Department of Oral and
Maxillofacial Surgery
Hebrew University Hadassah
School of Dental Medicine
Place and date of birth: Levov, Poland, 30.6.41
Nationality: Israeli
Business address: Department of Oral & Maxillofacial Surgery, Hadassah School of Dental Medicine, Jerusalem, Israel
Home address: 8, Giladi St. Jerusalem
1950 - Immigrated to Israel.
1959 - Graduated High School in Haifa.
1959 - 1962 Served in the Israeli Defense Forces.
1962 - 1968 Attended the Hebrew University, Hadassah School of Dental Medicine, Jerusalem
1968 - Graduated D.M.D. degree with distinction.
Feb 1969 Started residency in the Dept. of Oral & Maxillofacial Surgery, Hadassah School of Dental Medicine, Jerusalem.
Dec 1972 Resident in Anesthesiology Dept., Hadassah Medical Center, Jerusalem.
Jun-Sep 1973 Resident in Plastic Surgery Dept., Hadassah Medical Center, Jerusalem.
Feb-May 1974 Resident in General Surgery Dept., Hadassah Medical Center, Jerusalem.
June 1974 Completed residency. Appointed full-time specialist at the Dept. of Oral & Maxillofacial Surgery, Hadassah School of Dental Medicine, Jerusalem.
1978 - 1979 On Sabbatical leave with the Dept. of Oral & Maxillofacial Surgery, University of the Witwatersrand, Johannesburg, South-Africa.
1983 - Two months Sabbatical leave in the Dept. of Oral Pathology, University of the Witwatersrand, Johannesburg, South-Africa.
1984 - Three months Sabbatical leave in the Laboratory of Oral Biology and Physiology, National Institute of Dental Research, NIH, Bethesda, Maryland, U.S.A.
1988 - Two months Sabbatical leave at the Nippon Dental University, Tokyo, Japan.
Academic Appointments at The Hebrew University
1973 - Instructor in Oral & Maxillofacial Surgery.
1975 - Lecturer in Oral & Maxillofacial Surgery.
1978 - Senior Lecturer in Oral & Maxillofacial Surgery.
1992 - Associate Professor in Oral & Maxillofacial Surgery.
Activities and Committees in the Faculty
· Committee for evaluation of instrument armamentarium in the Dental Faculty.
· Curriculum Committee of the Dental Faculty.
· Program Committee of the Dental Faculty.
· Chairman of Committee for equipment acquisition and its usage organization.
· Chairman of Space Committee of the Dental Faculty.
· Chairman of the Committee for clinical teaching aids and working methods.
Professional Activities Outside the Faculty
1971-1977 Reviewer of the Israel Journal of Dental Medicine
1976-1978 Member of the Ethics Committee of the Israel Dental Association.
1976-1978 Committee for Odontological nomenclature, the Academy of the Hebrew language.
1976-1978 Secretary and treasurer of the Israel Association of Oral & Maxillofacial Surgery.
1988 - Scientific Committee, 14th World Congress of the Israel Medical Association, Jerusalem, Israel.
1989 - Organizing Committee, 10th International Conference on Oral and Maxillofacial Surgery, Jerusalem, Israel.
1990 - Organizing Committee, 2nd World ISLD Congress, Paris, France.
1991 - Organizing Committee, 1st Mediterranean Congress of Oral and Maxillofacial Surgery, Athens, Greece.
1992-1993 Scientific committee,3rd Jerusalem International Dental Conference.
1993 - Organizing committee, 2nd Mediterranean Congress of Oral and Maxillofacial Surgery, Corfu, Greece.
1993 - Scientific committee, 1993 Congress of the Israel Dental Association.
Membership in Associations
· Alpha Omega Fraternity
· Israel Dental Association
· Israel Association for Dental Research
· International Association for Dental Research (IADR)
· Israel Association of Oral & Maxillofacial Surgery
· Israel Society for Electron Microscopy
· International Association of Oral & Maxillofacial Surgery
· Israel Society for Laser Surgery and Medicine.
