I began my medical education at the P.J. Safarik School of Medicine in Kosice, Czechoslovakia in 1964, planning to make aliyah after finishing my medical education. But while I was enrolled in medical school, the spring 1968 Prague uprising opened a window for emigration, and I came to Israel with my wife. After six months of ulpan, I enrolled in the Hebrew University – Hadassah School of Medicine in 1969, completed my internship at Hadassah in 1972, and began my residency in the Department of Pathology at Hadassah in 1973. Both my residency and preparation of my medical thesis were interrupted by the Yom Kippur War, during which I served as a physician on the Egyptian front. After the war I continued my residency, completing my medical thesis and receiving my MD in 1976.

During my residency I became interested in nephropathology. In 1977 my mentor, Prof Alexander Laufer, Chairman of Pathology at that time, sent me to Professor Jacob Churg for a clinical fellowship at Mt Sinai School of Medicine in New York. Professor Churg was a world-renowned leader in nephropathology. At Mt Sinai I also worked and trained as a general pathologist. In 1978 I returned to Jerusalem and the Department of Pathology at Hadassah, and completed my Board Certification in Pathology. I joined Hadassah’s Department of Pathology as an attending pathologist with special interest specialist in nephropathology. In 1980 I spent three months at the Karl Eberhardt University, Tubingen, Germany under Professor Bohle, an eminent nephropathologist. In the ensuing years I have worked in nephropathology, while being actively engaged in research, teaching inflammation, gynecopathology, and nephropathology to medical students and young physicians.

From 1986 – 1988 I continued my advanced training with a research and clinical fellowship in nephropathology at Beth Israel Hospital, of the Harvard School of Medicine in Boston. During these years I was also an Instructor at the Harvard School of Medicine. In addition to my full clinical responsibilities in general pathology at Beth Israel, I conducted research focusing on morphological changes in isolated perfused kidneys of rats under various experimental conditions.

During these years we published several articles (original articles 19, 22, 23, case report 32). My most important work in Boston was to evaluate morphological changes along the nephron in response to hypoxia and reperfusion. In an attempt to ameliorate the effect of hypoxia in the isolated, perfused kidney, polyethylene glycol (PEG) was added to the perfusate in oxygenated and hypoxic kidneys. PEG produced similar changes in the S1-S2 segment, which consisted of reduction of cell thickness, organelle compaction, and internalization of brush border in the tubulovesicular system. In the S3 segment, the cellular volume loss was more limited, the brush border was transformed to membranous whorls and the cytoplasm contained large irregular clear zones. Mitochondrial swelling was pronounced. It was demonstrated that PEG does not protect against hypoxic injury. (original article 22). Thus mild-moderate hypoxic changes in isolated perfused kidneys can be reversible, whereas severe change is irreversible. Moderate injury to the medullary, thick, ascending limb has the capacity to regress in acute renal failure, because morphological changes are limited.

Upon returning to Israel in 1988, I joined the Wolfson Medical Center in Holon as Chairman of Department Pathology. Wolfson is an affiliate hospital of the Sackler School of Medicine of Tel Aviv University. After two busy clinical years in Holon, in 1991 I was invited to become Chairman of the Department of Pathology at Sheba (Tel HaShomer) Medical Center, also an affiliate of the Sackler School of Medicine of Tel Aviv University.

During my tenure as Chairman of Pathology at Sheba I reorganized the Department, introducing subspecialities in neuropathology, hematopathology, gastrointestinal pathology, lung pathology, genitourinary and prostatic pathology, breast, and of course nephropathology. I also brought new methodologies in clinical pathology, including immunohistochemical and molecular analysis for clinical application across the pathological subspecialties at Sheba. We began to routinely use techniques in immunofluorescence, electron microscopy, and fluorescent in situ hybridization (FISH) in the Department, for both diagnostic and research purposes. We brought three PhD biologists into the Department to support our clinical service and participate in research programs. They head laboratory programs for routine pathological examinations, as well as molecular and immunohistochemical studies.

We now conduct weekly multidisciplinary meetings in a number of these subspecialty areas, and physician subspecialists teach at the Sackler School of Medicine of Tel Aviv University. I am a Clinical Professor at the Sackler School of Medicine, responsible for teaching a course in nephropathology in both the Israeli and American programs. Today the Department processes surgical specimens for 25,000 patients per year across the medical specialties. 

