· Born in London, UK, 1961
· BSc in Neurobiology from King’s College, London, 1983
· MBBS from Westminster Medical School, London 1986
· Completed Neurosurgery residency at Hadassah University Hospital, Jerusalem in, 1995
· Fellow in Stereotactic and Functional Neurosurgery, Oregon Health Sciences University, Portland, OR, USA, 1999-2001
Dr. Israel has a special interest in Stereotactic and Functional Neurosurgery, including:
· Surgical management of movement disorders
· Essential Tremor
· Parkinson’s Disease
· Deep Brain Stimulation
· Management of chronic and neuropathic pain syndromes
· Trigeminal Neuralgia
· Phantom Limb pain
· Failed Back Surgery Syndrome
· Brachial Plexus Avulsion Pain
· Treatment of brachial plexus and peripheral nerve disorders
· Entrapment syndromes
· Nerve Trauma
· Peripheral nerve tumors
Research interests
· Pathophysiology of tremor
· Delivery of novel therapeutic agents to the CNS
For List of Publications
see: PubMed
Book
Microelectrode Recording in Movement Disorder Surgery. Z. Israel, K. Burchiel Eds, Thieme 2002 (in preparation)
Book Chapters
1. Polymeric Drug Delivery to the Brain, Z. Israel, A.J. Domb, In: Handbook of Biomaterials Engineering. D. L. Wise Ed., Marcel Dekker Inc., 2000
2. Pain: General Historical Considerations, Z. Israel, K. Burchiel In: Youmans Neurological Surgery. H. Richard Winn Ed., WB Saunders Company, 2002 - in press
3. Surgical treatment of painful peripheral nerve injuries. Z. Israel, K. Burchiel In: Surgical management of pain. K. Burchiel Ed., Thieme, 2002
4. Classification of Pain. Z. Israel, K. Burchiel, In: The Handbook of Stereotactic and Functional Neurosurgery. M. Schulder Ed., Marcel Dekker Inc., 2002- in press
5. Surgery for Other Movement Disorders,. Z. Israel, K. Burchiel, In: The Handbook of Stereotactic and Functional Neurosurgery. M. Schulder Ed., Marcel Dekker Inc., 2002- in press
6. Orofacial pain: Differential Diagnosis and Treatment. F. Hsu, Z. Israel, J. Burgess, K. Burchiel, In: Handbook of pain management, 3rd Edn. CD Tollison Ed., William & Wilkins, 2002 - in press
7. The history of microelectrorecording. Z. Israel, M. Schulder, In: Microelectrorecording in Movement Disorder Surgery, Z. Israel, K. Burchiel Eds., Thieme, 2002 - in press
Presentations
Suprasellar Meningiomas: Visual and General Outcome following craniotomy in 30 consecutive patients. Y.Shoshan, I.Anteby, Z.Israel, E.Ashkenazi, S.Pomeranz, F.Umansky, M.Shalit. AANS, 1994
Safety of Perioperative "Mini-Dose" Heparin in the Prevention of Thromboembolic Phenomena in Neurosurgical Patients Operated on for the removal of Brain Tumors. Winner of the Mahaley Clinical Research Award, 1994. S.Constantini, A.Friedman, Y.Shoshan, Z.Israel, E.Ashkenazi, N.Muallem, M.Gartel, Y.Shevach, A.Even, Z.Rappaport, M.Shalit, F. Umansky. AANS, 1994
Safety and Outcome in a Phase II Clinical Trial of Dexanabinol in Severe Head Trauma. N. Knoller, L. Levi, Z. Israel, N. Razon, E. Reichenthal, Z. Rappaport, N. Ehrenfreund, A. Biegon, CNS, Seattle, October 1998
Dexananbinol Phase II Trial-Management of ICP/CPP in Severe Head Trauma Patients. N. Knoller, L. Levi, Z. Israel, N. Razon, E. Reichenthal, Z. Rappaport, A. Friedman, N. Ehrenfreund, A. Biegon CNS, Boston, 1999
Early experience with the BAK-c threaded titanium cage for cervical spine fusion. E. Ashkenazi, Z. Israel. AANS/CNS Section on Disorders of the Spine and Peripheral Nerves Annual Meeting, Orlando, Florida, 1999
Early experience with the BAK-c threaded titanium cage for cervical spine fusion. E. Ashkenazi, Z. Israel. 11th European Congress of Neurosurgery, Copenhagen, 1999
Y. Shoshan, O. Chernova, SS Jeun, RP Somerville, Z. Israel, HG Barnett, JK Cowell Radiation-induced meningioma: a distinct molecular genetic pattern. 44th Oholo conference on Blood Brain Barrier drug delivery and brain pathology. September 2000.
