Personal Data

Date and Place of Birth: l8th April, l943, Durban, South Africa

Nationality: Israeli

Address: 3 Mevo Halilach, Moza Illit, Israel il-90820

Marital Status: Married, three children (28, 26 and 23 years of age)

Education

l956 - l959 Durban High School, Durban, South Africa

l960 - University of Natal, Durban, South Africa

l962 - l966 University of the Witwatersrand, Johannesburg

l966 - M.B., B.Ch. (Rand)

l970 - M.R.C.P. (U.K.) (Internal Medicine Boards)

l972 - M.Sc. (Biochemistry), University of London

l973 - Ph.D. (Medicine), University of London     

Thesis : The Effects of Enzyme Inducing Agents on Cholecalciferol Metabolism

l98l - Boards in Nephrology (Israel)

l988 - F.R.C.P. (U.K.)

Awards and Honors

l973  - Van den Bergh and Jurgens Nutritional Award, Royal Society of Medicine, London

1998 - Ullman prize of the Israel Society of Nephrology

2002 - Samuel and Paula Elkeles Prize for the Outstanding Scientist in Medicine in Israel for 2002, administered by the Keren Kayemet of Israel (Jewish National Fund)

Awards to other members of my laboratory:

l987 - Work on the calcitonin gene in my lab was acknowledged with two prizes to Dr. Tally Naveh-Many, the senior scientist in my laboratory.

(l) Van Recklinghausen Prize of the German Society of Endocrinology for outstanding research work in the field of calcium regulating hormones and bone metabolism by a European research worker under the age of 40.

(2) The Norwich Eaton International Young Investigator Award by the American Society of Bone and Mineral Research.

1993 - Chovers prize of the Israel Society of Endocrinology for the outstanding publication  in endocrinology and metabolism by a young Israeli investigator was awarded to Dr.Tally Naveh-Many in my laboratory.

1994 - Aurbach prize of the Israel Society of Calcified Tissue was awarded to E. Moallem a PhD student in my lab.

1999 - Faculty prize for an outstanding M.S. graduate was awarded to Yulia Moz, a graduate student in my laboratory.

2000 - Yulia Moz was awarded a Horowitz Foundation prize as an outstanding Ph.D. student at the Hebrew University ($23,500 p.a. for 3 years)

Professional Employment

l967 Jan.-June House Physician, Baragwanath Hospital and University of Witwatersrand, Johannesburg

July-Dec.  House Surgeon, Baragwanath Hospital and University of Witwatersrand, Johannesburg

l968 July-Dec. Senior House Officer in Neurology, Baragwanath Hospital and University of Witwatersrand, Johannesburg

l969 Jan.-July  Registrar in Cardiology, Wentworth Hospital and University of Natal, Durban

Oct.-Dec.  Course in Advanced Medicine, Royal Postgraduate Medical School, London

l970 Feb.-July  Senior House Officer in Gastroenterology, Hammersmith Hospital, London

l969 -l973  Research Assistant and Honorary Registrar in Gastroenterology, Royal Postgraduate Medical School, London

l990     Director, Mineral Metabolism Unit, Hadassah University Hospital, Jerusalem

l992     Director, Minerva Center in Calcium and Bone Metabolism

1995 (Sept-Dec)  Visiting Research Scientist Massachusetts General Hospital

2001‏‏  Chief, Nephrology and Hypertension Services, Hadassah University Hospital, Jerusalem

Academic Status

l974 Lecturer in Medicine, Hebrew University of Jerusalem

l979 Senior Lecturer in Medicine, Hebrew University of Jerusalem

l984 Associate Professor of Medicine, Hebrew University of Jerusalem

1990 Professor of Medicine, Hebrew University of Jerusalem

1995 (Sept-Dec)  Visiting Professor of Medicine Harvard Medical School

List of Publications

Moallem, E, Silver, J, Naveh-Many, T. Regulation of parathyroid hormone messenger RNA levels by protein kinase A and C in bovine parathyroid cells. J Bone Miner Res  10: 447-452, 1995.

Kilav R, Silver J, Biber J, Murer H, Naveh-Many T. Coordinate Regulation of the Rat Renal Parathyroid Hormone Receptor mRNA and the Na/Pi-cotransport mRNA and Protein. Amer J Physiol  268: F1017-F1022, 1995.

Kilav R, Silver J, Naveh-Many T. Parathyroid hormone gene expression in hypophosphatemic rats. J Clin Invest  96: 327-333, 1995.

Naveh-Many T, Rahamimov R, Livni N, Silver J. Parathyroid cell proliferation in normal and chronic renal failure rats: the effects of calcium, phosphate and vitamin D. J Clin Invest  96: 1786-1793, 1995.

Schilling T, Blind E, Baier R, Sinn H-P, Moallem E, Silver J, Ziegler R, Raue F. Effects of passive immunization against parathyroid hormone-related protein: PTHrP is the responsible factor in mediating hypercalcemia in the Walker carcinosarcoma 256 rat model. J Bone Miner Res 10: 7-16, 1995.

