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Home > Physicians, Researchers
  Physicians, Researchers

Prof. Benjamin E. Reubinoff. MD, PhD

Updated Feb. 2012

 

 

Professor of Obstetrics and Gynecology

Director

Hadassah Human Embryonic Stem Cell Research Center,

Dept. of Obstetrics and Gynecology

The Goldyne Savad Institute of Gene Therapy

Sydney Swartz Chair in

Human Embryonic Stem Cell Research

Hadassah University Medical Center, Jerusalem

Phone:  972-2-677-8726     

Fax: 972-2-643-0982

Email: benjaminr@ekmd.huji.ac.il

 

 

Academic Rank

Full Professor of Obstetrics & Gynecology 

 

Affiliation

Hadassah-Hebrew University Medical Center, Jerusalem, Israel

 

Education

1984  B.Sc. in Medical Science, with excellence, (cum laude) Hebrew University - Hadassah Medical School, Jerusalem

 

1990  M.Sc. in Neurobiology, with special distinction (summa cum laude) Hebrew University - Hadassah Medical School, Jerusalem

 

1988  Medical training, Hebrew University - Hadassah Medical School, Jerusalem

 

1989 - M.D. Graduation Hebrew University - Hadassah Medical School, Jerusalem.

 

1989  Internship, Hadassah Medical School, Jerusalem

 

1995  Residency in Obstetrics and Gynecology, Hadassah Medical School, Jerusalem

 

1995 - Israel Boards of Obstetrics and Gynecology

 

1999  Ph.D. in Developmental Biology at Monash University, Victoria, Australia

 

Clinical Interests

-          Female infertility

-          Male infertility

-          In vitro fertilization

-          Preimplantation genetic diagnosis

 

Research Interests

-          Human embryonic stem cells for transplantation therapy and regeneration

-          Reproduction

-          Stem cells for the improvement of reproduction

 

Awards

 

2007: The AYALA (The Israeli Fertility Association-IFA) prize for distinctive basic research during the years 2005 - 2006.

 

2005-2004:  distinctive scientist prize in the field of medicine awarded by thefund in memory of Samuel and Paula Elkales by the Keren Kayemet Le’yisrael.

 

‏2004: Elected for excellence in teaching in the faculty of medicine for the year 2003 – 2004.

 

2004: ESHRE (European Society of Human Reproduction and Embryology) Established Scientist Award for the study: "Human embryonic stem cell-derived neural progenitors correct behavioral deficits in Parkinsonian rats."

 

2000: HWZOA (Hadassah Women Zionist Organization of America) Award for Middle Level Investigators for Excellence in Research.

 

2000: The ALPHA (International Forum for Scientists in Reproductive Medicine) Award for Research Work on Human Embryonic Stem Cells.

 

1998: Sir J. McNeil Scholarship Prize towards Ph.D. thesis research.

 

1997: Elected as Teacher with Special Distinction at the Faculty of Medicine.

 

1996: Honored to be included in the Rector's List of Outstanding Teachers

 

1995: Israel Fertility Society Award for Most Outstanding Work in Fertility Research.

 

1994: Dr. M. Stich . Faculty Prize for Special Distinction in Clinical Work

 

1990: Dr. A. Heler Faculty Prize for Special Distinction of M.Sc. Thesis in Neurobiology.

 

1985: Korenfeld Scholarship Prize toward research of Master's thesis.

  

Publications

 

1.  Amar A, Battat S, Anteby SO, Brautbar C, Reubinoff BE (1993). Invasive squamous cell carcinoma of the cervix: is HLA - DQ  a disease marker in Jewish patients? European Journal of Immunogenetics. 20:327-333. 

 

2.  Reubinoff BE, Mor-Yosef S, Shushan A, Brzezinski A, Tanos V, Anteby SO (1994). Hyperreactio luteinalis associated with nonimmune   hydrops fetalis - the role of pituitary hormones. European Journal of Obstetrics and Gynecology and Reproductive Biology. 53:144-146.  