Research Grants
1. Ultraviolet 193 nm excimer laser ablation of bone. The authority for research and development, 1990, 1991, $ 1000. (038-5123)
2. Tumors in children. The authority for research and development, 1990, 1991, $ 1000. (038-5118)
3. Histometrical study of initial experimental gingivitis associated with deciduous teeth. The authority for research and development, 1991-1992, $ 1250. (035-5020)
4. The impact of ultraviolet 193 nm (ArF) and 248 nm (KrF) excimer laser ablation on bone. From the Chief Scientist of the Israeli Ministry of Health 1991-1992. NIS 8000. (1933-0)
5. The impact of ArF excimer laser irradiation (193nm) on the pulp of teeth-an in-vivo study. The authority for research and development 1993-4, $ 4000
DMD Theses Under My Supervision
1. Sialolithiasis:1-Symptomatology, Roentgenological Features and Therapeutic approach. 2 - What is its relation to Hyperparathyroidism? - Y. Melamed. Instructors: J. Lustmann., Z. Gimom.
2. Trauma to primary teeth. - N. Guzner. Instructor: J. Lustmann , 1978.
3. The inflamatory effect of the E.D.T.A. on the parotid glauds of the rats. E. Abramov. Instructors: J. Lustmann, A. Soskolne.
4. The correlation between pain sensitivity and blood pressure in man. E. Shover. Instructors: J. Lustmann, N. Zamir - 1980.
5. Apicoectomy (Apical root surgery) in premolars and molars - The influence of various factors on the results of apicoectomies in posterior teeth. - V. Shaharabany. Instructors: J. Lustmann, S. Friedmann - 1988.
6. Lining, amalgam margin angle, marginal breakdown and failure of restoration; A study on extracted permanent teeth with amalgam fillings. - Y. Kadar. Instructors: R. Grajover, J. Lustmann. 1989.
7. Tumors in children - N. Belkin. Instructors: J. Lustmann, M. Ulmansky - 1990.
8. Sialolithiasis - Nephrolithiasis: possible correlation between these two phenomena in the Israeli population suffering from nephrolithiasis. Y. Nesher . Instructor: J. Lustmann. 1990.
9. Maxillofacial fractures: Clinical and epidemiologic aspects. An 8-years' retrospective study. - A. Sadan. Instructors: J. Lustmann,S. Constantini,R. Zeltser - 1991.
10. The influence of surgical extraction of impacted supernumerary teeth in the premaxilla, at different age groups, on the development of the adjacent permanent teeth in children. - E. Sharon. Instructors:G. Holen, J. Lustmann , 2000.
List of Publications (since 1990)
38. Bimstein,E., Lustmann, J., Sela, MN., Ben-Neriah, N., Soskolne, A.W.: Periodontitis associated with Papillon Lefevre syndrome. J. Periodontol. 61:373-377, 1990.
39. Lustmann,J., Regev, E., Melamed, Y.: Sialolithiasis: A survey on 245 patients and a review of the literature. Int. J. Oral Maxillofac. Surg. 19:135-138, 1990.
40. Schwartz-Arad,D., Lustmann, J., Ulmansky, M.: Squamous odontogenic tumor. Review of the literature and case report. Int. J. Oral Maxillofac. Surg. 19:327-330, 1990.
41. Lustmann, J., Ulmansky, M.: Paraganglioma of the tongue. J. Oral Maxillofac. Surg. 48:1317-1319, 1990.
42. Friedman,S., Lustmann, J., Shaharabany, V.: Treatment results of apical surgery in premolar and molar teeth. J. Endodont. 17:30-33, 1991.
43. Lustmann,J., Ben-Yehuda, D., Somer, M., Ulmansky, M.: Gaucher's disease affecting the mandible and maxilla. Report of a case. Int. J. Oral Maxillofac. Surg. 20:7-8, 1991.
44. Lustmann,J., Friedman, S., Shaharabany, V.: Relation of pre- and intra-operative factors to prognosis of posterior apical surgery. J. Endodont. 17: 239-241, 1991.
45. Lustmann, J., Ulmansky, M., Fuxbrunner, A. Lewis, A.: 193 nm excimer laser ablation of bone.Lasers Surg. Med. 11:51-57, 1991.
46. Regev, E., Zeltser, R., Lustmann, J.: Lip carcinoma in renal allograft recipient with long-term immunosuppressive therapy. Oral Surg. 73:412-414, 1992.
47. Lustmann,J., Ulmansky,M., Fuxbrunner, A. Lewis, A.: Photoacoustic injury and bone healing following 193 nm excimer laser ablation. Lasers Surg Med 12:390-396, 1992.
48. Moncarz,V., Ulmansky,M., Lustmann, J.: Lichen Planus. Exploring its malignant potential. JADA 124: 102-108, 1993.
49. Markitziu, A., Lustmann, J., Uzieli, B., Krauz, Y., Chisin, R.: Salivary and lacrimal gland involvement in a thyroidectomized radioiodine treated thyroid cancer patient. Oral Surg 75:318-322, 1993.
