Education
1976–1983 The Hadassah Medical School Medicine.
1983 M.D of the Hebrew University, Jerusalem, Israel, License No.: 17271
1990 Specialization Internal Medicine, Specialist No.: 11302
1995 Specialization: Gastroenterology, Specialist No.: 14275
Further Studies (postdoctoral training)
1983–1984 Hadassah University Hospital Internship, Ein Kerem, Jerusalem
1984–1985 Hadassah University Hospital, Residency in Pathology, Jerusalem
1985–1990 Hadassah University Hospital, Residency in Internal Medicine Jerusalem
1987–1990 Hadassah University Hospital, Fellowship, Liver Unit, Tel-Aviv University–Sackler Faculty Of Medicine Ran Oren, M.D.
1992–1993 Hadassah University Hospital, Fellowship, Gastroenterology Unit, Jerusalem
1994–1995 Tel-Aviv Sourasky Fellowship, Department of Gastroenterology, Medical Center, Tel-Aviv
1996–1998 Liver Research Center, Albert Einstein College of Medicine, Research Fellowship, Bronx, N.Y.
Academic Experience
1989–1990 Hebrew University, HadassahMedical School, Jerusalem, Medicine Instructor
1990-1995 Hebrew University, Hadassah Medical School, Jerusalem, Medicine Lecturer
1995 Weizmann Institute of Science Rechovot, Visiting Scientist
1996–2000 Tel-Aviv University, Sackler Faculty of Medicine, Senior Lecturer
2000– Tel-Aviv University, Sackler Faculty of Medicine, Associate Professor
Clinical Experience (hospital appointments)
1990–1992 Hadassah University Hospital, Internal Medicine Mount Scopus, Jerusalem, Senior Physician
1995–1996 Tel-Aviv Sourasky Center, Gastroenterology, Senior Physician
1997–1998 The Mount Sinai Center, New York, Liver Disease, Medical Division Visiting Associate
1999– Tel-Aviv Sourasky Medical Center, Tel-Aviv, Gastroenterology, Head Liver Unit
2004– Tel-Aviv Sourasky Medical Center, Gastroenterology Deputy Director
2008- Tel-Aviv Sourasky Medical Center,Medical Chief of Medicine
Academic and professional Awards
(Prizes, Fellowships, Scholarships, etc.)
1992 Hadassah Medical School Fund Hebrew University of Jerusalem of the Year—Dean Award: Distinguished Teacher
1993 Ministry of Health Fund, Israel
1997 American Association for the Young Investigator: Award Study of Liver Diseases
1999 United States Israel Binational Science Foundation (BSF)
2002 Tnuva Research Fund
2003 Nassan R Jacob Fund, Liver Tx
2005 Faculty of Medicine ,Tel Aviv University
2005 Ministry of Health Fund, Israel Role of the integrin AlphaVbeta 3 and Syndecan 4 in the phenotypic changes in quiescent vs activated hepatic stellate cells
2003-2006 Ministry of Industry and Trade Bereshit Program (Magnet) Stem Cell Consortium
2007- Ministry of Health Fund, Israel
2008- MSD- Fund: The role of chronic elevation in GLP-1 in DPPIV deficient models on insulin and insulin secretion
2009- Faculty of Medicine, Tel Aviv University, Award for Diabetes Research
2009- Weizman-Sourasky Fund A metabolic circuit linking HBV and liver cancer
2009- ISF-Israel Science Foundation: Mechanism of stellate cell activation by thyroid hormones via activation of p75 expression and activation of Rho.
Patents
1) Method for prevention and arresting liver damage in humans. U.S. Patent No. 6,143,752 dated November 7, 2000.
2) Methods and kits for predicting liver fibrosis progression rate in chronic hepatitis C patients (pending 2005).
Membership In Professional Societies
1984– Israel Medical Association Israel
1990– Israel Association for the Study of the Liver
1990– Israel Association of Israel Internal Medicine
1993– Israel Association for Israel Gastroenterology
1998– International Liver USA Transplantation Society
1998– American Association for the USA, Study of Liver Diseases
1999– European Association for the Europe, Study of Liver Diseases
1999– Israel Liver Transplantation Society Israel
2006- American Gastroenterology Association USA
Professional Activities
1994–1998 Reviewer, New England Journal of Medicine
1995–1996 Organizing Committee, European Association for the Study of Liver
2006– Member of Editorial Board, World Journal of Gastroenterology
2009- Editorial board- Clinical Science
List Of Scientific Publications
Chapters in Books
1) Gilat, T., Moshkowitz, M., Oren, R.: Methotrexate therapy for ulcerative colitis. In: Jewel, D.P., Sandborn, W.J., Schölmerich, J., Stange, D.F. (eds.) Immunosuppression in Chronic Inflammatory Bowel Disease—Standards, New Developments and Future Trends. Kluwer Academic Publishers, Dordecht. In press (2001).
2) Gilat, T., Moshkowitz, M., Oren, R.: Methotrexate therapy for ulcerative colitis. In: Fellermann (eds.) Immunosuppression in Inflammatory Bowel Diseases. Falk Symposium 119. Kluwer Academic Publishers, U.S., pp. 128–130, 2001.
Articles
Original Articles
1) Zajicek, G., Oren, R., Weinreb, M. Jr. The streaming liver. Liver 5:293–300, 1985.
2) Levy, M., Oren, R., Paracetamol overdosage in Jerusalem. Isr. J. Med. Sci. 21:30–36, 1985.
3) Kopolovic, J., Shvil,, Y., Pomeranze, R., Rubinger, D., Oren, R.: IgM nephropathy: Morphological study related to clinical findings. Am. J. Nephrol. 7:275–280, 1988.
4) Mosseri, M., Hasin, Y., Kopolovic, J., Kotan, C., Yarom, R., Oren, R., Admon, D., Gotsman, M.: Coronary thrombi formation in acute coronary syndromes—histological confirmation obtained by PTCA. CV World Report 1:250–253, 1988.
5) Oren, R., Shouval, D., Tur-Kaspa, R.:Direction of hepatitis A virus RNA in serum of patients with acute viral hepatitis. J. Med. Virol. 28:261–263, 1989.
6) Sonnenblick, M., Oren, R., Tur-Kaspa, R.: Non-A non-B hepatitis in the aged. Postgrad. Med. J. 66:462–464, 1990.
