Personal Data
Place of Birth: Tel Aviv, Israel.
Marital Status: Married and a mother of 3 children
Current position
Director of Gaffin Center for Neuro-Oncology, Sharett Institute of Oncology, Hadassah Hebrew University Hospital, Jerusalem, Israel.
Current Academic Status
1997 - Full Professor in Neurology (Neuro-Oncology), Hebrew University and Hadassah Medical School, Jerusalem, Israel.
Education and Professional Experience
1974 – 1976 Residency in Neurology, Department of Neurology, Shiba Medical Center, Ramat Gan, Israel.
1976 - M.D. Degree, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel.
1976 - 1978 Fellowship in Neuro-Oncology, Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, U.S.A.
1977 - The University of The State of New-York, Education Department, Qualification to Practice Medicine, License Number 136340.
1979 - 1980 Residency in Neurology, Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel.
1980 - Instructor in Neurology, Hebrew University and Hadassah Medical School, Jerusalem, Israel.
1981 - Board Certified in Neurology.
1981 - Senior Physician, established the Neuro-Oncology Service, Department of Radiation and Clinical Oncology, Hadassah Hebrew University Hospital, Jerusalem, Israel.
1982 - Lecturer in Neurology, Hebrew University and Hadassah Medical School, Jerusalem, Israel.
1987 - Senior Lecturer in Oncology, Hebrew University and Hadassah Medical school, Jerusalem, Israel.
1988 - Visiting Scientist, Neuro-Oncology Laboratory, Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, U.S.A.
1991 - Associate Professor in Neurology (Neuro-Oncology), Hebrew University and Hadassah Medical School, Jerusalem, Israel.
1991 - Visiting Professor in Daniel den Hoed Cancer Center, Rotterdam, The Netherland.
1993 - Visiting Scientist, Neuro-Oncology Laboratory, Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, U.S.A.
1995 - Training in the blood-brain barrier program, Oregon Health Science University, Portland, Oregon, U.S.A.
1997 - Establishment of the blood-brain barrier program in Hadassah University Hospital, Neuro-Oncology Clinic, Jerusalem, Israel.
1997 - Full Professor in Neurology (Neuro-Oncology), Hebrew University and Hadassah Medical School, Jerusalem, Israel.
1998 - Visiting professor, laboratory and service of the the blood-brain barrier program, Oregon Health Science University, Portland, Oregon, U.S.A.
1999 - Director of the Neuro-Oncology center, Sharett institute of Oncology, Hadassah University Hospital, Jerusalem, Israel.
2003 - Director of the Leslie and Michael Gaffin multidisciplinary center for neuro-oncology - center of excellence.
2003 - Chairmain of the Israeli Neuro-Oncology Forum.
Membership in Professional Societies
· Israel Medical Association
· Israel Neurological Association
· Israel Oncological Association
· The Medical Society of London
· American Academy of Neurology
· The New York Academy of Sciences
· Membership of the Turkish Association of Orthopaedic Surgery & Traumatology
· European Neurological Society
· European Association of Neuro-Oncology
· The Society for Neuro-Oncology
· European Federation for Neurological Sciences,
Scientific Activities
Ad Hoc Reviewer:
· Am J Cancer
· J Neurology
· J Neuro-Oncology
· Cancer
· Acta Neurologica Scandinavica
· J Neurological Sciences
· European J Cancer
· Am J Drug Delivery
· European J Clin Investigation
· International J Cancer
· Medical Science Monitor
· Expert Review of Neuropatics
· Lancet Oncology
· Neuro-Oncology
International Scientific Commitees
· European Association for Neuro-Oncology
· International Cerebrovascular Biology and Blood-Brain Barrier Conference
· Drug Delivery and Pathogen Invasion Across the Blood-Brain Barrier
· European Association for Palliative Care
· American Academy of Neurology - Neuro-Oncology section
· European Federation for Neurological Sciences - Neuro-Oncology Section
· Member of the International Scientific Advisory Board for Schering Plough
Reviewer of Grants
· Israel Ministry of Health
· Israel Cancer Association
· Joint Research grants of Hadassah and Medical School
· The Israel Academy of Sciences and Humanities
· United States-Israel Binational Science Foundation (BSF)
· Cancer Research United Kingdom
Teaching Activities
Hadassah Hebrew University Medical School
· Neurology and Neurosurgery - 5th year students
· Oncology - Haematology - 6th year students
· Oncology -5th year students
· Nursing school
· General Physicians
Tel-Aviv University Medical School
· Post graduate courses for Neurology
· Post graduate courses for Oncology
· Post graduate courses for Neurosurgery
· Post graduate courses for General Physicians
International Teaching Courses (partial list):
· Spine pathology -neoplastic spinal cord compression - Badalona,Spain - 1991
· International course of spinal pathophysiology - Valencia, Spain - 1995
· European School of Oncology - Neuro-Oncology 1995: Leptomeningeal metastases
Teaching courses for the European Association of Neuro-Oncology (EANO)
· Spinal Cord Comppression 1994
· Leptomenigeal metastases 1996
· Mechanisms of spinal injury 2002
Teaching courses for the European Neurologic Society (ENS)
· Leptomeningeal metastases 1996
· Neurologic complications of lymphoproliferative disorders 2000
· The Cleveland Clinic Foundation: Neuro-Oncology 2001: Current Concepts.
