June 2009
Department of Pediatric Hematology/ Oncology
Hadassah- Hebrew University Medical Center
POB 12000, il-91120 Jerusalem Israel
Tel: 972-2-6777408 Fax: 972-2-6777833
E-mail: shoshanav@hadassah.org.il
Born: 9.12.1966, Married, 5 children
1986-1992: M.D. degree, Hebrew university-Hadassah medical school, Jerusalem, Israel
2006-2009: MSc, Clinical Epidemiology, Hebrew university-Hadassah medical school, Jerusalem, Israel
Professional Experience
1993: Rotating internship, Bikur-Cholim Hospital, Jerusalem, affiliated with Hebrew University-Hadassah Medical School, Jerusalem, Israel
1994-1998: Pediatric residency, Bikur-Cholim Hospital, Jerusalem, affiliated with Hebrew University-Hadassah Medical School, Jerusalem, Israel
1997:Basic science residency, Department of Bone-Marrow-Transplant, Hadassah Hospital, Ein-Karem, Jerusalem, Israel
1999-2001:Clinical fellowship, Department of Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Canada
2001-2002: Clinical/research fellowship in Pediatric Thrombosis and Hemostasis, Department of Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Canada
2002:Staff, Pediatric Hematology/Oncology Department, Hadassah Medical Center, Hebrew University, Jerusalem, Israel
Appointments at the Hebrew University
1998-1999: Clinical teaching assistant, Department of Pediatrics, Hebrew University-Hadassah Medical School, Jerusalem, Israel
2002-2004:Clinical teaching assistant, Department of Pediatrics, Hebrew University-Hadassah Medical School, Jerusalem, Israel
2005: Lecturer, Department of Pediatrics, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Teaching Experience
1994-1998: Involved with teaching of medical students, Department of Pediatrics, Bikur- Cholim Hospital, affiliated with the Hebrew University-Hadassah Medical School, Jerusalem, Israel
1999–200: Involved with teaching of medical students. Department of Hematology/Oncology, Hospital for Sick Children, University of Toronto, Canada
2002: Involved with teaching of medical students (4th and 6th year). Department of Pediatric Hematology/Oncology, Hadassah Medical Center, Hebrew University-Hadassah Medical School, Jerusalem, Israel
2008: Involved with teaching of medical students (5th year). Department of Public health, Hebrew University-Hadassah Medical School, Jerusalem, Israel
2008: Involved with teaching of clinical pharmacology students. Department of Pediatric Hematology/Oncology, Hadassah Medical Center, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Supervision of medical students and basic-science residents
2006-2009: Supervision, Basic science resident for MD, Dr. Moti Menahem: Topic "Post thrombotic syndrome in children with cancer treated with central venous catheter"
2006-2009: Supervision, Thesis for Medical students, Yael Shecter: Topic "Is routine screening for coagulation abnormalities prior to ova extraction needed?
2008: Supervision, Thesis for Dental students, Irit Midan: Topic "Randomized cross-over study of curcumin for prevention of oral mucositis in children receiving chemotherapy"
2008: Supervision, Thesis for Medical students, Rosana Blechter: Topic "Comparison of the effect of the treatments of thalassemia major on growth"
2008: Supervision, Basic science resident for MD, Dr. Giora Wieser: Topic "Peripheral blood smear consultations: can we do better?"
2008: Supervision, Thesis for Medical students, Tememi Abdalla: Topic "Helicobacter pylori. Prevalence in children receiving chemotherapy or bone marrow transplantation"
Awards/Grants
1999: American Physicians Fellowship for Medicine in Israel )AFP)
1999: Pearl Foundation Grant for Fellowship, Israel
2001: Research training competition (Restracomp) award, The Hospital for Sick Children, University of Toronto, Canada for a research project entitled: “Pilot study: Low molecular weight heparin (LMWH) in association with low dose chemotherapy as an anti-angiogenesis agent in pediatric patients with refractory solid tumors”
2001: Baxter Bioscience Pediatric Hemostasis Fellowship, The Hospital for Sick Children, Toronto, Canada.
