Investigator

Department of Nephrology

Hadassah University Hospital Ein-Karem

Jerusalem, Israel

Tel: 972-2-6776884/1

E-mail: Spnina@hadassah.org.il

Born: August 9, 1953, Yavneel, Israel

Education

1967-1971  Berl Katznelson highschool, Kfar Saba

1976 - B.Sc. in Biology, Hebrew University, Jerusalem

1979 - M.Sc. in Pharmacology, Hebrew University-Hadassah Medical School, Jerusalem (Supervisors: Prof. Y. Gutman, Prof. J.W. Czaczkes, Dr. H. Wald).

1984 - PH.D. Hebrew University, Jerusalem ("Na-K-ATPase activity in various segments of the nehron isolated from the rabbit kidney". Supervisors: Prof. J.W. Czaczkes, Dr. H. Wald).

2001 - Courses of the "Israel Laboratory Accreditation Authority" (ISRAC):

1] ISO/FDIS 15189

2] ISO/IEC 17025

3] Courses in writing of SOP

4] Courses in Good Laboratory Practices (GLP)

5] Courses in professional testing of laboratories for Israel Laboratory Accreditation Authority

Positions

1976 - Research at the Nephrology and Hypertension Laboratories, Hadassah University Hospital, Jerusalem

1992-1993  Visiting Scientist at the University College Hospital of London, London, Great Britain

1994 - Collaborative research project with Lise Bankir, Ph.D., Director of Research, Renal Physiological Laboratory, Hôpital Necker, Paris, France

1995 - Collaborative research project with Ehud Ziv, Ph.D., Diabetic Unit, Hadassah University Hospital, on “The Psammomys: 1) the effect of nutrition on its urinary concentration, 2) the diabetic kidney.

1997 -  Collaborative research project with Prof. A. Bzezinski, M.D., Department of Gynecology and Obstetrics, Hadassah University Hospital, on osteoporosis in postmenopausal women.

2000 - Collaborator with Dr.Anca Gal Moscovici, MD, Nephrology Services, Hadassah University Hospital, on Bone Changes in Postmenopausal Patients with ESDR.

2005 - Collaborative research project with Prof. Moshe Levi on FXR, LXR ,SREBP1c and PPARalpha in Renal Disease of Metabolic Syndrome and Aging.

Teaching

Participated in teaching residents in Nephrology a course in the physiology and pathophysiology of the kidney.

Participates in teaching of Nephrology to 6th year medical students at the Hebrew University-Hadassah Medical School, Jerusalem

Supervision of M.Sc. Thesis (E. Nachliel), “Renal Na-K-ATPase hyperactivity in diabetic Psammomys Obesus”.

Supervision of M.Sc. Thesis (N. Hamani), “The activity and gene expression changes of Na-K-ATPase subunits in the diabetic kidney of Psammomys Obesus”.

Supervision of 6th year medical student (Shahaf Katlan), in cooperation with Professor E. Ziv, Developing complications of nephropathy in the Psammomys, an animal model of diabetes Type 2.

Supervision of 6th year medical student (Guy Gott), in cooperation with Prof. E. Ziv,  The Psammomys – A model of diabetic nephropathy.

Society Memberships

§         Israel Society of Nephrology and Hypertension

§         Israel Diabetes Association (IDA)

§         American Society of Nephrology (ASN)

§         International Society of Nephrology (ISN)

Awards

The Ziegler Prize for outstanding research in medicine, Technion Medical School, Haifa, 1988

The Israel Society of Nephrology and Hypertension Award for research in Na-K-ATPase activity in isolated nephron segments using RT-PCR, 2001.

Grants

2002 - Israel Society of Nephrology Grant

2003 - Hadassah Women's Health Grant

2006 - NIH Grant , in collaboration with Prof. Moshe Levi: "FXR in Renal Disease of Metabolic Syndrome and Aging".

List of Publications

Articles

1. Scherzer P, H Wald, JW Czaczkes. Na-K-ATPase in isolated rabbit tubules after unilateral nephrectomy and Na+-loading. Am J Physiol 248(Renal Fluid Electrolyte Physiol 17): F565-F573, 1985.

