Symposia, Chapters and Reviews

·         Kaiser, N., and Cerasi, E.  Long-term monolayer culture of adult rat islets of Langerhans: an experimental model for studying chronic modulation of ß-cell function. In: Neuroendocrine Research Methods (Greenstein, B., ed), Harwood Academic Publishers, Reading, Berkshire, England, pp 131-147, 1991

·         Kaiser N.  Chronic glucose effect on ß function.  In: Progress in Endocrinology (Mornex, R., Jaffiol, J., and Leclere, J., eds), The Parthenon Publishing Group, NY, pp 807-810, 1993

·         Kaiser, N., and Cerasi, E.  Modulation of insulin release in long term cultures of pancreatic islets.  In: Frontiers of Insulin Secretion and Pancreatic ß-Cell Research (Flatt, P.R., and Lenzen, S., eds)  Smith-Gordon, London, pp 403-410, 1994

·         Kaiser, N., Gadot, M., Leibowitz, G., Cerasi, E., and Gross, D.J. Hyperproinsulinaemia and islet dysfunction in the NIDDM-like syndrome of Psammomys obesus. In: Physiology and Pathophysiology of the Islets of Langerhans (Soria, B., ed), Advances in Experimental Medicine and Biology, Plenum Press, NY, Vol 426:371-378, 1997

·         Leibowitz, G., Yuli, M., Donath, M., Nesher, R., Melloul, D., Cerasi, E., Gross, D., and Kaiser, N.  ß-Cell glucotoxicity in the Psammomys obesus model of type 2 diabetes.  Diabetes 50 (Suppl. 1):S113-S117, 2001

·         Leibowitz, G., Melloul, D., Yuli, M., Gross, D.J., Apelquist, A., Edlund, H., Cerasi, E., and Kaiser, N. Defective glucose-regulated insulin gene expression associated with PDX-1 deficiency in the Psammomys obesus model of Type 2 diabetes.  Diabetes 50 (Suppl. 1):S138-S139, 2001

·         Marshak, S., Benshushan, E., Shoshkes, M., Leibowitz, G., Kaiser, N., Gross, D., Bertuzzi, F., Cerasi, E., and Melloul, D.  ß-Cell specific expression of insulin and PDX-1 genes.  Diabetes 50 (Suppl. 1):S131-S132, 2001

·         Nesher, R., Anteby, E., Yedovizky, M., Warwar, N., Kaiser, N., and Cerasi, E.  ß-Cell protein kinases and the dynamics of insulin response to glucose.  Diabetes 51 (Suppl. 1):S68-S73, 2002

·         Kaiser, N., Leibowitz, G., and Nesher R.  Glucotoxicity and ß-cell failure in type 2 diabetes.  J. Pediatr. Endocrinol. Metab. 6: 5-22, 2003 (Review)

Selected Representative Publications

·         Kaiser, N., Corcos, A.P., Tur-Sinai, A., Ariav, Y., and Cerasi, E.  Monolayer culture of adult rat pancreatic islets on extracellular matrix: Long term maintenance of differentiated ß-cell function.  Endocrinology 123:834-840, 1988

·         Kaiser, N., Corcos, A.P., Tur-Sinai, A., Ariav, Y., Glaser, B., Landau, H., and Cerasi, E.  Regulation of insulin release in persistent hyperinsulinemic hypoglycemia of infancy studied under long-term culture of pancreatic tissue.  Diabetologia 33:482-488, 1990

·         Kaiser, N., Corcos, A.P., Sarel, I., and Cerasi, E.  Monolayer culture of adult rat pancreatic islets on extracellular matrix:  Modulation of ß-cell function by chronic exposure to high glucose.  Endocrinology 129:2067-2076, 1991

·         Schuppin, G.T., Bonner-Weir, S., Montana, E., Kaiser, N., and Weir G.C.  Replication of pancreatic ß-cells cultured on bovine corneal endothelial cell extracellular matrix.  In Vitro Cell. Dev. Biol. 29A:339-344, 1993

·         Gadot, M., Leibowitz, G., Shafrir, E., Cerasi, E., Gross, D.J., and Kaiser, N.  Hyperproinsulinaemia and insulin deficiency in the diabetic Psammomys obesus.  Endocrinology 135:610-616, 1994 