2001: The Canadian Hematology Society, 2001, Wyeth-Ayerst Travel Award for travel to ASH 2001 for presentation of an abstract entitled: “Incidence of congenital prothrombotic disorders in children with venous thromboembolic disease: A prospective cohort study”
2002: The American Society of Pediatric Hematology/Oncology, 2002 Young Investigator Award for an abstract entitled: “Desmopressin (DDAVP) responsiveness in children with von Willebrand Disease”
2003: Outstanding teacher (nominated by the students), Hebrew University-Hadassah Medical School, Jerusalem, Israel
2006: Israel cancer association, research grant, "Israeli Pediatric Oncology Registry on Central Venous Line related complication"
2007: Israel Pediatric Ambulatory Association grant, "Helicobacter Pylori and Iron deficiency: prevalence of association and effect of therapy"
2007: Hadassah Medical Center, Eizenberg grant, "Randomized cross-over study of curcumin for prevention of oral mucositis in children receiving chemotherapy"
2007: Hadassah Hebrew-University Hospital, Clinical investigator position (50% research time)
2008: The Joint Research Fund between the Hebrew University Faculty of Medicine, and between Hadassah University Hospital, Shaare Zedek Medical Center, and Bikur Holim hospital, "Bio-availability of curcumin in the human body: pharmacokinetic study"
2008: Hebrew University- Hadassah School of Public Health and Community Medicine, Perelman Leon award for master thesis, "Incidence and risk factors for central venous line-related complication in the Israeli Pediatric Oncology Registry"
2009: Outstanding teacher (nominated by the students), Hebrew University-Hadassah Medical School, Jerusalem, Israel
PUBLICATIONS
Original reports:
1. Morecki S, Revel-Vilk S, Nabet C, Pick M, Ackerstein A, Nagler A, Naparstek E, Shahar MB, Slavin S. Immunological evaluation of patients with hematological malignancies receiving ambulatory cytokine-mediated immunotherapy with recombinant human interferon-a2a and interleukin-2. Cancer Immunol Immunother 35:401-411, 1992.
2. Seidman DS, Ergaz Z, Paz I, Laor A, Revel-Vilk S, Stevenson DK, Gale R. Predicting the risk of jaundice in full-term healthy newborns: a prospective population-based study. J Perinatol 19:564-7, 1999.
3. Revel-Vilk S, Tamary H, Broide E, Zoldan M, Dinari G, Zahavi I, Yaniv I, Shamir R. Serum transferrin receptor in children and adolescents with inflammatory bowel disease. Eur J Pediatr 159:585-9, 2000.
4. Klar A, Gross-Kieselstein E, Shazberg G, Israeli T, Revel-Vilk S, Hurvitz H. Hepatitis A associated with other focal infections. Isr Med Assoc J 2:598-600, 2000.
5. Shazberg G, Revel-Vilk S, Shoseyov D, Ben-Ami A, Klar A, Hurvitz H. The clinical course of bronchiolitis associated with acute otitis media. Arch Dis Child 83:317-9, 2000.
6. Revel-Vilk S, Blanchette VS, Sparling C, Stain AM, Carcao MD. DDAVP challenge tests in boys with mild/moderate haemophilia A. Br J Haematol 117:947-51, 2002.
7. Schenk B, Imbach T, Frank CG, Grubenmann CE, Raymond GV, Hurvitz H, Korn-Lubetzki I, Revel-Vilk S, Raas-Rotschild A, Luder AS, Jaeken J, Berger EG, Matthijs G, Hennet T, Aebi M. MPDU1 mutations underlie a novel human congenital disorder of glycosylation, designated type If. J Clin Invest 111:925, 2003 (corrigendum for original citation J Clin Invest 108:1687-95, 2001).
8. Revel-Vilk S, Chan A, Bauman M, Massicotte P. Prothrombotic disorders in an unselected cohort of children with venous thromboembolic disease. J Thromb Haemost 1:915-921, 2003.