2. Wald H, P Scherzer, MM Popovtzer. Parallel changes in red blood cell and renal Na-K-ATPase activity in adrenal and electrolyte disorders in the rat. Pflugers Arch 404: 56-60, 1985.

3. Wald H, P Scherzer, MM Popovtzer. Enhanced renal tubular ouabain sensitive ATPase in streptozotocin diabetes mellitus. Am J Physiol 251: F164-F170, 1986.

4. Scherzer P, H Wald, MM Popovtzer. Enhanced glomerular filtration and Na-K-ATPase with furosemide administration. Am J Physiol 252: F910-F915, 1987.

5. Wald H, P Scherzer, MM Popovtzer. Inhibition of thick ascending limb Na-K-ATPase activity in salt loaded rats by furosemide. Am J Physiol 256: F549-F555, 1989.

6. Scherzer P, H Wald, MM Popovtzer. Reduced Na-K-ATPase in distal nephron in glycerol-induced acute tubular necrosis (ATN). Kidney Int 37: 870-874, 1990.

7. Rubinger D, H Wald, P Scherzer, MM Popovter. Renal sodium handling and stimulation of medullary Na-K-ATPase during blockade of prostaglandin synthesis. Prostaglandins 39: 179-194, 1990.

8. Wald H, P Scherzer, D Rubinger, MM Popovtzer. Effect of indomethacin in vivo and PGE2 in vitro on MTAL Na-K-ATPase of the rat kidney. Pflügers Arch 415: 648-650, 1990.

9. Popovtzer MM, H Wald, P Scherzer. The diabetic kidney - lesson in the resetting of tubuloglomerular feedback. Proceedings, 4th Asian-Pacific Congress of Nephrology. Eds: Jinhong Z, Zuehal D, Zhihong L, Leishi L. International Academic Publishers, Beijing 1991, pp 379-382.

10. Popovtzer MM, H Wald, Mm Friedlaender, D Rubinger, P Scherzer. Renal tubular actions of vitamin D: An example of physiological complexity. Proceedings, 4th Asian-Pacific Congress of Nephrology. Eds: Jinhong Z, Zuehal D, Zhihong L, Leishi L. International Academic Publishers, Beijing 1991, pp 18-20.

11. Wald H, P Scherzer, Y Yagil, D Rubinger, MM Friedlaender, A Moran, MM Popovtzer. Vitamin D blocks the PTH effects on phosphate uptake in OK cells: evidence for interference with adenylate cyclase (AC)/cAMP activation. 24th Annual Meeting of the American Society of Nephrology. Baltimore, November 1991. Journal of the American Society of Nephrology 2: 642, 1991.

12. Wald H, P Scherzer, MM Popovtzer. Na-K-ATPase isolated nephron segments in rats with experimental heart failure: correlation with severity of sodium retention. Circul Res 68: 1051-1058, 1991.

13. Scherzer P, H Wald, D Rubinger, MM Popovtzer. Indomethacin and sodium retention in the rat. Role of inhibition of prostaglandin-E2 synthesis. Clin Sci 83: 307-311, 1992.

14. Wald H, P Scherzer, R Rasch, MM Popovtzer. Renal tubular Na-K-ATPase in diabetes mellitus; relationship to metabolic abnormality. Am J Physiol 265: E96-E101, 1993.

15. Scherzer P, I Nachliel, E Ziv, H Bar-On, MM Popovtzer. Effects of variation in food intake on renal sodium pump activity in its gene expression in Psammomys kidney. Am J Physiol (Renal Physiology)279: F1124-F1131, 2000.

16. Scherzer P, I Nachliel, H Bar-On, MM Popovtzer, E Ziv. Renal Na-K-ATPase hyperactivity in diabetic Psammomys Obesus is related to glomerular hyperfiltration but is insulin-independent. J Endocrinol 167: 347-354, 2000

17. Scherzer P, MM Popovtzer. Segmental localization of mRNAs encoding Na-K-ATPase  and  subunits in the diabetic rat kidneys using reverse transcription of mRNAs (RT-PCR). Am J Physiol 282: F492-500, 2002.