During my first decade as Chairman at Sheba, my first focus was on building infrastructure and expertise in multiple subspecialty areas within the larger field of Pathology. During these years I was also a very busy clinical pathologist myself, working within my nephropathology subspecialty as well as in general pathology. However research and teaching have remained central to my role as a Pathologist and as Chairman.

Research

During my years at Sheba I was privileged to be a member of several close-knit teams of active scientists, with research focused on three areas: autoimmunity, atherosclerosis, and extracellular matrix in malignancies of the female genital tract. My role in this research encompassed defining research objectives and programs, interpretation of the morphological findings, conducting experiments, reaching conclusions, and writing the papers.

Autoimmunity  We have shown in an experimental SLE model that mice experienced complete clinical and morphological remission following treatment with intravenous gamma globulin. Our results suggest a possible clinical application of intravenous gamma globulin preparations containing antiidiotypic activity to anti DNA and aCL in patients with SLE or anti-phospholipid syndrome (original article 34).

To better understand autoimmune diseases we employed an experimental murine model for evaluation of autoimmune vasculitis. We demonstrated that active immunization of naïve mice with WG patient-derived AECA leads to the development of circulating mouse anti-endothelial cell antibodies, and a vasculitis-like disorder in immunized mice. This animal model of vasculitis provides the first direct proof of the pathogenicity of anti-endothelial cell antibodies (original article 41).

A variety of additional research focused on other experimental and morphological aspects of autoimmunity (original articles 33, 40, 41, 67)

Atherosclerosis  We showed enhanced atherosclerosis and a clear difference in plaque formation between β2GPI immunized mice and a control group. In addition, the atherosclerotic plaques of Apo-E deficient mice were rich in CD4+, CD8+, and macrophages, which may play an active role in the development of disease. This study provided experimental evidence for the role of the immune response against β2GPI in initiation and progression of atherosclerosis (original article 66).

In other research we found that β2GPI was abundantly expressed in the subendothelial region and the intimal-media junction in human atherosclerotic plaque. CD4+ lymphocytes densely infiltrated the areas in which β2GPI was expressed, while there was a relative paucity of CD8+ lymphocytes. The presence of β2GPI together with CD4+ lymphocytes in human atherosclerotic plaque may serve as a target for an immune-mediated reaction that can influence lesion progression (original article 77).

We have pursued further research to understand the role of immunity in the development and progression of atherosclerosis (original articles 56, 67, 71, 77, 78, 81, 88)

The extracellular matrix in malignancies of the female genital tract  In the last few years I and my colleagues studied the role of the extracellular matrix in local invasion, metastasis, angiogenesis, and prognosis in female genital tract malignancies. We found that three proteins – matrix metalloproteinase-2 (MMP2), the tissue inhibitor of metalloproteinase-2 (TIMP-2), and membrane-type metalloproteinase (MT1-MMP) – were upregulated in invasive carcinoma compared to carcinoma in situ and control cervices. When they are present, these proteins are associated with aggressive tumors and are markers of poor prognosis (original article 75).

In serous effusions of ovarian cancer, we analyzed the expression of MMP-2, MT1-MMP, MT2-MMP, and MT3-MMP mRNA. Production of these enzymes may enhance extracellular matrix degradation of peritoneal tissue, and possibly facilitate cancer cell invasion of abdominal structures (original article 115).

The expression of mRNA of MMP, TIMP-2, and angiogenic genes was evaluated in tumors from patients with advanced-stage ovarian carcinoma. mRNA expression of TIMP-2 was a marker of poor prognosis. This supports the central role of metalloproteinases in local invasion and distant metastases. The lack of correlation between the angiogenic gene expression and survival may have a profound therapeutic implications (original article 109).

We have reported our findings regarding the role of the extracellular matrix in progression and prognosis for female genital tract malignancies in many other publications (original articles 60- 63, 76, 83-86, 99-101, 103, 108-110, 115, 121, 125, 126).

