Head Diabetes Unit
Department of Medicine
Hadassah University Hospital
Ein-Karem, Jerusalem
Fax: 972-2-642-4514
E-mail: ntv502@netvision.net.il
Born in Jerusalem, 1948
MD – Hebrew University Medical School, 1980
Professor Raz received his M.D. from Hebrew University and completed post graduate studies at Hadassah Medical Center.
He is the director of the Hadassah Center for the Prevention of Diabetes.
He also serves as the president of the Israel Diabetes Association, the head of the Israel National Council of Diabetes and president of D-Cure, a foundation that supports research in the field of diabetes.
In addition, he serves as the president of DIRECT - Diabetes International Research and Educational Co-operative Team, a group of professional physicians from Central, Eastern and Southern Europe as well at the Mediterranean, who aim to develop ways to help prevent and control diabetes and enhance the quality of life of those suffering from diabetes.
He serves on several advisory boards and is a member of several editorial boards, including the Israeli Medical Association Journal (IMAJ).
Professor Raz has published extensively in the area of Diabetes Mellitus with over 160 publications to his credit.
Professor Raz's research interests have focused on the pathologic mechanisms leading to diabetic complications, mainly the relationship to vasoactive peptide. A large part of his research is searching for the pathophysiology of beta cell dysfunction and loss in diabetes.
Professor Raz maintains an active clinical research program.
He heads the Diabetes Clinical Research Center which is involved in numerous projects studying the efficacy of different and novel therapies for diabetes.
He is the director of the newly formed Hadassah Diabetes Research Center which focuses on experimental and innovative therapies for diabetes.
As president of the Israel Diabetes Research Group, he collaborates with 18 other diabetologists in Israel, conducting clinical research aimed at improving the treatment of diabetic patients.
At Hadassah, Professor Raz is studying the effects of a large number of medications on diabetic complications and is also conducting studies with novel vaccines to prevent Diabetes.
Recent Publications
· Raz, I., Elias, D., Avron, A., Tamir, M., Metzger, M., Cohen IR.: Beta–cell function in new- onset type 1 diabetes by specific immunomodulation with heat shock protein peptide (Diapep 277) :a randomized, double-b phase II trial. LANCET, 358 (9295):1749-53,2001.(10.232;3/105;0)
· Lewis, EJ., Hunsiker, lG., Clarke, WR., Berl,T., Polh, M., Lewis, JB., Ritz, E., Atkins, RC., Rohde, R., Raz, I.: Collaborative Study Group. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. NEJM, 345,12,851-860.2001(29.512;1/105;17;17)
· Wainstein, J., Metzger, M., Wexler, ID., cohen, J., Raz, I.: The use of continuous insulin delivery systems in severely insulin-resis patients. Diabetes Care, 24 (7):1299, 2001.
· Raz, I.: Editor's Foreword. Diabetes Obes Metab, 3 suppl 1:1-2. 2001
· Metzger, M., Leibowitz, G., Wainstein, J., Glaser, B., Raz, I.: Reproducibility of glucose measurements using the glucose sensor. Diabetes Care., 25 (7): 1185-91, 2002 (4.992:12/89)
· Keynan, S., Dahan, R., Khamaisi, M., Barnes, K., Jackson, CD., Turner, AJ., Raz, I. :Increased expression of endothelin converting enzyme –1c isoform in response to high glucose levels in endothelial cells. Journal of Vascular Research, 18 (7): 1293-8, 2002.
· Raz, I., Wexler, I., Weiss, O., Flyvbjerg, A., Segev, Y., Rauchwerger, A., Raz, G., Khamaisi, M.: Role of insulin and the IGF system in renal hypertrophy in diabetic Psammomys obesus (sand rat).Nephrol Dia Transplant, 18 (7):1293-8, 2002.
· Khamaisi, M., Schrijvers, BF., S. De Vriese, AS., Raz, I., Flyvbjerg, A.: The emerging role of VEGF in diabetic kidney disease. Nephrol Dial Transplant, 18 (8):1427-30,2003.
