Born: Be’er Sheva, Israel, 1951
1977 - Completed M.D.: Hadassah-Hebrew University Medical School, Jerusalem.
1980-1986: Resident in Obstetrics and Gynecology, Hadassah University Hospital, Mt. Scopus, Jerusalem, Israel; Instructor in and Gynecology, Hadassah University Hospital.
1987-1988: Post - doctoral fellowship (MRC Scholar). P.K. Lala, M.D. PhD, Professor and Chair, Obstetrics and Gynecology, Hebrew University - Hadassah Medical School.
1985-1986: One year of laboratory research at the Lautenberg Center for General and Tumor Immunology, Hebrew University - Hadassah Medical School, Jerusalem, Israel, as part of residency program.
1986: Lecturer in Obstetrics Department of Anatomy, Supervisor.
1987-1988: Departments of Anatomy and Cancer Research, Dr. D.T. Denhart, Chair, University of Western Ontario, London, Ontario, Canada.
1988: The Division of Cancer and Cell Biology, headed by Dr. R.S. Kerbel; Mt. Sinai Research Institute; headed by Dr. L. Simonovitch; and the University of Toronto, Toronto, Ontario, Canada.
1989: Senior physician in Obstetrics and Gynecology, Hadassah University Hospital, Mt. Scopus, Jerusalem, Israel.
1989: Senior lecturer in Obstetrics and Gynecology, Faculty of Medicine of the Hebrew University - Hadassah Medical School, Jerusalem, Israel.
1990: Founder and vice-chairman of the Israel Society of Ultrasound in Obstetrics
and Gynecology.
1992: Head of the Ultrasound Unit, Department of Obstetrics and Gynecology, Hadassah University Hospital, Mt. Scopus, Jerusalem, Israel.
1992: Head of the Ultrasound Unit, Department of Obstetrics and Gynecology, Hadassah University Hospital, Mt. Scopus, Jerusalem, Israel.
1992-1993: Sabbatical, Laboratory of Radiobiology, University of California, San Francisco, with Profs. Zena Werb and Susan Fisher.
1994: Professor of Obstetrics and Gynecology, Faculty of Medicine of the Hebrew University - Hadassah Medical School, Jerusalem, Israel.
1999: Member of Morphological Sciences Table of the Department of Anatomy and Cell Biology of the Hebrew University - Hadassah Medical School, Jerusalem, Israel.
1999-2002: Chairman of the Israel Society of Ultrasound in Obstetrics and Gynecology.
1999: Member of the Scientific Board of Biomedicom Creative Biomedical Computing, Ltd., Jerusalem, Israel.
2000: Editor of Imaging Column in Israel , Medical Association Journal, IMAJ.
2000: Full Professor of Obstetrics and Gynecology, Faculty of Medicine of the Hebrew University - Hadassah Medical School, Jerusalem, Israel.
2001 - Member of the Editorial Board, Journal of Ultrasound in Medicine.
2002 - Member of the Editorial Board, Journal of Ultrasound in Obstetrics and Gynecology.
Clinical Areas:
Obstetrics and Gynecology, Perinatology
All aspects of obstetrics and gynecology, prenatal care, vaginal delivery, cesarean delivery, all phases of women’s health, fertility, menopause, screening tests for PAP, breast cancer.
All aspects of obstetric ultrasound, including: targeted organ scanning, fetal echocardiography, 3-D ultrasound, Doppler investigations, fetal anatomic and chromosomal anomalies, and nuchal translucency.
Ultrasound guided invasive procedures such as amniocentesis, cordocentesis, chorionic villus sampling, fetal blood transfusion, multifetal pregnancy reduction.
Gynecologic ultrasound, including 3-D and Doppler evaluation, hysterosalpingography, aspiration of cysts.
Female fertility, including follicle scanning and ovulation induction, timing of conception.
Research Areas
Basic Research: Molecular biology of the placenta; immunosurveillance at the maternal fetal interface; mechanisms of preeclampsia.
Clinical Research: 3-D fetal echocardiography; evaluation of ultrasound-diagnosed fetal tumors with MRI; evaluation of ultrasound-diagnosed fetal ventriculomegaly using MRI; the efficacy of cervical cerclage in preventing preterm birth.
Grants and Awards
The involvement of interluekines in hCG production by trophoblasts. Pharmacia, 1988-89.
Medical Research Council Grant of Canada, 1986-88.