Teaching

As Chairman, I directed Israeli and American 3^rd and 4^th medical student rotations in the Department of Pathology at the Sheba Medical Center for the Sackler School of Medicine of Tel Aviv University. In addition I taught Nephropathology with the accompanying course Laboratories in Nephropathology to the Israeli and American medical students at Sackler. Immediately after assuming the Chairmanship at Sheba, I introduced an active residency program into the Department of Pathology, and I directed this program throughout my years as Chairman, training 10 residents through receipt of full board certification. In 1995 and 1998 I gave a course in nephropathology to pathology residents in Sackler’s Postgraduate School of Medicine. I also mentored the advanced research efforts of several residents and MSc students during my years at Hadassah and Sheba. While on my fellowship at Harvard I taught nephropathology, and earlier, in the years at Hadassah, I taught Nephropathology, Gynecological Pathology, and General Pathology (Inflammation and Amyloidosis) to 3^rd year medical students at the Hebrew University – Hadassah School of Medicine.

In the next years I will again combine intensive administrative work as the incoming Chairman of Hadassah’s Department of Pathology with active research efforts. At Hadassah I will also remain active training residents in Pathology as the leader of this important program in my new Department. On the research front I intend to investigate the expression of other transcription factors such as Snail and Sp 1 (specificity protein 1) in short- and long-term survivors of ovarian carcinoma. Sp 1 plays a critical role in the growth and metastasis of many tumor types by regulating expression of cell cycle genes and vascular endothelial growth factors. In addition we are planning to evaluate the phosphatidylinositol 3’-kinase-Akt signaling pathway, which regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival in primary ovarian cancer. We will compare our results with results from comparable studies of metastatic carcinoma as well as with the cells in effusions.

I look forward to building on the solid base in the Department of Pathology that has been established by Professor Dov Soffer, as I return to my roots at Hadassah.

List of Publications

Books Edited

Chapters in Collections

1.                  Weshler Z, Gotsman MS, Okon E, Pizoff G, Kopolovic J, Biran S, Eldor A. (1990) Inhibition by irradiation of smooth muscle cell proliferation in the de-endothelialized rat aorta. In: Riklis E. (ed) Frontiers in radiation biology, 21^st annual meeting of the European Society for Radiation Biology, pp133-138. Balaban Publ, Tel Aviv, Israel.

2.                  Kopolovic J. (1992) Peripheral vascular disease: normal morphology and pathological considerations. In: Kim D and Oron D (eds) Peripheral vascular disease and intervention, pp 39-49. Mosby Inc., Baltimore, MD.

Original Papers in Peer Reviewed Journals

PI         Principle Investigator

S          Student

C         Co-researcher

T          Technician/laboratory assistant

1.                  Kopolovic J^PI, Fields M^C, and Laufer A^PI. (1978) Effects of papain on experimental amyloidosis. Experientia 34:524-535,  2.072;  8/51;1.

2.                  Gatt S^PI, Dinur T^PI, and Kopolovic J^PI. (1978) Niemann Pick disease: presence of the magnesium-dependent sphingomyelinase in brain of the infantile form of the disease. J Neurochem 31(2):547-550. 4.604  51/261;  28/200;  25;  25

3.                  Friedman G^PI, Granot H^C, Kopolovic J^C, and Friedlaender M^PI. (1981) "Pulse" methylprednisone and cyclophosphamide therapy in idiopathic rapidly progressive glomerulonephritis. Postgrad J Med 57:54-56.  0.659;  65/105;  0

4.                  Beyth Y^PI, and Kopolovic J^PI. (1982) Accessory tubes: a possible contributing factor in infertility. Fertil Steril 38(3):382-383. 3.114;  6/57;  6/24;  11; 11

5.                  More R^PI, Amir N^C, Meyer S^C, Kopolovic J^C, and Yarom R^PI. (1982) Platelet abnormalities in Down's syndrome. Clin Genet 22(3):128-136. 3.276;  45/124;  6;  6

6.                  Shalev O^PI, Rubinger D^C, Barlatzky Y^C, Kopolovic J^PI, and Drukker A^PI. (1982) Eosinophilia associated with acute allograft kidney rejection. Nephron 31(2):182-183. 1.561;  14/41;  12;  12

