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Updated Oct. 2011
Attending physician at the Hematology department
and Coagulation Unit
Hadassah University hospital, Jerusalem.
Tel: 972-77-5145057 (home)
972-2-6779414 (work)
Fax: 972-2-6449580
E-mail: galias@hadassah.org.il
Date of birth: 25.3.1968
Place of birth: Jerusalem, Israel
Citizenship: Israeli
Military service: An interviewer and course instructor.
Marital status: Married, 3 children
MD license no.: 30063 (1997)
Expert license no.:
Internal medicine - 19384 (2002)
Hematology - 21397 (2005)
Higher Education
1989-95: Hadassah Medical School, Hebrew University of Jerusalem, Israel
1992: B.Med.Sc. – Hebrew University of Jerusalem
1997: MD degree - Hebrew University of Jerusalem.
1997: ECFMG certificate (American board exams)
2006-to date: PhD studies at the Dept. of medicine, clinical pharmacology unit, Karolinska Institute, Stockholm, Sweden. Subject: Platelets in type 2 Diabetes Mellitus. (Expected to be completed during 2013)
Postgraduate medical practice:
1996-1997: Internship: Hadassah Medical Center, Jerusalem, Israel
1997-2002: Residency: Department of Internal Medicine, Hadassah University hospital, Mt. Scopus, Jerusalem (completed – February 2002)
2000: Passed both parts of the Israeli boards in internal medicine.
2002-2004: Fellowship: Dept. of Hematology, Hadassah University hospital, Jerusalem.
2005: Board certification in Hematology
2005-2006: Attending physician at the Hematology department and Coagulation Unit, Hadassah University hospital, Jerusalem.
2006-2008: Research fellowship, clinical pharmacology unit, Karolinska Institute, Stockholm, Sweden.
2009-to date: Attending physician at the Hematology department and Coagulation Unit, Hadassah University hospital, Jerusalem.
Appointments at the Hebrew University:
2002: Instructor in Medicine, Hebrew University, Jerusalem.
2008: Lecturer in Medicine (Hematology), Hebrew University, Jerusalem
Additional Functions/Tasks at the Hebrew University/Hadassah:
2009: Member, 4th year examination in Internal Medicine
2009-2011: Oral examination, internal medicine 6th year graduate students
2011: Reviewer of MD thesis, Medical school, Hebrew University, Jerusalem
Other Activities:
Reviewer (journals):
2009-to date: Harefuah
2009-to date: IMAJ
2011: British Journal of hematology
2011: Drugs and aging
Reviewer (grants):
2011: National Science Center, Krakow,
Poland
Other :
2010-2011: Member in the national final exams boards in Hematology
2010: Oral examination, national final exams boards in Hematology
2011: Organizing a workshop in bleeding and coagulation disorders for hematology residents
Research Grants
2008: Grant from the Swedish heart lung foundation 10.000$. Platelet function in type 2 diabetes.
2009: Grant from the Swedish heart lung foundation 10.000$. Platelet function in type 2 diabetes.
2009: Grant from the Berman foundation for cardiovascular research. Aspirin resistance in type 2 diabets mellitus 35,000 NIS
Teaching at the Hebrew University:
1997-to date: Internal Medicine/ Hematology for 4th and 6th Year Medical students, Hadassah Hebrew University.
2010-to date: Supervision of Medical Student Thesis: Amit Ritter, co-supervisor Dr. Ronny Alcalai
LIST OF PUBLICATIONS
Original articles Peer reviewed
1. Zlatkin S, Amar S, Spectre G, Leibowitz D, Simanovsky N, Yeshurun D, Heyman S. Takayasu’s arteritis identified by computerized tomography :revealing the submerged portion of the iceberg? Isr Med Assoc J 1999 Dec; 1(4): 245-249.
2. Gil Z, Spectre G, Gomori M J, Matot I, Rayn A, Constantini S. Association between increased central venous pressure and hydrocephalus in children undergoing cardiac catheterization: A prospective study. Child’s Nervous System.2001 Aug;17(8): 478-82.
3. Gatt ME, Spectre G, Paltiel O, Hiller N, Stalnikowicz R. Chest radiographs in the emergency department: is the radiologist really necessary? Postgrad Med J.2003 Apr;79(930):214-7.
4. Spectre G, Gural A, Amir G, Lossos A, Siegal T, and Paltiel O. Central Nervous System Involvement in Indolent Lymphomas. Annals of Oncology. 2005 Mar; 16(3):450-4.