Award for excellent abstract, 43rd Annual Meeting of the SOGC, 1988, Vancouver, British Columbia, Canada.
Award for excellent presentation, 11th Annual Trophoblast Research Meeting, 1988, Rochester, NY, USA.
Grant from The Joint Fund of the Hebrew University and Hadassah, $5,000, 1990: The effect of extracellular matrix on the activation, secretion, and mRNA expression of collagenase and TIMP by rat granulosa cells.
Special grant from the Lautenberg Center for Immunology, $30,000, 1990-91.
Special grant by the Hadassah Medical Organization, $15,000, 1990: In-vitro fertilization - Molecular mechanisms involved in blastocyst implantation.
Grant of the Israel Ministry of Health, 25,000/year, 1992-3: In-vitro fertilization - Molecular mechanisms in the implantation process.
Grant of the United States - Israel Binational Science Foundation, 1994, for 3 years, $36,500 for the first year: Transcriptional regulation of HLA-G expression by cytotrophoblasts and preeclampsia.
Grant of the Chief Scientist’s Office, Israel Ministry of Health, 1998, 60,000 NIS/year: The role of invasive trophoblasts and endometrial cells on the regulation of plasminogen activator and metalloproteinases.
Grant of the Office of the Administrator General of Israel, 1998, 60,000 NIS/year: The role of invasive trophoblasts and endometrial cells on the regulation of plasminogen activator and metalloproteinases.
Award of the Israel Minister of Health for Outstanding Research, 1998: The role of invasive trophoblasts and endometrial cells on the regulation of plasminogen activator and metalloproteinases.
Grant of the Israel-U.S. Binational Industrial Research and Development Foundation, 1998: “Fetal Weight Measurement Using 3-D Ultrasound”; $1,600,000, over two years, with Biomedicom, Israel, and ATL, Seattle, Washington, USA.
Hadasit – Applied research award – “The use of antisense HLA-G nucleotides as a women’s centered anti-implantation contraceptive”- $36,000/year.
PI with Prof. Gomori, MR Guided focused ultrasound surgery in the treatment of uterine fibroids, $100,000.
PI: Professor Simcha Yagel, Dr. Ofer Mandelboim, The role of CD66a (CEACAM 1)-mediated inhibition of activated decidual lymphocytes in normal pregnancy and in maternal CMV and other bacterial and viral infections. Women’s Health Grant, 120,000 NIS. 2002.
(Advisor) PI: Professor Aryeh Hurwitz, Professor Joseph Orly, Expression and significance of sprouty proteins in human granulosa luteinized cells extracted from follicular fluid aspiration in in-vitro fertilization (IVF) Women’s Health Grant, 87,000 NIS; Chief Scientist and The Public Committee for the Designation of Estate Funds, 80,000 NIS. 2002.
(Advisor) PI: Dr. Ronit Haimov-Kochman and Professor Reuven Reich, The role of heparanase in morphogenesis, angiogenesis and sprouting of mouse and human villous placentae. Women’s Health Grant, 100,000 NIS, Chief Scientist and The Public Committee for the Designation of Estate Funds, 80,000 NIS.
(Advisor) PI: Dr. Ronit Haimov-Kochman, Dr. Zahava Rengini, The involvement of heparanase in the invasive process of trophoblast cells in human placentas of normal and toxemic pregnancies.
List of Publications
1. Noonan syndrome: A cryptic condition in early gestation. Achiron-R, Greisaro-D, Goldman-B, Lipitz-S, Yagel-S, Friedman-M. Am-J-Med-Genetics, 2000; 92:159-65.
2. Tie2 and angiopoietin-2 expression at the maternal fetal interface: A receptor ligand model for vascular remodeling. Goldman-Wohl DS, Ariel I, Greenfield C, Lavy Y and Yagel S. Mol Hum Reprod 2000;6:81-87.
3. HLA-G expression in extravillous trophoblasts is an intrinsic property of cell differentiation: A lesson learned from ectopic pregnancies. Goldman-Wohl DS, Ariel I, Greenfield C, Hanoch Y and Yagel S. Mol Hum Reprod, 2000;6:535-540.
4. Lack of HLA-G expression in extravillous trophoblasts is associated with preeclampsia. Goldman-Wohl DS, Ariel I, Greenfield C, Hochner-Celnikier D, Cross J, Fisher S and Yagel S. Mol Hum Reprod 2000;6:88-95.
