Updated Nov. 2010
Head, Laboratory of Radiobiology and Biotechnology.
Sharett Institute of Oncology
Hadassah Hebrew University Medical Center
Jerusalem 91120, Israel
Academic affiliation
Assoc. Professor, Hebrew University, Faculty of Medicine
Other affiliations
Founder and Chief Scientist, Hapto Biotech Israel (A subdivision of Forticell Bioscience NY)
Present position
Head of Laboratory for Biotechnology and Experimental Radiobiology; in the Cancer Research Laboratories of the Sharett Institute of Oncology.
Main Scientific Interests
1. Fibrin based technologies for adult stem cells isolation expansion and implantation
2. Tissue regeneration by cell implants
3. Fibrin-related family of new cell binding and penetrating peptides (Haptides) to coat matrices and for enhancing penetration and transfection of drugs, materials, liposomes and viruses into cells. Studies on mechanism of action and applications
4. Effect of Haptides and fibrin degradation products on the cardiovascular system
5. Bioengineering: Assembly of devices to non-invasively measure the physical properties of the skin
Education
1985-1988 Post Doctoral Program and Research Associate in Radiobiological Sciences, UCLA Medical Center, Laboratories of Experimental Radiation Oncology. Supervisor: H. Rodney Withers, M.D., D.Sc.,
1980-1985 Ph.D. (Experimental Medicine and Cancer Research) Hadassah Medical School and Institute of Life Sciences, Hebrew University Jerusalem: Dissertation: "Correlation of trace elements content in blood fractions with metastatic spread in malignant diseases" Supervisors: Z. Fuks, M.D., H. Ginsburg, Ph.D.
1974-1979 M.Sc., (Physiology and Neurobiology), with distinction, Hebrew University Jerusalem. Thesis:" In-vivo analysis of the dissolution of intra-ocular copper foreign bodies; comparison with electroretinography and ophthalmoscopy. Supervisors: A. Weinreb, Ph.D., (Physics) and U. Inon, Ph.D., (Neurobiology).
1971-1974 B.Sc. (Biology), Hebrew University, Jerusalem.
Previous positions
1985-1988: Research Associate: Experimental Radiation Oncology, Dept. of Radiation Oncology, University of California Los-Angeles (UCLA), Medical Center. Studies on normal tissue radiobiology: Evaluation of late effects of radiation on the skin as expressed by impaired wound healing.
1979-1985: Researcher in the Sharett Institute of Oncology, Hadassah University Hospital in collaboration with Racah Institute of Physics, The Hebrew University, Jerusalem, Israel. Set-up of a clinical DXS Laboratory for non-invasive trace elements analysis . Main projects: Assembly of a diagnostic first prototype of the Diagnostic X-ray Spectrometry (DXS) for the non-invasive evaluation of trace elements in external tissues. Research on the variation of trace elements in various clinical conditions. Studies on protoporphyrins in erythrocytes in metastatic carcinomas and other malignancies.
1974-1978: Research Associate, Medical Physics Group, Racah Institute of Physics, The Hebrew University, Jerusalem. Main Project: Development of new non-invasive technique for the evaluation of transition metals in eyes harboring intraocular foreign bodies.
Honors and Prizes
1980,1982,1992 - 3 Faculty prizes for distinctive research at different stages of the career The faculty of Medicine, Hebrew University - Hadassah Medical School, Jerusalem.
1994 - Tchorsh Prize for distinctive cancer research at Hadassah University hospital.
1995-2008: Recent Research Support Grants Include:
· Israel Cancer association- 2 years
· Israeli academy of sciences (ISF) - 6 years,
· NJ Institute for Molecular Biology – 1year
· German Israeli Foundation (GIF) Co-PI for 3 years
· NIH-BARDA co-PI with NcBride UCLA for 1.5 years
· Bereshith, National Consortium for Cell Therapy 3 years
Memberships in major Societies
1. International Society Stem Cells Research (ISSCR)
2. Radiation Research Society (RRS)
3. Israel Stem Cells Society (ISCS)
4. European Tissue repair Society (ETRS)
5. Society of Investigative Dermatology (SID)
6. Israeli Society of Hematology (ISH)
Biotechnology- Main Activities
2000-2008 Co-Founder of Hapto Biotech, a Fibrin based tissue regeneration company, through Hadasit, Hadassah's technology transfer company. Chief Scientist of the company since it's establishment.
