Professor of Endocrinology
Director
Endocrinology and Metabolism Service
Hadassah-Hebrew University Medical Center
Tel: (+972) 2 677 6599, (+972) 2 6776788
Fax: (+972) 2 643 7940
E-mail: beng@cc.huji.ac.il
Education
M.D. - University of Maryland, Baltimore Maryland, 1975;
Internal Medicine Residency - Washington Hospital Center, Washington, DC, 1978;
Endocrinology Fellowship - University of Michigan, Ann Arbor, 1980
Employment
1981-1984 - Senior Endocrinologist, Carmel Hospital and Linn Clinics, Haifa
1984-present - Senior Endocrinologist, Hadassah-Hebrew University Medical Center.
2001-present- Professor of Endocrinology
2001-present - Director: Endocrinology and Metabolism Service
Clinical Specialty
General endocrinology
Pituitary disease
Neuroendocrine tumors (Carcinoid, Islet-cell tumors)
Thyroid disease
Diabetes
Areas of Research Interest
Genetics of Type 2 Diabetes Mellitus
Genetics of Diabetic Complications
Genetics of Persistent Hyperinsulinemic Hypoglycemia of Infancy
Control of Human Pancreatic Beta-cell Proliferation
Genetic Etiology of Monogenic Endocrine Diseases
Clinical Use of Somatostatin Analogues in the Treatment of Endocrine Diseases
Professional Organizations
American Endocrine Society
American Diabetes Association
European Association for the Study of Diabetes
Israel Diabetes Association
Israel Endocrine Society
Recent publications
Glaser, B., Hirsch, H.J., Landau, H. Persistent Hyperinsulinemic Hypoglycemia of Infancy: Long-term Octreotide Treatment Without Pancreatectomy. J Pediatr 123:644-650, 1993.
Glaser, B., Chiu, K.C., Anker, R., Nestorowicz, A., Landau, H., Ben-Bassat, H., Shlomai, Z., Kaiser, N., Thornton, P.S., Stanley, C.A., Spielman, R.S., Gogolin-Ewens, K., Cerasi, E., Baker, L., Rice, J., Donis-Keller, H., Permutt, M.A. Familial Hyperinsulinism maps to chromosome 11p14-15.1 — 30 cM centromeric to the insulin gene. Nature Genet 7:185-188, 1994.
Leibowitz, G., Glaser, B., Higazi, A.A., Salameh, M., Cerasi, E., Landau, H. Hyperinsulinemic Hypoglycemia of Infancy (Nesidioblastosis) in Clinical Remission: High Incidence of Diabetes Mellitus and Persistent B~eta-cell Dysfunction at Long-term Follow-up. J Clin Endocrinol Metab 80:386-392, 1995.
Glaser, B., Chiu, K.C., Liu, L., Anker, R., Nestorowicz, A., Cox, N., Landau, H., Kaiser, N., Thornton, P.S., Stanley, C.A., Cerasi, E., Baker, L., Donis-Keller, H., Permutt, M.A. Recombinant mapping of the Familial Hyperinsulinism gene to an 0.8 cM region on chromosome 11p15.1 and demonstration of a founder effect in Ashkenazi Jews. Hum. Mol. Genet.4:879-886, 1995.
Sheffield, V.C., Kraiem, Z., Beck, J.C., Nishimura, D., Stone, E.M., Salameh, M., Sadeh, O., Glaser, B. Pendred's Syndrome maps to Chromosome 7q21-34 and is caused by an intrinsic defect in thyroid iodine organification. Nature Genetics 12:424-427, 1996.
Nichols, C.G., Shyng, S.-L., Nestorowicz, A., Glaser, B., Clement, J.P. IV, Gonzalez, G., Aquilar-Bryan, L., Permutt, M.A., Bryan, J. Adenosine Diphosphate as an intracellular regulator of insulin secretion. Science 272:1785-1787, 1996.
Leibowitz, G., Weintrob, N., Pikarsky, A., Josefsberg, Z., Landau, H., Glaser, B., Hales, C.N., and Cerasi, E. Normal Proinsulin Processing Despite Beta-Cell Dysfunction in Persistent Hyperinsulinaemic Hypoglycaemia of Infancy (Nesidioblastosis). Diabetologia 39:1338-1344, 1996.