50. Lustmann, J., Nahlieli, O., Harary, D., Casap, N., Neder, A., Slotogora, J.: Gerodermia Osteodysplastica. Report on two patients and surgical correction of facial deformity. Am J Med Genetics 47:261-267, 1993.
51. Hasson, O., Kirsch, G. Lustmann, J.: Hemangiopericytoma of the tongue in an 11-year-old girl. Pediat Dent.16:49-52, 1994.
52. Lustmann, J., Segal, N., Markitziu, A.: Salivary gland involvement in Wegener's Granulomatosis: A case report and review of the literature. Oral Surg 77:254-259, 1994.
53. Lustmann, J., Milhem, I.: Mandibular fractures in infants: Review of the literature and report of 7 cases. J Oral Maxillofac Surg 52:240-245, 1994.
54. Bimstein, E., Matsson, L., Soskolne, A.W., Lustmann, J.: Histologic characteristics of the gingiva associated with the primary and permanent teeth of children. Pediatr dent 16:206-210, 1994.
55. Ulmansky, M., Bodner, L., Lustmann, J.: Ameloblatic fibrodentinoma: Report on two new cases. J Oral Maxillofac Surg 52:980-984, 1994.
56. Lustmann, J., Lewinstein, I.: Interpositional bone grafting technique to widen narrow maxillary ridge. Int J Oral Maxillofac Implantol 10:568-577, 1995.
57. Shapira, J., Peylan-Ramu, N., Lustmann, J.: Retrospective epidemiological study of Burkitt's lymphoma in Israel and diagnosis by a conservative incisional biopsy.Oral Oncology, Eur J Cancer, 31B:319-322,1995
58. Becker, A., Lustmann, J., Shteyer, A.: Cleidocranial Dysplasia. Part I: General principles of the orthodontic and surgical treatment modality. Am J Orthod Dentofac Orthop 111:28-33, 1997.
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59. Becker, A., Shteyer, A., Bimstein, E., Lustmann, J.: Cleidocranial Dysplasia, Part II: Treatment protocol for the orthodontic and surgical modality. Am J Orthod Dentofac Orthop 111: 173-183, 1997.
60. Deutsch, D., Fermon, E., Lustmann, J., Dafni, L., Mao, Z., Leytin, V. and Palmon, A.: Tuftelin mRNA is Expressed in a human Ameloblastoma Tumer. Counect. Tiss. Res. 39 (1-3) 177-184[481-488], 1998.
61. Ulmansky, M., Lustmann, J. and Balkin, N.: Tumors and Tumor-like lesions of the Oral Cavity and related structures in Israeli children. Int. J. Oral Maxillofac. Surg. 28: 291-294, 1999.
62. Heling, I., Lustmann, J., Hover, R. and Bichacho, N. Complications of apexification resulting from poor patient compliance: Report of case. J Dent. Child. 66: 415-418, 1999.
63. Heling, I. Slutzky-Goldberg, I. Lustmann, J. Ehrlich, Y. and Becker, A.: Bone-like tissue growth in the root canal of immature permanent teeth after traumatic injuries. Endod Dent Traumatol 16: 298-303, 2002.
64. Bimstein, E., Soskolne, A. and Lustmann, J.: Histolomorphologic changes in the gingiva and pulp of over retaind primary teeth. J. Dent child 67: 403-407, 2002.
65. Aframian, DJ., Lustmann, J., Fisher, D. and Markitziu, A.: An unusual cause of obstructive sialadenitis. Dentomaxillofac. Radiol 30:226-229, 2001.
66. Mao, Z., Shay, B., Hekmati, M., Fermon, E., Taylor, A., Dafni, L., Heikinheimo, K., Lustmann, J.,Fisher, L.W., Young, M.F., Deutsch, D.: The human tufteline gene: cloning and characterization. Gene 279: 181 – 196, 2001.
Proceedings
p-1. Lustmann, J., Klein, H., Ulmansky, M.: Odontodysplasia. 5th Congress of the International Association of Dentistry for Children. July 1975, Proc. pp. D 3-6.
P-2. Lustmann,J., Azaz, B., Lewin-Epstein, J.: The use of CO2 laser in oral and maxillofacial surgery: Lasers In Dentistry, Excerpta Medica, Amsterdam pp. 175-180, 1989.