1995-1999 Head of the team and co-inventor of Viscoelastic Skin Analyzer (VESA) through Hadasit, Hadassah's technology transfer company
1975-1979 Co-inventor of the DXS, Diagnostic-X-ray spectrometry for non-invasive trace elements analysis in-vivo.
PUBLICATIONS (Since 2000)
56. Richter, E., El-Sharif, N., Fischbein, A., Konijn, A., Gorodetsky, R., El-Sharif, H., Kaul, B., Hershko, C., Grauer, F., Foner, H., Al-Baba, A., Dweik, Z., Lihsounat, M. Re-emergence of lead poisoning from contaminated flour in a west bank Palestinian village Int J Occup Environ Health. 2000 Jul;6(3):183-6.
57. Gorodetsky, R., Vexler, A., An, J., Levdansky, L., Clark, RAF. and Marx, G. Fibrin microbeads (FMB) as biodegradable carriers for culturing cells and for accelerating wound healing. Jourmal des Plais et Cicatrisations, 26: 15-21, 2001.
58. Gurevitz, O., Vexler, A., Marx, G., Bar-Shavit, Z., Prigozhina, T., Levdansky, L., Slavin, S., and Gorodetsky, R. Fibrin microbeads for isolating and growing bone marrow-derived progenitor cells capable of forming bone tissue. Tissue Engineering, 8: 661-672, 2002.
59. Zangi,L, Levdansky,L, Marx,G, Gorodetsky, R: Isolation with fibrin microbeads of bone marrow-derived pluripotent cell lines. Cell Transplantation 12:193-194, 2003
60. Gorodetsky R., Vexler A., Shamir M., An J., Levdansky L., Shimeliovich I., Marx G. New cell attachment peptide sequences from conserved epitopes in the carboxy termini of fibrinogen. Exper. Cell Res. 2003; 287, 116-129.
61. Marx G, Ben-Moshe M, Magdassi S, and Gorodetsky R, Fibrinogen C-terminal peptidic sequences (Haptides) modulate fibrin polymerization. Thromb Haemost. 91:43-51, 2004.
62. Gorodetsky R, Levdansky L, Vexler A, Shimeliovich I, Kassis I, Ben-Moshe M, Magdassi S, Marx G. Liposome transduction into cells enhanced by haptotactic peptides (Haptides) homologous to fibrinogen C-chain termini. J Controlled Release 95 477-488, 2004.
63. Gorodetsky R. , Peilin-Ramu N., Reshef A., Gaberman E. and Marx G. Interactions of carboplatin with fibrin sealant for slow-release, local chemotherapy J Controlled Release, 102 235–245, 2005.
64. Shimony N., Gorodetsky R., Marx G., Rivkin R., Ben-Ari A., Landsman A. and Haviv HS. (2006) Fibrin Microbeads (FMB) as a 3-D Platform for Kidney Gene and Cell Therapy. Kidney International, 69:635-633.
65. Kassis I., Zangi L., Rivkin R., Samuel S., Levdansky L., Marx G. and Gorodetsky R. (2006). Isolation of mesenchymal stem cells from G-CSF-mobilized human peripheral blood using fibrin Microbeads (FMB). Bone Marrow Transp. 37:967-976
66. Zangi L., Rivkin R., Kassis I., Levdansky L., Marx G., Gorodetsky R (2006). High yield isolation, expansion and differentiation of rat bone-marrow-derived mesenchymal stem-cells with fibrin-microbeads (FMB) Tissue Engineering. 12: 2343-54
67. Nagler A., Ohana M., Leiba M., Levdansky L. and Gorodetsky R. Effect of halofuginone, a collagen a1(I) inhibitor, on wound healing in normal and irradiated skin., Acta Haematol 118:77-83, 2007
68. Marx G, Hotovely-Salomon A., Levdansky L., Gaberman E., Adler .T , Shimeliovich I., Snir G., Zivner I., Klauzner Y., Silberklang M., Lesnoy D and Gorodetsky R. Haptide-coated collagen sponge as a bioactive matrix for tissue regeneration., J. Biomed. Materials Res. Part B: Applied biomaterials 84:571-83, 2008.