Ilkova, H., Glaser, B., Tunçkale, A., Bagriaçik, N., Cerasi, E. Induction of Long-Term Glycemic Control in Newly Diagnosed Type 2 Diabetic Patients by Transient Intensive Insulin Treatment. Diabetes Care 20:1353-1356, 1997.
Everett, L.A., Glaser, B., Beck, J.C., Idol, J.R., Buchs. A., Heyman, M., Adawi, F., Hazani, E., Nassir, E., Baxevanis, A.D., Sheffield, V.C., Green, E.D. Pendred Syndrome is Caused by Mutations in a Putative Sulphate Transporter Gene (PDS). Nature Genetics 17:411-422, 1997.
Glaser, B., Kesavan, P., Heyman, M., Davis, E., Cuesta, A., Buchs, A., Stanley, C.A., Thornton, P.S., Permutt, M.A., Matschinsky, F.M., Herold, K.C. Familial Hyperinsulinism Caused By A Novel Glucokinase Mutation With Increased Glucose Affinity. NEJM 338:226-230, 1998.
Ryan, F., Devaney, D., Joyce, C., Nestorowicz, A., Permutt, M.A., Glaser, B., Barton, D.E., Thornton, P.S. Hyperinsulinism: The molecular aetiology of focal disease. Arch Dis Child 79:445-447, 1998.
Glaser, B., Furth, J., Stanley, C.A., Baker, L., Thornton, P.A., Landau, H., Permutt, M.A. Intragenic Single Nucleotide Polymorphism Haplotype Analysis of SUR1 Mutations in Familial Hyperinsulinism. Human Mutation, 14:23-29, 1999.
Glaser, B., Ryan, F., Stanley, C.A., Baker, L., Barton, D., Thornton, P.S. Familial Hyperinsulinism: Paternal Inheritance of a Recessive Mutation in a Non-Imprinted Gene Results in Clinical Disease. Diabetes, 48:1652-1657, 1999.
Kassem, S. A., Ariel I., Thornton P.S., Cell Proliferationb Scheimberg I., and Glaser B. and Apoptosis in the Normal Fetal and Neonatal Human Pancreas and in Persistent Hyperinsulinemic Hypoglycemia of Infancy (PHHI). Diabetes 49:1325-1333, 2000.
Bitner-Glindzicz, M., Lindley, K., Rutland, P., Blaydon, D., Smith, V., Hussain, K., Scanlan, M., Furth, J., Cosgrove, K.E., Shepherd, R.M., Barnes, P.D., O’Brien, R.E., Dunne, M.J., Malcolm, S., Farndon, P., Liu, X., Aynsley-Green, A., Glaser, B. Usher 1c gene identified by genetic evaluation of novel recessive contiguous gene syndrome which includes both hyperinsulinism and deafness. Nature Genetics 26:56-60, 2000.
Straub, S.G., Cosgrove, K.E., Ammala, C., Shepherd, R.M., O'Brien, R.E., Barnes, P.D., Kuchinski, N., Chapman, J.C., Schaeppi, M., Glaser, B., Lindley, K.J., Sharp, G.W.G., Aynsley-Green, A., Dunne, M.J. Hyperinsulinism of Infancy; The regulated release of insulin by KATP channel-independent pathways. Diabetes, 50:329-339, 2001.
Permutt, M.A., Wasson, J.C., Suarez, B.K., Lin, J., Thomas, J., Meyer, J., Lewitzky, S., Rennich, J.S., Parker, A., DuPrat, L., Maruti, S., Chayen, S., Glaser, B. A genome scan for Type 2 Diabetes Mellitus susceptibility loci in a genetically isolated population. Diabetes, 50:681-685, 2001.
Kadouri, L, Easton, D.F., Edwards, S., Hubert, A., Kote-Jarrai, Z., Glaser, B., Abeliovich, D., Peretz, T., Eeles, R.A. CAG and GGC repeat polymorphisms in the androgen receptor gene and breast cancer susceptibility in BRCA1/2 carriers and Non-carriers of Ashkenazi Origin. Brit J Cancer, 85:36-40, 2001.