· Primary CNS lymphoma-Blood Brain Barrier disruption
· Italian Association of Neuro-Oncology: Strategies for increasing drug delivery to the brain: Focus on brain lymphoma - 2001
· European Association of Neuro-Oncology (EANO): Meet the Expert: Methods to increase drug delivery to the brain-2002
Temozolomide: Global Investigators Meeting
· Rare gliomas workshop 2004
· Newly diagnosed high grade gliomas 2004
· European Federation for Neurological Sciences: Vascular, Metabolic and Infectious Complications of Systemic Cancer-2004.
Publications
For list of publications in journals
see PubMed
Chapters in Books
1. Siegal T, Siegal Tz. Treatment of malignant epidural cord and cauda equina compression. In Prog Exp Tumor Res 29: 225-234, 1985. FC Rose & WS Fields (eds), Krager, Basel.
2. Siegal Tz, Siegal T. The management of malignant epidural tumors compressing the spinal cord. In Operative Neurosurgical Techniques Vol 2 Chapter 132, 1988 pp 1539-1562. Sweet & Schmideck (eds), Grune & Stratton Inc.
3. Siegal Tz, Siegal T. Surgical intervention for neoplastic involvement of the lumbar spine. In Tumors of the Spine: Diagnosis and Clinical Management. Chapter 37, 1990 pp 380-390. N Sundaresan, HH Schmidek, AL Schiller, DI Rosenthal (eds), W.B. Saunders Company.
4. Siegal T, Siegal Tz. Neurologic compromise due to spinal tumors. In Tumors of the Spine: Diagnosis and Clinical Management. Chapter 28, 1990 pp 272-278. N Sundaresan, HH Schmidek, AL Schiller, DI Rosenthal (eds), W.B. Saunders Company.
5. Siegal T, Siegal Tz. Epidural spinal metastases from solid tumours. In Neuro-Oncology. Chapter 10, 1993 pp 283-305. Keyser A, Ongerboer de Visser BW, Twijnstra A (eds), Elsevier Science Publishers B.V.
6. Siegal T, Siegal Tz. Epidural metastases from haematological tumours. In Neuro-Oncology. Chapter 11, 1993 pp 313-327. Keyser A, Ongerboer de Visser BW, Twijnstra A (eds), Elsevier Science Publishers B.V.
7. Siegal Tz, Siegal T. Management of malignant epidural tumors compressing the spinal cord. In Operative Neurosurgical Techniques Third Edition, Vol 2 Chapter 162, 1995 pp 1997-2025 Sweet & Schmideck (eds), W.B. Saundress Company. Philadelphia.
8. Siegal Tz, Siegal T. Management of malignant epidural tumors compressing the spinal cord. In Operative Neurosurgical Techniques Fourth Edition, Vol 2 Chapter 164, 2000 pp 2171-2197 Sweet & Schmideck (eds), W.B. Saundress Company. Philadelphia.
9. Siegal T, Siegal Tz, Brada M. Spinal metastatic disease. In Oxford Textbook of Oncology. Second Edition, Vol 1 Chapter 5.5, pp 977-993, Souhami RL, Tannock I, Hohenberger P, Horiot J-C (eds), Oxford University Press 2002
10. Siegal T. Neurologic manifestations of lymphoproliferative disorders. In Brain diseases: Therapeutic strategies and repair. Abramski O, Compston DAS, Miller A, Said G (eds), Martin Dunitz Publishers. London 2001
11. Siegal T. Strategies for increasing drug delivery to the brain. Lessons derived from treatment of primary brain tumors. In: Blood-Brain Barrier. Drug Delivery and Brain Pathology. Chapter 22 pp. 251-271, Kobiler D, Lustig S, Shapira S (eds). Kluwer Academic Plenum Publishers 2001
12. Ovadia H, Abramsky O, Itzik A, Siegal T. The effect of hyperosmotic blood-brain barrier disruption on experimental Autoimmune encephalomyelitis. In: Blood-Brain Barrier. Drug Delivery and Brain Pathology. Chapter 19 pp. 227-231, Kobiler D, Lustig S, Shapira S (eds). Kluwer Academic Plenum Publishers 2001
13. Siegal T, Siegal Tz. Spinal metastases. In Cancer of the Nervous System. Chapter 27 pp. 581-606 O'Niell BP, Schiff D (eds). McGraw Hill Publishers, New York 2005
14. Siegal T, Siegal Tz. Spinal metastases. In Neuro-Oncology. Chapter pp Rees J, Dropcho E (eds) Butterworth Heinemann, Elsevier, Inc, Blue books of Practical Neurology 2005.
Administration and Clinical Activities
·
· Out-patient Neuro-Oncology Clinic
· In-patients Neuro-Oncology Center
· In-patients Consultations in Neuro-Oncology
· Day Care - Neuro-Oncology Center
· Laboratory for Molecular diagnosis of Brain Tumors
· Neuro-Immunology Laboratory - Paraneoplastic antibodies
· Clinical Studies –PI and co PI