·         Gadot M., Ariav, Y., Cerasi E., Kaiser, N., and Gross, D.J. Hyperproinsulinemia in the diabetic Psammomys obesus is a result of increased secretory demand on the ß-cell.  Endocrinology 136:4218-4223, 1995

·         Gross, D.J., Leibowitz, G., Cerasi, E., and Kaiser, N.  Increased susceptibility of islets from diabetes-prone Psammomys obesus to the deleterious effects of chronic glucose exposure. Endocrinology 137:5610-5615, 1996

·         Kaiser, N., Bailys, E.M., Schneider, B.S., Cerasi, E., Steiner, D.F., Hutton, J.C., and Gross, D.J. Characterization of the unusual insulin of Psammomys obesus, a rodent with nutrition-induced NIDDM-like syndrome. Diabetes 46:953-957, 1997

·         Cerasi, E., Kaiser, N., and Gross, D.J.  From sand rats to diabetic patients: Is NIDDM a disease of the ß-cell?  Diab. Metab. 23:47-51, 1997

·         Nesher, R., Gross, D.J., Donath, M.Y., Cerasi, E., and Kaiser, N.  Interactions between genetic and dietary factors determine ß-cell function in Psammomys obesus, an animal model of NIDDM. Diabetes 48:731-737, 1999

·         Donath, M.Y., Gross, D.J., Cerasi, E., and Kaiser, N.  Hyperglycemia-induced ß-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.  Diabetes 48:738-744, 1999

·         Marshak, S., Leibowitz, G., Bertuzzi, F., Socci, C., Kaiser, N., Gross, D.J., Cerasi, E., and Melloul, D. Impaired ß-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose.  Diabetes 48:1230-1236, 1999

·         Kaiser, N., Donath, M.Y., Gross, D.J., and Cerasi, E. Diabete non-insulinodependant et apoptose de cellules beta.  Journ. Annu. Diabetol. Hotel Dieu 1999;(8 Suppl):13-23, 1999

·         Melloul, D., Kaiser, N., and Cerasi, E.  Chronic exposure to high glucose impairs multiple ß-cell functions in cultured human pancreatic islets.  Current Opinion in Endocrinology & Diabetes 7:44-48, 2000.

·         Ferber, S., Halkin, A., Cohen, H., Ber, I., Einav, Y., Goldberg, I., Barshack, I., Seijffers, R., Kopolovic, J., Kaiser, N., and Karasik, A. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozocin-induced hyperglycemia.  Nature Med. 6:568-572, 2000

·         Khamaisi, M., Kavel, O., Rosenstock, M., Porat, M., Yuli, M., Kaiser, N., and Rudich, A.  The effect of inhibition of glutathione synthesis on insulin action.  Biochem. J. 349:579-586, 2000

·         Nesher, R., Warwar, N., Khan, A., Efendic, S., Cerasi, E., and Kaiser, N.  Defective signals to release insulin in islets of Psammomys obesus, an animal model for type 2.  Diabetes 50:308-314, 2001

·         Maedler, K., Spinas, G.A., Dyntar, D., Moritz, W., Kaiser, N., and Donath, Y.  Distinct effects of saturated and mono-unsaturated fatty acids on ß-cell turnover and function.  Diabetes 50:69-76, 2001

·         Leibowitz, G., Ferber, S., Apelquist, A., Edlund, H., Gross, D.J., Cerasi, E., Melloul, D., and Kaiser, N.  IPF1/PDX1 deficiency and ß-cell dysfunction in Psammomys obesus, an animal with type 2 diabetes.  Diabetes 50:1799-1806, 2001

·         Meadler, K., Spinas, G.A., Lehmann, R., Sergeev, P., Weber, M., Fontana, A., Kaiser, N., and Donath, M.Y.  Glucose-induces ß-cell apoptosis via upregulation of the Fas receptor in human islets: A link between Type 1 and Type 2 diabetes.  Diabetes 50: 1683-1690, 2001