7.                  Knobler H^PI, Kopolovic J^PI, Kleinman Y^C, Rubinger D^C, Silver J^C, Friedlaender MM^C, and Popovtzer MM^PI. (1983) Multiple myeloma presenting as dense deposit disease. Light chain nephropathy. Nephron 34(1):58-63. 1.561;  14/41;  12;  12

8.                  Ben-Dov I^PI, Berry EM^PI and Kopolovic J^PI (1985) Poststreptococcal nephritis and acute rheumatic fever in two adults. Arch Intern Med 145(2):338-339.  8.016;  8/105; 7; 7

9.                  Milgalter E^PI, Uretzky G^C, Siberman S^C Appelbaum Y^C, Shimon DV, Kopolovic J^PI, Cohen D^C, Jonas H^C, Appelbaum A^C, and Borman JB^PI. (1985) Pericardial meshing: an effective method for prevention of pericardial adhesions and epicardial reaction after cardiac operations. J Thorac Cardiovasc Surg 90(2):281-286. 3.727;  9/72; 8/33;  8/139;  20;  20

10.              Shalit M^PI, Flugelman MY^C, Harats N^C, Galun E^C, Ackerman Z^C, Kopolovic J^PI, and Eliakim M^PI. (1985) Quinidine-induced vasculitis. Arch Intern Med 145(11):2051-2052.  8.016;  8/105;  16;  16

11.              Rubinger D^PI, Friedlaender MM^C, Silver J^C, Kopolovic J^PI, Czaczkes WJ^C, and Popovtzer MM^PI. (1986) Progressive vascular calcification with necrosis of extremities in hemodialysis patients: a possible role of iron overload. Am J Kidney Dis 7(2):125-129.  4.412;  3/51;  37;  37

12.              Kopolovic J^PI, and Oren R^PI. (1986) IgM nephropathy – clinicopathological entity. Harefuah 110:156-157 [Hebrew].  x;  x;  0

13.              Navot D^PI, Laufer N^C, Kopolovic J^PI Rabinowitz R^C, Birkenfeld A^C, Lewin A^C, Granat M^C, Margalioth EJ^C, and Schenker JG^PI. (1986) Artificially induced endometrial cycles and establishment of pregnancies in the absence of ovaries. N Engl J Med 314(13):806-811. 44.016;  1/105;  158;  158

14.              Rubinger D^PI, Drukker A^C, Shvil Y^C, Kopolovic Y^C Friedlaender MM^C Shalit M^C, and Popovtzer MM^PI. (1986) Combined cyclophosphamide and corticosteroid-induced remission in severe glomerulopathy associated with systemic vasculitis. Am J Nephrol 6(5):346-352. 2.459;  13/51;  6;  6

15.              Friedlander MM^PI, Rubinger D^C, Ben-Chetrit E^C, and Kopolovic J^PI. (1986) IgA nephropathy and acute reversible renal failure. Isr Med Sci J IMAJ 22:888-891 [Hebrew]. 0.456;  62/110;  2;  2

16.              Kopolovic J^PI, Shvil Y^C, Pomeranz A^C Ron N^C, Rubinger D^C, and Oren R^PI. (1987) IgM nephropathy: morphological study related to clinical findings. Am J Nephrol 7(4):275-280.  2.459;  13/51;  16;  16

17.              Weshler Z^PI, Ligumsky M^C, Brufman G^C, Kopolovic J^C, Tochner Z^C, Karmeli F^C, and Rachmilewitz D^PI. (1987) Functional and morphological alterations following isolated rat stomach irradiation. A model for estimation of radiation injury. In Vivo 1(6):357-361. 1.037;  52/72;  1; 1

18.              Gur H^PI, Kopolovic Y^PI, and Gross DJ^PI. (1987) Chronic predominant interstitial nephritis in a patient with systemic lupus erythematosus: a follow up of three years and review of the literature. Ann Rheum Dis 46(8):617-623. 6.956;  2/22;  16;  16

19.              Brezis M^PI, Kopolovic J^PI, and Rosen S^PI. (1988) Hypoxic injury to medullary thick ascending limbs in perfused rat kidneys: reversible and irreversible phases. J Electron Microsc Tech 9(3):293-298.  2.323;  3/15;  13/65;  2/9;  9;  8

