Born 1973, Israel
Education
1997: B.Med.Sc., Hebrew University-Hadassah, Jerusalem, Israel
2001: D.M.D., Hebrew University-Hadassah, Jerusalem, Israel
2001: M.Sc., Hebrew University-Hadassah, Jerusalem, Israel
2005: Specialist in Endodontics. Hebrew University-Hadassah, Jerusalem, Israel
2007: Ph.D. Hebrew University-Hadassah, Jerusalem, Israel
Awards and Honours
B.Med.Sc. Cum Lade, the Hebrew University-Hadassah, Jerusalem, Israel.
1997-1998: Scholarship for distinct M.Sc Students, Faculty of Dental Medicine, The Hebrew University-Hadassah, Jerusalem, Israel.
1998: Award for best lecture. Research Day, Faculty of Dental Medicine, The Hebrew University-Hadassah Jerusalem, Israel.
2000,2001,2002: The Rector's Ph.D. Scholarship for distinction , The Hebrew University, Jerusalem, Israel.
2002: The Golda Meir Fellowship, The Hebrew University, Jerusalem, Israel.
Research Interests
§ Molecular and dvelopmental biology of the cranio-facial copmplex.
§ Endodontic instruments development.
§ Endodontic instrument enhancement
§ Novel endodontic material development.
§ Hereditary dental diseases.
Research Projects
Improving the fatigue resistance of Nickel Titanium (NiTi) endodontic files by selectively coating the files with metal/ inorganic-fullerene (IF) nanoparticles. Since IF nanoparticles are known as a superior lubricant it is assumed that such a friction reducing coating would lower the incidence of file breakage during root canal treatment and would contribute to the clinical performance of NiTi files.The friction reduction of the IF-nanoparticles coated NiTi files lowered the stress applied onto the file during simulated treatment. This process might minimize file breakage during treatment and consequently prevent tooth loss. Moreover, the coating methods developed in this research can be easily applied to a vast repertoire of friction correlated medical appliances (i.e., cardiovascular stents, guide wires, orthopedic implants etc.), possibly improving their performance and lifetime.
The efficiency of a novel root end filling materials using micro-Computerized Tomography (micro-CT), demonstrating the compaction and durability of the filling materials and the retrograde cavity preparation in all planes. Since micro-CT is a non-destructive procedure, it allows us to further investigate the specimens for bacterial leakage studies.
Prototype development of rotary Niti endodontic files.
Deciphering a rare human genetic dental disease of hereditary multiple idiopatic root resorption. Up to date, very few individual cases were reported, but there was no indication for familial inheritance. The family identified by me includes 10 siblings with at least 5 affected members (father and at least 4 siblings- additional siblings might develop the disease as well when their permanent dentition will erupt).
Public Activity
2006-Date: Forum Manager, Endodontic Forum, Hadassah-Ynet Medical Forums.
2006-2008: Treasurer, Alpha Omega Fraternity, Jerusalem Branch.
2009-Date: President, Alpha Omega Fraternity, Jerusalem Branch.
2009-Date: Member, Board of directors, The Israeli Endodontic Society
Recent publications
Haze A(P), Taylor AL(C), Haegewald S(C), Leiser Y(C), Shay B(C), Rosenfeld E(C), Gruenbaum-Cohen Y(C), Dafni L(T), Zimmermann B(C), Heikinheimo K(C), Gibson CW(C), Fisher LW(C), Young MF(C), Blumenfeld A(C), Bernimoulin JP(C), Deutsch D(P). Regeneration of bone and periodontal ligament induced by Recombinant amelogenin after periodontitis. J Cell Mol Med. 2009 Feb 17. [Epub ahead of print] PubMed PMID: 19228267. J Cell Mol Med. Jun 2009 : 13(6): 1110-1124. (5.114 ; 50/275, 37/157, 8/83 ; 1:1)
Shay B(P), Gruenbaum-Cohen Y(C), Tucker AS(C), Taylor AL(C), Rosenfeld E(C), Haze A(C), Dafni L(T), Leiser Y(C), Fermon E(C), Danieli T(C), Blumenfeld A(C), Deutsch D(P). High yield expression of biologically active recombinant full length human tuftelin protein in baculovirus-infected insect cells. Protein Expr Purif. 2009 Nov;68(1):90-8. Epub 2009 Jun 17. PubMed PMID: 19539764. (1.621 ; 45/65, 200/275, 87/144 ; X:X)
