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Dr. Ann Saada (Reisch)

 

 

Laboratory Chief

Metabolic Disease Unit

Hadassah Medical Organization

Ein-karem, Jerusalem

Phone: +97-2-6778644   fax: +972-2 -6779018

E-mails:  annsr@hadassah.org.il

saada-ann@macam.ac.il

 

 

Date and place of birth: 1959  Vasteras  Sweden

Date of immigration: 1978

Marital status: married to Joel + 4

 

Education

 

1979-1981  B.Sc. biology, Faculty of  Sciences Hebrew University Jerusalem

 

1981-1983  M.Sc.microbiology, Hebrew University, Faculty of Medicine.

 

1985-1990  Ph.D.microbiology, Department of Membrane and Ultra- Structure, Faculty of Medicine Hebrew University  Jerusalem

 

1990-1993 Post. Doc.  neurobiology  Department of Anatomy and Embryology Hadassah Medical School, Hebrew University Jerusalem

 

Employment History

 

2005-  Laboratory chief, Metabolic Disease Unit Hadassah Medical  Center Jerusalem

 

2005-  Senior lecturer Ben Gurion University of the Negev

 

1994-2005  Laboratory chief, Metabolic Disease Unit  Shaare Zedek   Medical Center Jerusalem

 

1993-2005  lecturer     Michlala College Jerusalem, Lifshiz College Jerusalem

 

1985-1990  Instructor Hadassah Medical School Hebrew University, Jerusalem

 

1983-1985  Biochemistry, Fermentation Unit Hebrew University / Koor Jerusalem

 

Scientific Publications

Book Chapters

 

Saada A, Rahamim E, Kahane I, Beyth Y.1993. Detection of adherence of Ureaplasma urelyticum to bovine fallopian tube cells in culture. In Rapid  diagnosis of Mycoplasmas  111-110 Eds: Kahane I, Adoni A. Plenum Press N.Y

 

Saada Reisch A, Elpeleg O. 2005. Mitochondrial DNA depletion. In Focus on DNA research. Ed. Pappas J. Nova Sciences.

 

Saada Reisch A, Elpeleg O. Enzymatic assays of TCA and PDHc. In Mitochondrial 2nd ed. Eds Pon and Schon Academic Press USA (in press)

 

Articles in Scientific Journals

 

Kahane I, Granek J, Reisch-Saada A 1984. The adhesins of Mycoplasma  gallisepticum and M. Pneumoniae  Ann.Microbiol. 135 A:25-32

 

Saada AB, Kahane I. 1988. Purification and characterization of urease from Ureaplasma urealyticum.  Zentralbl Bakteriol Mikrobiol Hyg [A].;269:160-167

 

Saada AB, Deutch V, Kahane I. 1998.Interaction  of a monoclonal antibody with the urease of Ureaplasma urealyticum. FEMS lett. 1988 55: 187-190

 

Kahane I. Reisch-Saada A. Almagor M. Abeliuch P. Yatziv S. 1990.Glycosidase activites of mycoplasmas Zentralbl   Bakteriol  Mikrobiol Hyg. 273:300-305

 

Saada AB, Terespolski Y, Adoni A, Kahane I.  1991.Adherence of Ureaplasma  urealyticum to human erythrocytes.  Infect Immun.;59: 467-9

 

Aamar S, Saada A, Rotshenker S. 1992. Lesion-induced changes in the production of newly synthesized and secreted apo-E and other molecules are independent of the  concomitant recruitment of blood-borne macrophages into Injured peripheral  nerves. J Neurochem. 59:1287-92

 

Reichert F, Saada A, Rotshenker S.  1994 Peripheral nerve injury induces Schwann cells to express two macrophage phenotypes: phagocytosis and the galactose-specific lectin MAC-2.  J Neurosci. 14:3231-45

 

Saada A, Dunaevsky-Hutt A, Aamar A, Reichert F, Rotshenker S. 1995.  Fibroblasts that reside in mouse and frog injured peripheral nerves produce apolipoproteins. J Neurochem. 64:1996-2003