20.              Friedlaender MM^PI, Wald H^C, Kopolovic J^C, and Popovtzer MM^PI. (1988) Colchicine does not interfere with the antiphosphaturic effect of 25(OH) vitamin D3 in the rat. Miner Electrolyte Metab 14(2-3):103-109.  1.025;  56/85;  4;  4

21.              Weshler Z^PI, Ligumski M^C, Tochner Z^C, Kopolovic J^C, Carmeli F^C, and Rachmilewitz D^PI. (1988) Functional and morphological alterations following irradiation of isolated rat stomach: a model for estimation of radiation injury. Pharmacol Ther 39(1-3):85-87.  8.357;  6/193;  1;  1

22.              Kopolovic J^PI, Brezis M^C, Spokes K^C, and Rosen S^PI. (1989) Polyethylene glycol effect on the oxygenated and hypoxic isolated perfused rat kidney. Virchows Arch A Pathol Anat Histopathol 414(5):429-437. 2.224;  21/66;  4;  4

23.              Kopolovic J^PI, Brezis M^C, Spokes K^C, Silva P^C, Epstein F^C, and Rosen S^PI. (1989) The vulnerability of the thin descending limbs of Henle’s loop in the isolated perfused rat kidney. Am J Kidney Dis 14(1):25-30.  4.412;  3/51;  0

24.              Bercovici B^PI, Lewin A^C, Rabinowitz R^C, Kopolowitz J^PI, Smilow PC^C, Rosenberg JL^C, and Laufer N^PI. (1988) The cytology of vaginal, cervical and endometrial smears obtained at the time of embryo transfer during in vitro fertilization. Acta Cytol 32(6):789-793. .022;  129/153;  48/66;  2;  2

25.              Smetana S^PI, Khalef S^C, Kopolovic G^C, Bar-Khayim Y^C, Birk Y^C, and Kacew S^PI (1992) Effect of interaction between gentamicin and pyridoxal-5-phosphate on functional and metabolic parameters in kidneys of female Sprague-Dawley rats. Ren Fail 14(2):147-153.   0.540;  45/51;  4;  4

26.              Tepper R^PI, Nahum R^C, Rahamim E^C, Kapolovitz Y^C, Segal Y^C, Karib N^C, and Beyth Y^PI. (1992) Effects of methotrexate on rabbit oviducts and on cell cultures of bovine oviduct epithelium. Gynecol Obstet Invest 33(2):65-68.  0.810;  48/57;  1;  1

27.              Blank M^PI, Faden D^C, Tincani A^C, Kopolovic J^C, Goldberg I^C, Gilburd B^C, Allegri F^C, Balestrieri G^C, Valesini G^C, and Shoenfeld Y^PI. (1994) Immunization with anticardiolipin cofactor (beta-2-glycoprotein I) induces experimental antiphospholipid syndrome in naive mice. J Autoimmun 7(4):441-455.  2.491;  53/115;  126;  123

28.              Blank M^C, Manosroi J^C, Tomer Y^C, Manosroi A^C, Kopolovic J^C, Charcon-Polak S^C, and Shoenfeld Y^PI. (1994) Suppression of experimental systemic lupus erythematosus (SLE) with specific anti-idiotypic antibody-saporin conjugate. Clin Exp Immunol 98(3):434-441. 2.805;  46/115;  20;  19

29.              Gurevitz O^PI, Goldschmied-Reuven A^C, Block C^C, Kopolovic J^C, Farfel Z^C and Hassin D^PI. (1994) Cryptococcus neoformans vertebral mmunohistoche. J Med Vet Mycol 32(4):315-318.   x;  x;  4;  4

30.              Blank M^PI, Krause I^C, Buskila D^C, Teitelbaum D^C, Kopolovic J^C, Afek A^C, Goldberg I^C, and Shoenfeld Y^PI. (1995) Bromocriptine mmunohistochemi of experimental SLE and primary antiphospholipid syndrome via induction of nonspecific T suppressor cells. Cell Immunol 162(1):114-122.  1.588;  115/153;  85/115;  43;  43