Gruenbaum-Cohen Y(P), Tucker AS(C), Haze A(C), Shilo D(C), Taylor AL(C), Shay B(C), Sharpe PT(C), Mitsiadis TA(C), Ornoy A(C), Blumenfeld A(C), Deutsch D(P). Amelogenin in cranio-facial development: the tooth as a model to study the role of amelogenin during embryogenesis. J Exp Zool B Mol Dev Evol. 2009 Jul 15;312B(5):445-57. Review. PubMed PMID: 19097165. (3.364 ; 10/38, 15/39, 4/125 ; X:X )
Leiser Y(P), Blumenfeld A(C), Haze A(C), Dafni L(T), Taylor AL(C), Rosenfeld E(C), Fermon E(C), Gruenbaum-Cohen Y(C), Shay B(C), Deutsch D(P). Localization, quantification, and characterization of tuftelin in soft tissues. Anat Rec (Hoboken). 2007 May; 290(5):449-54. PubMed PMID: 17393536. (1.569 ; 8/17 ; 3:2)
Haze A(P), Taylor AL(C), Blumenfeld A(C), Rosenfeld E(C), Leiser Y(C), Dafni L(T), Shay B(C), Gruenbaum-Cohen Y(C), Fermon E(C), Haegewald S(C), Bernimoulin JP(C) , Deutsch D(P). Amelogenin expression in long bone and cartilage cells and in bone marrow progenitor cells. Anat Rec (Hoboken). 2007 May; 290(5):455-60. PubMed PMID: 17393535. (1.569 ; 8/17 ; 9:7)
Deutsch D(P), Haze-Filderman A(C), Blumenfeld A(C), Dafni L(T), Leiser Y(C), Shay B(C), Gruenbaum-Cohen Y(C), Rosenfeld E(C), Fermon E(C), Zimmermann B(C), Haegewald S(C), Bernimoulin JP(C), Taylor AL(P). Amelogenin, a major structural protein in mineralizing enamel, is also expressed in soft tissues: brain and cells of the hematopoietic system. Eur J Oral Sci. 2006 May;114 Suppl 1:183-9; discussion 201-2, 381. PubMed PMID: 16674683. (1.957; 18/55 ; 9:7)
Taylor AL(P), Haze-Filderman A(C), Blumenfeld A(C), Shay B(C), Dafni L(T), Rosenfeld E(C), Leiser Y(C), Fermon E(C), Gruenbaum-Cohen Y(C), Deutsch D(P). High yield of biologically active recombinant human amelogenin using the baculovirus expression system. Protein Expr Purif. 2006 Jan;45(1):43-53. Epub 2005 Jun 21. PubMed PMID: 16055347. (1.621 ; 45/65, 200/275, 87/144 ; 6;3)
Deutsch D(P), Leiser Y(C), Shay B(C), Fermon E(C), Taylor A(C), Rosenfeld E(C), Dafni L(T), Charuvi K(C), Cohen Y(C), Haze A(C), Fuks A(C), Mao Z(P). The human tuftelin gene and the expression of tuftelin in mineralizing and nonmineralizing tissues. Connect Tissue Res. 2002;43(2-3):425-34. Review. PubMed PMID: 12489194. (1.113 ; 144/157, 29/49 ; 11:8 )
Mao Z(P), Shay B(P), Hekmati M(C), Fermon E(C), Taylor A(C), Dafni L(C), Heikinheimo K(C), Lustmann J(C), Fisher LW(C), Young MF(C), Deutsch D(P). The human tuftelin gene: cloning and characterization. Gene. 2001 Nov 28;279(2):181-96. PubMed PMID: 11733143. (2.578 ; 70/138 ; 12:9 )
Abstracts
Haze-Filderman A.(P), Taylor A.L.(C), Blumenfeld A.(C), Dafni L.(T), Shay B.(S), Cohen-Gruenbaum Y.(S), Rosenfeld E.(S), Leiser Y.(S), Fermon E.(S), Shai E.(C), Haegewald S.(C), Bernimoulin J.P.(C), Zimmermann B.(C) and Deutsch, D.(P) (2005). Amelogenin Expression Pattern May Explain Periodontal Regeneration. J Dent Res 84: Abs. 2800. ( 3.142 ; 3/55 ; X:X)
Deutsch D.(P), Haze A.(C), Taylor A.(C), Dafni L.(T), Blumenfeld A.(C), Shay, B.(S), Rosenfeld E.(S), Fermon E.(S), Cohen Y.(S), Haegewald S.(C), Jawor P.(C), Zimmermann B.(C), Bernimoulin J.P.(C) (2003). Regeneration of the Periodontal Tissues in-vivo, using the Recombinant Human Amelogenin Protein. J. Dent. Res. 82: B292-B292 2252 Sp. Iss. B . ( 3.142 ; 3/55 ; X:X)
Leiser Y.(P), Dafni L.(T), Mao Z.K.(S), Taylor A.L.(S), Rosenfeld E.(S), Shay B.(S), Fermon E.(S), Haze A.(S) and Deutsch D(P) (2002). The expression of the acidic tuftelin protein in developing and mineralizing enamel and in non-mineralizing soft tissues. J Dent Res 81: B307-B307 Sp. Iss. B. ( 3.142 ; 3/55 ; 1:0)
Leiser Y.(P), Dafni L.(T); Mao Z.K.(C), Taylor A.L.(S), Rosenfeld E.(S), Shay B.(S), Fermon E.(S); Haze-Filderman A.(S), Cohen Y.(S) and Deutsch D.(P) (2002). Quantitation and Localization of Tuftelin Expression in the Mouse Brain (Poster). 7th European Symposium on Calcium Binding Proteins in Normal and Transformed Cells, Bruxelles. 133-4.
