Head of Tissue Typing Laboratory, Bone Marrow and
Cord Blood Bank Registry
Hadassah University Hospital
Telephone: 972-2-6777801, 0508573220
Fax: 972-2-6422403
Email: israels@hadassah.org.il
Born September 1, 1950, Wroclaw, Poland
Academic Education
1970-1973: B.Sc., Biology ,Hebrew University, Jerusalem
1974-1976: M.Sc., Clinical Microbiology, Hebrew University, Jerusalem
1977-1978: Research Assistant, Hematology Dept., Hadassah Hospital, Jerusalem
1979-1983: Ph.D. Biological Chemistry, Hebrew University, Jerusalem.
1984-1985 Post-doctoral fellow, Dept. of Virology, Weizmann Institute of Science, Rehovot ,Israel.
1986-1987: Post-doctoral fellow, Dept. of Molecular Genetics, Hebrew University - Hadassah Medical School, Ein Kerem, Jerusalem.
Employment
2003: Director, Tissue Typing Laboratory and Bone Marrow/Cord Blood Bank Registry, Hadassah Medical Center
2002-2003: Acting Director, Tissue Typing Laboratory and Bone Marrow /Cord Blood Bank Registry, Hadassah Medical Center
1993-2001: Assistant director, Molecular laboratory, Tissue Typing Laboratory, Hadassah Medical Center
1988-1993: Research associate, Molecular Genetics, Hebrew University , Hadassah Medical School
Membership in Scientific Societies
· American Society for Histocompatibility and Immunogenetics.
· Israeli Transplantation Society
Research Interest
· HLA and MS
· Pathways regulated by immunomodulators
· HLA and Type1 Diabetes
· Population genetics
· Cyp21 gene mutations and 21OH deficiency in the various Israeli ethnic groups
Publications
1. Israel S, Ginsberg D., Laster Y., Zakai N., Milner Y. and Loyter A. Fusion of Sendai virus envelopes with human erythrocytes: a possible involvement of virus-associated protease. Biochem. Biophys. Acta 732:337-346, 1983.
2. Vaintstein A., Hershkowitz M., Israel S., Rabin S., and Loyter A. A new Method for reconstitution of high fusogenic Sendai virus envelopes. Biochem. Biophys. Acta 27:773(2):181-188, 1984.
3. Israel S., Haan T., Holtman H. and Wallach D. Binding of TNF-ά to high affinity cell surface receptors: effect of IFN. Immunology Letters 12:217-224, 1986.
4. Israel S., and Honigman A. A bioluminescence assay for gene expression by continuously growing mammalian cells: application for detection of human immunodeficiency virus type 1 (HIV-1). Gene 104:139-145, 1991.
5. Israel S., Mendelovitz M. and Honigman A. Transactivation of human T cell leukemia virus Type 1 by Herpes Simplex virus Type 1. Virus genes 9:269-276, 1995.
6. Nir-Paz R. Israel S., Honigman A. and Kahane I. Mycoplasmas Regulate HIV-LTR-dependent gene expression. FEMS Microbiol Letters 128:63-68, 1995.
7. Israel S., Kwon O.J., Safirman C., Miller K.., Brautbar C., Hansen J.A. and Smith A.J. Two new DR2 alleles, DR16 identified in a Jewish Ashkenazi and DRB1*15022 identified in a single Caucasian individual. Tissue Antigens 49 (2): 173-5, 1997.
8. Israel S., Kwon O.J., Weintrob N., Sprecher E., Bloch K, Assa S., Brautbar C. and Vardi P. HLA class II immunogenetics of IDDM in Yemenite Jews. Human Immunology, 59:728-733, 1998.
9. Kaushansky A., Frydman M., Assa S., Kwon O.J., Israel S., Lazard D., Bloch K., Brautbar C., Sprecher E., Vardi P. D-Penicillamine (D-PA) induced pancreatic islet autoantibodies production is independent of the immunogenetic background: a lesson from patients with Wilson’s disease. Clinical Immunology and Immunopathology, 89(3):279-283, 1998.
10. Shinar Y., Pras E., Siev-Ner I., Ganus D., Brautbar C., Israel S. and Achiron A. Analysis of allelic association between D65461 and multiple sclerosis in Ashkenazi and Iraqi Jewish patients. J. Molecular Neuroscience, 11, 265-69, 1998.