31.              Blank M^PI, Tomer Y^C, Stein M^C, Kopolovic J^C, Wiik A^C, Meroni PL^C, Conforti G^C, and Shoenfeld Y^PI. (1995) Immunization with anti-neutrophil cytoplasmic antibody (ANCA) induces the production of mouse ANCA and perivascular lymphocyte infiltration. Clin Exp Immunol 102(1):120-130.  2.805;  46/115;  57;  57

32.              Friedlaender M^PI, Popovtzer MM^C, Weiss O^C, Nefesh I^C, Kopolovic J^PI, and Raz I^PI. (1995) Insulin-like growth factor-1 (IGF-1) enhances recovery from HgCl2-induced acute renal failure: the effects on renal IGF-1, IGF-1 receptor, and IGF-binding protein-1 mRNA. J Am Soc Nephrol 5(10):1782-1791.  7.240;  1/51;  33;  33

33.              Shoenfeld Y^PI, Gilburd B^C, Hojnik M^C, Damianovich M^C, Hacham S^C, Kopolovic Y^C, Polak-Charcon P^C Goldberg I^C, Afek A^C, and Hun-Chi L^PI. (1995) Induction of Goodpasture antibodies to noncollagenous domain (NC1) of type IV collagen in mice by idiotypic manipulation. Hum Antibod Hybridomas 6(4):122-128.  x;  x;  6;  6

34.              Krause I^PI, Blank M^C, Kopolovic J^PI, Afek A^C, Goldberg I^C, Tomer Y^C, and Shoenfeld Y^PI. (1995) Abrogation of experimental systemic lupus erythematosus and primary antiphospholipid syndrome with intravenous gamma globulin. J Rheumatol 22(6):1068-1074. 3.010;  8/12;  56;  54

35.              Oren R^PI, Laufer J^C, Goldberg I^C, Kopolovic J^C Waldherr R^C and Passwell JH^PI. (1995) C3, C4, factor B and HLA-DR alpha mRNA expression in renal biopsy specimens from patients with IgA nephropathy. Immunology 86(4):575-583.  3.507;  31/115;  17;  16

36.              Davidson B^PI, and Kopolovic J^PI. (1995) Molecular biology of human papilloma virus infection of the female genital tract. Harefuah 129(10):417-420 [Hebrew].  x;  x;  0

37.              Barzilai A^PI, Goldberg I^C, Shibi R^C, Kopolovic J^PI, and Trau H^PI. (1996) Mycosis fungoides expressing gamma/delta T-cell receptors. J Am Acad Dermatol 34(2 Pt 1):301-302.  2.402;  5/39;  9;  9

38.              Kopolovic J^PI and Wolman M^PI. (1996) Reasons underlying discrepancies in results between immunohistochemistry and molecular biology. Eur J Histochem 40(3):177-180. 0.990;  131/153;  3;  3

39.              Kanety H^PI, Kattan M^C, Goldberg I^C, Kopolovic J^C, Ravia J^C, Menczer J^C, and Karasik A^PI. (1996) Increased insulin-like growth factor binding protein-2 (IGFBP-2) gene expression and protein production lead to high IGFBP-2 content in malignant ovarian cyst fluid. Br J Cancer 73(9):1069-1073.  4.115;  32/123;  29;  29

40.              Ziporen L^PI, Goldberg I^C, Arad M^C, Hojnik M^C Ordi-Ros J^C, Afek A^C, Blank M^C, Sandbank Y^C, Vilardell-Tarres M^C, de Torres I^PI, Weinberger A^C, Asherson RA^C, Kopolovic Y^PI, and Shoenfeld Y^PI. (1996) Libman-Sacks endocarditis in the antiphospholipid syndrome: immunopathologic findings in deformed heart valves. Lupus 5(3):196-205.  2.400;  10/22;  46;  44

41.              Damianovich M^PI, Gilburd B^C, George J^C, Del Papa N^C, Afek A^C, Goldberg I^C, Kopolovic Y^PI, Roth D^C, Barkai G^C, Meroni PL^C, and Shoenfeld Y^PI. (1996) Pathogenic role of anti-endothelial cell antibodies in mmunohist. An idiotypic experimental model. J Immunol 156(12):4946-4951.           6.387;  12/115;  60;  60

