Updated December 7th , 2008
Director, Center for Clinical Genetics
Department of Genetics and Metabolic Diseases
Hadassah University Hospital
Phones:
(Mobile) 972-50-7874163
(Office) 972-2-6776329
(Office) 972-2-6777618
E.mail: vmeiner@hadassah.org.il
Personal details
Date of birth: 8.3.1959
Country of birth: Israel
Nationality: Israeli
Family status: Married
Number of children:2
Higher education
1982 - Hebrew University-Hadassah Medical School Jerusalem Medical studies BSc. Graduated cum laude
1986 - Hebrew University-Hadassah Medical School Jerusalem, Medicine, M.D
1987-1991 Hebrew University-Hadassah Medical School Jerusalem, Internal Medicine B, Residency
1992-1994 Hebrew University-Hadassah Medical School Jerusalem Department of Human Genetics, Residency
1994-1997 University of California, San Francisco (UCSF), The Gladstone Institute of Cardiovascular Disease, Post doctoral fellowship. Host: Prof Robert Mahley; Robert V. Farese Jr
Appointments at the Hebrew University
1/10/1993 Lecturer in Human Genetics. Faculty of Medicine
28/10/2002 Senior lecturer in Human Genetics. Faculty of Medicine
2008 - Associate Professor in Human Genetics. Faculty of Medicine
Additional Functions/Tasks at the Hebrew University
1998 - Chairman of the Gertrud Kohn Fund for Excellence in Human Genetics
2000 - Member of the Admission committees for Genetic Counseling Education Programs in the Hebrew University and Hadassah School of Medicine
2002 – 2005 Member of the Admission committees for medical students in the Hebrew University and Hadassah School of Medicine
Service in other Academic and Research Institutions
2000 – Sackler Faculty of Medicine School of Continuing Medical Education, Lecturer
2005 – 'Bashaar' - Academic Community for Israeli Society, The Science Club, Lecturer
2008 – The Jerusalem Center for Ethics, Lecturer
2008 – The National Council for Pediatrics & Child Health, Consultant
Other activities
Prizes and Awards
1992 – Gabriel Isaac Prize, the Hebrew University and Hadassah School of Medicine: A Common Lithuanian Mutation Causing Familial Hypercholesterolemia in Ashkenazi Jews
1994 – Gertrud Kohn Prize for Excellence in Human Genetics Research, the Hebrew University and Hadassah School of Medicine: Genetic Characteristics of CTX in Israel
1998 – Spencer Award for Research, Hadassah University Hospital: Characterization of ACAT-deficient macrophages: Investigations into processes related to atherosclerosis
2001 – Excellent teaching award
2003 – Excellent teaching award
2007 – Excellent teaching award
2008 – Faculty Prize for Best Teacher of the year in Pre-Clinical Teaching, the Hebrew University and Hadassah School of Medicine
List of Publications
Chapters in Collections
1. Meiner V, Leitersdorf E: Cerebrotendinous xanthomatosis. In: Handbook of Ataxia Disorders, T. Klockgether, Ed. (Marcel Dekker, New York), 2000.
Articles
a) Articles in refereed journals
1. Shalev, O., Meiner-Lavie, V., Hebbel, R.P., Eaton, J. (1985). Erythrocyte (Ca+ Mg+)-ATPase activity: increased sensitivity to oxidative stress in glucose 6-phosphate dehydrogenase deficiency. Am J Hematol 19:131-6.
2. Meiner, V., Landsberger, D., Berkman, N., Reshef, A., Segal, P., Seftel, H.C., van der Westhuyzen, D.R., Jeenah, M.S., Coetzee, G.A., Leitersdorf, E. (1991). A common Lithuanian mutation causing familial hypercholesterolemia in Ashkenazi Jews. Am J Hum Genet 49:443-9.
3. Landsberger, D., Meiner, V., Reshef, A., Levy, Y., van der Westhuyzen, D.R., Coetzee, G.A., Leitersdorf, E (1992). A nonsense mutation in the LDL receptor gene leads to familial hypercholesterolemia in the Druze sect. Am J Hum Genet 50:427-33.
4. Reshef, A., Meiner, V., Dann, E.J., Granat, M., Leitersdorf, E. (1992). Prenatal diagnosis of familial hypercholesterolemia caused by the "Lebanese" mutation at the low density lipoprotein receptor locus. Hum Genet 89:237-9.