18. Gal-Moscovici A.,Scherzer P. ,Rubinger D.,Weiss R.,Dranitzki-Elhalel M.,Popovtzer MM. Stimulation of osteoclastic bone resorption in a model of glycerol-induced acute renal failure:evidence for a parathyroid hormone-independent mechanism. Bone,31,488-91,2002

Articles in press

Progressive Changes in Na Pump Gene Expression, Protein Abundance and Activity in Dissected Isolated Nephron Segments:
Underlying mechanism for functional changes of the aging kidney. P.Scherzer and M.M.Popovtzer, AJP (2006)

Bone Turnover in Experimental Menopause: Impact of SuperimposedChronic Renal Disease (CKD). Anca Gal-Moscovici, Mordechai M. Popovtzer, Michael Gal, Yosef  Foldes and Pnina Scherzer, Bone(2006)

Developing Complications of Nephropathy in Psammomys, an animal Model of Diabetes Type 2. P. Scherzer, S. Katalan, G. Got, G. Pizov, M. Bendayan,  E.Ziv. Diabetes(2006)

Papers Selected for Presentation at International Meetings

1. Popovtzer MM, A Rosler, E Cerasi, P Scherzer, JW Czaczkes. Na+-K+-ATPase deficiency: A possible mechanism of renal salt-wasting in a newborn baby with “pseudohypoaldosteronism”. Clin Res Vol 28, 1980.

2. Scherzer P, JW Czaczkes. Total and Na-K-ATPase activity in cortical isolated segments of the rabbit nephron as influenced by different Na and osmolar concentrations before and after unilateral nephrectomy. VIIIth International Congress of Nephrology, Athens, June 1981.

3. Wald H, P Scherzer, JW Czaczkes, MM Popovtzer. Red blood cell Na-K-ATPase activity in adrenal insufficiency: Evidence for close relationship with renal enzyme activity. VIIIth International Congress of Nephrology, Athens, June 1981.

4. Scherzer P, JW Czaczkes. Na-K-ATPase activity in rabbit cortical kidney segments affected by changes in sodium and osmotic concentrations before and after unilateral nephrectomy. Congress of the Israel Society of Nephrology, Herzliya, January 1982.

5. Scherzer P, JW Czaczkes. The effect of unilateral nephrectomy (UNPX) and Na-loading on Na-K-ATPase in isolated rabbit tubules. IXth International Congress of Nephrology. Los Angeles, June 1984.

6. Pomeranz A, A Drukker, P Scherzer, H Wald, MM Popovtzer. The effect of acute extracellular volume expansion on red blood cell (RBC)( Na-K-ATPase activity in man: evidence for a circulating inhibitor of sodium transport. IXth International Congress of Nephrology. Los Angeles, June 1984.

7. Wald H, P Scherzer, MM Popovtzer. Na-K-ATPase is altered similarly in the kidney and in the RBC’s in disorders of electrolytes. 1984 Regional Meeting of the International Union of Physiological Sciences. Jerusalem, August 1984. IXth International Congress of Nephrology. Los Angeles, June 1984.

8. Wald H, P Scherzer, MM Popovtzer. Na-K-ATPase is altered similarly in the kidney and in the RBCs in disorders of electrolytes. 1984 Regional Meeting of the International Union of Physiological Sciences. Jerusalem, August 1984.

9. Wald H, P Scherzer, MM Popovtzer. Effect of streptozotocin-induced diabetes mellitus on Na-K-ATPase activity in isolated tubules of the rat. Yearly Congress of the Israel Society of Nephrology and Hypertension. Kfar Hamakabi, February 1985.

10. Scherzer P, H Wald, MM Popovtzer. Glomerular filtration rate and Na-K-ATPase in isolated nephrons after chronic furosemide administration. Yearly Congress of the Israel Society of Nephrology and Hypertension, Kfar Hamakabi, March 1986.

11. Wald H, H Markovich, P Scherzer, MM Popovtzer. Streptozotocin-induced diabetes mellitus protects against Hgd2-induced acute tubular necrosis in rats: possible role of enhanced renal Na-K-ATPase. Medax, Jerusalem, September 1986

12. Scherzer P, H Wald, MM Popovtzer. The effect of chronic salt load on Na-K-ATPase in the thick ascending limb of Henle’s loop of the rat. Medax, Jerusalem, September 1986.