42.              Orenstein A^PI, Kostenich G^C, Roitman L^C, Shechtman Y^C, Kopolovic Y^C, Ehrenberg B^C, and Malik Z^PI. (1996) A comparative study of tissue distribution and photodynamic therapy selectivity of mmunohi e6, Photofrin II and ALA-induced protoporphyrin IX in a colon carcinoma model. Br J Cancer 73(8):937-944.  4.115;   32/123;  34;  34

43.              Orenstein A^PI, Klein D^C, Kopolovic J^C, Winkler E^C, Malik Z^C, Keller N^C, and Nitzan Y^PI. (1997) The use of porphyrins for eradication of Staphylococcus aureus in burn wound infections. FEMS Immunol Med Microbiol 19(4):307-314. 2.371;  56/115;  22/43;  7;  7

44.              Davidson B^PI, Goldberg I^PI, and Kopolovic J^PI. (1997) Angiogenesis in uterine cervical intraepithelial neoplasia and squamous cell carcinoma: an mmunohistochemical study. Int J Gynecol Pathol 16(4):335-338.  1.817;  57/96;  31/66;  13;  12

45.              Davidson B^PI, Goldberg I^PI, and Kopolovic J^PI. (1997) Inflammatory response in cervical intraepithelial neoplasia and squamous cell carcinoma of the uterine cervix. Pathol Res Pract 193(7):491-495.  1.049;  45/66;  11;  10

46.              Finkelstein Y^PI, Malik Z^C, Kopolovic J^PI, Bernheim J^C, Djaldetti M^C, and Ophir D^PI. (1997) Characterization of smoking-induced nasopharyngeal lymphoid hyperplasia. Laryngoscope 107(12 Pt 1):1635-1642.  1.617;  43/72;  6/29;  6;  6

47.              George J^PI, Afek A^C, Gilburd B^C, Levy Y^C, Blank M^C, Kopolovic J^C, Harats D^C, and Shoenfeld Y^PI. (1997) Atherosclerosis in LDL-receptor knockout mice is accelerated by immunization with anticardiolipin antibodies. Lupus 6(9):723-729.         2.411;  10/22;  54;  53

48.              Inbal B^PI, Cohen O^C, Polak-Charcon S^C, Kopolovic J^C, Vadai E^C Eisenbach L^C, and Kimchi A^PI. (1997) DAP kinase links the control of apoptosis to metastasis. Nature 390(6656):180-184.  29.273;  2/48;  160;  160

49.              Talmi YP^PI, Liokumovitch P^C, Wolf M^C, Horowitz Z^C, Kopolovitch J^PI, and Kronenberg J^PI. (1997) Anatomy of the postauricular island “revolving door” flap (“flip-flop” flap). Ann Plast Surg 39(6):603-607.  0.906;  78/139;  3;  3

50.              Afek A^PI, Shibi R^PI, and Kopolovic J^PI. (1997) Benign and premalignant breast lesions—clinico-pathological correlation. Harefuah 133(9):375-378 [Hebrew].  x;  x;  0

51.              Amital H^PI, Levi Y^C, Blank M^C, Barak V^C, Langevitz P^C, Afek^C A, Nicoletti F^C, Kopolovic J^C, Gilburd B^C, Meroni PL^C, and Shoenfeld Y^PI. (1998) Immunomodulation of murine experimental SLE-like disease by interferon-gamma. Lupus 7(7):445-454. 2.411;  10/22;  8;  8

52.              Barshack I^PI, Goldberg I^C, Davidson B^C, Ravid A^C, Schiby G^C, Kopolovic J^C, Leviav A^C, and Friedman E^PI. (1998) Expression of rasGTPase activating protein in basal cell carcinoma of the skin. Mod Pathol 11(3):271-275.  x;  x;  4;  4

53.              Barshack I^PI, Goldberg I^C, Nass D^C, Olchovsky D^C, and Kopolovic J^PI. (1998) CD44 expression in normal adrenal tissue and adrenal tumours. J Clin Pathol 51(1):52-54.  2.170;  22/66;  4;  4

