Date of Birth: 1957, Tel Aviv, Israel
Marital Status: Married +3 children
Education
1976-1979 - Bar-Ilan University, Area of specialization – Biochemistry, Degree - Bs.C.
1980-1983 - Bar-Ilan University, Area of specialization - Endocrinology/ Fertility, Degree - Ms.C.
1992-1996 - Hebrew University, Area of specialization - Molecular Genetics/ Neurodegeneration, Degree - Ph.D.
1997-2001 - Hebrew University, Area of specialization - Neurobiology/ Neurodegeneration, Degree - Post Doc.
Employment
1983-1987 - Bikur Cholim Hospital, Jerusalem, Area of specialization - Endocrinology / Fertility
1988-1991 - Hebrew University, Area of specialization - Molecular Biology
2001- Hadassah University Hospital, Area of specialization - Neurology, Title – Investigator Molecular Genetics/ Alzheimer’s disease
Awards
1978 - Dean's list of distinguished students, Bar-Ilan University, Ramat- Gan
1979 - Graduated BSc with excellence, Department of Life Sciences, Bar-Ilan University, Ramat-Gan
1992-1996 - PhD Scholarship, Hadassah University Hospital, Jerusalem
Research areas
1. Generating animal models for Alzheimer's disease and tauopathies
2. Genetic and environmental risk factors for Alzheimer's disease and tauopathies
3. Autoimmune aspects of Alzheimer's disease and tauopathies
4. Neurodegenerative and genetic aspects in other neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and prion diseases
5. Developing new neuroprotective therapeutic approaches against neurodegenerative disorders
Patents
2005- New neuroprotective drugs for use against neurodegenerative disorders
Publications (last 10 years)
5. Friedman G., Gabizon R., Shapira A., Castel H., Wertman E., Matsa D., Rosenmann H., Schurr D. Wirtheim E., Friedlander Y., Ben Yehuda A. Association of apoliprotein E4 alleles with Alzheimer 's disease, but not with Down's syndrome or Creutzfeldt- Jakob disease among Israeli Jews. Alzheimer's Research 1:45-48, 1995.
6. Spudich S., Mastrianni J.A., Wrensch M., Gabizon G., Kahana I., Rosenmann H., Kahana E., Prusiner S.B. Complete penetrance of Creutzfeldt-Jakos Disease in Libyan Jews carrying the E200K mutation in the prion protein. Molecular Medicine 6:607- 613, 1995.
7. Ovadia H., Rosenmann H., Halimi M., Ofran I., Shezen E., Gabizon R. Depressed activity of neuronal nitric oxide synthase in Scrapie infected brains and neuroblastoma cells. J. Biol. Chem 271(28): 16856-16861, 1996.
8. Rosenmann H., Halimi M., Kahana E., Biran I., Gabizon R. Differential allelic expression of PrP mRNA in carriers of the E200K mutation. Neurology 49:851-856, 1997.
9. Rosenmann H., Meiner Z., Kahana E., Halimi M., Lenetsky E., Abramsky O., Gabizon R. Detection of 14-3-3 protein in the cerebrospinal fluid of genetic CJD. Neurology 49:593-595, 1997.
10. Rosenmann H. , Finkeltein I. , Rosenberg P. , Michaelov I. , Gabizon R. , Vardi J. Identification in Israel of 2 Jewish CJD patients with a mutation at codon 178 at their PrP gene. Acta. Neurol. Scand. 97:184-187, 1998.
11.Rosenmann H., Kahana E., Kahana I., Korczyn A.D., Chapman J., Gabizon R. Preliminary evidence for anticipation in genetic E200K CJD. Neurology 53(6):1328-1329, 1999.
12. Rosenmann H., Shaked Y., Talmor G., Gabizon R. A C-terminal-truncated PrP isoform is present in mature sperm. J. Biol. Chem. 274(45):32153-32158, 1999.
13. Simon E.S., Kahana E., Chapman J., Treves T.A., Gabizon R., Rosenmann H., Zilber N., Korczyn A.D. CJD profile in patients homozygous for the PRNP E200K mutation. Annl. Neurol. 47(2):257-260, 2000.
14. Argov Z., Sadeh M., Mazor K., Soffer D., Kahana E., Eisenberg I., Mitrani-Rosenbaum S., Richard I., Beckmann J., Keers S., Bashir R., Bushby K., Rosenmann H. Muscular dystrophy due to dysferlin deficiency in Libyan Jews: clinical and genetic features. Brain 123(6):1229-1237, 2000.
15. McNally E M., Ly C.T., Rosenmann H., Mitrani-Rosenbaum S., Jiang W., Anderson L.V.B., Soffer D., Argov Z. A splicing mutation in dysferlin produces limb-girdle muscular dystrophy with inflammation. Amer. J. Med. Genet. 91(4):305-312, 2000.