Matsubara, A., Wasson, J.C., Donelan, S.S., Welling, C.M., Glaser, B. and Permutt, M.A. Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and lack of association with Type II (non-insulin-dependent) diabetes mellitus Diabetologia, 44:910-913, 2001.
Chen, H., Jawahar, S., Qian, Y., Duong, Q., Chan G., Parker, A., Meyer, J.M., Moore, K.J., Chayen, S., Gross, D.J., Glaser, B., Permutt, M. A., Fricker, L.D. Missense Polymorphism in the Human Carboxypeptidase E Gene Alters Enzymatic Activity. Hum Mutat 18:120-131, 2001.
Kassem, S.A., Ariel, I., Thornton, P.S., Hussain, K., Smith, V., Lindley, K.J., Aynsley-Green, A., Glaser, B. p57KIP2 Expression in Normal Islet Cells and in Hyperinsulinism of Infancy. Diabetes 50:2763-2769, 2001.
Metzger, M., Leibowitz, G., Wainstein, J., Glaser, B., Raz, I. Reproducibility of glucose measurements using the glucose sensor. Diabetes Care, 25:1185-1191, 2002.
Hussain, K., Cosgrove, K.E., Shepherd, R.M., Chapman, J.C., Swift, S.M., Smith, V.V., Kassem, S.A., Glaser, B., Lindley, K.J., Aynsley-Green, A., Dunne, M.J. Uncontrolled insulin secretion from a childhood pancreatic beta-cell adenoma is not due to the functional loss of ATP-sensitive potassium channels. Endocr Relat Cancer 9:221-226 2002.
Permutt, M.A., Wasson, J., Love-Gregory, L., Ma, J., Skolnick, G., Suarez, B., Lin, J., and Glaser, B. Searching for type 2 diabetes genes on chromosome 20. Diabetes 51 Suppl 3:S308-315 2002.
McCarthy, J.J., Lewitzky, S., Reeves, C., Permutt, M.A., Glaser, B., Groop, L.C., Thomas Lehner, Meyer, J. Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations. Human Heredity 55:163-70, 2003.
Kadouri L, Kote-Jarai Z, Hubert A, Durocher F, Abeliovich D, Glaser B, Hamburger T, Eeles RA, Peretz T: A single-nucleotide polymorphism in the RAD51 gene modifies breast cancer risk in BRCA2 carriers, but not in BRCA1 carriers or noncarriers. Br J Cancer 90:2002-2005, 2004
Kadouri, L., Kote-Jarai, Z., Easton, D.F., Hubert, A., Hamoudi, R., Glaser, B., Abeliovich, D., Peretz, T., and Eeles, R.A. Polyglutamine repeat length in the AIB1 gene modifies breast cancer susceptibility in BRCA1 carriers. Int J Cancer 108:399-403, 2004.
Love-Gregory LD, Wasson J, Ma J, Jin CH, Glaser B, Suarez BK, Permutt MA: A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an Ashkenazi Jewish population. Diabetes 53:1134-1140, 2004
Reviews and Chapters
Glaser, B., Thornton P., Otonkoski, T. Junien, C. The Genetics of Hyperinsulinism, Arch Dis Child Fetal Neonatal Ed 82:F79-F86, 2000 (review).
Glaser, B. Genetics of Hyperinsulinism of Infancy. Seminars in Perinatology 24:150-163, 2000 (review).
Glaser, B., Aguilar-Bryan, L. The role of ATP-sensitive K+ channels in familial Hyperinsulinism, in: F. Lehmann-Horn and K. Jurkat-Rott eds. Channelopathies - Common Mechanisms in Aura, Arrhythmia and Alkalosis. Advances in Molecular and Cell Biology. Elsevier Science B.V., 2000.
Glaser, B. Familial Hyperinsulinism (FHI), In: GeneReviews at GeneTests: Medical Genetics Information Resource (database online). Copyright, University of Washington, Seattle. 1997-2003. Available at http://www.genetests.org. Update: 19 August, 2003.
Glaser, B., Leibowitz, G. Hypoglycemia. In: Kahn, C.R. ed. Joslin Textbook of Diabetes Mellitus (Publication planned for 2004)
Books
Glaser, B. Genetics for Endocrinologists. REMEDICA Publishing Ltd, London, UK. 2003.