 

3.  Shushan A, Simon A, Reubinoff BE, Lewin A, Schenker JG, Laufer N (1994). The use of vaginal tablets as a vehicle for steroid replacement in a donor oocyte program. Fertility and Sterility. 62(2):412-414.

 

4.  Lewin A, Schenker JG, Safran A, Zigelman N, Avrech O, Abramov Y, Friedler S, Reubinoff BE (1994). Embryo growth rate in vitro as an indicator of embryo quality in IVF cycles. J Assisted Reproduction and Genetics. 11:1-4.  

 

5.                  Reubinoff BE, Weinstein D, Langer O, Samueloff A (1995). Antenatal bleeding and fetal heart rate. Gynecologic and Obstetric Investigation. 39: 19-23.

 

6.                  Reubinoff BE, Grubstein A, Meirov D, Berry E, Schenker JG, Brzezinski A (1995). Effects of low-dose estrogen oral contraceptives on weight, body composition, and fat distribution in young women. Fertility and Sterility. 63: 516-521.  

 

7.         Reubinoff BE, Wurtman J, Rojansky N, Adler D, Stein P, Schenker JG, Brzezinski A (1995). Effects of hormone replacement therapy on weight, body composition, fat distribution, and food-intake, in early postmenopausal women - a prospective study. Fertility and Sterility. 64: 963-968.  

 

8.         Reubinoff BE, Har-el R, Kitrossky N, Friedler S, Levi R, Lewin A, and Chevion M (1996). Increased levels of redox - active iron in follicular fluid: a possible cause of free radical -mediated infertility in -thalassemia major. Am J Obstet Gynecol. 174: 914-8. 

 

9.         Avner R, Reubinoff BE, Simon A, Zentner B, Friedmann A, Mitrani-Rosenbaum S, Laufer N (1996). Preimplantation Rh blood group typing in the management of Rh isoimmunization. Molecular Human Reproduction. 2:60-62.

 

10.       Reubinoff BE, Avner R, Rojansky N, Manny N, Friedmann A, Laufer N, Mitrani-Rosenbaum S (1996). RhD Genotype determination by single sperm cell analysis.  Am J Obstet Gynecol. 174: 1300-5.

 

11.              Reubinoff BE, Samueloff A, Ben-Haim M, Friedler S, Schenker JG, Lewin A (1997). Is the obstetrical outcome of in vitro fertilized singleton gestations different from natural ones? A controlled study. Fertility Sterility. 67:1077-1083.

 

12.              Reubinoff BE, Lewin A, Verner M, Safran A, Schenker JG, Abeliovich D (1997). Intracytoplasmic sperm injection combined with preimplantation genetic diagnosis for the prevention of recurrent gestational trophoblastic disease. Human Reproduction. 12:805-808.

 

13.              Rojansky N, Tanos V, Reubinoff B, Shapira S and Weinstein D (1997). Effect of epidural analgesia on duration and outcome of induced labor. Int J Gynecol Obstet. 56:237-244.

 

14.              Rojansky N, Reubinoff BE, Tanos V, Shushan A, and Weinstein D (1997). High risk pregnancy outcome following induction of labor. European Journal of Obstetrics and Gynecology and Reproductive Biology. 72:153-158.

 

15.              Safran A, Reubinoff BE, Porat-Katz A, Neiger M, Friedler S, Lewin A (1998). Intracytoplasmic sperm injection allows fertilization and embryonic development of a chromosomally balanced embryo from a binovular zona pellucida. Human Reproduction. 13:2575-2578.

 

16.              Reubinoff BE, Abeliovich D, Verner M, Schenker JG,  Safran A and Lewin A (1998). A birth in non-mosaic Klinefelter's syndrome after testicular fine needle aspiration, intracytoplasmic sperm injection and preimplantation genetic diagnosis. Human Reproduction. 13:1887-1892.