13. Wald H, P Scherzer, MM Popovtzer. Enhanced renal tubular Na-K-ATPase in streptozotocin-induced diabetes mellitus: possible role in electrolyte homeostasis. 3rd Asian-Pacific Congress of Nephrology, Singapore, October 1986.

14. Wald H, P Scherzer, MM Popovtzer. Na-K-ATPase in isolated nephron segments in rats with experimental heart failure (HF): correlation with severity of Na retention. Xth International Congress of Nephrology, London, July 1987.

15. Scherzer P, H Wald, MM Friedlaender. The effect of 25(OH)D3 on parathyroid hormone (PTH)-activated adenylate-cyclase (AC) in isolated nephron segments in male rats. Xth International Congress of Nephrology, London, July 1987.

16. Wald H, Scherzer P, MM Popovtzer. Enhanced Na-K-ATPase in the ascending limb of  Henle’s loop in chronic salt loading in the rat: A mechanism of water conservation. 72nd Annual Meeting of the Federation of American Societies for Experimental Biology, Las Vegas, May 1988. Israel Nephrological Society, Tel Aviv, March 1988.

17. Scherzer P, H Wald, MM Popovtzer. reduced Na-K-ATPase activity in distal nephron in glycerol-induced acute renal failure (ARF): relation to severity of functional impairment. Israel Nephrological Society, Tel Aviv, March 1988. The American Society of Nephrology, 21st Annual Meeting, San Antonio, December 1988.

18. Wald H, D Rubinger, P Scherzer, MM Friedlaender, A Moran, MM Popovtzer. 25-hydroxylated vitamin D3 derivatives block PGE2 and PTH-stimulated cAMP in OK cell line. The American Society of Nephrology, 21st Annual Meeting. San Antonio, December 1988.

19. Wald H, P Scherzer, D Rubinger, MM Popovtzer. Indomethacin enhances Na retention by inhibiting PGE2 synthesis in MTAL. The American Society of Nephrology, 22nd Annual Meeting. Washington DC, December 1989.

20. Wald H, P Scherzer, D Rubinger, MM Popovtzer. Opposite direct effects of prostaglandin E2 (PGE2) on Na-K-ATPase activity in proximal and distal segments of the nephron in rat kidney. XIth International Congress of Nephrology. Tokyo, Japan 1990.

21. Wald H, P Scherzer, D Rubinger, MM Popovtzer. Direct effect of GE2 on renal Na-K-ATPase in the rat: opposite response in the proximal and in the distal tubules. 4th Asian-Pacific Congress of Nephrology. Beijing, October 1990.

22. Wald H, P Scherzer, R Rasch, MM Popovtzer. Renal tubular Na-K-ATPase in diabetes mellitus: Relationship to metabolic abnormality. 24th Annual Meeting of the American Society of Nephrology. Baltimore, November 1991. Journal of the American Society of Nephrology 2: 301, 1991.

23. Scherzer P, H Wald, MM Popovtzer. Augmented Na-K-ATPase activity in henle’s loop in diabetes mellitus (DM) is determined by the magnitude of glomerular hyperfiltration. 24th Annual Meeting of the American Society of Nephrology. Baltimore, November 1991. Journal of the American Society of Nephrology 2: 297, 1991.

24. Wald H, P Scherzer, Y Yagil, D Rubinger, MM Friedlaender, A Moran and MM Popovtzer. Vitamin D blocks the PTH effects on phosphate uptake in OK cells: evidence for interference with adenylate cyclase (AC)/.cAMP activation. 24th Annual Meeting of the American Society of Nephrology. Baltimore, November 1991. Journal of the American Society of Nephrology 2: 642, 1991.

25. Wald H, P Scherzer, D Rubinger, MM Popovtzer. Pathophysiologic perspectives of Na+-K+-ATPase (invited lecture). XIIth International Congress of Nephrology. Jerusalem, June 1993.

26. Scherzer P, H Wald, MM Popovtzer. The effect of aging on Na-K-ATPase activity in isolated nephron segments. XIIth International Congress of Nephrology. Jerusalem, June 1993.

27. Scherzer P, I Nachliel, E Ziv, MM Popovtzer. The role of nutrition in Psammomys kidney osmotic gradient: The importance of urea. 30th Annual Meeting of the American Society of Nephrology. San Antonio November 1997. Journal of the American Society of Nephrology 8: 25A, 1997.