5. Sklair-Levy M, Amir G, Spectre G, Lebensart P, Applbaum Y, Agid R, Lieberman S, Ben-Yehuda D, Sherman Y, Libson E. Image-guided cutting-edge-needle biopsy of peripheral lymph nodes and superficial masses for the diagnosis of lymphoma. J Comput Assist Tomogr. 2005 May-Jun;29(3):369-72.
6. Spectre G, Brill A, Gural A, Shenkman B, Touretsky N, Mosseri E, Savion N, Varon D. A new point-of-care method for monitoring anti-platelet therapy: application of the cone and plate(let) analyzer. Platelets. 2005 Aug;16(5):293-9.
7. Spectre G, Libster D, Grisariu S, Da'as N, Ben Yehuda D , Gimmon Z, Paltiel O. Bleeding, obstruction and perforation in a series of patients with aggressive gastric lymphoma treated with primary chemotherapy. Annals of Surgical Oncology. 2006 Nov;13(11):1372-8.
8. Spectre G, Kalish Y, Schliamser L, Varon D. Heparin induced thrombocytopenia in myeloproliferative diseases: a rare or under-diagnosed complication? Am J Hematol 2008 May; 83(5):420-3.
9. Goldschmidt N, Spectre G (First Co-author), Brill A, Zelig O, Goldfarb A, Rachmilewitz E and Varon D. Increased platelet adhesion under flow is induced by both Thalassemic platelets and red blood cells. Thromb Haemost 2008 Nov;100(5):864-70.
10. Spectre G, Roth B, Ronen G, Rosengaten D, Elstein D, Zimran A, Varon D, Revel-Vilk S. Platelet adhesion defect in type I Gaucher Disease is associated with a risk of mucosal bleeding. Br J Haematol. 2011 May;153(3):372-8
11. Spectre G, Arnetz L, Ostenson CG, Brismar K, Li N, Hjemdahl P. Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications. Thromb Haemost. 2011 Aug 31;106(3):491-9.
12. Spectre G, Mosseri M, Abdelrahman NM, Briskin E, Bulut A, Loncar S, Varon D, Alcalai R. Clinical and Prognostic Implications of the Initial Response to Aspirin in Patients With Acute Coronary Syndrome. Am J Cardiol. 2011 Aug 5. [Epub ahead of print]
Case reports and reviews:
1. Reichman JM, Alcalai R, Spectre G. Haemophilus influenzae pyelonephritis in adults(1999). Arch Intern Med 159 (12), June 28, 1999. 7.9; 8/103;0.
2. Alcalai R, Spectre G, Burztyn M. Smoking, cough and polyuria(2002). Arch Intern Med 162 (2), Jan 28, 2002. 7.9; 8/103;1
3. Goldschmidt N, Gural A, Kornberg A, Spectre G, Shopen A, Paltiel O. Prolonged fever of unknown origin and hemophagocytosis evolving into acute lymphoblastic leukemia. Am J Hematol. 2004 Aug;76(4):364-7.
4. Spectre G, Varon D. New antiplatelet agents. Curr Opinion Hematol 2009 Sep 116(5):365-70.
5. Varon D, Spectre G. Antiplatelet agents. Hematology Am Soc Hematol Educ Program. 2009:267-72.
6. Varon D, Shai E, Spectre G. Frontiers in platelet inhibition. Discov Med. 2009 Dec;8(43):242-6.
7. Yuval Ramot, Galia Spectre , Abraham Nyska. Drug induced thrombosis. Chapter 15 in Toxicology of the Blood & Bone Marrow book, second edition, published by CRC ; Taylor & Francis Group Dec, 2010. Editor: Jacques Descotes.
Participation in international Scientific Conferences:
Abstracts:
1. Spectre G, Gural a, Lossos A, Siegal T, Paltiel O. Central nervous system involvement in indolent lymphomas. The American Society of Hematology, 45rd Annual meeting and exposition. Dec 2003,San Diego, California. Blood. Nov 2003 102(11) 265B-266B.
2. Spectre G, Goldchmidt N, Gural A, Ben Yehuda D. Gemcitabine, etoposide and dexamethasone in the treatment of heavily pretreated patients with non-Hodgkin's lymphoma. The 40th Annual Meeting of the American Society of Clinical Oncology .June 2004, Denver Colorado. Journal of Clinical Oncology. 2004 22(14): 605S. Abstract no 6691.
3. Spectre G, Brill A, Gural A, Shenkman B, Touretsky N, Mosseri E, Savion N, Varon D. A new point-of-care method for monitoring anti-platelet therapy: application of the cone and plate(let) analyzer. The 18th International congress on prof. Varon).