Epstein E., Silver J, Almogi G., Livni N., Naveh-Many T. 1995. Parathyroid hormone mRNA levels are increased by progestins and vary during the rat estrus cycle. Am. J. Physiol. 33:E158-E163, 1996.

Marks KH, Kilav R, Berman E, Naveh-Many T, Silver J. Parathyroid Hormone Gene Expression In Hyp Mice Fed A Low Phosphate Diet. Nephrol Dialysis Transplantation. 12:1581-1585, 1997.

Cohen Y, Rahamimov R, Naveh-Many T, Silver J, Rahamimoff R. Where is the ‘Inverting Factor’ in hormone secretion from Parathyroid cells? Am. J. Physiol. 36:E630-E637, 1997.

Moallem E, Kilav R, Silver J, Naveh-Many T. RNA-protein binding and post-transcriptional regulation of PTH gene expression by calcium and phosphate. J. Biol. Chem. 1998 273:5253-5259.

Kilav R, Silver J, Biber J, Murer H, Naveh-Many T. Coordinate Regulation of the Rat Renal Parathyroid Hormone Receptor mRNA and the Na/Pi-cotransport mRNA and Protein. Amer J Physiol  268: F1017-F1022, 1995.

Kilav R, Silver J, Naveh-Many T. Parathyroid hormone gene expression in hypophosphatemic rats. J Clin Invest 96: 327-333, 1995.

Parathyroid cell proliferation in normal and chronic renal failure rats: the effects of calcium, phosphate and vitamin D. Naveh-Many T,

Rahamimov R, Livni N, Silver J. J Clin Invest  96: 1786-1793, 1995.

Epstein E., Silver J, Almogi G., Livni N., Naveh-Many T. 1995. Parathyroid hormone mRNA levels are increased by progestins and vary during the rat estrus cycle. Am. J. Physiol. 33:E158-E163, 1996.

Marks KH, Kilav R, Berman E, Naveh-Many T, Silver J. Parathyroid hormone gene expression in Hyp mice fed a low phosphate diet. Nephrol Dialysis Transplantation. 12:1581-1585, 1997.

Cohen Y, Rahamimov R, Naveh-Many T, Silver J, Rahamimoff R. Where is the ‘Inverting Factor’ in hormone secretion from Parathyroid cells? Am. J. Physiol. 36:E630-E637, 1997.

Moallem E, Kilav R, Silver J, Naveh-Many T. RNA-protein binding and post-transcriptional regulation of PTH gene expression by calcium and phosphate. J. Biol. Chem. 273:5253-5259, 1998.

Sela-Brown A, Russell J, Koszewski NJ, Michalak M, Naveh-Many T Silver J. Calreticulin inhibits vitamin D’s action on the PTH gene in vitro And may prevent vitamin D’s effect in vivo in hypocalcemic rats. Molecular Endocrinology 12:1193-1200, 1998.

Yalcindag C, Silver J, Naveh-Many T. Mechanism of increased PTH mRNA in experimental uremia: roles of protein RNA binding and RNA degradation. J Amer Soc Nephrol 10:2562-2568, 1999.

Moz Y, Silver J, Naveh-Many T. Protein-RNA interactions determine the stability of the renal Na/Pi-2 cotransporter mRNA and its translation in hypophosphatemic rats. J Biol Chem 274:25266-25272, 1999.

Epstein E, Sela-Brown A, Ringel I, Rachel Kilav, King SM, Benashski S, Yisraeli JK, Silver J, Naveh-Many T. Dynein light chain (Mr 8000) binds the parathyroid hormone mRNA 3'-untranslated region and mediates its association with microtubules. J Clin Invest 105:505-512,2000.

Sela-Brown A, Silver J, Brewer G, Naveh-Many T. Identification of AUF1 as a parathyroid hormone mRNA 3’-untranslated region binding protein that determines parathyroid hormone mRNA stability. J Biol Chem 275:7424-7429, 2000.

Kilav R, Silver J, Naveh-Many T. A conserved cis-acting element in the parathyroid hormone 3’-untranslated region is sufficient for regulation of RNA stability by calcium and phosphate. J Biol Chem 276:8727-33, 2001.

Chapters in Books

Naveh-Many T, Silver J. Parathyroid hormone synthesis, secretion and action. In: Coe FL, Favus MJ, Pak C, Parks J, Preminger G (eds). Kidney Stones: Medical and Surgical Management. Raven Press (New York) 1996 pp175-199.

Silver J, Kronenberg HM. Parathyroid hormone - molecular biology. In: Principles of Bone Biology. Bilezikian JB, Raisz LG, Rodan GA (eds). Academic Press (San Diego) 1996 pp 325-338.

Naveh-Many T, Silver J. Vitamin D and the parathyroid. In: Vitamin D. Feldman D, Glorieux F, Pike JW (eds). Academic Press (San Diego) 1997 pp 353-368.