 

Saada A, Reichert F, Rotshenker S. 1996.Granulocyte macrophage colony stimulating factor produced in lesioned peripheral nerves induces the up-regulation  of cell surface  expression of MAC-2 by macrophages and Schwann cells.  J Cell Biol. 133:159-67

 

Berger I, Elpeleg ON, Saada A.1996 Lipoamide dehydrogenase activity in lymphocytes.  Clin Chim Acta 256:197-201

 

Elpeleg ON, Saada AB, Shaag A, Glustein JZ, RuitenbeekW, Tein I, Halevy  J. 1996. Lipoamide dehydrogenase deficiency: a new cause for recurrent   myoglobinuria Muscle Nerve. 20:238-40

 

Elpeleg ON, Shaag A, Glustein JZ, Anikster Y, Joseph A, Saada A. 1997.  Lipoamide dehydrogenase deficiency in Ashkenazi Jews: an insertion  mutation in the  mitochondrial leader sequence. Hum Mutat. 10:256-257

 

Aptowitzer I, Saada A, Faber J, Kleid D, Elpeleg ON.1997.  Liver disease in the Ashkenazi-Jewish lipoamide dehydrogenase deficiency. J Pediatr Gastroenterol Nutr.  24:599-601

 

Shaag A, Saada A, Steinberg A, Navon P, Elpeleg ON.1997. Mitochondrial  encephalomyopathy  associated with a novel mutation in the mitochondrial  tRNA(leu)(UUR) gene (A3243T). Biochem Biophys Res Commun. 233:637-639

 

Be'eri H, Reichert F, Saada A, Rotshenker S. 1998The cytokine network of Wallerian degeneration: IL-10 and  GM-CSF.  Eur J Neurosci. 10:2707-2713

 

Link G, Saada A, Pinson A, Konijn AM, Hershko C.  1998.Mitochondrial respiratory   enzymes are a major target of iron toxicity in rat heart cells. J Lab Clin Med. 131:466-474

 

Cohen O, Steiner I, Argov Z, Ashkenazi A, Diment J, Saada A, River Y. 1998.  Mitochondrial  myopathy with atypical subacute presentation. J Neurol Neurosurg Psychiatry. 64:410-411

 

Shaag A, Saada A, Berger I, Mandel H, Joseph A,  Feigenbaum A, Elpeleg   ON. 1999. Molecular basis of lipoamide dehydrogenase deficiency in Ashkenazi  Jews. Am J Med Genet. 82:177-182

 

Shany E, Saada A, Landau D, Shaag A, Hershkovitz E,  Elpeleg ON.1999. Lipoamide  dehydrogenase deficiency due to a novel mutation in the interface domain. Biochem Biophys Res Commun. 262:163-166

 

Saada A, Aptowitzer I, Link G, Elpeleg ON. 2000. ATP synthesis in lipoamide dehydrogenase deficiency. Biochem Biophys Res  Commun 269:382-386

 

Elpeleg ON, Hammerman C, Saada A, Shaag A, Golzand E, Hochner-Celnikier   D, Berger I, Nadjari M. 2001. The antenatal presentation of carnitine palmitoyl   transferase II deficiency. Am J Med Genet. 102:183-187

 

Mandel H, Szargel R, Labay V, Elpeleg O, Saada A, Shalata A, Anbinder Y,  Berkowitz D, Hartman C, Barak M, Eriksson S, Cohen N. 2001.The deoxyguanosine kinase gene is mutated in  individuals with depleted hepatocerebral mitochondrial DNA. Nat genet. 337-41

 

Saada A  , Mandel H, Nevo Y, Eriksson S, Elpeleg O.2001. Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy. Nat Genet. 29:342-343.