7) Ilan, Y., Oren, R., Ben-Chetrit, E.: Etiology, treatment and prognosis of large pericardial effusions. A study of 34 patients. Chest 4:985–987, 1991.
8) Ilan, Y., Oren, R., Ben-Chetrit, E. Acute pedicarditis: Etiology, treatment and prognosis. A study of 115 patients. Jpn. Heart J. 22(3):513-521, 1991.
9) Oren, R., Rachmilewitz, D.: Preoperative diagnostic clues for Crohn’s disease in the evaluation of acute appendicitis. J. Clin. Gastroenterol. 15:306–310, 1992.
10) Oren, R., Levy, M.: Paracetamol overdosage in Jerusalem, 1984–1989. Has a steady state been reached? Isr. J. Med. Sci. 28:795–796, 1992.
11) Glickson, M., Galun, E., Oren, R., Tur-Kaspa, R., Shouval, D.: Relapsing hepatitis A—Review of 14 cases ad literature survey. Medicine 71:14–211, 1992.
12) Oren, R., Ligumsky, M., Lysy, J., Zimmerman, J.: Gastrointestinal injury associated with intake of 100–325 mg aspirin daily. Post. Grad. Med. J. 69(815):712–714, 1993.
13) Ilan, Y., Oren, R., Tur-Kaspa, R.: Elevated growth hormone levels in patients with non-alcoholic chronic liver disease. J. Gastroenterol. Hepatol. 8:1–3, 1993.
14) Oren, R., Lossos, I.S.: Elevated creatine phosphokinase and creatine phosphokinase-MB in hyper-ventilation. Am. J. Med. 94:1, 1993.
15) Oren, R., Matzner, Y.: Assembling a coherent story. N. Engl. J. Med. 330:48–50, 1994.
16) Oren, R., Hilzenrat, N., Maaravi, Y., Yaari, A., Sikuler, E.: Hemodynamic effects of hypothyroidism in normal and portal hypertensive rats. Dig. Dis. Sci. 40(9):1941–1945, 1995.
17) Eliakim, R., Alpers, D.H., Oren, R., DeSchryver-Kesckemeti, K.: Duodenal surfactant-like particles are decreased in patients with peptic ulcer disease. Gut 39(3):353–359, 1996.
18) Oren, R., Arber, N., Odes, S., Moshkowitz, M.N., Keter, D., Pomerantz, I, Ron, Y., Reisfeld, I., Broide, E., Lavy, A., Fich, A., Eliakim, R., Patz, J., Bardan, E., Villa, Y., Gilat, T.: Methotrexate in chronic ulcerative colitis: A double blind, randomized, multicenter Israeli trial. Gastroenterology 110:1416–1421, 1996.
19) Oren, R., Dotan, I., Papa, M., Maaravi, Y., Aeed, H., Barg, J., Zaidel, L., Bruck, R., Halpern, Z.: Inhibition of experimentally induced liver cirrhosis in rats by hypothyroidism. Hepatology 24:419–423, 1996.
20) Oren, R., Beeri, M., Hubert, A., Kramer, M.R., Stalnikowicz, R., Zajicek, G., Matzner, Y.: The effect of theophylline on erythrocytosis in chronic obstructive pulmonary disease. Arch. Intern. Med. 157:1474–1478, 1997.
21) Oren, R., Zajicek, G., Maaravi, Y., Kenet, G., Karmely, F., Hubert, A., Raanani, P., Baratz, M., Arber, N.: Methimazole slows hepatocyte streaming in rats. Dig. Dis. Sci. 42(7):1433–1437, 1997.
22) Oren, R., Maaravi, Y., Karmely, F., Kenet, G., Zaidel, L., Hubert, A., Eliakim, R.: Anti-thyroid drugs decrease mucosal damage in a rat model of experimental colitis. Alim. Pharm. & Therap. 11:341–345, 1997.
23) Moshkowitz, M., Oren, R., Tishler, M., Konikoff, F.M., Graf, E., Gilat, T.: The absorption of low dose methotrexate in patients with inflammatory bowel disease. Alim. Pharm & Therap. 11(3):569–573, 1997.
24) Oren, R., Shulman-Manor, O., Stalnikowicz, R., Ackerman, Z., Eliakim, R.: Open-access endoscopy. Is it indicated and efficient? A retrospective and prospective study. Isr. J. Med. 33:771–776, 1997.
25) Oren, R., Moshkowitz, M., Odes, S., Becker, S., Arber, N., Keter, D., Pomerantz, I., Shirin, C., Reisfeld, I., Broide, E., Lavy, A., Fich, A., Eliakim, R., Patz, J., Villa, Y., Gilat, T.: Methotrexate in chronic active Crohn’s disease: A double blind randomized Israeli multicenter trial. Am. J. Gastrol. 92:2203–2209, 1997.
26) Bruck, R., Oren, R., Shirin, H. Aeed, H., Matas, Z., Zaidel, L., Avni, Y., Halpern, Z.: Hypothyroidism minimizes liver damage in thioacetamide-induced fulminant hepatic failure in rats. Hepatology 27:1013–1020, 1998.
27) Laconi, E., Oren, R., Mukhopadhyay, D., Hurston, E., Laconi, S., Pani, P., Dabeva, M.D., Shafritz, D.A.: Long term, near total liver replacement by transplantation of isolated hepatocytes. Am. J. Pathol. 153(1):319–329, 1998.
28) Oren, R., Resnick, M.B., Brill, S., Dotan, I., Zaidel, L., Lifshits-Mercer, B., Villa, Y., Halpern Z.: Distinct proliferation of normal versus injured hepatocytes in response to thyroxine. J. Hepataol. 29:634–637, 1998.
29) Oren, R., Brill, S., Dotan, I., Halpern, Z.: Liver function in cirrhotic patients in the euthyroid—versus the hypothyroid state. J. Clin. Gastroenterol. 27:339–341, 1998.
30) Dabeva, M., Laconi, E., Oren, R., Petkov, P., Hurston, E., Shafritz, D.: Liver regeneration and α-fetoprotein mRNA expression in the retrosine model for hepatocyte transplantation. Cancer Research 58:5825–5834, 1998.
31) Oren, R., Dabeva, M., Petkov, P., Hurston, E., Laconi, E., Shafritz, D.A.: Restoration of normal serum albumin in the Nagase analbuminemic rats by hepatocyte transplantation. Hepatology 29:75–81, 1999.