4. Spectre G, Brill A, Gural A, Shenkman B, Touretsky N, Mosseri E, Savion N, Varon D. Application of the cone and plate(let) analyzer as a point of care method for monitoring anti- platelet therapy. The American Society of Hematology, 46rd Annual meeting and exposition. Dec 2004, San Diego, California. Blood. Nov 2004 104B-104B Abstract no 4071.
5. Spectre G, Libster D, Grisariu S, Da'as N, Gimmon Z and Paltiel O. Surgical complications in patients treated with chemotherapy for gastric diffuse large B cell lymphoma. The American Society of Hematology, 47rd Annual meeting and exposition. Dec 2005 Atlanta, Georgia. Blood. Nov 2005. Abstract no 4732.
6. Spectre G, Roth B, Bonstein L, Elinav H, Zelig O, Peleg H, Lossos A, Brill A, Varon D. Successful rituximab treatment in a patient with acquired Glanzmann’s thrombasthenia, hemolytic anemia , ophtalmoplegia and a lung mass. Platelets , May 2006 Ma’ale Hachamisha, Israel.
7. Spectre G, Erosy M, Hjemdahl P, Savion N, Varon D and Li N. Platelets and matrix protein differentially support adhesion of lymphocyte subpopulations under arterial shear stress. The XXI congress of the International Society on Thrombosis and Haemostasis. (ISTH) July 2007, Geneva.
8. Spectre G, Goldschmidt N, Brill A, Zelig O, Goldfarb A, Rachmilewitz E and Varon D. Increased platelet adhesion under flow is induced by both Thalassemic platelets and red blood cells. Platelets June 2008 Woods Hole, Massachusetts.
9. Spectre G, Roth B, Ronen G, Rosengaten D, Elstein D, Zimran A, Varon D, Revel-Vilk S. Platelet adhesion defect in type I Gaucher Disease is associated with a risk of mucosal bleeding. Platlets May 2010 Ma’ale Hachamisha, Israel
10. Spectre G, Arnetz L, Ostenson CG, Brismar K, Li N, Hjemdahl P. Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications. American heart Association, Nov 2010 Chicago (oral presentation)
11. Spectre G, Mosseri M, Abdelrahman NM, Briskin E, Bulut A, Loncar S, Varon D, Alcalai R. Clinical and Prognostic Implications of the Initial Response to Aspirin in Patients With Acute Coronary Syndrome. The XXIII congress of the International Society on Thrombosis and Haemostasis.(ISTH) July 2011 Kyoto, Japan.
12. Spectre G., Ostenson CG, Li N, Hjemdahl P. Is postprandial platelet activation related to insulin rather than glucose levels in patients with type 2 diabetes mellitus? The XXIII congress of the International Society on Thrombosis and Haemostasis.(ISTH) July 2011 Kyoto, Japan.
13. Spectre G. Anti platelet therapy in Diabetes- more harm or good?
The Second international congress of the Bildrici Diabetes Center Laniado Hospital. January 2012 ( an invited lecture)
Ongoing research:
1. Spectre G., Östenson CG , Li N, Hjemdahl P. Postprandial platelet activation is related to postprandial insulin rather than glucose in patients with type 2 diabetes mellitus. Submitted.
2. Livnat T , Shenkman B , Spectre G. , Tamarin I , Dardik R , Israeli A, Rivkind A, Shabtai M, Marinowitz U, Salomon O. To treat or not to treat asymptomatic patients with factor VII deficiency before surgery. Submitted.
3. Spectre G., Östenson CG , Li N, Hjemdahl P. Does insulin activate platelets in patients with type 2 diabetes mellitus? A hyperinsulinemic, euglycemic clamp study.
4. Stalsen R, Spectre G, Östenson CG , Li N, Hjemdahl P. Meal induced platelet activation in diabetes – a comparison between patients with type 1 and type 2 diabetes mellitus.
5. Spectre G., Varon D, Hjemdahl P, Eldor R. Effect of glucose control on the response to aspirin in type 2 diabetic patients.
6. Spectre G., Ritter A, Alcalai R. The Association between Hyperglycemia and Resistance to Clopidogrel Treatment in Patients with Acute Coronary Syndrome
7. Spectre G., Gersh B, Alcalai R. Impact of Citalopharm and fluvoxamine on platelet response to clopidogrel, a randomized, double-blind, placebo-controlled, crossover trial in healthy volunteers.
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