 

17.              Lewin A, Reubinoff B.E, Porat-Katz A, Weiss D, Eisenberg V, Arbel R, Bar-El H, Safran A (1999). Testicular fine needle aspiration: the alternative method for sperm retrieval in non-obstructive azoospermia. Human Reproduction. 14:1785-1790.

 

18.              Simon I, Tanzen T, Reubinoff BE, Hillman D, McCarrey J, Cedar H (1999). Asynchronous replication of imprinted genes is established in the gametes and maintained during development. Nature. 401:929-32.

 

19.              Reubinoff BE, Pera MF, Fong CY, Trounson A Bongso A (2000). Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nature Biotechnology. 18(4):399-404.

 

20.              Reubinoff BE, Pera M, Vajta G, Trounson AO (2001). Effective cryopreservation of human embryonic stem cells by the open pulled straw (OPS) vitrification method. Human Reproduction. 16:2187-94.

 

21.              Mostoslavsky R, Singh N, Tenzen T, Goldmit M, Gabay C, Elizur S, Oi P, Reubinoff BE, Chess A, Ceder H and Bergman Y (2001). Asynchronous replication and allelic exclusion in the immune system. Nature. 414:221-5.

 

22.              Reubinoff BE, Itsykson P, Turetsky T, Pera M, Reinhartz E, Itzik A, Ben-Hur T (2001). Neural progenitors from human embryonic stem cells. Nature Biotechnology. 19:1134-40.

 

23.              Lewin A, Pisov G, Turgeman R, Fatum M, Shufaro Y, Simon A, Laufer N, Revel A, Reubinoff B, Safran A (2002). Simplified artificial endometrial preparation, using oral estradiol and novel vaginal progesterone tablets: a prospective randomized study. Gynecol Endocrinol. 16:131-6.

 

24.              Cooper S, Bennett W, Andrade J, Reubinoff BE, Thomson J, Pera MF (2002). Biochemical properties of a keratan sulphate/chondroitin sulphate proteoglycan expressed in primate pluripotent stem cells. J Anat. 200(Pt 3):259-65.

 

25.              Drukker M, Katz G, Urbach A, Schuldiner M, Markel G, Itskovitz-Eldor J, Reubinoff B, Mandelboim O, Benvenisty N (2002). Characterization of the expression of MHC proteins in human embryonic stem cells. Proc Natl Acad Sci U S A. 99:9864-9.

 

26.              Goldstein RS, Drukker M, Reubinoff BE, Benvenisty N (2002). Integration and differentiation of human embryonic stem cells transplanted to the chick embryo. Developmental Dynamics. 225:80-6.

 

27.              Gropp M, Itsykson P, Singer O, Ben-Hur T, Reinhartz E, Galun E, and Reubinoff BE (2003). Stable genetic modification of human embryonic stem cells by lentiviral vectors. Molecular Therapy. 7:281-7.

 

28.              Simon A, Safran A, Revel A, Aizenman E, Reubinoff B, Porat-Katz A, Lewin A, Laufer N (2003). Hyaluronic acid can successfully replace albumin as the sole macromolecule in a human embryo transfer medium. Fertility Sterility. 79(6):1434-8.

 

29.              Pera MF, Andrade J, Houssami S, Reubinoff BE, Trounson A, Stanley EG, Ward-van Oostwaard D, Mummery C (2004). Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin. J Cell Sci. 117:1269-1280.

 

30.              Ben-Hur T, Idelson M, Khaner H, Pera M, Reinhartz E, Itzik A, Reubinoff BE (2004). Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats. Stem Cells. 22(7):1246-55.

 

31.              Itsykson P, Ilouz N, Turetsky T, Goldstein RS, Pera MF, Fishbein I, Segal M, Reubinoff BE (2005). Derivation of Neural Precursors from Human Embryonic Stem Cells in the Presence of Noggin. Molecular and Cellular Neuroscience. 30(1): 24-36.

