Updated September 2007

Head Department of Human Genetics

Hadassah University Hospital, Jerusalem, Israel

Tel: 972-2-67 79197

Cell Phone: 050 4048765

Fax: 972-2- 67 77499

E-mail: judithme@hadassah.org.il

j.melki@genopole.inserm.fr

Personal Details

Birth date: January 20th 1957

Place of birth: Neuilly sur Seine (Hauts de Seine), France

Nationality: French and Israeli

Speciality: Geneticist

Higher Education In Medicine

1974, Bachelor of Science (Sciences and Mathematics), Paris

Date: Oct. 16 1974- Sept 30, 1982

Name of institution: Lariboisière Saint-Louis Medical School, Paris, University Paris 7

Medical Studies

Diploma: Medicine, M.D.

Date: may, 10th 1991

Name of institution: Lariboisière Saint-Louis Medical University, University of Paris 7

Title of Thesis: “Genetic mapping of childhood spinal muscular atrophy”

Name of supervisor: Pr Arnold Munnich, Genetic Medical Department,

Necker-Enfants Malades Hospital, Paris

Date: July 4, 1991: Medical Licence Registration at the Medical Council of Paris (n°55778)

Date: Sept. 11, 1997: Medical Licence Registration at the Medical Council of Bas Rhin (n°7429)

Date: July 4, 2001: Medical Licence Registration at the Medical Council of Essonne (n°11445)

Date: July 4, 2005: Board Certification as a Specialist in Medical Genetics.

French National Council of Medicine

Academic Experience in Medicine

Date: 1982-1986

Name of institution: Hospitals of Paris

Degree: Residency (Internship, Interne des Hôpitaux de Paris), rank: 76/270

Areas of Study: Pediatrics and Genetics

Date: 1988 to 1996

Name of institution: Department of Genetics, Necker - Enfants-Malades Hospital, Paris, France

Areas of Study: Genetics and Neuromuscular Diseases

Rank: Consultant (part time)

Head of Department: Pr. J. M. Saudubray and Pr J. Frezal

Date: 1996 to 1999

Name of institution: Department of Neurology, Hôpital Civil de Strasbourg, Strasbourg, France

Areas of Study: Neurogenetics

Rank: Consultant (part time)

Head of Department: Pr Jean Marie Warter

Date: 2000 to 2002

Name of institution: Department of Pediatrics, Sud Francilien Hospital, Evry, France

Areas of Study: Genetics

Rank: Consultant (part time)

Head of Department: Dr. Antoine Leblanc

Date: 2004-2007

Name of institution: Department of Genetics, Necker –Enfants Malades Hospital, Paris, France

Areas of Study: Genetics

Rank: Consultant (part time)

Head of Department: Pr. Arnold Munnich

Date: 2005-2007

Name of institution: Medicine Faculty, University of Paris 11, National Education

Rank: Professor of Medical Genetics, University Medical School, University of Paris 11 and Head of the Medical Genetics Unit, Department of Pediatrics, Sud Francilien Hospital, Evry (half time), France

Areas of Study: Medical Genetics

Higher Education In Science

Date: September 1986

Name of institution: University Pierre and Marie Curie (Paris 6)

Degree: DEA (Master degree)

Areas of Study: Study of Wobbler and paralysé mutant mice, Neuroscience

Supervisor: Pr. Michel Fardeau

Date: November 16, 1990

Name of institution: University Paris 6

Degree: Ph.D.

Areas of Study: Neurogenetics

Title: “Genetic mapping of childhood spinal muscular atrophy”

Supervisor: Pr Arnold Munnich

Date: 1994

Name of institution: University of René Descartes (Paris 5)

Degree: Qualification to manage research

Areas of Study: Neurogenetics

Academic Experience in Science

Date: 1991- 1994

Name of institution: National Institute of Health and Medical Research (Inserm)

Rank: Senior Researcher, 1^st class, Inserm

Areas of Study: Neurogenetics, identification of the gene responsible for spinal muscular atrophy

Host: Pr Arnold Munnich

Date: 1994- 1996

Name of institution: National Institute of Health and Medical Research (Inserm)

Rank: Research Director, 2^nd class, Inserm

Areas of Study: Neurogenetics, characterization of the gene responsible for spinal muscular atrophy