16. Rosenmann H., Halimi M., Talmor G., Yanai A., Gabizon R., Meiner R. Prion protein with the E200K mutation displays properties similar to those of the cellular isoform PrPC. J. Neurochem. 76:1-10, 2001.
17. Shaked Y., Rosenmann H., Hijazi N., Halimi M., Gabizon R.. Copper binding to the PrP isoforms: a putative marker of their conformation and function. J. Virol. 75(17): 7872-7874, 2001.
18. Shaked G., Engelstein R., Avraham E., Rosenmann H., Gabizon R. Valproic acid treatment results in increased accumulation of prion proteins. Ann. Neurol. 52(4):416-420, 2002.
19. Lossos A., Ekstein D., Soffer D., Gal A., Neheman Y., Reches A., Biran I., Meiner Z., Halimi M., Abramsky O., Rosenmann H. A P301S mutation in the tau gene in a Jewish- Algerian family Affected by frontotemporal dementia and parkinsonism (FTDP). J. neurol. 250(6):733-740, 2003.
20. Rosenmann H., Meiner Z., Kahana E., Aladjem Z., Friedman G., Ben-Yehuda A., Grenader T., Wertman E., Abramsky O. Polymorphism in the complement component C1r is not associated with sporadic Alzheimer’s diseases. Neurosci. Lett. 336:101-104, 2003.
21. Rosenmann H., Meiner Z., Kahana E., Aladjem Z., Friedman G., Ben-Yehuda A., Grenader T., Wertman E., Abramsky O. Genetic Variation in the pro-apoptotic gene p53 and the risk for Alzheimer’s disease- no evidence for association. Neurosci. Lett. 340:29-32, 2003.
22. Rosenmann H., Ginzburg I. Regulation of localization and phosphorylation of tau. 8th Alzheimer’s disease book of proceedings, 287-301, 2003.
23. Hijazi N., Shaked Y., Rosenmann H., Meiner Z., Gabizon R. PrPSc binding and accumulation can be regulated by copper. Brain Res. 993:192-200, 2003
24. Rosenmann H., Meiner Z., Kahana E., Friedman G., Ben Yehuda A., Tal G., Wertman E., Abramsky O. The Fas promoter polymorphism at position – 670 is not associated with late-sporadic Alzheimer’s disease. Dement. Geriatr. Cogn. Disord. 17:143-146, 2004.
25. Rosenmann H., Meiner Z., Kahana E., Aladjem Z., Friedman G., Ben-Yehuda A., Grenader T., Wertman E., Abramsky O. An association study of a polymorphism in the heparane sulfate proteoglycan gene (perlecan, HSPG2) and Alzheimer’s disease. Am. J. med. Genet. (Neuropsychi Genet) 128B(1):123-125, 2004.
26. Rosenmann H., Meiner Z., Dresner-Pollak R., Kahana E., Tal G., Wertman E., Abramsky O. Lack of association of a polymorphism in the IL-1B gene in the Jewish population. Neurosci. Lett. 363:131-133, 2004.
27. Lossos A., Soffer D., Wood NW., Steiner-Birmanns B., Linetski E., Hassin-Baer S., Sadeh M., Sagi M., Abramsky O., Argov Z., Rosenmann H. Extended phenotype in the transthyretin Tyr77 familial amyloid polyneuropathy. Eur Neurol. 53: 55-59, 2005.
28. Soffer D., Newman JP., Meiner Z., Rosenmann H., Steiner I. Primary progressive visual-spatial dementia with ubiquitinated neuronal inclusions. Neurology. In press, 2005.
29. Lossos A., Khoury M., Rizzo W., Gomori M., Banin E., Zlotogorski A., Nashef Y., Abramsly O., Argov Z., Rosenmann H. The clinical course of Sjogren-Larsson syndrome in adults. Arch. Neurol . In press, 2005.
30. Rosenmann H, Meiner Z. Geylis V, Steinitz M. Naturraly occuring antibodies against unphosphorylated and phosphorylated tau protein in sera of AD and healthy subjects. Submitted 2005.
31. Miner V., Weinberg N., Safran A., Lere I., Sagi M., Rosenmann H., Abeliovitch D., Lauffer N., Simon A. Preimplantation genetic diagnosis by exclusion for inherited prion diseases. Submitted 2005.
32. Rosenmann H., Grigoriadis H., Karussis D., Mizrachi-Koll R.., Boimel M., Touloumi O.,Haim Ovadia.., Oded Abramsky. Experimental Autoimmune Tauopathy: immunoreactivity against tau- microtubule-associated protein induces a neurological disease in mice. Submitted 2005.
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