5. Leitersdorf, E., Eisenberg, S., Eliav, O., Friedlander, Y., Berkman, N., Dann, E.J., Landsberger, D., Sehayek, E., Meiner, V., Wurm, M., Bard, J-M., Fruchart, J-C., Stein, Y. (1993).Genetic determinants of responsiveness to the HMG-CoA-reductase inhibitor Fluvastatin (XU 62-320), in patients with molecularly defined heterozygous familial hypercholesterolemia. Circulation 87[suppl III]:35-44.
6. Leitersdorf, E., Reshef, A., Meiner, V., Dann, E.J., Beigel, Y., van Roggen, F.G., van der Westhuyzen, D.R., Coetzee, G.A. (1993). A missense mutation in the low density lipoprotein receptor gene causes familial hypercholesterolemia in Sephardic Jews. Human Genet. 91:141-7.
7. Leitersdorf, E., Reshef, A., Meiner, V., Levitzki, R., Pressman-Schwartz, S., Dann, E.J., Berkman, N., Cali, J.J., Klapholz, L., Berginer, V.M. (1993). Frameshift and splice-junction mutations in the sterol 27-hydroxylase gene cause cerebrotendinous xanthomatosis in Jews of Moroccan origin. J Clin Invest. 91:2488-96.
8. Leitersdorf, E., Eisenberg, S., Eliav, O., Berkman, N., Dann, E.J., Landsberger, D., Sehayek, E., Meiner, V., Peters, T.K., Bard, J-M., Fruchart J-C., Stein, Y. (1993). Efficacy and safety of high Dose Fluvastatin in patients with familial hypercholesterolemia. Europ J Clin Pharmacol. 45:513-8.
9. Meiner, V., Meiner, Z., Reshef, A., Björkhem, I., Leitersdorf, E. (1994). Cerebrotendinous xanthomatosis: molecular diagnosis enables pre-symptomatic detection of a treatable disease. Neurology 44:288-90.
10. Reshef, A., Meiner, V., Berginer, V.M., Leitersdorf, E. (1994). Molecular genetics of cerebrotendinous xanthomatosis in Jews of North African origin. J Lipid Res. 35:478-83.
11. Meiner, V., Marais, D.A., Reshef, A., Björkhem, I., Leitersdorf, E. (1994). Premature termination codon at the Sterol 27-hydroxylase gene causes Cerebrotendinous Xanthomatosis in an Afrikaner case. Hum Mol Genet. 3:193-4.
12. Leitersdorf, E., Muratti, E.N., Eliav, O., Meiner, V., Eisenberg, S., Dann, E.J., Sehayek, E., Peters, T.K., Stein, Y. (1994). Efficacy and safety of a combination fluvastatin-bezafibrate treatment for familial hypercholesterolemia: Comparative analysis to a fluvastatin-cholestyramine combination. Am J Med. 96:401-7.
13. Lerer, I., Meiner, V., Pashut-Lavon, I., Abeliovich, D. (1994). Molecular diagnosis of Prader-Willi syndrome: parent-of-origin dependent methylation sites and non-isotopic detection of (CA)n dinucleotide repeat polymorphisms. Am J Med Genet. 52:79-84.
14. Leitersdorf, E., Safadi, R., Meiner, V., Reshef, A., Bjorkhem, I., Friedlander, Y., Morkos, S., Berginer, V.M. (1994). Cerebrotendinous xanthomatosis in the Israeli Druze: molecular genetics and phenotypic characteristics. Am J Hum Genet 55:907-15.
15. Abeliovich, D., Dagan, J., Werner, M., Lerer, I., Shapira, Y., Meiner, V. (1995). Simultaneous formation of inv dup (15) and dup (15q) in a girl with developmental delay: origin of the abnormal chromosomes. Eur J Hum Genet. 3:49-55.
16. Gross, D.J., Avishai, N., Meiner, V., Filon, D., Zbar, B., Abeliovich, D. (1996). Familial pheochromocytoma associated with a novel mutation in the von Hippel-Lindau gene. J Clin Endocr Metab. 81:147-9.