32) Shirin, H., Dotan, I., Papa, M., Maaravi, Y., Aeed, H, Zaidel, L., Matas, Z., Bruck, R., Halpern, Z., Oren, R.: Inhibition of Concanavalin A-induced acute T-cell dependent hepatic damage in mice by hypothyroidism. Liver 19:206–211, 1999.
33) Bruck, R., Frenkel, D., Shirin, H., Matas, Z., Zaidel, L., Avni, Y., Oren, R., Halpern, Z.: Hypothyroidism protects rat liver from acetaminophen hepatotoxicity. Dig. Dis. Sci. 44(6):1228–1235, 1999.
34) Oren, R., Dabeva, M., Petkov, P.M., Karnezis, A.N., Rosencrantz, R., Sandhu, J., Moss, S., Wang, S., Hurston, E., Laconi, E., Holt, P.R., Thung, S.N., Zhu, L., Shafritz, D.A.: Role of thyroid hormone in stimulating liver repopulation in the rat by transplanted hepatocytes Hepatology 30:903–913, 1999.
35) Oren, R., Dotan, I., Brill, S., Jones, B.E., Benhaim, M., Sikuler, E., Halpern, Z.: Altered thyroid status modulates portal pressure in normal rats. Liver 19:423–426, 1999.
36) Dabeva, M.D., Petkov, P.M. Sandhu, J., Oren, R., Laconi, E., Hurston, E., Shafritz, D.A.: Proliferation and differentiation of fetal liver ephithelial progenitor cells after transplantation into adult rat liver. Am. J. Pathol. 156(6):2017–2031, 2000.
37) Oren, R., Sikuler, E., Wong, F., Blendis, L.M., Halpern, Z.: The effects of hypothyroidism on liver status of cirrhotic patients. J. Clin. Gastroenterol. 31(2):162–163, 2000.
38) Brill, S., Weinberg, M., Graff, E., Oren, R.: The status serum of serum iron and transferring saturation in acute non (A-E hepatitis) viral infections. J. Med. 31(5-6):271–277, 2001.
39) Sorkin, P., Ben Avraham, R., Szold, O., Biderman, P., Kidron, A., Merchav, H., Brill, S., Oren, R.: Role of molecular adsorbent recycling system (MARS) in the treatment of patients with acute exacerbation of chronic liver failure. Critical Care Med. 29(7):1332–1336, 2001.(6.6, 2/19)
40) Brill, S., Zvibel, I., Halpern, Z., Oren, R.: The role of fetal and adult hepatocyte extracellular matrix in the regulation of tissue-specific gene expression in fetal and adult hepatocyte. Eur. J. Cell. Biol. 81(1):43–50, 2002.(3.3, 71/154)
41) Gur, E., Deckel, R., Zvibel, I., Brazovsky, E., Kariv, R., Brill, S., Halpern, Z., Oren, R.: A novel method for liver repopulation: Heterografting of micro-liver slices in a rat model. Liver Transpl. 9(4):421–424, 2003. (3.7, 13/50)
42) Kariv, R., Enden, A., Zvibel, I., Rosner, G., Brill, S., Shafritz, D.A., Halpern, Z, Oren, R.: Triiodotyronine and interleukin-6 (IL-6) induce expression of HGF in an immortalized rat hepatic stellate cell line. Liver 23(3):187–193, 2003. (2.6, 20/50)
43) Deckel, R., Zvibel, I., Brill, S., Brazovsky, E., Halpern, Z, Oren, R.: Gliotoxin ameliorates development of fibrosis and cirrhosis in a thioacetamide rat model. Dig. Dis. Sci. 48(8):1642–1647, 2003. (1.3, 41/50)
44) Zvibel, I., Brill, S., Kariv, R., Traister, A., Golan, T., Chebath, J., Halpern, Z., Revel, M., Oren, R.: Chimeric molecule IL-6/soluble IL-6 receptor is a potent mitogen for fetal hepatocytes. J. Cell Physiol. 200(2):245–252, 2004. (3.6, 22/68)
45) Lurie, Y., Rouzier-Panis, R., Webster, G.J., Dusheiko, G.M., Laughlin, M., Jackson, M.L., Oren, R. Optimal dosing frequency of pegylated interferon alfa-2b monotherapy for chronic hepatitis C virus infection. Clin. Gastroenterol. Hepatol. 3(6):610–615, 2005. (5.4, 8/50)
46) Oren, R., Breitman, Y., Gur, F., Traister, A., Zvibel, I. Brazovsky, E. Shafritz, D.A., Halpern, Z.: Whole fetal liver transplantation—a new approach to cell therapy. Liver Transpl. 11(8):929–933, 2005. (3.7, 13/50)
47) Traister, A., Breitman, I., Bar-Lev, E., Zvibel, I., Harel, A., Halpern, Z., Oren, R.: Nicotinamide induces apoptosis and reduces collagen I and proinflammatory cytokines expression in rat hepatic stellate cells. Scan. J. Gastroenterology. 40(10):1226–1234, 2005. (1.7, 37/50)
48) Zelber-Sagie, S., Kessler, A., Brazowsky, E., Webb, M., Lurie, Y, Santo, M., Leshno, M., Blendis, L., Halpern, Z., Oren, R.: A double-blind randomized placebo-controlled trial of orlistat for the treatment of non-alcoholic fatty liver disease. Clin. Gastroenterol. Hepatol. 4(5): 639-442, 2006. (5.4, 8/50)
49) Kariv, R., Leshno, M., Beth-Or, A., Strul, H., Blendis, L., Kokia, E., Noff, D., Zelber-Sagie, S., Sheinberg, B. Oren, R., Halpern, Z.: Re-evaluation of serum alanine aminotransferase upper normal limit and its modulating factors in a large-scale population study. Liver Int. 26 (4):445–50, 2006. . (2.6, 20/50
50) Leshno, M., Brazowski, E., Rosner G., Halpern, Z., Oren, R.: Role of CYP2D6 polymorphism in predicting liver fibrosis progression rat in Caucasian patients with chronic hepatitis C. Liver Int. 26(3):279–84, 2006. . (2.6, 20/50)
51) Rosner, G., Lurie, Y., Blendis, L., Halpern, Z., Oren, R.: Acute hepatitis B in the era of immunization: pitfalls in the identification of high risk patients. Postgrad. Med. J. 82(965):207–10, 2006. (1.2, 50/100)