9. Klar A, Shoseyov D, Berkun Y, Brand A, Braun J, Shazberg G, Moise J, Gross-Kieselstein E, Revel-Vilk S, Hurvitz H. Intestinal permeability defect, clevated fecal a1 antitrypsin excretion and hypoalbuminemia in children with pneumonia. J Pediatr Gastroenterol Nutr 37:120-3, 2003.
10. Revel-Vilk S, Schmugge M, Mannuel C, Blanchette P, Rand M, Blanchette V. Desmopressin (DDAVP) responsiveness in children with von Willebrand Disease. J Pediatr Hematol Oncol 25:874-9, 2003.
11. Schmugge M, Revel-Vilk S, Hiraki L, Rand M, Blanchette V, Silverman E. Thrombocytopenia and thromboembolism in pediatric systemic lupus erythematosus. J Pediatr 143:666-9, 2003.
12. Revel-Vilk S, Sharathkumar A, Massicotte P, Dix, D, Marzinotto, V, Chan, A. Natural history of arterial and venous thrombosis in children treated with low molecular weight heparin: a longitudinal study by Doppler ultrasound. J Thromb Haemost 2:42-6, 2004.
13. Revel-Vilk S, Golomb M, Achonu C, Stain AM, Armstrong D, Sung L, Logan W, Barnes MA, McNeely M, Blanchette V, Feldman B. Effect of intracranial bleeds on the health and quality of life of boys with hemophilia. J Pediatr 144:490-5, 2004.
14. Hedlund-Treutiger I, Revel-Vilk S, Blanchette VS, Curtin JA, Lillicrap D, Rand ML. Reliability and Reproducibility of Classification of Children as "Bleeders" Versus "Non-Bleeders" Using a Questionnaire for Significant Mucocutaneous Bleeding. J Pediatr Hematol Oncol. 26:488-91, 2004.
15. Kenet G, Waldman D, Lubetsky A, Kornbrut N, Khalil A, Koren A, Wolach B, Fattal A, Kapelushnik J, Tamary H, Yacobovitch J, Raveh E, Revel-Vilk S, Toren A, Brenner B. Paediatric cerebral sinus vein thrombosis. A multi-center, case-controlled study. Thromb Haemost .92:713-8, 2004.
16. Klar A, Branski D, Akerman Y, Nadjari M, Berkun Y, Moise J, Shazberg G, Revel-Vilk S, Israeli T, Kats G, Levy A, Ben Ami A, Hurvitz H. Sludge ball pseudolithiasis, cholethiasis and choledocholithiasis from intrauterine life to 2 years: a 13-year follow-up. J Pediatr Gastroenterol Nutr, 40:477-480, 2005.
17. Berkun Y, Padeh S, Barash J, Uziel Y, Harel L, Mukamel M, Revel-Vilk S, Kenet G. Antiphospholipid syndrome in children with recurrent thrombosis. Arthritis Rheum. 55:850-855, 2006.
18. Rozovsky K, Koplewitz BZ, Krausz Y, Revel-Vilk S, Weintraub M, Chisin R, Klein M. Added value of SPECT/CT for correlation of MIBG scintigraphy and diagnostic CT in neuroblastoma and pheochromocytoma. Am J Roentgenol 190:1085-90, 2008.
19. Revel A, Revel-Vilk S, Aizenman E, Porat-Katz A, Safran A, Ben-Meir A, Weintraub M, Shapira M, Achache H, Laufer N. At what age can human oocytes be obtained? Fertil Steril. 2008 (upub head of print)
20. Shteyer E, Saada A, Shaag A, Al-Hijawi FA, Kidess R, Revel-Vilk S, Elpeleg O. Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene. Am J Hum Genet. 84:412-7, 2009.