 

32.              Pomp O, Brokhman I, Ben-Dor I, Reubinoff B, Goldstein R. S (2005). Generation of peripheral sensory and sympathetic neurons and neural crest cells from human embryonic stem cells. Stem Cells. 23 (7):923-30.

 

33.              Banin E, Obolensky A, Idelson M, Hemo I, Reinhardtz E, Pikarsky E, Ben-Hur T, Reubinoff BE (2006). Retinal Incorporation and Differentiation of Neural Precursors Derived from Human Embryonic Stem Cells. Stem Cells. 24(2):246-257.

 

34.              Herszfeld D, Wolvetang E, Langton-Bunker E, Chung TL, Filipczyk AA, Houssami S, Jamshidi P, Koh K, Laslett AL, Michalska A, Nguyen L, Reubinoff BE, Tellis I, Auerbach JM, Ording CJ, Looijenga LHJ, Pera MF (2006). CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells. Nature Biotechnology. 24:351–357.

 

35.              Shveiky D, Simon A, Gino H, Safran A, Lewin A, Reubinoff B, Laufer N, Revel A (2006). Sibling oocyte submission to IVF and ICSI in unexplained infertility patients: a potential assay for gamete quality. Reproductive BioMedicine Online. 12(3):371–374. 

 

36.              Ben-Dor I, Itsykson P, Goldenberg D, Galun E, Reubinoff B. E (2006).  Lentiviral Vectors Harboring a Dual-Gene System Allow High and Homogeneous Transgene Expression in Selected Polyclonal Human Embryonic Stem Cells. Molecular Therapy. 14(2):255-67.

 

37.              Biton S, Gropp M, Itsykson P, Pereg Y, Mittelman L, Johe K, Reubinoff B, Shiloh Y (2007). ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells. DNA Repair. 6(1):128-34.

 

38.              Ben-Hur T, van Heeswijk R. B, Einstein O, Aharonowiz M, Xue R, Frost E. E, Mori S, Reubinoff B. E, Bulte J. W (2007). Serial in vivo MR tracking of magnetically labeled neural spheres transplanted in chronic EAE mice. Magnetic Resonance in Medicine. 57(1):164-71.

 

39.              Schlesinger Y, Straussman R, Keshet I, Farkash S, Hecht M, Zimmerman J, Eden E, Yakhini Z, Ben-Shushan E, Reubinoff B. E, Bergman Y, Simon I, Cedar H (2007). Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nature genetics. 39(2):232-6.

 

40.              Shin S, Sun Y, Liu Y, Khaner H, Svant S, Cai, J Xu, X. Q, Davidson B. P, Stice S. L, Smith A. K, Goldman S. A, Reubinoff B. E, Zhan M, Rao M. S, Chesnut,J. D (2007).  Whole genome analysis of human neural stem cells derived from embryonic stem cells and stem and progenitor cells isolated from fetal tissue. Stem Cells. 25(5):1298-306.

 

41.              Tsafrir A, Simon A, Revel A, Reubinoff B, Lewin A, Laufer N (2007). Retrospective analysis of 1217 IVF cycles in women aged 40 years and older. Reprod Biomed Online. 14(3):348-55.

 

42.              International Stem Cell Initiative, Adewumi O…. Reubinoff BE, … Zhang W (2007). Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol. 25(7):803-16.

 

43.              Gropp M, Reubinoff BE (2007). Lentiviral-RNA-interference system mediating homogenous and monitored level of gene silencing in human embryonic stem cells. Cloning Stem Cells. 9(3):339-45.

 

44.              Brokhman I, Gamarnik-Ziegler L, Pomp O, Aharonowiz M, Reubinoff BE, Goldstein RS (2008). Peripheral sensory neurons differentiate from neural precursors derived from human embryonic stem cells. Differentiation. 76(2):145-55.