52) Zvibel, I., Bronstein, M., Hubel ,E., Bar-Lev, E., Halpern, Z., Oren, R.: Isolation, characterization and culture of Thy1-positive cells from fetal rat livers. World. J. Gastro 12: 3841-3847, 2006. (2.0, )
53) Zelber-Sagie, S., Nitzan-Kaluski, D., Halpern, Z., Oren, R.: Prevalence of primary NAFLD in a population-based study and its association with biochemical and anthropometric measures. Liver Int. 26: 856-863, 2006. . (2.9, 20/50)
54) Bruck, R., Wise, S, Traister A, Zvibel, I., Aeed, H, Halpern, Z., Oren, R. Induced-hypothyroidism accelerates the regression of liver cirrhosis in rats: a possible effect on collage synthesis and reduction of metalloproteinase secretion. J Gastroenterol Hepatol 22:2189-2194, 2007. (2.3, 40/50)
55) Lurie, Y., Landau, D.A., Kanevsky, A. Pel, S., Zelber-Sagie, S., Oren, R. Medex Test, a novel modality for liver disease diagnosis – a pilot study. Journal of Clinical Gastroenterology, 41(7):700-5, 2007. (2.9, 18/59)
56) Lurie, Y., Landau D-A., Blendis, L., Baruch, Y., Veitsman, E., Ackerman, Z., Halpern, Z., Zelber-Sagie, S., Oren, R. Acute hepatitis C in Israel—a predominantly latrogenic disease? Journal of Gastroenterology and Hepatology 22(2):158-64, 2007. (1.7, 38/50)
57) Zelber-Sagi S, Nitzan-Kaluski D, Goldsmith R, Webb M, Blendis L, Halpern Z, Oren R. Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study. J Hepatol. 47:711-777, 2007. (7.1, 4/50)
58) Zelber-Sagi S, Nitzan-Kaluski D, Halpern Z, Oren R. NAFLD and hyperinsulinemia are major determinants of serum ferritin levels. J Hepatol. 46(4):700-7, 2007. (7.1, 4/50)
59) Lurie, Y., Landau, D.A., Pfeffer, J. Oren, R. Celiac disease diagnosed in the elderly. A case series. Journal of Clinical Gastroenterology, 42(1):59-61,.2008. (2.9, 18/50)
60) Zvibel I, Bar-Zohar D, Kloog Y, Oren R, Reif S. The effect of Ras inhibition on the proliferation, apoptosis and matrix metalloproteases activity in rat hepatic stellate cells. Dig. Dis. Sci 53:1048-1053, 2008 .(1.6, 41/50)
61) Zvibel I, Halfon P, Fishman S, Penaranda G, Leshno M, Bet Or A, Halpern Z, Oren R. Syndecan 1 (CD138) serum levels: a novel biomarker in predicting liver fibrosis stage in patients with hepatitis C. Liver International Liver Int. 2009; 29(2):208-12. (2.9 , 20/50)
62) Zelber-Sagi S, Nitzan-Kaluski D, Goldsmith R, Webb M, Zvibel I, Goldiner I, Blendis L, Halpern Z, Oren R. Role of leisure-time physical activity in nonalcoholic fatty liver disease: a population-based study. Hepatology. 48(6):1791-8, 2008. (11.4, 2/50)
63) Webb M, Yeshua H, Zelber-Sagi S, Santo E, Brazowski E, Halpern Z, Oren R. Diagnostic value of a computerized hepatorenal index for sonographic quantification of liver steatosis. AJR Am J Roentgenol. 2009 Apr;192(4):909-14. (2.7, 3/7)
64) Maor Y, Halfon P, Bashari D, Naranda PG, Morali, Klar R, Bar-Meir S, Martinowitz U, Oren R,: Fibrotest or fibroscan for evaluation of liver fibrosis in haemophilia patients infected with hepatitis c Haemophilia (2009), 1–7 (2.4, 32/62)
65) Zvibel I , Atias D, Phillips A, Halpern Z, Oren R. Thyroid hormones induce activation of primary rat hepatic stellate cells via increased expression of p75 neurotrophin receptor and direct activation of Rho. Lab Invest 2010 (in press). (4.6, 8/68)
66) Ben Shlomo S, Zvibel I, Shnell M, Shlomai A , Chepurko E, Halpern Z, Barzilai N, Oren R, Fishman S Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase J. Hepatol (2011 in press) (7.1, 4/50)
67) Zelber-Sagi S , Yeshua H, Shlomai A , Blendis LA, Leshno M, Levit S, Halpern Z , Oren R : Sampling variability of Transient Elastography according to probe location European Journal of Gastroenterology & Hepatology ( in press)
Case Reports
1) Ben-Chetrit, E., Oren, R., Gefel, D. Potentiation of anaphylactic reaction by propranolol. Harefuah 105:410–411, 1983 (Hebrew).
2) Oren, R., Harats, N., Polak, A., Libson, E., Naparstek, Y. Granulomatous colitis 10 years after presentation with isolated Crohn’s gastritis: A case report. Am. J. Gastroenterol 84:449–450, 1989.
3) Ilan, Y., Oren, R., Shouval, D.: Postpartum Budd-Chiari syndrome with prolonged hypercoagulability state. Am. J. Obstet. Gynecol. 162(1):1164–1165, 1990.
4) Ilan, Y., Hilllman, M., Kaufman, B., Oren, R.: Prolonged course of a cutaneous T-cell lymphoma with late systemic involvement: An unusual case report. Br. J. Clin. Pract. 44(11):731–733, 1990.
5) Ilan, Y., Hillman, M., Oren, R.: Intravenous verpamil for tachyarrhythmia in Duchenne’s muscular dystrophy. Pediatr. Cardiol. 11:177–178, 1990.
6) Ilan, Y., Hillman, M., Oren, R., Zlotogorski, A., Shouval, D. Vasculitis and cryglobulinemia associated with persisting cholestatic hepatitis A virus infection. Am. J. Gastroenterol 85:586–587, 1990.
7) Lugassy, G., Michaeli, J., Hurwitz, N., Oren, R., Wishnitzer, R., Eliraz, A., Berrebi, A.: Pulmonary alveolar proteinosis preceding recurrence of Hodgkin’s disease in the lung. Isr. J. Med. Sci. 26:446–449, 1990.