54.              Barzilai A^PI, Goldberg I^C, Yulash M^C, Pavlotsky F^C, Zuckerman A^C, Trau H^C, Azizi E^C, and Kopolovic J^PI. (1998) Silver-stained nucleolar organizer regions (AgNORs) as a prognostic value in malignant melanoma. Am J Dermatopathol 20(5):473-477.  1.377;  18/39;  11;  11

55.              Rothmann C^PI, Barshack I^C, Kopolovic J^PI, and Malik Z^PI. (1998) Spectrally resolved morphometry of the nucleus in hepatocytes stained by four histological methods. Histochem J 30(8):539-547.  1.397;  89/139;  5;  4

56.              George J^PI, Afek A^C, Gilburd B^C, Blank M^C, Levy Y^C, Aron-Maor A^C, Levkovitz H^C, Shaish A^C, Goldberg I^C, Kopolovic J^PI, Harats D^C, and Shoenfeld Y^PI. (1998) Induction of early atherosclerosis in LDL-receptor-deficient mice immunized with beta2-glycoprotein I. Circulation 98(11):1108-1115.  11.632;  1/72;  1/60;  1/51;  83;  78

57.              Goldberg I^PI, Davidson B^C, Lerner-Geva L^C, Gotlieb WH^C, Ben-Baruch G^C Novikov I^C, and Kopolovic J^PI. (1998) Expression of extracellular matrix proteins in cervical squamous cell carcinoma—a clinicopathological study. J Clin Pathol 51(10):781-785. 2,170;  22/66;  6;  5

58.              Levy Y^PI, Afek A^C, Sherer Y^C, Bar-Dayan Y^C, Shibi R^C, Kopolovic J^C, and Shoenfeld Y^PI. (1998) Malignant thymoma associated with autoimmune diseases: a retrospective study and review of the literature. Semin Arthritis Rheum 28(2):73-79.  3.580;  6/22;  11;  11

59.              Davidson B^PI, Agulansky L^C, Goldberg I^C, Friedman E^C, Ramon J^C, Barshack I^C, and Kopolovic J^PI. (1998) Immunohistochemical analysis of rasGTPase activating protein (rasGAP) in prostate cancer. Pathol Res Pract 194(6):399-404.  1.049;  45/66;  2;  2

60.              Davidson B^PI, Goldberg I^C, Gotlieb WH^C, Ben-Baruch G^C, and Kopolovic J^PI. (1998) Expression of matrix proteins in uterine cervical neoplasia using immunohistochemistry. Eur J Obstet Gynecol Reprod Biol 76(1):109-114. 1.141;  34/57;  21/24;  4;  4

61.              Davidson B^PI, Goldberg I^C, Gotlieb WH^C, Ben-Baruch G^C, and Kopolovic J^PI (1998) CD44 expression in uterine cervical intraepithelial neoplasia and squamous cell carcinoma: an mmunohistochemical study. Eur J Gynaecol Oncol 19(1):46-49. 0.591;  121/123;  55/57;  4;  4

62.              Davidson B^PI, Goldberg I^C, Gotlieb WH^C, Lerner-Geva L^C, Ben-Baruch G^C, and Kopolovic J^PI. (1998) Ulex Europaeus lectin and anti-CD31 staining in squamous cell carcinoma of the uterine cervix: potential prognostic markers. Int J Gynecol Pathol 17(3):205-210.  1.817;  19/57;  31/66;  3;  3

63.              Davidson B^PI, Goldberg I^C, Liokumovich P^C, Kopolovic J^PI, Gotlieb WH^C, Lerner-Geva L^C, Reder I^C, Ben-Baruch G^C, and Reich R^PI. (1998) Expression of metalloproteinases and their inhibitors in adenocarcinoma of the uterine cervix. Int J Gynecol Pathol 17(4):295-301.  1.817;  19/57;  31/66;  2;  2

64.              Gotlieb WH^PI, Flikker S^C, Davidson B^C, Korach Y^C, Kopolovic J^PIand Ben-Baruch G^PI. (1998) Borderline tumors of the ovary: fertility treatment, conservative management, and pregnancy outcome. Cancer 82(1):141-146.            4.800; 21/123;  48;  45

65.