P-3. Azaz,B., Zeltser, R., Lustmann, J.: Sialolithotomies with CO2 Laser. Lasers In Dentistry, Excerpta Medica, Amsterdam pp. 221-226, 1989.
Chapter in Book
Becker, A. Shteyer, A. and Lustmann, J. Chapter 3-Surgical exposure of impacted teeth. in Becker, A. The orthodontic treatment of Impacted teeth. London: Martin Dunitz publishers, 1998, pp 25-41.
Abstracts
A-1 Lustmann, J., Ulmansky, M., Shteyer, A.: Enamel anomalies - a scanning electron microscopic study. Scientific Congress of the I.D.A., March 1975, Proc. pp. 6-7.
A-2 Lewin-Epstein, J. Lustmann, J., Shteyer, A., Azaz, B.: Salivary and dental calculi - a scanning electron microscopic study. Scientific Congress of I.D.A., March 1975, pp. 5-6.
A-3 Soskolne, W.A., Lustmann, J. Lewin-Epstein, J.: Central giant cell granuloma - Fibro osseous lesions. Are they the same disease entity? XII Congress of the International Academy of Pathology, September, 1978.
A-4 Lustmann,J., Shteyer, A.: Ultrastructural study of salivary calculi. J. Dent. Res. 57: (special issue) 172, 1978.
A-5 Guzner,N. Lustmann, J. Shteyer, A.: Trauma to primary teeth. J. Dent. Res. 57: (special issue) 192, 1978.
A-6 Lustmann, J., Markitziu, A.: The response of irradiated jaw bones to surgical treatment: The Fifth Congress of Nuclear Medicine in Israel. 4:28-29, 1980.
A-7 Lustmann, J.: Radicular cysts arising from primary teeth. Israel Dental Association, Scientific meeting, 1982.
A-8 Ben-Bassat,Y., Lustmann,J., Zilberman, Y., Fuks, A., Brin, I.: Developmentaldisturbances of the roots of permanent incisors following trauma to their predecessors. J. Dent. Res. 65:576, 1986.
A-9 Lustmann, J., Zeltser, R.: Advantages of the CO2 laser in surgical excision of oral hemangioma and lymphangioma. International Congress of Laser in Dentistry. Tokyo 1988, p.45.
A-10 Lustmann, J. Lewin-Epstein, J.: The use of CO2 laser in oral and maxillofacial surgery. International Congress of Laser in Dentistry, Tokyo 1988, p. 39.
A-11 Azaz, B., Lustmann, J.: Removal of salivary calculi with CO2 laser. International Congress of Laser in Dentistry, Tokyo, 1988, p.48.
A-12 Lustmann, J.: The CO2 laser in oral and maxillofacial surgery. Advantages and Disadvantages. 2nd World Dental Conference, Jerusalem 1988, p. 68.
A-13 Lustmann, J. Lewin-Epstein, J.: Applications of Co2 laser in oral and maxillofacial surgery. 14th World Congress of the Israel Medical Association, Jerusalem 1988, p. 6.
A-14 Zeltser,R., Lustmann, J., Shteyer, A.: Unicystic ameloblastoma - conservative approach for treatment by marsupialization. Tenth International Conference on Oral and Maxillofacial Surgery, Jerusalem 1989, p.14.
A-15 Regev, E., Lustmann, J.: Sialolithiasis: Survey of 245 cases. Tenth International Conference on Oral and Maxillofacial Surgery, Jerusalem 1989, p. 41.
A-16 Lustmann, J., Ulmansky, M., Fuxbrunner, A. Lewis, A.: Quantitative excimer laser surgery of bone. 1st Mediterranean Congress of Oral & Maxillofacial Surgery, Athens, Greece, June 1991.
A-17 Lustmann, J., Ulmansky, M., Fuxbrunner, A. Lewis, A.: Bone healing following excimer laser surgery. 1st Mediterranean Congress of Oral & Maxillofacial Surgery, Athens, Greece, June, 1991.
A-18 Casap,N., Engelhard, D., Sela, M., Lustmann, J.: A microbiological and clinical retrospective study of the acute dento-alveolar abscesses. 1st Mediterranean Congress of Oral & Maxillofacial Surgery, Athens, Greece, June 1991.
A-19 Moncarz,V., Lustmann, J., Ulmansky, M.: Lichen Planus and its malignant potential. 1st Mediterranean Congress of Oral & Maxillofacial Surgery. Athens, Greece, June 1991.