 

45.              Turetsky T, Aizenman E, Gil Y, Weinberg N, Shufaro Y, Revel A, Laufer N, Simon A, Abeliovich D, Reubinoff BE (2008). Laser-assisted derivation of human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis. Hum Reprod. 23(1):46-53.

 

46.              Aharonowiz M, Einstein O, Fainstein N, Lassmann H, Reubinoff BE*, Ben-Hur T* (2008). Neuroprotective Effect of Transplanted Human Embryonic Stem Cell-Derived Neural Precursors in an Animal Model of Multiple Sclerosis. PLoS ONE. 3(9):e3145.

(*) Equal contributing authors, both serving as corresponding authors. 

 

47.              Tzur G, Levy A, Meiri E, Barad O, Spector Y, Bentwich Z, Mizrahi L, Katzenellenbogen M, Ben-Shushan E, Reubinoff BE, Galun E (2008). MicroRNA expression patterns and function in endodermal differentiation of human embryonic stem cells. PLoS ONE. 3(11):e3726.

 

48.              Idelson M, Alper R, Obolensky A, Ben-Shushan E, Hemo I, Yachimovich-Cohen N, Khaner N, Smith Y, Wiser O, Gropp M, Cohen MA, Even-Ram S, Berman – Zaken Y, Matzrafi L, Rechavi G, Banin E* and Reubinoff B* (2009). Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells. Cell Stem Cell. Oct 2;5(4):396-408. (*) Equal contributing authors.

 

49.              Tzur G, Israel A, Levy A, Benjamin H, Meiri E, Shufaro Y, Meir K, Khvalevsky E, Spector Y, Rojansky N, Bentwich Z, Reubinoff BE, Galun E (2009). Comprehensive gene and microRNA expression profiling reveals a role for microRNAs in human liver development. PLoS One. Oct 20;4(10):e7511.

 

50.              Lavon I, Zrihan D, Granit A, Einstein O, Fainstein N, Cohen MA, Zelikovitch B, Shoshan Y, Spektor S, Reubinoff BE, Felig Y, Gerlitz O, Ben Hur T, Smith Y, Siegal T (2010). Gliomas display a microRNA expression profile reminiscent of neural precursor cells. Neuro-Oncology, May;12(5):422-33.

 

51.              Yachimovich-Cohen N, Even-Ram S, Shufaro Y,  Rachmilewitz J, Reubinoff BE (2010). Human embryonic stem cells suppress T cell responses via Arginase I - dependent mechanism. The Journal of Immunology, Feb 1;184(3):1300-08.

 

52.              Shufaro Y, Lacham-Kaplan O, Tzuberi BZ, McLaughlin J, Trounson A, Cedar H, Reubinoff BE (2010). Reprogramming of DNA replication timing. Stem Cells Jan 13 [Epub ahead of print].

 

53.              Cohen M, Itsykson P, Reubinoff BE (2010). The role of FGF-signaling in early neural specification of human embryonic stem cells. Developmental Biology Feb 8 [Epuub ahead of print].

 

54.              Valensi-Kurtz M, Lefler S, Cohen M, Aharonowiz M , Cohen-Kupiec R, Sheinin A, Ashery U, Reubinoff BE, Weil M (2010). Enriched Population of PNS Neurons Derived from Human Embryonic Stem Cells as a Platform for Studying Peripheral Neuropathies. PLoS One. Feb 18;5(2):e9290.   

 

55.              Steiner D, Khaner H, Cohen M, Even-Ram S, Gil Y, Itsykson P, Turetsky T, Idelson M, Aizenman E, Ram R, Reubinoff BE (2010). Derivation, propagation and controlled differentiation of human embryonic stem cells in suspension. Nature Biotechnology. Apr;28(4): 361-4. 

 

B.      Case reports in peer-reviewed journals:

 

56.       Reubinoff BE, Eldor A, Laufer N, Sadovsky E (1992). Maternal hemorrhagic complications following prophylactic low-dose aspirin and dipyridamole therapy. Gynecol Obstet Invest  33: 241-243.