8) Ilan Y., Hillman, M., Oren, R., Galun, E., Shalit, M.: Undetected ceruloplasmin values in an autoimmune chronic active hepatitis patient. Gut 32:549–5501, 1991.
9) Oren, R., Schnur, L.F., Ben-Yehuda, D., Mayner, V., Okon, E., Rachmilewitz, E.A.: Visceral leishmaniasis: A difficult diagnosis and unusual causative agent. J. Inf. Dis. 164:746–749, 1991.
10) Oren, R., Fich, A.: Oral contraceptive-induced esophageal ulcer. Dig. Dis. Sci. 36:1489–1490, 1991.
11) Oren, R., Goldin, E., Harats, N., Libson, E., Shouval, D.: Localized primary sclerosing cholangitis mimicking a post cholecystectomy structure, relieved by an endoprosthesis. Postgrad. Med. J. 67:482–484, 1991.
12) Oren, R., Ilan, Y.: Reversible hepatic injury induced by chronic vitamin A ingestion. Am. J. Med. 93:703–704, 1992.
13) Oren, R., Samuel, D., Tur-Kaspa, R.: Kaposi sarcoma following liver transplantation. Harefuah 123(5-6):192–195, 1992 (Hebrew).
14) Ashkenazi, E., Constantini, S., Oren, R., Pappo, O., Umansky, F.: Fine needle aspiration biopsy for skull tumors: technical note and two demonstrative case reports. Clin. Neuropath. 11:74–76, 1992.
15) Ilan Y., Hillman, M., Oren, R., Wolf, D.: Elevated CPK and CPK-MB levels in acute laryngitis. Keio J. Med. 40(1):19, 1992.
16) Cohen, O., Ackerman, Z., Mevorach, D., Oren, R.: Thrombocytopenic purpura as a manifestation of acute hepatitis A. J. Clin. Gastroenterol. 17(2):166–167, 1993.
17) Oren, R., Pizuv, G., Naparstek, Y. Rubinow, A.: Cochicin induced remission in amyloid nephrotic syndrome. J. Clin. Rheumathol. 12(4):532–534, 1993.
18) Lossos, I.S., Oren, R.: Recurrent ineffective endocarditis—a new variant of an old disease Postgrad. Med. J. 69:816–818, 1993.
19) Mevorach, D., Lossos, I.S., Oren, R.: Cefuroxime induced drug fever. Ann. Pharmacother. 27:881–882, 1993.
20) Oren, R., Granat, E., Shtrussberg, S., Matzner, Y. Closapine induced agranulocytosis treated by GMCSF. Br. J. Psychiat. 162:686–687, 1993.
21) Oren, R., Ligumsky, M.: Indomethacin induced colonic ulceration and bleeding. Ann. Pharmacother. 28:883–885, 1994.
22) Sherer, D.M., Dayal, A.K., Schwartz, B.M., Oren, R., Abilafia, O.: Extensive spontaneous retroperitoneal hemorrhage: an unusual complication of herapin anticoagulation during pregnancy. J. Matern. Fetal Med. 8(4):196–199, 1999.
Papers At Scientific Meetings
Invited Papers at Scientific Meetings
1) Oren, R.: Portal hypertension—a relative hyperthyroidal state. Second Joint Spanish–Israeli meeting on Liver and Biliary Diseases, Toledo, Spain, 1995.
2) Oren, R.: Modulation of liver function by thyroid hormones. Marion Bessin Liver Research Center. Albert Einstein College of Medicine, Bronx, New York, November 1996.
3) Oren, R.:Modulation of liver function by thyroid hormones. Liver Transplant Research Conference. The Mount Sinai Medical Center, New York, New York, February 1998.
4) Oren, R.: Modulation of liver function by thyroid hormones. Department of Gastroenterology, St. Lukes—Roosevelt Hospital, New York, New York, July 1998.
5) Oren, R.: The role of thyroid hormone in stimulating liver repopulation by transplanted hepatocytes. New York Thyroid Club Montifiore Hospital, Bronx, New York, October 1998.
Papers Presented at Scientific Meetings
1) Schnur, L.F., Oren, R.:Definitive proof that Leishmania Tropica can cause visceral Leishmaniasis in man. 36th Annual Meeting of the American Society of Tropical Medicine and Hygiene, Los Angeles, 1987.
2) Oren, R., Tur-Kaspa, R. Detection of hepatitis A virus RNA in serum of patients with acute viral hepatitis. American Association for the Study of Liver Diseases, Chicago, 1988.
3) Sonnenblick, M., Oren, R., Tur-Kaspa, R. Non-A, non-B hepatitis in the aged. International Association for the Study of the Liver, Toronto, 1988.
4) Schnur, L.F., Youssef, M., Oren, R. Origins and causes of visceral Leishmaniasis in Israel and Egypt. The 39th Annual Meeting of the American Society of Tropical Medicine and Hygiene. New Orleans, 1990.
5) Ilan, Y., Oren, R., Ben-Chitrit, E. Etiology, treatment and prognosis of large pericardial effusion. The International Monitor of Cardiovascular Disease, 1992.
6) Oren, R., Hilzenrat, N., Maaravi, Y., Sikuler, E.: Hemodynamic effects of hypothyroidism induced by methimazole in normal and portal hypertensive rats. American Association for the Study of Liver Diseases, Chicago, Illinois, November 1993.
7) Oren, R., Hubert, A., Stalnikowicz, R., Zajicek, G., Matzner, Y. Effect of theophylline on erythrocytosis in chronic obstructive pulmonary disease (COPD). The Israel Association of Pulmonary Diseases, Kfar Sava, 1993.
8) Tiommy, E., Reich, C., Oren, R., Becker, S., Gilat, T. Acemannan in active ulcerative colitis—preliminary results. World Congress of Gastroenterology, Los Angeles, 1994.
9) Moshkowitz, M., Santo, M., Konikoff, F., Hallak, A., Oren, R., Peled, Y., Gilat, T. High bacterial density is associated with low eradication rate of helicobacter pylori during triple therapy. Israel Association of Gastroenterology, Zichron Yaakov, 1994.
10) Oren, R., Hilzenrat, N., Maaravi, Y., Sikuler, E. Hemodynamic effects of hypothyroidism induced by methimazole in normal and portal hypertensive rats. Falk Symposium No. 79, Freiburg, Germany, 1994.