A-20 Lustmann, J., Ulmansky, M., Fuxbrunner, A. Lewis, A.: Quantitative l93 nm excimer laser ablation of bone. International Congress on Lasers and Optics in Medicine. Budapest, Hungary, June 1991, p. 30.
A-21 Lustmann, J., Ulmansky, M., Fuxbrunner, A. Lewis, A.: Photoacoustic injury and bone healing following l93 nm excimer laser surgery. International Congress on Lasers and Optics in Medicine. Budapest, Hungary, June 1991. p. 36.
A-22 Milhem, I., Lustmann, J.: Mandibular fractures in infants.15th World Congress of the Israel MedicalAssociation, Jerusalem, 1991, p. 10.
A-23 Casap, N., Engelhard, D., Sela, M.N., Lustmann, J.: Anarobic and aerobic bacteria in acute dento-alveolar abscesses. J. Dent Res 71(4): 1034, 1992.
A-24 Markitziu, A., Lustmann, J., Uzieli, B., Krausz, Y., Chisin, R.: Salivary gland imaging in long-term follow-up of radio iodine tgreated patients. The Drommelschlager Conference and post graduate course on head and neck imaging, October 1992.
A-25 Chachmati, M., Lustmann, J., Chosack, A., Palmon, A., Dafni, L. Dentsch, D.: The Tuftelin human gene and its possible involvement in Amelogenesis Imperfecta. J. Dent Res 74 (3): 958, 1995.
A-26 Parmon, E., Lustmann, J., Palmon, A., Dafni, L., Dentsch, D.: Gene expression of Tuftelin in Ameloblastoma. J. Dent Res 76 (5): 1161, 1997.
A-27 Becker, A. Lustmann, J. Shteyer, A.: Cleidocranial dysplasie: The Jerusalem orthodontic/surgery approach to its tretment. Bi- national orthodontic symposium. Jerusalem, september 1997.
A-28 Cohen, EC. Adout, M. Lustmann, J.: Aggressive Verrucous Carcinoma. 11th Israel Medical Week - MEDAX 97. 11 December 1997.
A-29 R. Barron D. Abd-El-Rasek, B. Kreiner, J. Lustmann and A. Shteyer. Severe infections of dental origion in the head & Neck. 2nd. Bi-national conference on Oral and Maxillofacial Surgery, 24-26 February 1999 Israel.
Research Activities
I. Surgical Clinical Research
a. Sialolithiasis: Clinical, radiographic and epidemiologic manifestations of sialolithiasis were evaluated for the first time in Israeli population. A new method for sialolithotomies by means of CO2 laser was introduced.
b. Clinical , radiographic and laboratory manifestations of disorders and disease in the maxillofacial region: Clinical, hereditary, microbiological and radiographic findings of disorders and diseases were studied and therapeutic interventions were suggested.
c. Cysts and tumorous conditions i n the maxillofacial region : A rare and new cystic entity was clarified and another uncommon cystic entity was documented in detail. Rare tumorous conditions were evaluated and we were the first to report in the English literature on a paraganglioma in the tongue.
d. Apical Surgery: The impact of preoperative and intraoperative factors on long-term treatment results of apical surgery in posterior teeth were studied.
e. Application of CO2 Laser to oral and maxillofacial surgery : The suitability of the CO2 Laser for soft tissue surgery in the maxillofacial region was studied and a new method to perform sialolithotomies using this laser was introduced.
f. Clinical and histological characterization of periodontal condition and periodontal disease in Association with the primary and permanent dentition in children.
g. Developing new surgical and bone grafting techniques in relation to implant surgery.
h. Developing treatment modality and surgical protocol for surgical - Orthodontic treatment of Impacted teeth.
II. Experimental Research
a. Salivary extraglandular calcifications and salivary gland endocytic capability: The ultrastructure of sialoliths and their aetiology were investigated by means of scanning and transmission electron micriscopy. The endocytotic capabiliity of the rat parotid ductal cells were studied and demonstrated.
b. Application of excimer laser for bone surgery: The ArF excimer laser was investigated quantitatively as a cutting-ablating tool for bone surgery and the bone healing following this irradiation was evaluated.
c. Identification and initial characterization of oncogene involvement in odontogenic tumors.
d. The involvement of the human Tuftelin gene in Amelogenesis Imperfecta.