11. Kwon O.J., Karni A., Israel S., Brautbar C., Amar A., Meiner Z., Abramsky O., Karusis D. HLA class II susceptibility to multiple sclerosis among Ashkenazi and non-Ashkenazi Jews. Archives of Neurology, 56, 555-560, 1999.
12. Amar A., Brautbar C., Motro U., Fisher T., Bonne-Tamir B., Israel S. Genetic variation of three tetrameric tandem repeats in four distinct Israeli ethnic groups. J. of Forensic Science, 44, 983-986, 1999.
13. Mora B., Battat S., Grillo R., Petronzelli P., Safirman C. Israel S., Brautbar C., Mazzilli M.C. Strong linkage disequilibrium of TAP1 and TAP2 genes with the HLA-A*01-B*35-DRB1*1104-DQA1*0103-DQB1*0603 extended haplotype in Ashkenazi Jews. European J. of Immunogenetics, 26, 331-335, 1999.
14. Israel S. and Brautbar C. A molecular method for diagnosis of congenital adrenal hyperplasia. Harefua, 139, 429-433, 2000 (in Hebrew).
15. Weintrob N., Sprecher E., Israel S., Pinhas-Hamiel O., Kwon O.J., Bloch K., Abramov N., Arbel A., Josefsberg Z., Brautbar C., Vardi P. Insulin dependent diabetes mellitus environmental factors and correspondence analysis of HLA class II genes in the Yemenite Jewish community in Israel. Diabetes Care 24, 650-653, 2001.
16. Weintrob N., Brautbar C., Perzelan A., Josefsberg Z., Dickerman Z., Kauschansky A., Kilos P., Peled D., Phillip M., Israel S., Genotype-phenotype associations in non classical steroid 21-hydroxylase deficiency. European J. of Endocrinology, 143, 397-403, 2001.
17. Kwon O.J., Brautbar C., Weintrob N., Sprecher E., Saphirman C., Bloch K., Pinhas-Hamiel O., Assah S., Vardi P., Israel S. Immunogenetics of HLA class II in Israeli Ashkenazi and non Ashkenazi Jewish and Arab patients. Human Immunology, 62, 85-91, 2001.
18. Weintrob N., Israel S., Lazar L., Lilos P., Brautbar C., Phillip M. and Pertzelan A. Decreased cortisol secretion in non classical 21-hydroxylase deficiency before and during glucocorticoid therapy. Journal of Pediatric endocrinology and metabolism, 15 (7), 985-91, 2002.
19. Zung A., Elizur M., Weintrob N., Bistritzer T., Hanukoglu A., Zadik Z., Phillip M., Miller K., Koren I., Brautbar C., Israel S. Type 1 diabetes in Jewish Ethiopian Immigrants in Israel: HLA Class II immunogenetics and contribution of new environment. Human Immunology 65: 1463-1468, 2004.
20. Eitan M., Shapira MY, Resnick IB., Zilberman I., MIron S., Samuel S.,Ackerstein A., Elad S., Israel S., Amar A., Fibach E., Or R., Slavin S. Successful transplantation of haploidentically mismatched peripheral blood stem cells using CD133+ purified stem cells. Exp Hematology 33 (6): 713-8, 2005.
21. Elram T., Simon A., Israel S., Revel A., Shveiky D., Laufer N. Treatment of recurrent IVF failure and human leukocyte antigen similarity by intravenous immunoglobulin. Reprod Biomed Online 11(6):745-9, 2005.
22. Admoni O., Israel S., Lavi I., Gur M., Tenenbaum – Rakover Y. Hyperandrogenism in carriers of CYP21 mutations: the role of genotype. Clin Endocrinol (Oxf) 2006 Jun; 64(6):645-651.
23. Israel S., Weinrib L., Weintrob N., Miller K., Brautbar C. Distribution of the V281L mutation of the CYP21 gene in Israeli congenital adrenal hyperplasia patients and its association with HLA-B14. Pediatric Endocrinol Reviews, Vol. 3, suppl 3, August 2006: 447-449.
24. Brautbar C., Israel S.,, Firro K., Safirman C., Miller K., Amar A., and Witt C. Population: Arab Druse from Israel, in 13th IHWS Anthropology/Human Genetic Diversity Joint Report – Chapter 3: Population Reports. In: 2006 International Histocompatibility Working Group Press, Fred Hutchinson Cancer Research Center, Seattle, Washington USA.