· Berl ,T., G. Hunsicker, LG., Lewis, JB., Pfeffer, MA., Porush, JG., Rouleau, JL., Drury, Pl., Esmatjes, E., Hricik, D., Parikh, RC., Raz,I., Vanhille, P., Wiegmann, TB., Wolfe, BM., Locatelli, F., Goldhaber, SZ., Lewis, EJ.: Irbesartan Diabetic Nephropathy Trial.Collaborative Study Group. Cardiovascular Outcomes in the Irbesartan Diabetic Nephropathy Trial (IDNT) of Patients with Type 2 diabetes and overt nephropathy. Ann Inter Med, 138 (7):143, 2002
· Khamaisi, M., Flyvbjerg, A., Haramati, Z., Raz, G., Wexler, ID., Raz,I.: Effect of mild hypoinsulinemia on renal hypertrophy: growth hormone/insulin –like growth factor I systems in mild streptozotocin diab. Int J Exp. Diabetes Res., 3 (4):257-64,2002
· Tepensky, D., Friedman, M., Raz, I., Hoffman, A.: Pharmacokinetic-pharmacodynamic analysis of the glucose-lowering effect of metforrmin in diabetic rats reveals first-pass pharmacodynamic effect.Drug Metab Dispos, 30(8):861-8, 2002.
· Khamaisi, M., Raz, I.: Diabetes epidemic and the thrifty gene. Irs. Med. Assoc.,4 (9):720-1, 2002.
· Roth,A., Kalter-Leibovici ,O., Kerbis ,Y., Tenenbaum-Koren ,E., Chen,J., Sobol, T., Raz, I: Prevalence and risk factors for erectile dysfunction in men with diabetes , hypertension, or both diseases: a community survey among 1,412 Israeli men. Clinical Cardil., 26 (1):25-30, 2003.
· Khamaisi, M., Wainstein, J., Hancu, N., Milicevic, Z., Raz, I.: Association of hyperglycemia and insulin with diabetic cardiovascular complications. Isr Med Assoc, 5 (2):116-9, 2003.
· Shafrir, E., Raz, I.: Diabetes: mellitus or lipidus?. Diabetologia, 46 (3):433-40, 2003.
· Gronbaek, H., Tanos, V., Meirow, D., Peretz, T., Raz, I., Flyvbjerg, A.: Effects of tamoxifen on insulin –like growth factors, IGF binding proteir and IGFBP-3 proteolysis in breast cancer patients. Anticancer Res, 23 (3C):2815-20, 2003.
· SHafrir, E., Raz, I.: Author's reply. Diabetologia, 46 (11):1587, 2003.
· Borsztyn, M., Podjarny, E., Dahan, R., Raz, I., Bernheim, J.: Insulin-induced hypertension, L-arginine, and endothelial nitric oxide synthase in pregnant rats. Hypertens Pregnancy, 22 (3):267-74, 2003.
· Khamaisi, M., Wexler, ID., Shrha, J., Strojek, K., Raz, I., Milicevic, Z.: Cardiovascular disease in type 2 diabetics: epidemiology, risk factors and therapeutic modalities. Isr Med Assoc J., 5 (11):801-6, 2003.
· Milicevic, Z., Raz, I.: Interventions in diabetic patients after myocardial infarction. Acta Diabetol, 40 Suppl 2:S348-53, 2003.
· Cernea, S., Hancu, N., Raz, I.: Diet and coronary heart disease in diabetes. Acta Diabetol, 40 suppl 2:S389-400, 2003.
· Raz, I., Mouritzen, U., Vaz, J., Hershkovitz, T., Wainstein, J., Boehm, I.: Addition of diphasic insulin aspart 30 to rosiglitaxone in type 2 diabetes mellitus that is poorly controlled with glibenclamide monotherapy. Clin Ther, 25 (12):3109-23, 2003.
· Elazary, AS., Lador, N., Shauer, A., Meir, K., Pollak, A., Wolf, DG., Raz, I., Leitersdorf, E., Mevorach, D.: Tongue necrosis and pericarditis. Lancet, 363 (9413):948, 2004.
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