Is outpatient trial for Spinal Cord Stimulation more cost-effective than inpatient trial? F. Hsu, F. Limonadi, Z. Israel, K. Burchiel. CNS, San Antonio, September 2000
Imaging neurovascular compression in patients with Trigeminal Neuralgia. K. Burchiel, Z. Israel. CNS, San Antonio, September 2000
Y. Shoshan, O. Chernova, SS Jeun, RP Somerville, Z. Israel, HG Barnett, JK Cowell Molecular analysis of post-radiation meningiomas and its implications on radiation therapy for benign tumor of brain. Israel Neurosurgical Society meeting. March 2001
Neuroendocrine and other complications of intrathecal opioid therapy. Z. Israel, R. Coffey, K. Burchiel. SUN, Portland, June 2001
Deep Brain Stimulator electrode localization using frame based stereotactic imaging. F. Hsu, Z. Israel, K. Burchiel. SUN, Portland, June 2001
Shoshan Y, Weisberg S, Atia M, Israel Z, Ashkenazi E, Umansky F, Brodie C. Expression of specific PKC isoforms in Benign and malignant meningiomas. 12th World Congress of Neurosurgery of the World Federation of Neurosurgical Societies, Sept 2001.
Posters
Delayed Apoplectic Post Traumatic Intracerebral Hematoma. Z.Israel, E.Ashkenazi, S.Constantini, S.Pomeranz. Israel Neurosciences Society Annual Meeting, Eilat, 1995
Taxol induces astrocytic differentiation and apoptosis in glioma cells. Roles of MAP Kinase and JUN Kinase. E. Ashkenazi, Z. Israel, G. Kazimirsky, C. Brodie. 5th IUBMB Conference on The Biochemistry of Health and Disease, Jerusalem, 1998
Intrathecal clonidine-opiate combinations for the management of neuropathic pain I. Z. Israel, L. Jefferys, K. Burchiel. AANS, San Francisco, April 2000
Intrathecal clonidine-opiate combinations for the management of neuropathic pain II. Z. Israel, L. Jefferys, B. Cooke, K. Burchiel. Worldwide Pain Conference / Neuromodulation, San Francisco, July 2000
Intrathecal Opioids: Reasons for changing from morphine therapy (Oral Poster). Z. Israel, L. Jefferys, B. Cooke, K. Burchiel. CNS, San Antonio, September 2000
Percutaneous electrode implantation for neuropathic facial pain. Technical note. K. Slavin, F. Hsu, Z.Israel, K Burchiel. AANS, Toronto, April 2001
Cervical ganglionectomy (C2 and C3) for the treatment of occipital neuralgia (Oral Poster). J. Golshani, Z. Israel, F. Hsu, K.Burchiel, CNS, San Diego, October 2001
Clinical Trials
The use of intravenous Dexanabinol in severe Head Trauma Patients. Z. Israel - Principle Investigator, Hadassah, 1997-1999. A Multicenter National Study sponsored by Pharmos $200,000
The use of Gliadelׂ (an implanted biodegradable wafer containing BCNU) in patients with newly diagnosed Glioblastoma. Z.Israel - Principle Investigator, Hadassah, A Multicenter International Double Blind Randomized controlled study sponsored by Rhone-Poulenc Rorer. $50,000. 1998
The use of threaded titanium cages for cervical spine fusion as a new fusion system. Z. Israel - Co-Investigator, Hadassah. Single center clinical study sponsored by Sulzer Medica: Spine Tech. $60,000. 1998
Tutor for MD Thesis
Moshe Atia, Hadassah University Hospital Medical School, 1998. Characterization of specific PKC isoforms in different types of meningiomas and the role of PKC in the proliferation of meningioma cells.
Society Memberships
- Israeli Neurosurgical Society
- Israeli Society for Palliative Medicine
- Intraoperative Neurophysiology Special Interest Group (INSIG)