 

57.       Rojansky N, Reubinoff BE, Shapira SC, Weinstein D (1994). Safety of surgical intervention during the second trimester of pregnancy. J  Reprod Med 39: 821-824.

 

58.       Reubimoff BE, Simon A, Friedler S, Schenker JG, Lewin A (1994). Defective oocytes as a possible cause of infertility in a -thalassaemia major patient. Human Reproduction 9(6):1143-1145.

 

59.       Tanos V, Meirow D, Reubinoff BE, Anteby SO (1994). Recurrent  gestational throphoblastic disease following in-vitro-fertilization. Human Reproduction 9(11): 2010-2013.

 

60.       Bonne OB, Reubinoff BE, Berry EM (1996). Delayed detection of pregnancy in patients with Anorexia Nervosa: two case reports. Int J of Eating Disorders 20 (4): 423-5.

 

61.       Revel A, Safran A, Laufer N, Lewin A, Reubinov BE, Simon A (2004). Twin delivery following 12 years of human embryo cryopreservation: case report. Hum Reprod. Feb;19(2):328-9.

 

C.      Letters in peer-reviewed journals:

 

62.       Reubinoff BE, Lewin A, Chevion M (1996). Infertility in -thalassemia major. Am J Obstet Gynecol 175: 1081.

 

63.       Reubinoff BE, Shushan A (1997). Preimplantation diagnosis in older patients. Human Reproduction 12: 871.

 

64.       Reubinoff BE, Schenker JG (1997). Gonadotropins and sex preselection? Fertil Steril  68: 380-381.

 

D.       Reviews, commentaries, hypotheses, editorials:

 

65.       Reubinoff BE, Schenker JG (1991). HELLP syndrome - a syndrome of  hemolysis, elevated liver enzymes and low platelet count - complicating preeclampsia-eclampsia. Int J Gynecol Obstet 36: 95-102.

Also published in: Giornale Italiano Di Ostetricia e Ginecologia  1992; 14: 387-393.

 

66.       Shushan A, Stemmer SM, Reubinoff BE, Eid A, Weinstein D (1992). Carcinoma of the colon during pregnancy. Obstet Gyncol  Survey  47: 222-225.

 

67.              Reubinoff BE, Fefer S, Anteby SO (1992). Sarcoma botryoides of the uterine cervix - current therapeutic approach. Harefuah 123:129-132 (Hebrew).

 

68.              Reubinoff BE, Mordel N, Weinstein D (1993). Saline solution amnioinfusion - its role in modern obstetric care. Harefua 124:619-625 (Hebrew).

 

69.       Reubinoff BE, Schenker JG (1996). New advances in sex preselection. Fertil Steril  66(3): 343-350.

 

70.       Reubinoff BE, Shushan A (1996). Preimplantation diagnosis in older patients: To biopsy or not to biopsy? Human Reproduction 11(10): 2071-75.

 

71.       Safran A, Reubinoff BE, Porat-Katz A, Schenker J and Lewin A (1998). Assisted reproduction for the treatment of azoospermia. Human Reproduction 13: 47-60.

 

72.       Reubinoff BE, Lewin A, Schenker JG Abeliovich D (1998). Preimplantation genetic diagnosis. Harefua 135:202-208 (Hebrew).

 

73.       Pera MF, Reubinoff BE, Trounson A (2000). Human embryonic stem cells. J. Cell Science 113: 5-10.

 

74.   Shufaro Y, Reubinoff BE (2004). Therapeutic applications of embryonic stem cells. Best Pract Res Clin Obstet Gynaecol. 18: 909-27.

 

75.    Reubinoff B E (2007).  Current status of human embryonic stem cell research. Reproductive BioMedicine Online. 14: (Suppl 1.):121-4.