Research Activities (1981-1992)
I. Surgical Clinical Research
L4
This part of my work was focused to expand the knowledge on maxillofacial diseases, disorders, cysts and tumors. An attempt was made to introduce new modalities in diagnosis and treatment of salivary glands and jaw bones pathologies.
a. Sialolithiasis (Publications 39,p-3)
Sialolithiasis is an obstructive disease of the salivary glands causing severe episodes of acute infections and progressive destruction of the affected glands. For the first time, the incidence, the clinical manifestations, radiographic presentation, symptomatology and recurrence rate were studied in a large sample of Israeli population. Possible relation to a wide range of systemic disorders, to nephrolithiasis and to PTH serum levels were evaluated (39). The removal of the obstructing sialo liths, the deeply situated and the small ones, especially during the acute phase of the disease, might be very difficult and even hazardous. My novel idea to use the CO2 laser for these sialoli thotomies was successfully introduced (p-3).
b. Clinical, radiographic and laboratory manifestations of disorders and diseases in the maxillofacial region. (Publications: 23,24,25,35,38,43,50). Clinical, radiographic and laboratory manifestations of a wide range of disorders and diseases, associated with the maxillofacial region, were studied. In Hypoglossia - Hypodactylia syndrome, typical soft tissue and bone changes have been recor ded. Treatment of this condition toward improving tongue, lip and mandibular function has been directed (23). The simultaneous occurrence of dermoid cysts, congenital hypothyroidism, cleft palate, oligodontia and orofacial defects was not previously described, and this case study might represent a new syndrome entity (25). The correlation between the predominant subgingival microflora and the host immune response before and after antibio tic therapy, in a genetically proved Papillon-Lefevre syndrome (PLS), was studied. The results support the role of Actinobacil lus actinomycotemcemitanse and polymorphonuclear leucocytes dys function in the pathogenesis of PLS (38). Two very rare parasi tic affections of the oral cavity, Cysticercosis (24) and Myiasis (35) have been studied and their clinical manifestations presen ted. Treatment modalities and preventive means were suggested. Radiologic characteristics of the jaw bones and teeth and haema tological findings in Gaucher's disease were recorded. The symp tomless involvement of the jaws should draw attention to this condition, especially in relation to Ashkenazi Jews (43).
The influence of radioiodine therapy (I131) for thyroid carcinoma and thyrotoxicosis, on the morphology, histopathology and function of major salivary glands was studied. These glands under went morphological alterations, advanced fatty degeneration of gland parenchyma and severe functional reduction. These phenomena were suggested to be related to direct sequela of theI131 sialotropism or alternatively, secondary to therapy-induced endocrine/metabolic pathology (50).
c. Cysts and tumorous conditions in the maxillofacial region (Publications: 26,29,32,36,37,40,41,46,48,51). Till the last decade, radicular cysts arising from deciduous teeth, although sporadically and very rarely mentioned in the literature, were not well established and were not regarded as a distinct entity. We were the first to present a series of 23 well- documented such cases (doubling the number of the reported cases since the first report at the turn of the century) and to establish clinically, radiographically and histologically this distinct entity (26). In a survey of dentigerous cysts associated with supernumerary teeth, the epidemiologic, radiographic and the clinico-pathological features of this rare entity were documented and the different treatment modalities were summarized (32). Chondromyxoid fibroma of the jaws is an extremely rare entity. We documented the up-to-date clinical and pathological data, discussed the differential diagnosis and were the first to present this tumor to affect the maxilla (29). The CT scan and the tomography of the TMJ were found to be very useful means to demonstrate the radiographic characteristics of TMJ synovial chondromatosis. The clinical data, the treatment approach and the recurrence rate were widely reviewed (37). Malignant transformation of benign thyroglossal duct cyst situated in the tongueis very rare.The correlation among the clinicl signs and symptoms, the radiographic presentation, the laboratory diagnostic data and the treatment approach were defined, and additional diagnostic means and criteria were proposed (36). The histopathologic characteristics of Squamous Odontogenic Tumor, due to its rarity, is not yet well established. Clinical and radiographic features ofthis condition are presented and extensive discussion concerning differential diagnosis with benign and malignant tumors mimicking its histopathology is documented (40). We were the first to report in the English literature on a paraganglioma of the tongue (41). The correlation betweenlong-term immunosuppressive therapy and the innocent appearance of lip carcinoma, and its incidence in these individuals is documented. Possible diagnostic faults due to its misleading innocence are discussed and we are the first to report such a case in the dental literature (46).