21. Stepenski P, Or R, Shapira MY, Revel-Vilk S, Stein J, Resnick IB. Second bone marrow transplantation for patients with thalassemia: risk and benefits. Heamatologica, 2009. (in press)
22. Revel-Vilk S, Blanchette V. Schmugge M, Clark DS, Lillicrap D, Rand ML. In vitro and in vivo stability of diluted recombinant Factor VIII for continuous infusion use. Haemophilia, 2009 (in press)
Reviews:
23. Revel-Vilk, S, Massicotte, P. Thromboembolic diseases of childhood. Blood Rev 17:1-6, 2003.
24. Revel-Vilk S, Chan AKC. Anticoagulation therapy in children Semin Thromb Hemost 29:425-432, 2003.
25. Revel-Vilk S, Kenet G. Thrombophilia in children with venous thrombosis. Thromb Res 118:59-65, 2006.
26. Revel-Vilk S. Central venous line related thrombosis in children. Acta Haematol 115:201-206, 2006.
27. Revel A, Revel-Vilk S. Pediatric fertility preservation: is it time to offer testicular tissue cryopreservation? Mol Cell Endocrinol 30:143-9, 2008
Case reports:
28. Korn-Lubetzki I, Revel-Vilk S, Steiner I, Shoshan Y, Hurvitz H. Continuous deterioration in subacute sclerosing panencephalitis during treatment with osiprinosine and intrathecal interferon alpha. Neurologic infections and epidemiology 2:163-165, 1997.
29. Revel-Vilk S, Hurvitz H, Klar A, Virozov Y, Korn-Lubetzki I. Recurrent acute disseminated encephalomyelitis associated with acute cytomegalovirus and Epstein-Barr virus infection. J Child Neurol 15:421-4, 2000.
30. Shayan K, Ye C, Revel-Vilk S. Pathologic Quiz Case: 6-Year-Old Girl with Thrombocytopenia. Arch Patho Lab Med 127:e305-6, 2003.
31. Weintraub M, Bloom AI, Gross E, Revel-Vilk S, Shahroor S, Koplewitz BZ, Freeman AI. Successful treatment of progressive stage 4s hepatic neuroblastoma in a neonate with intra-arterial chemoembolization. Pediatr Blood Cancer 43:148-51, 2004.
32. Kuperman T, Wexler I, Shoseyov D, Weintraub M, Revel-Vilk S, Kerem E. Plastic bronchitis caused by neoplastic infiltrate in a child. Pediatr Pulmonol. 41:893-6, 2006.
33. Weintraub M, Revel-Vilk S, Charit M, Aker M, Peer J. Secondary acute myeloid leukemia after etoposide therapy for retinoblastoma. J Pediatr Hematol Oncol. 29:646-8, 2007.
34. Stepensky P, Revel-Vilk S, Weintraub M, Waldman E, Harit M, Averbuch D, Weinberger J, Or R, Resnick I. Combination of umbilical cord blood with BM from a 2-month-old sibling as lifesaving BMT for very severe aplastic anemia. Bone Marrow Transplant 42:563-4, 2008.
Published and Presented abstracts at International Meeting:
1. Morecki S, Vilk S, Nabet C, Pick M, Nagler A, Ackerstein A, Naparstek E, Ben-Shahar MB, Slavin S. Immune evaluation of recombinant human alpha-2a Interferon (IFNa) and Interleukin-2 (rIL2) in ambulatory treatment. Cytokine 3:492, 1991.
2. Seidman DS, Ergaz Z, Revel-Vilk S, Paz I, Stark M, Stevenson DK, Gale R. The use of bilirubin measurements on the first day of life for prediction of neonatal jaundice. Program and abstracts of the Ross Special Conference, Hot topics '96 in Neonatology Washington, DC, 1996, pp 284-294.
3. Seidman DS, Ergaz Z, Paz I, Revel-Vilk S, Weinberg A, Armon Y, Verman HY, Stevenson DK, Gale R. Can bilirubin levels at age £ 24 hours predict the risk of neonatal jaundice? Pediatr Res 39:244A, 1996.
4. Revel-Vilk S, Doyle JJ, Calderwood S, Saunders FE., Abdolell M, Lau W, Freedman MH. Impaired pre-transplant CD34+ hematopoietic clonogenic activity predicts for recurrent neuroblastoma following autografting. Blood 96:424A, 2000 (poster).
5. Revel-Vilk S, Blanchette VS, Stain AM, Carcao MD. Interpreting DDAVP challenge tests in mild-moderate hemophilia A. Pediatr Res 49:879A, 2001 (oral presentation).