11) Oren, R., Dotan, I., Aeed, H., Maaravi, Y., Zaidel, L., Halpern, Z. Methimazole-induced hypothyroidism protects from acute liver injury mediated by concavalin A (con A) in mice. Falk Symposium No. 78, Freiburg, Germany, 1994.
12) Oren, R., Dotan, I., Aeed, H., Bruck, R., Zaidel, L., Halpern, Z. The effect of hypothyroidism on thioacetamide (TAA)–induced liver cirrhosis in rats. American Association for the Study of Liver Diseases, Chicago, 1994.
13) Oren, R., Aeed, H. Maaravi, Y., Halpern, Z. Effect of hypothyroidism on cirrhosis development in the rat. The Israel Association for the Study of the Liver, Jerusalem, 1994.
14) Bruck, R., Oren, R., Aeed, H., Halpern, Z. Inhibition of fulminant hepatic failure in rats by hypothyroidism. Israel Association of Gastroenterology, Tel-Aviv, 1995.
15) Oren, R.,, Ek, G., Maaravi, Y., Kenet, G., Karmely, F., Hubert, A., Raanani, P., Baratz, M, Arber, N. Methimazole slows hepatocyte streaming in rats. American Association for the Study of Liver Diseases, Chicago, 1995.
16) Oren, R., Arber, N., Odes, S., Moshkowitz, M, Keter, D., Pomerantz, I., Ron, Y., Reisfeld, I., Broide, E., Lavy, A., Fich, A., Eliakim, R., Patz, J., Bardan, E., Villa, Y., Gilat, T. Methotrexate in chronic ilcerative colitis: A double blind, randomized, multicenter Israeli trial. Israel Association of Gastroenterology, Tel-Aviv, 1995.
17) Oren, R., Sikuler, E., Blendis, L., Halpern, Z. Effects of hypothyroidism on patients with liver cirrhosis. Israel Association of Gastroenterology, Tel-Aviv, 1995.
18) Tiommy, E., Brill, S., Umansky, M., Oren, R., Jan, J., Gilat, T. A computerized image capturing system in gastroenterology practice. Binational Italian–Israel Gastroenterology Meeting, Eilat, 1995.
19) Shirin, H., Oren, R., Dotan, I., Aeed, H., Zaidel, L., Matas, Z., Halpern, Z. Hypothyroidism inhibits experimentally induced acute T-cell dependent hepatic damage in mice. Binational Italian–Israel Gastroenterology Meeting, Eilat, 1995.
20) Yerushalmi, R., Sikuler, E., Oren, R., Levi, R. The effect of methimazole on neutrophil superoxide generatin in BLD rats. Annual Meeting of the European Association for the Study of the Liver, Geneva, Switzerland, August 1996.
21) Oren, R., Moshkowitz, M., Becker, D., Keter, D., Albert, N., Lavy, A., Eidelman, S., Wengrover, D., Fich, A., Od, S., Reisfeld, I., Shirin, H., Ron Y., Pomeranz, I., Broide, E., Bardan, E., Patz, J., Eliakim, R., Villa, Y., Gilat, T. Methotrexate in chronic active Crohn’s disease: A double blind, randomized, Israeli multicenter trial. Israel Association of Gastroenterology, Zichron Yaakov, 1996.
22) Oren, R., Shulman-Manor, O., Stalnikowicz, R., Ackerman, Z., Eliakim, R. Open access endoscopy in Jerusalem: 1990–93. Israel Association of Gastroenterology, Zichron Yaakov, 1996.
23) Shabat, V., Shirin, C., Oren, R., Dotan, I., Papa, M., Maaravi, Y., Aeed, H., Zaidel, L., Matas, Z., Bruck, R., Halpern, Z. Inhibition of experimentally induced acute T-cell dependent hepatic damage in mice by thyroidism. Israel Association of Gastroenterology, Zichron Yaakov, 1996.
24) Laconi, E., Daveva, M., Laconi, A., Pani, P., Mukhopadhyay, D., Oren, R., Shafritz, D.A. Rapid proliferation of transplanted syngeneic DPPIV + hepatocytes in the liver of pyrrolizidine alkaloid treated DPPIV–Fischer rats. Annual Meeting of Professional Research Scientists, Experimental Biology, New Orleans, Los Angeles, April 1997.
25) Bruck, R., Frenkel, D., Shirin, H., Aeed, H., Matas, Z., Zaidel, L., Avni, Y., Oren, R., Halpern, Z. Hypothyroidism protects rat liver from hepatotoxicity induced by acetaminophen. 32nd Annual Meeting of the European Association for the Study of the Liver, London, United Kingdom, April 1997.
26) Oren, R., Dabeva, M., Petkov, P.M., Karnezis, A.N., Rosencrantz, R., Sandhu, J., Moss, S., Wang, S., Hurston, E., Laconi, E., Holt, P.R., Thung, S.N., Zhu, L., Shafritz, D.A. Role of thyroid hormone in stimulating liver repopulation by transplanted hepatocytes. American Association for the Study of Liver Diseases, Chicago, 1998.
27) Dabeva, M.D., Sandhu, J, Petkov, P.M., Laconi, E., Oren, R., Hurston, E., Shafritz, D.A. Differentiation and proliferation of fetal hepatoblasts in the liver of Fischer 344 rats. 8th Biennial International Congress on Liver Development, Gene Regulation and Disease, Orvieto, Italy, June 1999.
28) Katchman H., Zvibel I., Dekel R., Halpern Z., Oren R., Brill, S. Recruitment of hemopoietic stem cells to the liver improves liver function in cirrhotic rats. Hepatocyte Transplantation, Falk Symposium, Hannover, October
2-3 (First Prize), 2001.
29) Dekel, R., Gur, E., Zvibel, I., Brill, S., Halpern, Z., Oren R. Successful long-term engraftment of transplanted liver slices. Hepatocyte Transplantation, Falk Symposium, Hannover, October 2-3, 2001.
30) Zvibel, I., Dekel, R., Halpern, Z., Oren R., Brill, S. Gliotoxin ameliorates development of fibrosis and cirrhosis in a thioacetamide rat model. Cytokines and Liver Injury, Falk Symposium, Hannover, October 1-2, 2001.
31) Kariv, R., Enden, A., Zvibel, I., Brill, S., Halpern, Z., Oren R. Role of triiodothyronine in hepatocyte proliferation during liver injury. Cytokines and Liver Injury, Falk Symposium, Hannover, October 1-2, 2001.