·         Alpert, E., Gruzman, A., Totary, H., Kaiser, N., Reich, R., and Sasson, S.  A natural protective mechanism against hyperglycemia in vascular endothelial and smooth muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acids.  Biochem. J. 362: 413-422, 2002

·         Leibowitz, G., Uckaya, G., Oprescu, A.I., Gross, D.J., Cerasi, E., and Kaiser, N.  Glucose-regulated proinsulin gene expression is required for adequate insulin production during chronic glucose exposure.  Endocrinology 143:3214-3220, 2002

·         Pertusa J.A.G., Nesher, R., Kaiser, N., Cerasi, E., Henquin, J-C., Jonas, J-C.  Increased glucose sensitivity of stimulus-secretion coupling in islets from Psammomys obesus after diet induction of diabetes.  Diabetes 51:2552-2560, 2002

·         Maedler, K., Sergeev, P., Ris, F., Oberholzer, O., Joller-Jemelka, H.I., Spinas, G.A., Kaiser, N., Halban, P.A. and Donath, M.Y.  Glucose-induced ß-cell production of interleukin-1ß contributes to glucotoxicity in human pancreatic islets.  J. Clin. Invest. 110: 851-860, 2002

·         Leibowitz, G., Oprescu, A.I., Uckaya, G., Gross, D.J., Cerasi, E., and Kaiser, N.  Insulin does not mediate glucose stimulation of proinsulin biosynthesis.  Diabetes 52:998-1003, 2003

·         Uckaya, G., Delagrange, P., Chavanieu, A., Grassy, G., Berthault, M.F., Ktorza, A., Cerasi, E., Leibowitz, G. and Kaiser, N.  Improvement of metabolic state in an animal model of nutrition-dependent type 2 diabetes following treatment with S 23521, a new GLP-1 analogue. J. Endocrinol. 184:505-513, 2005

·         Kaiser, N., Yuli, M., Uckaya, G., Oprescu, A.I., Berthault, M.F., Krager, C., Donath, M.Y., Cerasi, E. and Ktorza, A.   Dynamic changes in beta-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in Psammomys obesus. Impact of glycemic control. Diabetes 54: 138-145, 2005

·         Alpert, E., Gruzman, A., Riahi, Y., Blejter, T., Aharoni, P., Weisinger, G., Eckel, J., Kaiser, N. and Sasson, S. Delayed autoregulation of glucose transport in vascular endothelial cells. Diabetologia 48: 752-755, 2005

·         Leibowitz, G., Khaldi, M.Z., Shauer, A., Parnes, M., Oprescu, A.I., Cerasi, E., Jonas J.C., and Kaiser, N. Mitochondrial Regulation of insulin production in rat pancreatic islets. Diabetologia 48:1549-1559, 2005

·         Kaiser, N., Nesher, R., Oprescu, A.I., Efendic, S., and Cerasi, E. Characterization of the action of S 21403 (mitiglinide) on insulin secretion and biosynthesis in normal and diabetic beta cells. Br. J. Pharmacol. 146:872-881, 2005 

·         Kaiser, N., Nesher, R., Donath, M.Y.,  Fraenkel, M., Behar, V., Magnan, C.,  Ktorza, A.,  Cerasi, E. and Leibowitz, G. Psammomys obesus, a model for environment-gene interactions in type 2 diabetes. Invited perspective article Diabetes 54 Suppl 2:S137-144, 2005

·         Totary-Jain, H.,  Naveh-Many. T.,  Riahi, Y.,  Kaiser, N.,   Eckel, J. and Sasson, S. Calreticulin destabilizes glucose transporter-1 mRNA in vascular endothelial and smooth muscle cells under high glucose conditions. Circulation Research 97:1001-1008, 2005

·         Attali, V., Parnes, M., Ariav, Y., Cerasi, E., Kaiser, N. and Leibowitz, G. Regulation of insulin secretion and proinsulin biosynthesis by succinate. Endocrinology 147:5110-5118, 2006

·         Yagil, C., Barkalifa, R., Sapojnikov, M., Wechsler, A., Ben-Dor, D., Weksler-Zangen, S., Kaiser, N., Raz, I. and Yagil, Y. Metabolic and genomic dissection of diabetes in the Cohen rat. Physiol Genomics  29:181-192, 2007