5. Short delay between indomethacin treatment for preterm labor and delivery is associated with severe neonatal complications. Oppenheimer-Gazit-V, Rosen-L, Hanoch-J, Bar-Oz-B, Zucker-D, Yagel-S, Isr J Obstet Gynecol 2000.
6. Tocolytic therapy for preterm labor. Anteby EY, Cohen SM, Yagel S. Isr J Obstet Gynecol, 2000.
7. Poor prenatal detection rate of cardiac anomalies in Noonan Syndrome Menashe-M, Arbel-R, Raveh-D, Achiron-R, Yagel-S. Ultrasound-Obstet-Gynecol 2002;19:51-55.
8. Re: The clinical significance of fetal isolated cerebral borderline ventriculomegaly: report of 31 cases and review of the literature, Ultrasound Obstet Gynecol 1999; 14(5):320-6 (letter). Eizenberg-V, Yagel-S Ultrasound Obstet Gynecol 15:265-7, 2000.
9. Abnormalities of fetal central veins and umbilico-portal system: prenatal ultrasonographic diagnosis and proposed classification. Achiron R, Hegesh J, Yagel S, Lipitz S, Cohen SB, Rotstein Z. Ultrasound Obstet Gynecol. 2000;16:539-48.
10. The great tocolytic debate: Some pitfalls in the study of safety. Rosen-LJ, Zuker-D, Oppenheimer-Gazit-V, Yagel-S, Am J Obstet Gynecol 184:1-7, 2001.
11. 3-D ultrasound in obstetrics and gynecology: An update. Yagel-S. Isr-J-Obstet-Gynecol 2001;12:44-52.
12. Sonographic evaluation of ovarian morphology and pelvic blood flow after bilateral tubal ligation. Revel-A, Abramov-Y, Yagel-S, Nadjari-M. 2001.
13. Risk of fetal loss in twin pregnancies undergoing second trimester amniocentesis. Yukobowich E, Anteby EY, Cohen SM, Lavy Y, Granat M, Yagel S. Obstet Gynecol. 2001;98:231-4.
14. [The ultrasound markers of the aneuploid fetus in the first and second trimesters of pregnancy] Haimov-Kochman R, Yagel S. Harefuah. 2001;140:531-40.
15. Isolated major congenital heart disease. Allan L, Benacerraf B, Copel JA, Carvalho JS, Chaoui R, Eik-Nes SH, Tegnander E, Gembruch U, Huhta JC, Pilu G, Wladimiroff J, Yagel S. Ultrasound Obstet Gynecol. 2001;17:370-9.
16. Lack of imprinting of HLA-G in the human placenta: A study of hydatidiform moles. Goldman-Wohl DS, Ariel I, Greenfield C, Hochner-Celnikier D, Fisher S and Yagel S. Am J Obstet Gynecol 2001;185:476-480.
17. Examination of the fetal heart by five short-axis views: A proposed screening method for comprehensive cardiac evaluation. Yagel-S, Cohen SM, Achiron-R. Ultrasound Obstet Gynecol. 2001;17:367-9.
18. Monopaternal superfecundation of quintuplets after transfer of two embryos in an in vitro fertilization cycle. Amsalem H, Tsvieli R, Zentner BS, Yagel S, Mitrani Rosenbaum S, Hurwitz A. Fertil Steril. 2001;76:621-3.
19. Regulation of trophoblast invasion: from normal implantation to pre-eclampsia. Goldman-Wohl DS, Yagel S. Mol Cell Endocrin 2002;187:233-238.
20. Single umbilical artery stenosis associated with intrauterine fetal death post-transfusion. Meir K, Yagel S, Amsalem H, Ariel I. Prenat Diagn. 2002;22:186-8.
21. Controversies in route of delivery of fetuses with structural anomalies - A review of the literature. Anteby-EY, Yagel-S. Eur-J-Obstet-Gynecol 2002:12.
22. The three vessels and trachea view (3VT) in fetal cardiac screening. Yagel-S, Arbel-R, Anteby-EY, Raveh-D, Achiron-R. Ultrasound Obstet Gynecol 2002;20:340-5.
23. Anomalies of the fetal aortic arch: A novel ultrasonographic approach to in-utero diagnosis. Achiron-R, Rotstein-Z, Heggesh-J, Bronshtein-M, Zimand S, Lipitz S, Yagel-S. Ultrasound Obstet Gynecol 2002 (in press).