32) Katchman, H., Zvibel, I., Dekel, R., Halpern, Z., Oren, R., Brill, S. Recruitment of hemopoietic stem cells to the liver improves liver function in cirrhotic rats. AASLD, Dallas, 2001.
33) Kariv, R., Enden, A., Zvibel, I., Brill, S., Halpern, Z., Oren, R.
Role of triiodothyronine in hepatocyte proliferation during liver injury.
AASLD, Dallas, 2001.
34) Traister, A., Ciuraru, N., Zvibel, I., Kraiem, Z., Halpern, Z., Oren R. Effect of nuclear hormone receptor ligands on proliferation and activation of hepatic stellate cells. AASLD, Boston, 2003.
35) Reif, S., Bar-Zohar, D., Izabel, Z., Halpern, Z., Oren, R. The effect of RAS inhibition on the proliferation, activation and matrix metalloproteases expression of hepatic stellate cells.
AASLD, Boston, 2004.
36) Zelber-Sagie, S., Kessler, A., Brazowsky, E., Webb, M., Lurie, Y, Santo, M., Leshno, M., Blendis, L., Halpern, Z., Oren, R. A double-blind randomized placebo-controlled trial of orlistat for the treatment of non-alcoholic fatty liver disease. AASLD, Boston, 2004.
37) Kessler, A., Levy, Y., Roth, A., Zelber-Sagie, S., Leshno, M., Blendis, L., Halpern, Z., Oren, R. Increased Prevalence of NAFLD in Patients with Acute Myocardial Infarction Independent of BMI AASLD, San Francisco, 2005.
38) Zelber-Sagie, S., Nitzan-Kalusky, D., Halpern, Z., Oren, R. Is NAFLD an independent predictor of the metabolic syndrome? AASLD, San Francisco, 2005
39) Zelber-Sagie, S., Nitzan-Kalusky, D., Halpern, Z., Oren R. Hyperinsulinemia is an independent predictor of elevated serum ALT levels even after adjustment to NAFLD and liver histology AASLD, San Francisco, 2005.
40) Zelber-Sagie, S., Nitzan-Kalusky, D., Halpern, Z., Oren R. Serum ALT is not a reliable screening tool for NAFLD in the general population EASL, Vienna, 2006.
41) Zelber-Sagi, S., Nitzan-Kalusky, D., Goldsmith, R., Webb, M., Blendis, M., Halpern, Z., Oren, R. The association between NAFLD and long term nutritional intake, a population based study. J. Hepatol. Sup. 1(46):291, 2007.
42) Zelber-Sagi, S., Nitzan-Kalusky, D., Goldsmith, R.,Webb, M., Blendis, M., Halpern, Z.,Oren, R. Role of physical activity in non-alcoholic fatty liver disease (NAFLD): A population bas study. Hepatology 46(4):1150, 2007.
43) Zelber-Sagi, S., Webb, M., Ratziu, V., Poynard, T., Halpern, Z., Oren, R. A comparison between the hepatorenal ultrasound index and steatotest for the invasive quantification of liver steatosis. J. Hepatol. Sup. 2(48): 368, 2008
44) Zelber-Sagi, S., Yeshua, H., Halpern, Z., Oren, R. Discordance between three successive Fibroscan measurements mirrors the variability of liver fibrosis. Journal of Hepatology. Sup. 1(50) 375. (2009).
45) Zelber-Sagi, S., Ratziu, V., Zvibel, I., Goldiner, I., Nitzan-Kaluski , D., Blendis, L., Gilles, M., Halpern, Z., Oren, R. Can serum leptin and adiponectin predict liver injury in patients with NAFLD? A study in the general population. Journal of Hepatology. Sup. 1(50) 375. (2009)
46) Zelber-Sagi, S., Webb, M., Leshno, M., Blendis, L., Yeshua, H., Ratziu, V., Halpern, Z., Oren, R. A comparison of fatty liver index with three non-invasive methods for the detection and Quantification of liver steatosis: Regular ultrasound, hepatorenal ultrasound index and steatotest. Journal of Hepatology. Sup. 1(52) 158. (2010)
47) Zelber-Sagi, S., Webb, M., Leshno, M., Blendis, L., Isaak Winocur, M., Yeshua, H., Halpern, Z., Oren, R. The hepatorenal ultrasound index is correlated with obesity, ALT, insulin and adipocytokines. Journal of Hepatology. Sup. 1(52) 158. (2010) - 26
Abstracts
1) Oren, R., Tur-Kaspa, R. Detection of hepatitis A virus RNA in serum of patients with acute viral hepatitis. Hepatology 18:4(2):512A, 1988.
2) Oren, R., Hilzenrat, N., Maaravi, Y., Sikuler, E.
Hemodynamic effects of hypothyroidism induced by methimazole in normal and portal hypertensive rats. Hepatology 18:4(2):248A–911, 1993.
3) Oren, R., Hubert, A., Stalnikowicz, R., Zajicek, G., Matzner, Y. Effect of theophylline on erythrocytosis in chronic obstructive pulmonary disease (COPD). Isr. J. Med. Sci. 22:4, 252A, 1993.
4) Oren, R., Dotan, I., Aeed, H., Bruck, R., Zaidel, L. Halpern, Z. The effect of hypothyroidism on thioacetamide (TAA)–induced liver cirrhosis in rats. Hepatology 20:4(2):778A, 1994.
5) Oren, R., Zajicek, G., Maaravi, Y., Kenet, G., Karmely, F., Hubert, A., Raanani, P., Baratz, M., Arber, N.
6) Oren, R., Sikuler, E., Blendis, L.M., Halpern, Z. Effects of hypothyroidism on patients with liver cirrhosis. .Hepatology 22(4):469A, 1995.
7) Eliakim, R., Alpers, D.H., Oren, R., DeSchryver-Kesckemeti, K. Duodenal surfactant-like particles are decreased in patients with peptic ulcer disease. Gastroenterology 108:A87, 1995.
8) Oren, R., Shirin, H., Dotan, I., Aeed, H., Zaidel, L, Matas, Z., Halpern, Z. Hypothyroidism inhibits experimentally induced acute T-cell dependent hepatic damage in mice. J. Hepatol. 23(1):213A, 1995.