17. Bar David, S., Lerer, I., Sarfaty, C.K., Kohan Z.G., Meiner, V., Zlotogora, J. (1996). Localization of two x linked mental retardation (XLMR) genes to XP MRX37 gene at Xp22.31 p22.32 and a putative MRX gene on Xp22.11 p22.2. Am J Med Genet 4:83-8.
18. Meiner, V., Cases, S., Myers, H.M., Sande, E.R., Bellosta, S., Schambelan, M., Pitas, R.E., McGuire, J., Herz, J., Farese, R.V. Jr (1996). Disruption of the acyl CoA cholesterol acyl transferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals. P Natl Acad Sci USA. 93:14041-6.
19. Meiner, V., Tam, C., Gunn, M.D., Dong, L.M., Weisgraber, K.H., Novak, S., Myers, H.M., Erickson, S.K., Farese, R.V. Jr (1997). Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice. J Lipid Res 38:1928-33.
20. Meiner, V., Welch, C.L., Cases, S., Myers, H.M., Sande, E., Lusis, A.J., Farese, R.V. Jr (1998). Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation. J Biol Chem 273:1064-9 .
21. Khelef,N., Buton, X., Beatini, N., Wang, H., Meiner, V., Chang, T.Y., Farese, R.V. Jr, Maxfield, F.R., Tabas, I. (1998). Immunolocalization of acyl-coenzyme A:cholesterol O-acyltransferase in macrophages. J Biol Chem 273:11218-24.
22. Lossos, A., Meiner, Z., Barash, V., Soffer, D., Schlesinger, I., Abramsky, O., Argov, Z., Shpitzen, S., Meiner, V. (1998). Adult polyglucosan body disease in Ashkenazi Jewish patients carrying the tyr329ser mutation in the glycogen branching enzyme gene. Ann Neurol 44:867-72.
23. Reshef, A., Brauner, P., Shpitzen, M., Gallili, E., Marbach, A., Motro, U., Shmueli, E., Meiner, V. (1999). Chorion villus sampling prior to pregnancy termination, as a tool for forensic paternity testing. J Forensic Sci 44:1065-8.
24. Durst, R., Colombo, R., Shpitzen, S., Ben Avi, L., Friedlander, Y., Wexler, R., Raal, F.J., Marais, D.A., Defesche, J.C., Mandelshtam, M.Y., Kotze, M.J., Leitersdorf, E., Meiner, V (2001). Recent origin and spread of a common Lithuanian mutation, G197del LDLR, causing familial hypercholesterolemia: positive selection is not always necessary to account for disease incidence among Ashkenazi Jews. Am J Hum Genet 68:1172-88.
25. Sagi, M., Meiner, V., Reshef, N., Dagan, J., Zlotogora, J. (2001). Prenatal diagnosis of sex chromosome aneuploidy: possible reasons for high rates of pregnancy termination. Prenat Diagn 21:461-5.
26. Meiner, V., Shpitzen, S., Mandel, H., Klar, A., Ben-Neriah, Z., Zlotogora, J., Sagi, M., Lossos, A., Bargal, R., Sury, V., Carmi, R., Leitersdorf, E., Zeigler, M. (2001). Clinical-biochemical correlation in molecularly characterized patients with Niemann-Pick type C. Genet Med 3:343-8.
27. Meir, K., Kitsberg, D., Alkalay, I., Szafer F., Rosen, H., Shpitzen, S., Ben Avi, L., Staels, B., Fievet, C., Meiner, V., Bjorkhem, I., Leitersdorf, E. (2002). Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis. J Biol Chem 277:34036-41.
28. Zamir, A., Shpitzen, M., Oz, C., Motro, U., Meiner, V., Gafny, R. (2002). Presentation of a three-banded allele pattern--analysis and interpretation. J Forensic Sci 47:824-6.
29. Dobson-Stone, C., Danek, A., Rampoldi, L., Hardie, R.J., Chalmers, R.M., Wood, N.W., Bohlega, S., Dotti, M.T., Federico, A., Shizuka, M., Tanaka, M., Watanabe, M., Ikeda, Y., Brin, M., Goldfarb, L.G., Karp, B.I., Mohiddin, S., Fananapazir, L., Storch, A., Fryer, A.E., Maddison, P., Sibon, I., Trevisol-Bittencourt, P., Singer, C., Caballero, I.R., Aasly, J.O., Schmierer, K., Dengler, R., Hiersemenzel, L.P., Zeviani, M., Meiner, V.,/…. 2002). Mutational spectrum of the CHAC gene in patients with chorea-acanthocytosis Eur J Hum Genet 10:773-81.