 

76.    Klassen H, Reubinoff BE (2008). Stem cells in a new light. Nat Biotechnol. 26(2): 187-8. 

 

77.              Andrews P.Reubinoff BE…Zhou Q.(2009).International Stem Cell Initiative Consensus guidance for banking and supply of human embryonic stem cell lines for research purposes. Stem Cell Reviews and Reports. Dec;5(4):301-14. IF 4.200. 

  

Chapters in Collections

 

1.      Schenker JG, Reubinoff BE. EPH gestosis complicated by HELLP syndrome. In: Perinatal Perspectives Caring For High Risk Fetus and Mother. 1990, p 22-29. Kovacs L, Resch BA, Rippmann ET (eds.) . Dept. of Obstet & Gynecol, Albert Szent-Gyergyi Medical University, Szeged, Hungary.

 

2.   Reubinoff BE. Biological mechanisms of gamete transport, fertilization and implantation. In: Female and Male Infertility.  1995, p 49-78. Schenker JG and Elchalal U (eds.) Akademon Press Jerusalem.

        

3.   Reubinoff BE. The clinical potential of human embryonic stem cells. In Reproductive Medicine in the 21st Century. Proceedings of the 17th World Congress on Fertility and Sterility. 2002, p 454-461. Healy DL, Kovacs GT, McLachlan R, Rodriguez-Armas O (eds.) Parthenon Publishing.

 

4.      Eiges R and Reubinoff BE. Human embryonic stem cells. In Textbook of Assisted Reproductive Techniques, Laboratory and Clinical Perspectives. 2004, p 413-424. Gardner DK, Weissman A, Howles CM and Shoham Z (eds.). Taylor and Francis.

 

5.   Reubinoff BE. Human embryonic stem cells – potential applications for regenerative medicine. In Advance in Fertility and Reproductive Medicine. Proceedings of the 18th World Congress on Fertility and Sterility. 2004, page 45-53.  Daya S, Harrison RF, Kempers RD (eds). Elsevier International Congress Series 1266.

 

6.      Gropp M, Reubinoff BE. Transduction of human ES cells by lentiviral vectors. In Handbook Of Stem Cells, Volume 2: Embryonic Stem Cells. 2004, pages 557-563. Lanza R, Gearhart JD, Hogan BLM, Mckay RD, Melton DA, Pedersen R, Thomson JA West MD (eds). Academic Press.

 

7.   Reubinoff BE, Khaner H. Identification and Maintenance of Neural Progenitors from human ES cells. In Handbook Of Stem Cells, Volume 2: Embryonic Stem Cells. 2004, pages 511-520. Lanza R, Gearhart JD, Hogan BLM, Mckay RD, Melton DA, Pedersen R, Thomson JA West MD (eds). Academic Press.

 

8.      Gropp M, Reubinoff B (2006). Lentiviral vector-mediated gene delivery into human embryonic stem cells. Methods in enzymology. 420: 64 – 81.

 

9.      Shufaro Y, Vajta G, Trounson AO, Reubinoff BE. Vitrification of human embryonic stem cells. In Vitrification In Assisted Repreoduction. 2007, pages 293-298. Tucker MJ and Liebermann J (eds). Informa Healthcare.

 

10.  Cohen M.A., Itsykson P., Reubinoff B.E. Neural differentiation of human embryonic stem cells. In Curr. Protoc. Cell Biol. 2007, pages 36:23.7.1-23.7.20. Bonifacino JS, Dasso M, Harford JB,  Lippincott-Schwartz J and Yamada KM (eds). Wiley.

 

Granted Patents

 

1.      Reubinoff BE, Pera MF, Fong CW, Trounson AO, Bongso A (1999). Embryonic stem cells. International patent application number PCT/AU1999/000990. International filing date: 09.11.1999. AU764684 ; CA2349415 ; US6875607.

 

2.      Reubinoff BE, Pera MF, Ben Hur T (2001). Embryonic stem cells and neural progenitor cells derived there from. International patent application number PCT/AU2001/000278. International filing date: 14.3.2001. US7,504,257 ; AU779694 ; AU2002301347 ; AU2005200148.