24. Localization of heparanase in normal and pathological human placenta. Haimov-Kochman R, Friedmann Y, Prus D, Goldman-Wohl DS, Greenfield C, Anteby EY, Aviv A, Vlodavsky I, Yagel S. Mol Hum Reprod 2002;8:566-573.
25. Re: Outcome of pregnancy in chromosomally normal fetuses with increased nuchal translucency in the first trimester. Yagel S, Imbar T, Valsky D. Ultrasound Obstet Gynecol 2002;19:417-421.
26. Re: Health toll of the Middle East crisis. Yagel S. Lancet 2002;359:1860.
27. Conservative management of two ectopic pregnancies implanted in previous uterine scars. Haimov-Kochman R, Sciaky-Tamir Y, Yanai N, Yagel S. Ultrasound Obstet Gynecol 2002;6:616-9.
28. The human fetal venous system: Normal embryologic, anatomic, and physiologic characteristics and developmental abnormalities Fasouliotis SJ, Achiron R, Kivilevitch Z, Yagel S. J Ultrasound Med 2002;21:1145–1158.
29. Pivitol role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions. Markel G, Wolf D, Hanna J, Gazit R, Goldman-Wohl D, Lavy Y, Yagel S and Mandelboim O. JCI 2002;110:943-953.
20. Evaluating the risk of tuberous sclerosis in cases with prenatal diagnosis of cardiac rhabdomyoma. Gamzu R, Achiron R, Hegesh J, Weiner E, Tepper R, Nir A, Rabinowitz R, Auslander R, Yagel S, Zalel Y, Zimmer E. Prenat Diagn 2002;22:1044-1047.
31. Fetal supraventricular tachycardia diagnosed and treated at 13 weeks of gestation: A case report. Porat S, Anteby EY, Hamani Y, Yagel S. Ultrasound Obstet Gynecol, 2002 (in press).
32. Complexes of HLA-G protein on the cell surface are important for the LIR-1 function. Gonen-Gross T, Achdout H, Gazit R, Hanna J, Mizrahi S, Markel G, Goldman-Wohl D, Yagel S, Horejsi V, Levy O, Baniyash M, Mandelboim O. (2002, submitted)
33. CXCL12 expression by invasive trophoblasts induces the specific migration of CD16 negative human natural killer cells.Hanna J, Wald O, Goldman-Wohl D, Prus D, Markel G, Gazit R, Katz G, Mizrahi S, Haimov-Kochman R, Nakamura F, Yagel S, Peled A, Mandelboim O. (2002, submitted)
More in PubMed
Books
Yagel-S, Palti-Z, Adoni-A, Ultrasound in Obstet Anteby-E, Yagel-S, “Fetal Echocardiography” in The Female Patient 20:63-69, 1995.Oobstetrics and Gynecology (132 pp, 300 figures and illustrations, 50 tables, in Hebrew); 1987.
Anteby-E, Yagel-S, “Immune response to viral infection during pregnancy” in Viral Diseases in Pregnancy, ed. Gonik-B, Springer-Verlag, New York, 1994.
Yagel-S, Gembruch-U, and Silverman-N, eds. Fetal Cardiology, Martin Dunitz Publishers, London, UK, 2002.
Chapters written by myself
First and early second trimester echocardiography
Abnormal systemic venous connections
Placental implantation and development
3-D applications in echocardiography
Peer Reviewed Chapters in Books
The combination of femoral length and BPD as an accurate index of fetal gestational age up to the 34th week of gestation. Yagel-S, Adoni-A, Oman-S, Wax-Y, Hochner-Celnikier-D; The Yearbook of Neonatal and Perinatal Medicine, 1989.
Regulation of trophoblast invasion: The requirement for proteinase cascade. Yagel-S, Lala-PK, Hochner-Celnikier-D; In-vitro Fertilization and Assisted Reproduction, Plenum Publishers 1990, pp. 715-728.
Molecular mechanisms of trophoblast invasiveness and its control. Lala-PK, Yagel-S, Parhar-RS; Graham Reproductive Immunology, Elsevier Lecture Publishers, 1990, pp. 271-278.
Extended fetal echocardiographic examination for detecting cardiac malformations in low-risk pregnancies. Achiron-R, Glaser-J, Gelernter-I, Hegesh-J, Yagel-S; Yearbook of Pediatrics, 1993.