30. Alcalai, R., Metzger, S., Rosenheck, S., Meiner, V., Chajek-Shaul, T. (2003). A recessive mutation in desmoplakin causes arrhythmogenic right ventricular dysplasia, skin disorder, and woolly hair. J Am Coll Cardiol. 42:319-27.
31. Ben-Avi, L., Durst, R., Shpitzen, S., Leitersdorf, E., Meiner, V. (2004). Apo E genotyping: accurate, simple, high throughput method using ABI Prism® SNaPshot™ Multiplex System. J Alzheimers Dis 6:497-501
32. Lossos, A., Dobson-Stone, C., Monaco, A.P., Soffer, D., Rahamim, E., Newman, J.P., Mohiddin, A., Fananpazir, L., Lerer, I., Linetski, E., Reches, A., Argov, Z., Abramsky, O., Gadoth, N., Sadeh, M., Gomori, J.M., Boher, M., Meiner, V. (2005) Early clinical heterogeneity in Chorea-Acanthocytosis. Arch of Neurol. 2:611-4
33. Bercovich, D., Friedlander, Y., Korem, S., Houminer, A., Hoffman, A., Kleinberg, L., Shochat, C., Leitersdorf, E., Meiner, V. (2006) The association of common SNPs and haplotypes in the CETP and MDR1 genes with lipids response to fluvastatin in familial hypercholesterolemia. Atherosclerosis 185:97-107
34. Meiner, V., Weinberg, N., Safran, A., Lerer, I., Sagi, M., Rosenmann, H., Aizenman, E., Abeliovich, D., Laufer, N., Simon, A. (2006). Pre-implantation exclusion of embryos at risk for prion diseases. Neurology 66:607-8.
35. Lerer, I., Sagi, M., Meiner, V., Cohen, T., Zlotogora, J., Abeliovich, D. (2005). Deletion of the ANKRD15 gene at 9p24.3 causes parent-of-origin-dependent inheritance of familial cerebral palsy. Hum Mol Genet. 14:3911-20
36. Siman-Tov T., Meiner, V., Gadoth, N. (2006). Could steroids mask the diagnosis of cerebrotendinous xanthomatosis? J Neurol Sci. 15;243(1-2):83-6
37. Lossos, A., Stevanin, G., Meiner, V., Argov, Z., Bouslam, N., Newman, J.P., Gomori, J.M., Klebe, S., Lerer, I., Elleuch, N., Silverstein, S., Durr, A., Abramsky, O., Ben Neriah, Z., Brice, A. (2006) Hereditary spastic paraplegia with thin corpus callosum: reduction of the SPG11 interval and evidence for further genetic heterogeneity. Arch of Neurol 63:756-60
38. Durst, R., Jansen, A., Erez, G., Bravdo, R., Butbul, E., Ben Avi, L., Shpitzen, S., Lotan, C., Leitersdorf, E., Defesche, J., Friedlander, Y., Meiner, V., Miserez, A.R. (2006) The discrete and combined effect of SREBP-2 and SCAP isoforms in the control of plasma lipids among familial hypercholesterolaemia patients. Atherosclerosis 189:443-50
39. Macarov, M., Zeigler, M., Newman, J.P., Strich, D., Sury, V., Tennenbaum, A., Meiner, V. (2007) Deletions of VCX-A and NLGN4: a variable phenotype including normal intellect. Journal of Intellectual Disability Research. 51:329-33
40. Korman, S.H., Pitt, J., Boneh, A., Dweikat, I., Zater, M., Meiner, V., Gutman, A., Brivet, M. (2006) A novel SLC25A20 splicing mutation in patients of different ethnic origin with neonatally-lethal carnitine-acylcarnitine translocase (CACT) deficiency. Mol Genet Metab 89:332-8
41. Friedlander, Y., Schwartz, S.M., Durst, R. , Meiner, V., Robertson, A.S., Leitersdorf, E., Siscovick, D.S. (2007) SREBP-2 and SCAP isoforms and risk of early onset myocardial infarction. Atherosclerosis Mar 23; [Epub ahead of print]