Fermon E.(P), Young M.(C), Fisher L.W.(C), Kulkarni A.B.(C), Dafni L.(T), Haze A.(S), Leiser Y.(S), Mao Z.K.(S), Rosenfeld E.(S), Shay B.(S), Taylor A.L.(S) and Deutsch D.(P) (2002). Isolation and characterization of the mouse tuftelin gene and preparation of tuftelin targeting constructs for future generation of a tuftelin "knock-out" mouse. J Dent Res 81: B307-B307 Sp. Iss. B. ( 3.142; 3/55; X:X)
Rosenfeld E.(P), Taylor A.L.(S), Shay B.(S), Mao Z.K.(S), Fermon E.(S), Leiser Y.(S), Haze A.(S), Daphni L.(T) and Deutsch D.(P) (2002). Production and characterization of the recombinant humans ameloblastin protein. J Dent Res 81: B308-B308 Sp. Iss. B. ( 3.142 ; 3/55 ; X:X)
Shay B.(P), Young M.(C), Fisher L.W.(C), Taylor A.L.(S), Fermon E.(S), Haze A.(S), Mao Z.K.(S), Rosenfeld E.(S), Leiser Y.(S), Danieli T.(C), Dafni L.(T) and Deutsch D.(P) (2002). Production of human and bovine recombinant tuftelin proteins. J Dent Res 81: B308-B308 Sp. Iss. B. ( 3.142 ; 3/55 ; X:X)
Mao Z.(P), Shay B.(C), Hekmati M.(S), Fermon E.(S), Taylor A.L.(S), Dafni L.(T), Heikinheimo K.(C), Rosenfeld E.(S), Leiser Y.(S), Fisher L.W.(C), Young M.F.(C) and Deutsch D.(P) (2002). Alternative splicing of the human and mouse tuftelin gene. J Dent Res 81: B311-B311 Sp. Iss. B. ( 3.142; 3/55 ; X:X)
Haze A.(P), Dafni L.(T), Mao Z.K.(S), Taylor A.L.(S), Rosenfeld E.(S), Shay B.(S), Fermon E.(S), Leiser Y.(S) and Deutsch D.(P) (2002). Expression of enamel proteins in developing rat molar root. J Dent Res 81: B311-B311 Sp. Iss. B. ( 3.142; 3/55; X:X)
Taylor A.L.(P), Shay B.(C), Mao Z.K.(S), Daphni L.(T), Rosenfeld E.(S), Leiser Y.(S), Fermon E.(S), Haze A.(S), Danieli T.(C), Young M.(C), Bernimoulin J.P.(C), Haegewald S.(C), Zimmermann B.(C) and Deutsch D.(P) (2002). Production and structural-functional characterization of recombinant human amelogenin proteins. J Dent Res 81: B311-B311 Sp. Iss. B. ( 3.142; 3/55 ; X:X)
Deutsch D.(P), Leiser Y.(C), Shay B.(C), Fermon E.(S), Taylor A.L.(S), Rosenfeld E.(S), Dafni L.(T), Cohen Y.(S), Haze A.(S), Fuks, A.(C) and Mao Z.K.(C) (2002). Tuftelin from Tooth to Brain. .(Oral presentation by Deutsch D) 7th European Symposium on Calcium Binding Proteins in Normal and Transformed Cells, Bruxelles. 20-22.
Shay, B.(P), Taylor, A.L.(S), Mao, Z.K.(S), Danieli, T.(C), Dafni, L.(T) and Deutsch, D.(P) (2001). High Expression of Tuftelin using Baculovirus. J Dent Res 80: 1315. ( 3.142; 3/55; X:X)
Mao, Z.K.(P), Dafni, L.(T), Shay, B.(C), Taylor, A.L.(S) and Deutsch, D.(P) (2001). The Structure of the Human Tuftelin Gene. J Dent Res 80: 1315. (3.142; 3/55; X:X)
Taylor, A.L.(P), Shay, B.(S), Mao, Z.K(S), Danieli, T.(C), Dafni, L.(T) and Deutsch, D.(P) (2001). High Expression of Human Amelogenin using Baculovirus. J Dent Res 80:1315. ( 3.142; 3/55; X:X)