6. Revel-Vilk S, Chan A, Knapp C, Koloshuk B, Carsons R, Massicotte P, Andrew M. Incidence of congenital prothrombotic disorders in children with venous thromboembolic disease: A prospective cohort study. Blood 98:50A, 2001 (poster).
7. Revel-Vilk S, Schmugge M, Mannuel C, Blanchette P, Rand M, Blanchette V. Desmopressin (DDAVP) responsiveness in children with von Willebrand Disease. J Pediatr Hematol Oncol 24:A1, 2002 (oral presentation).
8. Revel-Vilk S, Schmugge M,. Hiraki L, Blanchette V, Silverman E. Thrombocytopenia in children with Systemic Lupus Erythematosus (SLE). J Pediatr Hematol Oncol 24:A14, 2002 (poster).
9. Sharathkumar A, Revel-Vilk S, Chan AKC, Marzinotto V, Andrew M, Massicotte P. Outcome of children with thromboembolic events (TEs) treated with low molecular weight heparin (LMWH). J Pediatr Hematol Oncol 24:A1, 2002.
10. Revel-Vilk S, Stain AM, Achonu C, Barnes MA. Impact of intracranial bleeds on the health and quality of life of boys with hemophilia. Hemophilia 8:525 [abstract 09PO26), 2002 (poster).
11. Revel-Vilk, S, Sharathkumar A, Massicotte P, Dix, D, Marzinotto, V, Chan, A. Natural history of arterial and venous thrombosis in children treated with Low Molecular Weight Heparin. A longitudinal study by Doppler ultrasound. Blood 100, 279A, 2002 (poster).
12. Revel-Vilk S, Sharathkumar A, Dix D, Chan AKC, Marzinotto V, Massicotte P.Use of low molecular weight heparin in children with thromboembolic events; predictors for bleeding and recurrence on therapy. J Thromb Haemost Suppl 1, P0044, 2003 (poster).
13. Kenet G, Waldman D, A. Lubetsky, Chalil A, Rosenberg N, Kornbrut N, Koren A, Levin C, Tamary H, Yacobovitch J, Raveh E, Wolach B, Fatal A, Kapelushnik J, Revel-Vilk S, Toren A, Brenner B. Pediatric Cerebral Sinus Vein Thrombosis and Thrombophilia - A Multicenter Study. Blood 102, 533A, 2003.
14. Anderson PE, Feldman B, Miles B, Golomb M, Revel-Vilk S, McNeely M, Pond C, Stain AM, Achonu C, Minden D, Logan W, Blanchette V, Barnes MA. Impact of intracranial hemorrhage on neurocognitive functioning in boys with hemophilia. J Internl Neuropsychological Society 9, 204, 2003.
15. Roth B, Ronen G, Rosengarten D, Brill A, Vilk S, Futerman T, Boldin-Adamsky S, Zimran A, Varon D. Platelet Adhesion Defect Is Common in Gaucher Disease. Blood 108, 1105A, 2006.
16. Revel-Vilk S, Yacobovich J, Tamary H, Levy-Shraga Y, Shick S, Toren A , Fischer S. Yaniv I, Stepenski P, Weintraub M, Kenet G. Israeli Pediatric Oncology Registry on Central venous line related complications. J Thromb Haemost 5(suppl 2), PT493, 2007 (poster).
17. Revel-Vilk S, Yacobovich J, Tamary H, Goldstein Y, Toren A , Yaniv I, Stepenski P, Weintraub M, Kenet G. Risk factors for central venous lines related thrombosis and occlusion. Blood 112:1814A, 2008 (poster).
18. Menahem M, Weintraub M, Revel-Vilk S. Mild signs of post-thrombotic syndrome are not rare in childhood cancer survivors treated with Hickman catheters. . J Thromb Haemost 2009 (oral presentation) .
19. Revel-Vilk S, Schejter-Dinur Y, Revel A. Is routine screening for coagulation abnormalities prior to ova extraction needed? J Thromb Haemost 2009 (poster).