Laboratory chief
Department of Dermatology and Venereology
Hadassah Medical Center, Ein-Karem,
Jerusalem.91120, Israel
e-mail: malka@Hadassah.org.il
Education
1995, Ph.D. Hebrew University Jerusalem.
1970-1973: B.Sc. degree. Bar-Ilan University, Dept. of Life Sciences. Main subject: Biochemistry
1973-1975: M.Sc. degree. Bar- Ilan University, Dpt. of Life Sciences. Main subject: Immunology,
1990-1996: Hebrew University of Jerusalem, Faculty of Medical Science. Main subject: molecular genetics.
Academic and professional Experience
1998-present: Laboratory chief, Dermatology, Hadassah Medical Center, Ein-Karem, Jerusalem. Area of research interest: Immunology and Molecular biology of the skin, Skin cancer; Skin disorders; UV induced damage; Psoriasis.
1996-1998 Post-doc. Fellowship at the molecular biology research laboratory of the Dermatology department, Hadassah Medical Center, Ein-Karem, Jerusalem.
1989-1995- Ph.D. Hebrew University Jerusalem - Hadassah Medical School. Thesis topic: "Characterization of B-lymphoma cell lines and search for somatic mutations in the immunoglobulin variable region genes", under the supervision of Prof. Reuven Laskov.
1980-1988- Research Assistant, Clinical Immunology Unit, Internal Medicine Department, Hadassah Hospital, Ein Karem, Jerusalem. Topics: a."Structure of murine genes for autoantibodies against nuclear components: DNA, RNA, and histones". b."The preparation of monoclonal antibodies for nuclear components (DNA, RNA and histones) in autoimmune mice. In parallel: clinical work using advanced immunological techniques
1976-1979- Research Assistant, Dept. of Botany, Bar Ilan University. Topic: "fungi-inhibitors in tobacco" under the supervision of Prof. Yigal Cohen.
1973-1975: M.Sc., Dept. of Life Science, Bar Ilan University. Thesis topic: "The effects of various treatments on the reactions of the hemagglutinins from Pseudomonas aeruginosa with erythrocytes", under the supervision of Prof. Nechama Gilboa-Garber.
1970-1973: B.Sc., Cum Laude , Biochemistry Dept. Life Sciences, Bar Ilan University.
Publications
1. D. Eilat, M. Hochberg, R. Fischer and R. Laskov. 1982. Antibodies to RNA from autoimmune NZB/NZW mice recognize a similar antigenic determinant and show a large idiotype diversity. Proc. Natl. Acad. Sci. USA. 79: 3818-3822.
2. R. Laskov, S. Muller, M. Hochberg, H. Giloh, M. Van Regenmortel and D. Eilat. 1984. Monoclonal autoatibodies to histones from autoimmune NZB/NZW F1 mice. Eur. J. Immunol. 14: 74-81.
3. D. Eilat, M. Hochberg, J. Pumphrey and S. Rudkloff. 1984. Monoclonal antibodies to DNA and RNA from NZB/NZW F1 mice: antigenic specificities and NH2 terminal amino acid sequences. J. Immunol. 133: 489-494.
4. D. Eilat, M. Hochberg, F. Tron, L. Jacob and J. F. Bach. 1989. The VH gene sequences of anti-DNA antibodies in two different stains of lupus-prone mice are highly related. Eur. J. Immunol. 19: 1241-1246.
5. Jaffe, J., Hochberg, M., Riss, J., Hasin, T., Reich, L. and Laskov, R. 1995: Cloning, sequencing and expression of two isoforms of the murine oct-1 transcription factor. Biochim. et Biophys. Acta, 1261: 201-209
6. Baruch, M., Hochberg, M., Gabay, C., Ben-Bassat H., Shlomai, Z. and Laskov, R. (1996): Molecular chracterization of an unusual non-Hodgkin B-lymphoma cell line ("Farage") lacking the ability to produce immunoglobulin polypeptide chains. Leukemia and lymphoma, 21: 485-495.
7. Hochberg, M., Gabay, C. and Laskov, R. (1998): Somatic mutationsin the Ig varible region genes and expression of a novel Cm-germline transcripts in a B-lymphoma cell line (“Farage”) not producing Ig polypeptide chains. Leukemia and Lymphoma, 30: 637-649.
8. Hochberg, M. And C.D. Enk (1999) Partial protection against epidermal IL-10 transcription and Langerhans cell depletion by chemical and physical sunscreens after UVB exposure of human skin. Photochem. Photobiol.,
9. Hochberg, M., Lotem, M., Gimon, Z., Shiloni, E., Enk, CD. (2002): Expression of tyrosinase, MIA and MART-1 in sentinel lymph nodes with malignant melanoma. Br. J. Dermatol. 146: 244-249.
10. Enk CD, Hochberg M, Torres A, Lev O, Srebnik M, Dembitsky VM. Photoprotection by Chicorium endivia extracts: Prevention of UVB-induced erythema, pyrimidine dimer formation and IL-6. Skin Pharmacol Physiol 2004, 17: 42-48.
11. C. D. Enk, K. Gardlo, M. Hochberg, A. Ingber and T. Ruzicka (2003) [Cutaneous leishmaniasis]. Hautarzt, 54, 506-512.
12. Torres A, Hochberg M, Pergament I., Smoum R., Niddam V, Dembitsky VM, Temina M, Dor I, Lev O, Srebnik M and Enk C.D.: A new UV-B absorbing mycosporine, with photo protective activity from the lichenized ascomycete Collema crisatum. Eur. J. Biochem. 271: 780-784 (2004).
13. C. D. Enk, I. Shahar, N. Amariglio, G. Rechavi, N. Kaminski and M. Hochberg (2004) Gene expression profiling of in vivo UVB-irradiated human epidermis. Photodermatol.Photoimmunol.Photomed., 20, 129-137.
14. C.D. Enk, M. Lotem, Z. Gimon and M. Hochberg (2004) Molecular detection of MART-1, tyrosinase and MIA in peripheral blood, lymph nodes and metastatic sites of stage III/IV melanoma patients. Melanoma Res. Oct;14(5):361-5.
15. Enk CD, Jacob-Hirsch J, Gal H, Amariglio N, Ingber A, Givol D, Rechavi G, Hochberg M. The UVB induced gene expression profile of human epidermis in vivo is different from that of cultured keratinocytes. Oncogene 2006, 1-14.
16. Torres A., Enk CD, Hochberg M. And Srebnik M. Porphyra-334, a Potential Natural Source for UVA Protective Sunscreens. Photochem. Photobiol. Sci., 2006, 5: 432-435.
17. Hochberg M, Kohen R, Enk CD. Role of antioxidants in prevention of pyrimidine dimer formation in UVB irradiated human HaCaT keratinocytes. Biomed Pharmacother. Biomedicine & pharmacotherapy 60 (2006): 233-237.
18. Hochberg M, Zeligson S, Amariglio N, Rachavi G, Ingber A, Enk CD. Genomic-scale analysis of psoriatic skin reveals differentially expressed IGFBP7 after phototherapy. British Journal of Dermatology 2007 156, pp289–300.
19. Leibovici V., HershkoK., Ingber A., Westerman M., Leviatan N. and Hochberg M. Increased Prevalence of Onychomycosis among psoriasis patients in Israel. Acta Derm. Venerol 88(1) (2007) 31-3.
20. V. Leibovici, R. Alkalay, K. Hershko, A. Ingber, M.Westerman, N. Leviatan-Strauss and M. Hochberg: Prevalence of Candida on the tongue and interiginous areas of psoriatic and atopic dermatitis patients. Mycoses 51 (2008) 63-66.
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