 

Bar-Meir, Elpeleg O, Saada A.2001. Effect of various agents on adenosine triphosphate  synthesis in mitochondrial complex I deficiency. J   Pediatr. 139:868-870

 

Elpeleg O, Mandel H, Saada A.2002. Depletion of the other genome Mitochondrial depletion syndrome in humans. J.Molec. Med. 80:389-396

 

Nevo Y, Soffer D, Kutai M, Zelnik N, Saada A, Jossiphov J, Messer G, Shaag A, Shahar E, Harel S, Elpeleg O. 2002. Clinical characteristics and muscle pathology in myopathic mitochondrial DNA depletion.  Child Neurol. 17: 499- 504

 

Lev D, Gilad E, Leshinsky-Silver E, Houri S, Levine A, Saada A, Lerman-Sagie T. 2002.Reversible fulminant lactic  and liver failure in an Infant with Hepatic  Cytochrome C Oxidase Deficiency.  J Inherit Metab Dis. 25:371-377

 

Saada A, Shaag A, Elpeleg O. 2003.MtDNA depletion myopathy: elucidation of the Tissue specificity in the mitochondrial thymidine kinase (TK2) deficiency Molec Gen Metab.2003;79:1-5

 

Wang L, Saada A, Eriksson S. 2003. Kinetic properties of mutant thymidine kinase 2 suggest a mechanism for  mitochondrial DNA depletion myopathy. J. Biol. Chem. 278:6963-6968

 

Saada A, Ben-Shalom E, Zyslin R, Miller C, Mandel H, Elpeleg O.2003. Mitochondrial Deoxyribonucleoside triphosphate pools in thymidine kinase 2  deficiency. Biochem. Biophys. Res. Commun.; 310:963-966

 

Miller C, Saada A, Shaul N, Shabtai N, Ben-Shalom E, Shaag A, Herskowitz E,  Elpeleg O.2004 Defective mitochondrial translation due to a ribosomal protein  (MRPS16) mutation. Ann Neurol 56:734-738

 

Saada A. Bar-Meir M, Belaiche C, Miller C, Elpeleg O. 2004 Evaluation of enzymatic assays and compounds affecting ATP production in mitochondrial respiratory chain complex I deficiency.  Anal.Biochem 335:66-72

 

Saada-Reisch  A. 2004 Deoxyribonucleoside kinases in mitochondrial DNA depletion. Nucleotides,Nucleotides and Nucleic Acids: 23:127-137

 

Lamont PJ, Thorburn DR, Fabian V, Vajsar J, Hawkins C, Saada Reisch A, Durling H, Laing NG, Nevo Y.2004. Nemaline rods and complex I deficiency in three infants with hypotonia, motor delay and failure to thrive.  Neuropediatrics. 2004;35:302-306

 

Saada A. 2004 Deoxyribonucleotides and disorders of mitochondrial DNA integrity. DNA & Cell Biol  12:979-816

 

Bahat-Stroomza M, Gilgun-Sherki Y, Offen D, Panet H, Saada A, Krool-Galron N, Barzilai A, Atlas D, Melamed E. 2005. A novel thiol antioxidant that crosses the blood brain barrier protects dopaminergic neurons in experimental models of Parkinson's disease. Eur J Neurosci. 21:637-46

 

Elpeleg O, Miller C, Hershkovitz E, Bitner-Glindzicz M, Bondi-Rubinstein G, Rahman S, Pagnamenta A, Eshhar S, Saada A. 2005  Deficiency of the ADP-Forming Succinyl-CoA Synthase Activity Is Associated  with Encephalomyopathy and Mitochondrial DNA Depletion. Am J Hum Genet 76:1081-1086.

 

Leshinsky-Silver E, Lev D, Tzofi-Berman Z, Cohen S, Saada A, Yanoov-Sharav M, Gilad E, Lerman-Sagie T. 2005   Fulminant neurological deterioration in a neonate with Leigh syndrome due to a maternally transmitted missense mutation in the mitochondrial ND3 gene.. Biochem Biophys Res Commun 334 582-587.




Dr. Ann Saada (Reisch)



            
  
 


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