9) Yerushalmi, R., Sikuler, E., Oren, R., Levi, R. The effect of methimazole on neutrophil superoxide in BDL rats. J. Hepatol. 25(1):131A, 1995.
10) Bruck, R., Oren, R., Aeed, H., Zaidel, M.L., Halpern, Z. Inhibition of fulminant hepatic failure in rats by hypothyroidism. Gastroenterology 110:A1159, 1996.
11) Oren, R., Dabeva, M., Mukhopadhyay, D., Hurston, E., Shafritz, D.A., Laconi, S., Pani, P., Laconi, E. Retrosine/partial hepatectony: A new model for massive proliferation of transplanted hepatocytes. Hepatology 26(4):2, 1997.
12) Bruck, R., Oren, R., Frenkel, D., Aeed, H., Zaidel, L., Avni, Y., Halpern, Z. Reversal of thioacetamide-induced liver cirrhosis in rats by hypothyroidism.
Gastroenterology 11(4), 1997.
13) Oren, R., Dabeva, M., Petkov, P.M., Karnezis, AN., Rosencrantz, R., Sandhu, J., Moss, S., Wang, S., Hurston, E., Laconi, E., Holt, P.R., Thung, S.N., Zhu, I., Shafritz, D.A. Role of thyroid hormone in stimulating liver repopulation by transplanted hepatocytes. Hepatology 28(4, pt. 2):503A, 1998.
14) Sandhu, J.P., Petkov, P.M., Hurston, E., Oren, R., Laconi, E., Shafritz, D.A. Repopulation of the adult rat liver by transplanted fetal hepatoblasts. Hepatology 252A, 366, 1999.
15) Brill, S., Zvibel, I., Papa, M., Oren, R., Halpern, Z. Fetal and adult hepatocyte-derived extracellular matrix regulates proliferation and tissue-specific gene expression in tissue and adult hepatocytes. Hepatology 251A, 362, 1999.
16) Kariv, R., Enden, A., Zvibel, I., Brill, S., Halpern, Z., Oren, R. Role of triiodotyronine in hepatocyte proliferation during liver injury. Hepatology 34(4):281A, 2001.
17) Fishman, S., Zvibel, I., Oren, R., Brill, S., Halpern, Z. Effect of heparin disaccharides on proliferation and expression of growth factor receptors in colon cancer cell lines. Hepatology 34(4):492A, 2001.
18) Dekle, R., Zvibel, I., Halpern, Z., Oren, R., Brill, S. Gliotoxin ameliorates development of fibrosis and cirrhosis in a thioacetamide rat model. Hepatology 34(4):516A, 2001.
19) Katchman, H., Zvibel, I., Halpern, Z., Oren, R., Brill, S. Recruitment of hemopoietic stem cells to the liver improves liver function in cirrhotic rats. Hepatology 34(4):280A, 2001.
20) Rosner, G., Oren, R., Halpern, Z., Zvibel, I. Anoikis mechanisms during hepatocyte isolation. Hepatology 36(4):467A, 2002.
21) Lurie, Y., Oakula, R., Kariv, R., Blendis, L., Segal, A., Halpern, Z., Oren, R. Acute hepatitis C is a rare disease. Is it really so? Hepatology 36(4):556A, 2002.
22) Traister, A., Ciuraru, N., Zvibel, I., Kraiem, Z., Halpern, Z., Oren, R. Effect of nuclear hormone receptor ligands on proliferation and activation of hepatic stellate cells. Hepatology 38(2):167, 2003.
23) Reif, S., Bar-Zohar, D., Izabel, Z., Halpern, Z., Oren, R. The effect of RAS inhibition on the proliferation, activation and matrix metalloproteases expression of hepatic stellate cells. Hepatology 40(4):1; 2004.
24) Zelber-Sagie, S., Kessler, A., Brazowsky, E., Webb, M., Lurie, Y, Santo, M., Leshno, M., Blendis, L., Halpern, Z., Oren, R. A double-blind randomized placebo-controlled trial of orlistat for the treatment of non-alcoholic fatty liver disease Hepatology 40(4):1, 1069, 2004.
25) Kessler, A., Levy, Y., Roth, A., Zelber-Sagie, S., Leshno, M., Blendis, L.,Halpern, Z., Oren, R. Increased Prevalence of NAFLD in Patients with Acute Myocardial Infarction Independent of BMI. Hepatology 42(4):1, 1084, 2005.
26) Zelber-Sagie, S., Nitzan-Kalusky, D., Halpern, Z., Oren, R. Is NAFLD an independent predictor of the metabolic syndrome? Hepatology 42(4):1, 1069, 2005.
27) Zelber-Sagie, S., Nitzan-Kalusky, D., Halpern, Z., Oren, R. Hyperinsulinemia is an independent predictor of elevated serum ALT levels even after adjustment to NAFLD and liver histology. Hepatology 42(4):1, 1081, 2005.
28) Zelber-Sagie, S., Nitzan-Kalusky, D., Halpern, Z., Oren, R. Serum ALT is not a reliable screening tool for NAFLD in the general population. J. Hepatol. Sup. 2(44):727, 2006.
29) Zelber-Sagi, S., Nitzan-Kalusky, D., Goldsmith, R.., Blendis, M., Halpern, Z., Oren, R. The association between NAFLD and long term nutritional intake, a population based study. J. Hepatol. Sup. 1(46):291, 2007.
30) Zelber-Sagi, S., Nitzan-Kalusky, D., Webb, M., Blendis, M., Halpern, Z., Oren, R. Role of physical activity in non-alcoholic fatty liver disease : A population based study. Hepatology 46(4):1150, 2007.
32) Zelber-Sagi, S., Webb, M., Ratziu, V., Poynard, T., Halpern, Z., Oren, R.: A comparison between the hepatorenal ultrasound index and steatotest for the non-invasive quantification of liver steatosis J. Hepatol. Sup. 2(48): 368, 2008.
33) Zelber-Sagi, S., Yeshua, H., Halpern, Z. ,Oren, R. Discordance between three successive Fibroscan measurements mirrors the variability of liver fibrosis. Journal of Hepatology. , 2009.
34) Zelber-Sagi, S., Ratziu, V., Zvibel, I., Goldiner, I., Nitzan-Kaluski , D., Blendis, L., Gilles,M. Halpern, Z., Oren, R. Can serum leptin and adiponectin predict liver injury in patients with NAFLD? A study in the general population. Journal of Hepatology. 2009