69. Marx G, Mou X., Hotovely-Salomon A., Levdansky L., Gaberman E, and Gorodetsky R. Heat denaturation of fibrinogen to develop a biomedical matrix.. J Biomed Mater Res Part B: Appl Biomater B, 84: 49–57, 2008.
70. Rivkin R., Ben-Ari A, Kassis I., Gaberman E., Levdansky L., Hotovely Salomon A, Marx G., Gorodetsky R. Isolation, Expansion and Differentiation of Murine BM-Derived Mesenchymal Stem Cells Using Fibrin Microbeads (FMB). Cloning and Stem Cells 9: 157-75, 2007
71. Frankenburg S., Grinberg I., , Bazak Z, Fingerut L., Pitcovski J., Gorodetsky R., Peretz T, Spira R.M, Skornik Y, Goldstein RS. Immunological activation following transcutaneous delivery of HR-gp100 protein. Vaccine 25: 4564-70, 2007.
72. Machlenkin, A., Uzana, R., Frankenburg S, Eisenberg G, Eisenbach L, Pitcovski J, Gorodetsky R, Nissan A, Peretz T, Lotem M.Capture of tumor cell membranes by trogocytosis facilitates detection and isolation of tumor-specific functional CTLs. Cancer Res 68:2006-13, 2008
73. Shimony N., Avrahami I., Gorodetsky R., Elkin G., Tzukert K., Zangi L., Levdansky L., Krasny L. and Haviv Y.S. A 3D rotary renal and mesenchymal stem cell culture model unveils cell death mechanisms induced by matrix deficiency and low shear stress. Nephrol Dial Transplant, Nephrol Dial Transplant. 23:2071-2080, 2008.
74. Ben-Ari A., Rivkin R., Frishman M., Gaberman E, Levdansky L and Gorodetsky R. Isolation and implanting of bone marrow derived mesenchymal stem cells with fibrin micro beads (FMB) to repair a critical size bone defect in mice. Tissue Engineering 15:2537-2546, 2009).
75. Gorodetsky, R. The use of fibrin based matrices and fibrin microbeads (FMB) and for cell based tissue regeneration (Invited Review). Expert Opinion on Biological Therapy, 8,1831-1846,2008.
76. Tzukert K., Gorodetsky R., Avrahami I, Krasny L. Shimony N., Elkin G. Nettelbeck D. M., Haviv Y. S. A novel dynamic matrix detachment model reveals a shift from apoptosis to necrosis in melanoma cells. Cancer Letters 272: 345–354 (2008).
77. Gorodetsky, R., Fibrin-based matrix for stem cell isolation and as a basis for new technologies for tissue regeneration. Composite Interfaces 15,799–805 (2008).
78. Tzukert K., Shimony N., Krasny L., Urieli-Shoval S. Gorodetsky R. Avrahami I. Nettelbeck D.M. and Haviv Y.S. Human melanoma cells expressing the avb3 integrin are partially protected from necrotic cell death induced by dynamic matrix detachment. Cancer Letters early publ. (2009)
79. R Schäfer, M Dominici, I Müller, E Horwitz, T Asahara, JWM Bulte, K Bieback,K Le Blanc, HJ Bühring, MC Capogrossi, F Dazzi, R Gorodetsky, R Henschler, R Handgretinger, J Kajstura, PJ Kluger, C Lange,I von Luettichau,H Mertsching, H Schrezenmeier, KD Sievert, D Strunk, C Verfaillie, H Northoff. Basic research and clinical applications of non-hematopoietic stem cells. Cytotherapy, 16, 1-11 (2009).