25. Thomson G., Valdes A.M., Noble J.A., Kockum I., Grote M.N., Najman J., Erlich H.A., Cucca F., Pugliese A., Steenkiste A., Dorman J.S., Caillat-Zucman S., Hermann R., Ilonen J., Lambert A.P., Bingley P.J., Gillespie K.M., Lernmark A., Sanjeevi C.B., Ronningen K.S., Undlien D.E., Thorsby E., Petrone A., Buzzetti R., Koeleman B.P., Roep B.O., Saruhan-Direskeneli G., Uyar F.A., Gunoz H., Gorodezky C., Alaez. C., Boehm B.O., Mlynarski W., Ikegami H., Berrino M., Fasano M.E., Dametto E., Israel S. , Brautbar C., Santiago-Cortes A., Frazer de Llado T., She J.X., Bugawan T.L., Rotter J.I., Raffel L., Zeidler A., Leyva-Cobian F., Hawkins B.R., Chan S.H. Castano L., Pociot F. and Nerup J. Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a mega-analysis.
26. Tissue Antigens Vol. 70, 2007: 110-127.
27. Ferwerda B., McCall M.B., Alonso S., Giamarellos-Bourboulis E.J., Mouktaroudi M., Izagirre N., Syafruddin D., Kibiki G., Cristea T., Hijmans A., Hamann L., Israel S., ElGhazali G., Troye-Blomberg M., Kumpf O., Maiga B., Dolo A., Doumbo O., Hermsen C.C., Stalenhoef A.F., van Crevel R., Brunner H.G., Oh D.Y., Schumann R.R., de la Rua C., Sauerwein R., Kullberg B.J., van der Ven A.J., van der Meer J.W. and Netea M.G. TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proc Natl Acad Sci USA, Vol. 104 (42), Oct 16 2007: 16645-50.
28. Hirsch D., Narinski R., Klein T., Israel S., Singer J. Immunogenetics of HLA class II in Israeli patients with adult-onset type 1 diabetes mellitus. Hum Immunol 2007, 68 (7):616-22.
29. Gazit R., Hershko K., Ingbar A., Schlesinger M., Israel S., Brautbar C., Mandelboim O. and Leibovici V. Immunological assessment of familial linea corporis. J Eur Acad Dermatol Venereol, 2008, 22:871-874.
30. Benedek G., Brautbar C., Vardi P., Sharon N., Weintrob N., Zung A. and Israel S.
31. Effect of polymorphism in insulin locus and HLA on type 1 diabetes in four ethnic groups in Israel. Tissue Antigens, 2009, 73 (1): 33-38.
32. Asleh S.A., Lederman M., Weinstein O., Horowitz S., Meir T., Lahad A., Goldstein N., Sharon D., Israel S., and Chowers I. Lack of association between the C2 allele of transferring and age-related macular degeneration in the Israeli population. Ophthalmic Genet., 2009, 30 (4):161-4.
33. Unluhizarci K., Kula M., Dundar M, Tanriverdi F, Israel S, Colak R., Dokmetas H.S., Atmaca H., Bahceci M., Balci M.K., Comlekci A., Bilen H., Akarsu E., Erem C. and Kelestimur F. The prevalence of non-clasic adrenal hyperplasia among Turkish women with hyperandrogenism. Gynocol. Endocrinol. 2010, 26(2):139-43.
34. Benedek G., Paperna T, Avidan N., Lejbkowicz I, Oksenberg J.R., Wang J., Brautbar C., Israel S. and Miller A. Opposing effects of the HLA-DRB1*0301-DQB1*0201 haplotype on the risk for multiple sclerosis in diverse Arab populations in Israel. Genes Immun. 2010, 11(5):423-31.
35. Klitz W, Gragert L,, Maiers M., Fernandez-Vina M., Ben-Naeh Y., Benedek G., Brautbar C. and Israel S. Genetic differentiation of Jewish Populations. Tissue Antigens, 2010, 76(6):442-58.
36. Lotem M., Kadouri L., Merims S., Ospovat I., Nissan A., Ron I., Frankenburg S., Machlenkin A., Israel S., Steinberg H., Hamburger T., Peretz T. HLA-B35 correlates with a favorable outcome following adjuvant administration of an HLA-matched allogeneic melanoma vaccine. Tissue Antigens, 2011, Jun 7