42. Szalat, A., Gershkovich, P., Ben-Ari, A., Shaish, A., Liberman, Y., Boutboul, E., Gotkine, M., Hoffman, A., Harats, D., Leitersdorf, E., Meiner, V. Rifampicin-induced CYP3A4 activation in CTX patients cannot replace chenodeoxycholic acid treatment. BBA - Molecular and Cell Biology of Lipids. 1771:839-44
43. Baala, L., Audollent, S., Martinovic, J., Ozilou, C., Babron, M.C., Sivanandamoorthy, S., Saunier, S., Salomon, R., Gonzales, M., Rattenberry, E., Esculpavit, C., Toutain, A., Moraine, C., Parent, P., Marcorelles, P., Dauge, M.C., Roume, J., Le Merrer, M., Meiner, V.,/…/ (2007) Pleiotropic effects of CEP290 (NPHP6) mutations extend to Meckel-Gruber syndrome. Am J Hum Genet 81:170-9
44. Elleuch, N., Bouslam, N., Hanein, S., Lossos, A., Hamri, A., Klebe, S., Meiner, V., Birouk, N., Lerer, I., Grid, D., Bacq, D., Tazir, M., Zelenika, D., Argov, Z., Durr, A., Yahyaoui, M., Benomar, A., Brice, A., Stevanin, G.(2007) Refinement of the SPG15 candidate interval and phenotypic heterogeneity in three large Arab families. Neurogenetics. 8:307-315.
45. Stevanin G, Azzedine H, Denora P, Boukhris A, Tazir M, Lossos A, Rosa AL, Lerer I, Hamri A, Allegria P, Loureiro J, Tada M, Hannequin D, Anheim, Goizet C, Gonzales V, Erichsen AK, Le Ber I, Forlani S, Iwabuchi K, Meiner V, .,/…/ (2007) Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration. Brain. 2007 Dec 13; [Epub ahead of print].
46. Meiner V, Friedlander Y, Milo H, Sharon N, Leitersdorf E, Siscovick DS, Schwartz SM. (2008) Cholestryl Ester transfer Protein (CETP) Genetic Variation and Early Onset of Non-Fatal Myocardial Infarction. The Annals of Human Genetics 2008 Nov;72(Pt 6):732-41.
b) Case Reports
1. Oren, R., Shcnur, L.F., Ben-Yehuda, D., Meiner, V., Okon, E., Rachmilewitz, E.A (1991) Visceral leishmaniasis: A rare aspect of an old disease. J inf Dis 164:746-9
2. Lossos, A., Cohen, O., Meiner, V., Blumenfeld, A., Reches, A (1997) Intrafamilial heterogeneity of movement disorders: report of three cases in one family. J Neurol 244:426-30.
3. Ben Dov, I.S, Meiner, V.C, Eid, A.PI (2001) Kidney transplantation unraveling Wolfram syndrome Transplantation 72:958-60
Letters
1. Ackerman, Z., Lysy, J., Meiner, V. (1989) The association of fecal impaction and verapamil in a patient with scleroderma. Am J Gastroenterol 84:981-2.
Reviews, commentaries, hypotheses, editorials
1. Maayan, S., Meiner, V., Englehard, D (1991) Tb and AIDS. Isr J Med Sci 27:576-7
2. Leitersdorf, E. and Meiner V (1994) Cerebrotendinous xanthomatosis. Current Opinions in Lipidology 5:138-42
3. Arber, N., Pras, E., Copperman, Y., Schapiro, J.M., Meiner, V., Lossos, I.S., Militianu, A., Hassin, D., Pras, E., Shai, A., Moshkowitz, M., Sidi,Y. (1994) Pacemaker endocarditis. Report of 44 cases and review of the literature Medicine 73:299-305
e) Articles in foreign languages
1. Meiner, V. and Leitersdorf, E (1992) Lipoprotein (a) - A risk factor for atherosclerosis. Harefuah 123:115-8 (In Hebrew)
2. Meiner, V (1998) Genetic defects in cardiomyopathies and their clinical significance. Cardiology Update 18:20-26 1998 (In Hebrew)
f) Articles in Israeli Journals
1. Cahn, A., Meiner, V., Leitersdorf, E., Berkman, N. (2004). Identification of a novel mutation in the gene for bone morphogenetic protein receptor II in an Israeli patient with familial primary pulmonary hypertension. Isr Med Assoc J. 6:156-9.
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