Malignant transformation of oral Lichen Planus is controversial and in most instances is related to the erosive form. Our epidemiologic and histopathologic study disclosed that malignant transformations occurred in at least 2.85% of all LP cases. This high figure should be alarming for all clinicians (48). Hemangiopericytoma is a rare tumerous condition with veryhigh rate of malignant transformation and recurrence. Its relation to theoral cavity and to the pediatric age groupisdocumented (51).
d. Apical Surgery (Publications 42, 44). Based on clinical and on radiographic criteria, the relation of preoperative and intraoperative factors to the prognosis, and the long term treatment results, following apical surgery in premolar and molar teeth, were studied.
e. Application of CO 2 Laser to oral and maxillofacial surgery (Publications p-2, p-3) A prospective study was undertaken to find the suitability of the CO2 Laser for application in oral and maxillofacial soft tissue surgery. A wide range of soft tissue lesions were included and the results were strictly evaluated. Benign and malignant tumors and hemangiomas showed the best response to the CO2 Laser surgery, while L.P., hyperkeratotic and white lesions did not respond positively (p 2). We were the first to introduce the CO2 Laser to perform sialolithotomies and found this method superior to the conventional approach (p-3).
II. EXPERIMENTAL RESEARCH
In this aspect of my research activities I made an effort to combine my clinical experience with experimental methods. My main interest was focused on salivary extraglandular calcifications and its correlation to salivary gland function. Lately I concentrated on the interaction of excimer laser irradiation with bone and the possible application of this modality for bone surgery.
a. Salivary extraglandular calcifications and salivary gland endocytic capability (Publications: 22,31). Calcifications in the ductal system of salivary glands is of unknown definite aetiology. These calcifications cause obstruction of salivary secretion, recurrent ascending infections and progressive degeneration of the parenchyma of the gland. By means of the scanning and transmission electron miscroscopy, the ultra structure of these calcifications was clarified and the role of microorganisms and of microbial calcification was suggested as a possible aetiologic factor in their formation and growth (22). Extensive endocytosis by ductal cells in certain pathological conditions of salivary glands is well known. An attempt was made to clarify the mechanism of the intralobular duct cells of the rat parotid gland to take up protein from the lumen, in normal and in stimulated conditions. This may be a mechanism for remo ving abnormal or modified proteins from the saliva (31).
b. Application o f Excimer laser for bone surgery. (Publications: 45, 47).Different laser wavelengths, based on heat generation, were found effective in soft tissue surgery. Bone tissue, very sensitive to temperature elevation, requires "cold" laser irradiation, to be applied effectively. The argon fluoride excimer laser (193 nm) was investigated as a cutting-ablating tool for bone surgery. Quantitative measurements for various fluences of laser energy and number of pulses were studied. Histological data demonstrated clear and precisely defined cuts with minimal thermal damage (45). In vivo experiments disclosed 1.0-1.5 mm bone damage attributed to photoacoustic waves propagating in the bone and the healing was very much impaired (47).
CURRENT AND FURTHER RESEARCH UNDER MY DIRECT RESPONSIBILITY
SURGICAL CLINICAL RESEARCH
a. Sialolithiasis: In previous study, a possible correlation between sialolithiasis and nephrolithiasis was speculated. Since the number of cases studied was too small, we could not draw a definite conclusion. At present an attempt is made to examine a large enough sample of patients suffering from nephrolithiasis, and to explore by means of clinical and radiographical examinations a possible correlation between these two disorders. A positive correlation might give a hint that similar mechanisms are involved in the formation of these calcifications.
b. Tumorous conditions in the maxillofacial region. Tumors in children have to some extent unique clinical and pathological behaviour and different radiographic presentation, when compared to tumors in adults. In a survey on tumors in children, now in its final stage of completion, the incidence, the clinical behaviour, the radiographic presentation, the treatment modalities and reevaluation of the histopathological diagnosis were carried out. Possible correlations were examined among the different parameters that were studied. Other rare and unique pathological conditions in all age groups were evaluated as well.
c. Improvement of surgical techniques in apical surgery. Treatment results in apical surgery are related to various factors, some of which are dependent on the operator's skill. Residual infection in the apical bone cavity is very difficult to eradicate, especially when it is situated palatally or lingually to the amputated root. The current work is intended to evaluate the contribution of the CO2 laser irradiation to the infection control and to the success rate of this surgical procedure.
d. C l i n i c a l and pathological manifestations of systemic diseases in salivary glands. Systemic diseases and their treatment may cause severe and sometimes irreversible, direct or iatrogenic damage, to the salivary glands. Thyroid carcinoma patients after thyroidectomy and radioiodine therapy and thyrotoxicosis patient treated with I131, according to our findings, result in parotid gland degene ration. This current study intends to evaluate this damage by means of imaging and radioisotope modalities, to characterize the histopathological degenerative changes and to assess the function of the affected salivary glands. A similar attempt is undertaken to evaluate the salivary gland damage in relation to Wegener's granulomatosis.