 

3.      Reubinoff BE.(2002). Methods of transducing ES cells. International patent application number: PCT AU2002/001758. International filing date: 24.12.2002. GB2399819.

4.      Reubinoff B. (2003).  Generation of neural stem cells from undifferentiated human embryonic stem cells. International patent application number PCT/AU2003/000704. International filing date: 05.06.2003. AU2003229132 ; US7,604,992 ; UK2407821.

5.      Goldstein RS, Reubinoff B. (2005). Methods for generating neuronal cells from human embryonic stem cells and uses thereof. International patent application number: PCT US2005/011857. International filing date: 08.04.2005. GB2427876.

 

Research group

 

Aharonowiz, Michal (Post – Doctorate student)

Ben-Dor,Israel, Ph.D. Phone: 677-7908

Ben-Shushan, Etti,Ph.D. Phone:677-8823/8894

Berman-Zaken, Yael B.Sc.

Cohen, Malkiel (Ph.D. student) Phone: 677-7945

Even Ram, Sharona, Ph.D. Phone: 677-78920

Gil, Yaniv (Ph.D. student)

Gropp, Michal, Ph.D.Phone:677-8785

Idelson, Maria (Post – Doctorate student) Phone:677-7947

Ilouz, Nili,Ph.D. Phone:677-7908

Khaner, Hanita,Ph.D. Phone:677-8535

Mordecai-Daniel, Talya, (Ph.D. student) Phone:677-8273

Shufaro, Yoel,M.D.

Steiner, Deborah, Ph.D.

Singer, Orna,M.Sc. Phone:677-8894

Tannenbaum, Shelly,M.Sc. (Q&AManager) Phone:677-7947

Turetsky, Tikva, ,M.Sc. Phone:677-8785

Yechimovich – Cohen, Nurit, Ph.D. Phone:677-8826

 

Collaborators

 

Prof. Eithan Galun – The Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem Israel. Factors that have an effect on pluripotency and differentiation of human embryonic stem cells.

 

Prof. Tamir Ben-Hur -  The Agnes Ginges Center for Human Neurogenetics Department of Neurology, Hadassah Hebrew University Hospital, Jerusalem, Israel. Human embryonic stem cell-derived neural cells for transplantation in neurodegenerative disorders.

 

Prof. Eyal Banin -  The Hadassah Center for Retinal and Macular Degenerations, Department of Ophthalmology, Hadassah Hebrew University Hospital, Jerusalem, Israel. Human embryonic stem cell-derived retinal cells for transplantation in retinal degenerative disorders.

 

Prof. Dana Wolf – Clinical Virology Unit, Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew-University Hospital, Jerusalem, Israel. Viral infection and neural development.

 

Dr. Jacob Rachmilewitz – The Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem Israel.  Immunogenicity of human embryonic stem cells and their progeny.

 

Prof. Gabrielle Thuman –  Universitätsaugenklinik / IZKF Biomat, RWTH Aachen. RPE transplantation in age related macular degeneration.

Prof. Claude Bernard – Monash Immunology and Stem Cell Laboratories, Faculty of Medicine, Monash University, Australia. The use of pluripotent stem cells for studying the pathogenisis of MS.  

 

Prof. George Daley – Stem Cell Transplantation Program, Children's Hospital Boston, Boston, MA, USA. Motor neurons and oligodendroglial differentiation in induced pluripotent stem (iPS) cells.

 

Dr. Miguel Weil – Department of Cell Research and Immunology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel. Human embryonic stem cells for modeling and studying the pathogenisis of familial dysautonomia.

 

International Stem Cell Initiative (ISCI) Consortium – International collaboration for studying and characterizing the properties of multiple human embryonic stem cell lines.

                                                                                     




Prof. Benjamin E. Reubinoff


            
      		 


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