28. Scherzer P, I Nachliel, E Ziv, H Bar-On, MM Popovtzer. Renal Na-K- ATPase hyperactivity in diabetic Psammomys obesus is related to glomerular hyperfiltration but is insulin-independent. Acta Diabetologica 1998.

Carmiel-Hagai M, D Rubinger, H Wald, P Scherzer, MM Popovtzer. Expression of and  subunits of Na-K-ATPase during inhibition of prostaglandin (PG) synthesis in rat kidney. 31st Annual Meeting of the American Society of Nephrology Philadelphia October 1998. Journal of the American Society  of Nephrology 9: 410A, 1998.   

Rubinger D, P Scherzer, O Hochman, A Ahronson, MM Popovtzer. Adenosine antagonism prevents contrast nephropathy in experimental diabetes mellitus by activation of the NO system. 32nd Annual Meeting of the American Society of Nephrology Miami November 1999. Journal of the American Society of Nephrology 10: A3496, 1999.

31. Scherzer P, I Nachliel, E Ziv, H Bar-On and MM Popovtzer. Sodium pump activity and its  and  subunits in the Psammomys kidney.  Annual Meeting of the Israel Society of Nephrology and Hypertension, Eilat March 2000.

32. Scherzer P, MM Popovtzer. Segmental localization of mRNAs encoding Na-K-ATPase  and  subunits in the diabetic rat kidneys using RT-PCR.  Annual Meeting of the Israel Society of Nephrology and Hypertension, Eilat, Israel March 2000.

33. Scherzer P, MM Popovtzer. Segmental localization of mRNAs encoding Na-K-ATPase  and  subunits in the diabetic rat kidneys using reverse transcription of mRNAs (RT-PCR). 33rd Annual Meeting of the American Society of Nephrology Toronto, Ontario, Canada, October 2000.

34. Scherzer P, MM Popovtzer. Reduced Na-K-ATPase gene expression and activity in Henle’s loop: underlying mechanism for impaired urinary concentration and dilution in aging kidney. 35th Annual Meeting of the American Society of Nephrology, Philadelphia, 2002.

35. Scherzer P, MM Popovtzer.  Reduced Na-K-ATPase gene expression and activity in Henle's loop: Underlying mechanism for impaired urinary concentration and dilution in aging kidney. Annual Meeting of the Israel Society of Nephrology and Hypertension,  Eilat, Israel, March 2003.

36. Scherzer P, N. Hamani, MM Popovtzer, E Ziv.  Nephropathy in nutritionally-induced model of Type 2 diabetes: early and late stage with changes in Na-K-ATPase activity and its gene expression. 18th Congress of the International Diabetes Federation, Paris, France, 24-29 August, 2003, Abstract Number 985.

37. Scherzer P, MM Popovtzer. Progressive changes in Na Pump gene expression, protein abundance and activity in the dissected isolated nephron segments: underlying mechanism for functional changes of the ageing kidney.  Annual Meeting of the  Israel Society of  Nephrology and Hypertension, Eilat, Israel, March 2004.

38. Scherzer P, MM Popovtzer. Aldosterone-independent regulation of Na-K-ATPase in cortical collecting duct (CCD) in kidneys of aging rats: Role in K balance. 38th  Annual Meeting of the American Society of Nephrology Philadelphia, 2005.

39. Gal-Moscovici A, MM Popovtzer, M Gal, Y Foldes, P Scherzer. Bone turnover in experimental menopause: Impact of superimposed chronic kidney disease (CKD). 38th Annual meeting of the American Society of Nephrology, Philadelphia, 2005.

40. Scherzer P, S Katalan, G Got, G Pizov, M Bendayan, E Ziv. Developing complications of nephropathy in psammomys - an animal model of Diabetic Nephropathy. 23rd Meeting of the Israel Diabetes Association, Tel-Aviv, June 2006.

41. Scherzer P, S Katalan, G Got, G Pizov, M Bendayan, E Ziv. Developing complications of nephropathy in the psammomys – an animal model of diabetes type 2. 39th Annual Meeting of the American Society of Nephrology, San Diego, Ca.  2006. J Am Soc Nephrol 27: 396A, 2006.