Host: Pr Arnold Munnich

Date: 1996-1999

Name of institution: Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC)

Rank: Research Director, 2^nd class, Inserm

Areas of Study: Neurogenetics, Generation of mouse models of neuromuscular disorders

Host: Pr Pierre Chambon

Date: 1999-2002

Name of institution: National Institute of Health and Medical Research (Inserm)

Rank: Research Director, 2^nd class, Inserm

Areas of Study: Towards a better understanding of pathophysiology and therapeutic research in motor neuron diseases

Position: Head of the Molecular Neurogenetics Laboratory, Inserm and Evry University, E-1993

Date: 2002-2005

Name of institution: National Institute of Health and Medical Research (Inserm)

Rank: Research Director, 1^st class (Inserm, 2002-2005) and Contract with the Assistance Publique- Hôpitaux de Paris (2004-2005)

Areas of Study: Towards a better understanding of pathophysiology and therapeutic research in motor neuron diseases

Position: Head of the Molecular Neurogenetics Laboratory, Inserm and Evry University, E-223

Date: 2005-2007

Name of institution: Medicine Faculty, University of Paris 11, National Education

Rank: Professor of Medical Genetics, University Medical School, University of Paris 11

Position: Head of the Molecular Neurogenetics Laboratory, INSERM, Evry University, U-798  Head of the Medical Genetics Unit, Sud Francilien Hospital, Evry

Areas of Study: Molecular Neurogenetics

Date: from September 1^st 2007

Name of institution: Hadassah University Hospital, Jerusalem, Israel

Position: Head of the Department of Human Genetics, Hadassah University Hospital

Areas of Study: Human Genetics

Other Activities

Membership in editorial boards of academic journals

§         1996-2002: Neuromuscular Disorders, Editor in Chief: Pr Victor Dubowitz

§         1997-present:  Journal of Human Genetic, Editor in Chief: Pr Yusuke Nakamura

Organization of conferences

• 18-20 January 2002, 103^rd European Neuromuscular Center International Workshop,  Designing rational therapy of SMA based on the understanding of its pathophysiology. Naarden, The Netherlands;  Organizing committee: Judith Melki and Gerta Vrbova

§         30–31 mai 2005. Gis-Institute of Rare Diseases: Research on rare diseases. Groupama Foundation, 75008 Paris, France.  Organizing committee: Alain Fischer, Pascale Borensztein and Judith Melki

• 24-29 September 2005. The molecular and cellular mechanism underlying skeletal muscle formation and repair. Embo/FEBS Workshop, 2005. Abbaye Royale de Fontevraud, France.
• Organizing committee: Margaret Buckingham, Judith Melki, Laurent Schaeffer

Other activities or public functions in the academic field

§         1998 to present - Member of the American Society of Human Genetics

§         2004 to present - Member of the American Society of Neuroscience

§         1999-2001  Member of the Scientific Committee of the National Center of Sequençing

§         1999 to 2002 - Member of the Scientific Committee of INSERM (Genetics and Development)

§         1999 to present - Member of the Scientific Committee of the Association Française contre les Myopathies

§         2001- 2004  Member of the Scientific Committee of Curie Institute

§         2004- 2007  Member of the Scientific Committee of the Ville de Paris

§         2002-2005  President of the Scientific Committee of GIS- Rare Diseases Institute

§         2005- 2007  Member of the Scientific Committee of Inserm

§         2006-2007  Member of the Parisian College of Genetics

Teaching

a) Supervisor of Master’s and doctoral degree students

a-1) Master’s degree student

1987-1988  Chrystèle Bilhou-Nabera, co-supervisor: Prof. Munnich, Resident, Master of Human Genetics, University of Paris 6, degree completed

1989-1990  Afif Hentati, M.D., Tunisia, co-supervisor: Prof. Munnich, Master of Human Genetics, University of Paris 6, degree completed, Publications: n° 14

1989-1991  Sonia Abdelhak, co-supervisor: Prof. Munnich, Master of Human Genetics, University of Paris 6, degree completed, Publications: n°8,11,12,13,17,65,66,67

1992-1993  Barbara Paul, Medical student, Munich, Germany, Publications: n°17,67

1993-1994  Sophie Reboullet, Master of Development, degree completed, Publications: n°23,28