Levine F, Leibowitz G. Towards gene therapy of diabetes mellitus. Mol Med Today 1999; 5:165-171.

12. Leibowitz G, Levine F. Gene therapy for type 1 and type 2 diabetes. Diabetes Reviews 1999; 7:124-138.

13. Beattie GM, Leibowitz G, Lopez AD, Levine F, Hayek A. Protection from cell death in cultured human fetal pancreatic cells. Cell Transplantation 2000, 9:431-438.

14. Cerasi E, Kaiser N, Leibowitz G. Type 2 diabetes and ß-cell apoptosis. Diabetes Metab 2000; 26(Suppl 3):13-6 (in French).

15. Leibowitz G., Yuli M , Donath M., Nesher R., Melloul, D., Cerasi E., Gross D., Kaiser N. ß-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes. Diabetes 2001, 50  (Suppl. 1): S113-S117, 2001.

16. Leibowitz G,  Ferber S, Aperlqvist A, Edlund H, Gross DJ, Cerasi E, Melloul D, Kaiser N. ß-cell dysfunction due to lack of IPF1/PDX1 in Psammomys obesus, an animal model with diet-dependent type 2 diabetes. Diabetes 2001, 50:1799-1806.

17. Metzger M, Leibowitz G, Wainstein J, Glaser B, Raz I.  Low accuracy and reproducibility of glucose measurements using the glucose sensor. Diabetes care, 2002; 25:1185-1191

18. Leibowitz G, Uckaya G, Oprescu A, Cerasi E, Gross DJ, Kaiser N. Glucose-regulated proinsulin gene expression is required for adequate insulin production during chronic glucose exposure. Endocrinology 2002, 143: 3214-3220

19. Leibowitz G, Oprescu, AI, Uckaya G, Gross, DJ, Cerasi E, Kaiser N. Insulin does not mediate glucose stimulation of proinsulin biosynthesis. Diabetes 2003, 52: 998-1003

20. Kaiser N, Leibowitz G, Nesher R. Glucotoxicity and ß-cell failure in type 2 diabetes. J Ped Endocrinol Metab 2003; 16:5-22

Chapters in Books

1. Glaser B, Leibowitz G.  Hyopglycemia. In: Joslin’s Diabetes Mellitus, 14th edition. Kahn CR, Weir GC eds (in press).