e. Fractures in the maxillofacial skeleton. The treatment of maxillofacial fractures is intended to be without delay, with a view to restoring function and esthetics. Accompanied head injuries may require delay in the desired immediate treatment. The correlation between head injuries and maxillofacial fractures, the impact of neurological problems on the delay in the fracture fixation and the impact of this delay on healing and complications is now under investigation. Mandibular fractures in infants, under one year of age, are extremely rare and there is no consensus concerning the preferable treatment. This current study intends to evaluate the clinical and radiographical presentation of this trauma entity, to review the diagnostic means and to suggest a conservative treatment approach.
f. T h e efficacy of various antibiotic therapies in maxillofacial infections. Most abscesses in the maxillofacial region are odontogenic in origin. In a retrospective study, it was disclosed that whether or not the patients received antibiotics prior to pus sampling, mixed flora consisting of aerobic and anaerobic pathogens was isolated. A prospective randomized study is now in progress. The main objects of this study are to isolate and to identify the aerobic and the anaerobic microorganisms involved in these infections and to evaluate the efficacy of three regimens of antibiotic therapy.
g. Invention of surgical techniques. The use of dental implants to restore function and aesthetics in the elderly population is in great progress. In extreme cases, where advanced bone resorption took place, the reduced amount and the malshape of the jaw bone, prevent the use of implants. Two surgical techniques, one to widen narrow maxillary ridge by means of interpositional bone grafting and the other to reshape the mandibular symphysis by means of vertical osteotomy and bone rotation are in advanced stages of development.
EXPERIMENTAL
a. Evaluation of structure and composition alterations in bone following 193 nm irradiation. The argon fluorid excimer laser fulfils some basic requirements to be considered as a possible surgical tool for bone surgery. Previous studies demonstrated, on histological basis, the thermal damage following this wavelength irradiation to be minimal, although more profound alterations could be identified and were attributed to photoacoustic waves. In the current study, the structural and compositional alterations, following 193 nm irradiation, will be evaluated by means of scanning electron microscopy and Raman spectroscopy.
b. The impact of photoacoustic waves generated by ArF excimer laser radiation o n dental pulp and on tooth supporting structures. The photoacoustic waves propagating in hard tissues, rather than thermal changes, might be the major reason to cause distance damage following excimer laser irradiation. The impact of those waves on the dental pulp and on the supporting tooth structures is under investigation.
RESEARCH
Details regarding participation in papers which were not under my direct responsibility
1. (Publication 25) "Dermoid cysts, hypothyroidism, cleftpalate and hypodontia": The clinical and radiographical findings in the oral and maxillofacial region were established and written by me.
2. (Publication 27) "Calcification of non-collagenous matrix in human gingiva: a light and electron microscopic study": This patient affected by Amelogenesis Imperfecta and generalized gingival fibromatosis was treated and operated by me. It was my initiative to study this anomaly, where other soft and hard tissue anomalies were present.
3. (Publication 28 & 34) "A clinical and histometric study of gingivitis associated with the human deciduous dentition". "Gingivitis in the human deciduous dentition: A correlative clinical and block surface light microscopic study": To perform these two studies, the deciduous teeth had to be removed in one piece with the attached marginal gingiva, without distortion or tearing. The surgical technique and the appropriate instrumentation were conceived by me, and I carried out all the surgical procedures.
4. (Publication 31) "Endocytosis of proteins by salivary gland duct cells". I was involved in the surgical cannulation of the rats' salivary glands, followed by all the laboratory procedures of tissue preparation and examination of the samples with the electron microscope (three months' research at the NIH).
5. (Publication 38) "Periodontitis associated with papillon Lefevre syndrome": I performed the surgical intervention on this patient and was involved in planning and preparation of the manuscript.
6. (Publlcation 40) "Squamous Odontogenic Tumor. Review of the literature and case report". Except for the surgical intervention, all the work, starting with establishing the correct diagnosis of this rare and controversial tumor, the literature reviewing and the writing of the manuscript was performed by me.
7. (publication 50) "Salivary and lacrimal gland involvement in a thyroidectomized radioiodine treated thyroid cancer patient". I performed the surgical intervention and was involved in all stages of workup and writing of this study.
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