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Dr. Chana Lotan, MD

 

Senior Physician in the

Sharett Institute of Oncology

Hadassah University Hospital

Jerusalem, 91120

email: lotan_chana@lilly.com

 

 

Education

 

1987 - M.D, Sackler Schol of Medicine, Tel Aviv University, Tel Aviv

 

1978 – PhD,  Organic Chemistry, Hebrew University, Jerusalem

 

1973 – MSc, Organic Chemistry, CUNY, New York, USA

 

1969 – BSc, Chemistry & Physics, Hebrew University, Jerusalem

 

Licences

 

1988 – Board of Medicine

1996 -  Board of Oncology

 

Work Experience

 

1998 to date -  Medical Director, Eli Lilly, Israel

 

2005 to 2006 -   Medical Director, Eli Lilly, South Africa.

 

1998 to date -  Senior Physician in Oncology, part time, Hadassah Hospital, Jerusalem - Senior Physician in Oncology, Hadassah Hospital, Jerusalem

 

1990-1995 – Resident in Oncology, Hadassah Hospital, Jerusalem

 

1981-1983 -  Fogarty Fellow, Laboratory of Molecular Pharmacology, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, USA  

 

1978-1980 – Research Associate, Department of Biophysics, Michigan State University, USA

 

1973-1978 – Investigator & Lecturer, Chemistry, Hebrew University, Jerusalem

 

Associations Membership

 

ASCO – 1997

ESMO -  1996

Israel Oncology Association – 1991

Israel Medical Association - 1988

                            

 

List of Publications

 

1.      C. Zlotogorski, “Silver ion catalyzed synthesis of diaryl ethers from 4-bromoisophorone and phenols”, thesis, City University of NY.

 

2.      J. Blum, C. Zlotogorski and A. Zoran, “A simple route from Dicyclopentadiene to Trishomocubane”, Tethradon Lett., 13, 1117 (1975).

 

3.      C. Zlotogorski, “Carbon-carbon bond cleavage by transition-metal compounds”, Ph.D. dissertation, Hebrew University of Jerusalem (1978).

 

4.      J. Blum and C. Zlotogorski, “Isolation  of metalocyclic intermediate in [Ir (Co2) Cl] catalyzed rearrangement of 1,3-bishomocubane”, Tetrahedron Lett., 37. 3501 (1978).

 

5.      H. Hart, C. Zlotogorski et al., “Biannelation of arenes with bisayrne equivalents”, J. Am. Chem. Soc., 102, 6649 (1980).

 

6.      L.C. Erickson, C. Zlotogorski, E. Sariban, G. Laurent, K. Kohn, B. Smith and P. Kornblith, “Differences in chloroethylnitrosourea (CCNU)-induced DNA interstrand cross-linking among cell lines derived from human malignant gliomas”. Proc. A. Assoc. Cancer Res., 23, 641 (1982)

 

7.      C. Zlotogorski and L.C. Erickson, “Pretreatment of mer cells with methylating agents allows the formation of interstrand crosslinks by chloroethylnitrosoureas”, Proc.Am. Assoc. Cancer Res., 24, 372 (1983).

 

8.      C. Zlotogorski and L. C. Erickson, “MMNG pretreatment of normal human fibroblasts (mer+) allows the formation of previously unobserved DNA interstrand crosslinking by chloroethylnitrosoureas”, Journal of Cellular Biochemistry, 1024, Supplement 7B (1983).

 

9.      C. Zlotogorski and L. C. Erickson, “Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone"” Carcinogenesis, 4, 759-763 (1983).

 

10.  C. Zlotogorski and L. C. Erickson, “Pretreatment of human colon tumor cells with DNA methylating agents inhibits their ability to repair chloroethyl monoadducts”. Carcinogenesis, 1984, 5(1) 83-7.

 

11.  L. C. Erickson and C. Zlotogorski, “Induction and repair of macromolecular damage by alkylating agents”, Cancer Tret. Rev., 1984, Mar 11, Suppl A:25-35.

 

12.  L. C. Erickson and C. Zlotogorski, Induction and eparatur von macromolekularen schaden durch alkylantien”. Beitr. Onkol., vol. 18, pp 156-171 (Karger, Basel, 1984)

 

13.  C. Zlotogorski, J. Blum, E. Osawa, H. Schwarz, G. Hohne, “Carbonylation and valence isomerization of 1.3-dihomo-cubane derivatives by chlorodicarbonylrhodium dimer”, J. of Org. Chem, 49, 971-976, 1984.

 

14.  N.W. Gibson,  C. Zlotogorski, L. C. Erickson, “Specific DNA repair mechanisms may protect some human tumor cells from DNA interstand crosslinking by chloroethylnitrosoureas but not from crosslinking by other anti tumor alkylating agents”, Carcinogenesis, 1985, 6(3):445-50.

 

15.  E. Sariban, K. W. Kohn, C. Zlotogorski, G. Laurent, M. D’Incalci, R. Day, B.H. Smith, P.L. Kornblith, L.C. Erickson, “DNA cross-linking responses of human malignant glioma cell strain to chloroethylnitrosoureas, Cisplatin, and Diaziquone”. Cancer Res., 1987, 47 (15):3988-94.

 

16.  C. Lotan, T.Peretz, O. Lyass, P. Lepensart and R. Catane, “Tamoxifen may induce fatty change in the liver of breast cancer patients”, Proc.Am.Assoc. Cancer Res., 34, 1191 (1993)

 

17.  S. Gillis, O. Sofer, O, Zelig, E. Dann, C. Lotan, D. Ben Yehuda, R. Isacson, E. Rachmilewitz, I. Ben Bassat and A. Polliack, “Acute promyelocytic leukemia with t(15;17) following treatment of Hodgkin’s disease – a report of 4 Cases”. Annals of Oncology, 6:777-779, 1995.

 

18.  C. Lotan, O. Paltiel, E. Dann, L. Gordon, B. Uziely, A. Polliack, “MOPP-ABV for advanced Hodgkin’s disease: Results from Hadassah University Hospital 1990-1993”, Annals of Oncology,

 

19.  R. Gorodetsky, C. Lotan, K. Piggot, L. Pierce, I. Polyansky, S. Dische, M. Saunders, A. Lichter, A. Vexlwe, “Late Effects of dose fractionation on the mechanical properties of breast skin following post-lumpectomy radiotherapy”, Int. J. Radiation Oncology Biol. Phys., vol. 45, 4 (893-900), 1999.

                                                                                                                                                                  




Dr. Chana Lotan


            
     
 


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