Naveh-Many T, Silver J. Regulation of parathyroid hormine gene expression and secretion by vitamin D. In: Vitamin D: Molecular Biology, Physiology and Clinical Applications. Holick MF (ed). Humana Press, Totowa, NJ. 1998 pp 217-237.

Haviv YS, Silver J. Hypercalcemia. In: Oxford Textbook of Endocrinology. Wass JAH, Shalet SM (eds.). Oxford University Press, Oxford, UK. 2001 (in press).

Silver J, Naveh-Many T. Regulation of PTH synthesis and secretion and parathyroid cell proliferation. In: The Spectrum of Renal Osteodystrophy. Drueke T, Salusky I. (eds.). Oxford University Press, Oxford, UK. 2001, pp 25-52.

Silver J, Naveh-Many T. Parathyroid hormone - synthesis and secretion. In: Favus MJ, Coe FL (eds). Disorders of Bone and Mineral Metabolism. Raven Press  (New York) 2002, pp 74-101.

Silver J, Naveh-Many T, Kronenberg HM. Parathyroid hormone - molecular biology. In: Principles of Bone Biology, second edition. Bilezikian JB, Raisz LG, Rodan GA (eds). Academic Press (San Diego) 2002 pp 407-422.

Reviews and Editorials

Silver J. What stimuli control the activity of the parathyroid cell? Nephrology Dialysis Transplantation 10:599-560, 1995.

Naveh-Many T, Epstein E, Silver J. Estrogens and calcium regulatory hormone- potential implications for bone. Current Opinion in Nephrology and Hypertension 4:319-323, 1995.

Silver J, Epstein E., Naveh-Many T. Oestrogen deficiency - does it have a role in the genesis of skeletal problems of dialyzed women? Nephrology Dialysis Transplantation  11:565-566, 1996.

Silver J, Moallem E, Kilav R, Sela A, Naveh-Many T. New insights into the regulation of parathyroid hormone synthesis and secretion in chronic renal failure. Nephrology Dialysis Transplantation 11 (Suppl 3): 2-5, 1996.

Marks K.H., Kilav R., Naveh-Many T., Silver J. Calcium, Phosphate, Vitamin D and the Parathyroid. Pediatr. Nephrol. 10: 364-367, 1996.

Drueke T, Silver J. Mineral metabolism: editorial comment. Current Opinion in Nephrology and Hypertension. 6:305-307, 1997.

Silver J, Bar Sela S, Naveh-Many T. Regulation of parathyroid cell proliferation. Current Opinion in Nephrology and Hypertension, 6:321-326, 1997.

Silver J, Moallem E, Kilav R, Sela A, Naveh-Many T. Regulation of the parathyroid gene by calcium, phosphate and 1,25-dihydroxyvitamin D. Nephrology Dialysis Transplantation 13 (Suppl 1):40-44, 1998.

Beckerman P, Silver J. Vitamin D and the Parathyroid. American Journal of Medical Sciences 317:363-369, 1999.

Silver J, Drueke T. Master genes for bone growth, 1,25-dihydroxyvitamin D₃ synthesis, and renal conservation of phosphate and calcium: editorial comment. Current Opinion in Nephrology and Hypertension, 7:359-361, 1998.

Naveh-Many T, Sela-Brown A, Silver J. Protein-RNA interactions in the regulation of

PTH gene expression by calcium and phosphate. Nephrology Dialysis Transplantation 1999 14:811-813.

Silver J, Bushinsky D. Mineral metabolism prepares for the new millenium: editorial comment. Current Opinion in Nephrology and Hypertension. 8:405-406, 1999.

Silver J, Yalcindag C, Sela-Brown A, Kilav R, Naveh-Many T. Regulation of the parathyroid hormone gene by vitamin D, calcium and phosphate. Kidney International 56: suppl. 73, S2-S7, 1999.

Silver J, Kilav R, Sela-Brown A, Naveh-Many T. Molecular mechanisms of secondary hyperparathyroidism. Pediatr. Nephrol. 14:626-628, 2000.

Bushinsky D, Silver J. Calcium: Discovering the Details: editorial comment. Current Opinion in Nephrology and Hypertension 9:333-334, 2000.

Silver J. Molecular mechanisms of secondary hyperparathyroidism. Nephrology Dialysis Transplantation 15:2-7, 2000.

Silver J. Cycling with the parathyroid. J Clin Invest 107:1079-1080, 2001.

Silver J. Fine-wiring the parathyroid. IBMS BoneKEy 2001 10.1138/ibmske; 2001015. [Full Text].

Silver J. Pathogenesis of parathyroid dysfunction in ESRD.  Advances in Renal Replacement Therapy (in press) 2002.

Silver J, Kilav R, Naveh-Many T. Mechanisms of secondary hyperparathyroidism. American J of Physiology (Renal) 2002 (in press).

Silver J, Bushinsky D. The year of the phosphor: editorial comment. Current Opinion in Nephrology and Hypertension 2002 (in press).

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