80. Krasny L, Shimony N, Tzukert K, Gorodetsky R, Lecht S, Nettelbeck DM, Haviv YS. An in-vitro tumour microenvironment model using adhesion to type I collagen reveals Akt-dependent radiation resistance in renal cancer cells. Nephrol Dial Transplant. 82,:373-380, 2010.
81. Bahseer M, Schwalb H., Gilon D., Doviner V, Sherman Y , Shapira OM and Gorodetsky R. Short homologous peptides based on C-termini sequences of fibrinogen β and γ chains (Haptides) affect cardiovascular function by eNOS inhibition. J Vasc Resarch 47:507-518 (2009).
82. Bahseer M., Schwalb H, Nesher M., Gilon D., Shefler I. Mekori YA, Shapira OM and R. Gorodetsky. Mast cells activation by fibrinogen related homologous c-terminal peptides (haptides) modulate systemic blood pressure. J. Allergy & clin immunol (JACI), 126:1041-1048, 2010.
83. Shainer R, Gaberman E., Levdansky L., Gorodetsky R.: Efficient Isolation and chondrogenic Differentiation of Adult Mesenchymal Stem Cells with Fibrin Microbeads & Micronized Collagen Sponges. Regen. Med. 5, 255-65, 2010.
84. Shahar E, Gorodetsky R, Aizenshtein E and Pitcovski J. Targeted microbeads for attraction and induction of specific innate immune response in the tumor microenvironment. J. Vaccine 28 (2010) 7279–7287, 2010
85. Levy-Beladev L, Marx G., Levdansky L, Gaberman E, Benyamini H., Friedler A. & Gorodetsky R. A new family of cell adhesion peptides homologous to fibrinogen c-terminals. Biochemical and Biophysical Research Communications, 401: 124–130, 2010.
86. Gefen T., Pitcovski J, Jacob Vaya J, Soliman Khatib S, Dan-Heller E., Gaberman E, Gorodetsky R, Aizenshtein E. Coated cross-species antibodies by mannosamine-biotin adduct confer protection against snake venom without eliciting humoral immune response J. Vaccine, (49):6869-76, 2010.
87. R.Gorodetsky, E. Lubzens, E. Gaberman, L. Levdansky & W.H. McBride: Fibrin microbeads (FMB) loaded with mesenchymal cells support their long term survival while sealed at room temperature. Submitted, Tissue Engineering, 2010
Chapter in Books
88. Gorodetsky, R. and Withers, H.R. Assay of late radiation damage in mouse skin as expressed by wound healing. in: "Frontiers in Radiation Biology". Editor: E. Riklis. VCH and Balaban Publishers, pp 125-131 (1990).
89. Gorodetsky, R., Vexler, A. and Marx, G. Fibrin Microbeads (FMB) for wound healing and tissue engineering of skin. In Cultured Human Keratinocytes and Tissue Engineered Skin Substitutes, RE Horch, MunsterAM & Achauer BM Editors, Georg Thieme Verlag, 2001
90. Gorodetsky, R. A sensitive non-invasive analysis of trace elements in external tissues in clinical practice. In: "Trace Elements in Man and Animals", Editors: Anke M., D. Meissner C.F. Mills. Verlag Media Touristik Publishers., Germany, pp 75-80 (1993).
91. Gorodetsky, R., Vexler, A, Levdansky L. and Marx G.: Fibrin Microbeads (FMB) as biodegradable carriers for culturing cells and for accelerating wound healing. In Biopolymer Methods in Tissue Engineering, Editors A. Hollander and P. Hatton, p.11-23. Humana Press, 2004
92. Gorodetsky, R. Promises and limitations in the application of cell therapy for tissue regeneration, Chapter 1 and Introduction, in Stem Cell Based Tissue Repair, Royal Society of Chemistry, (RSC) Publishing, Thomas Graham House, Cambridge, United Kingdom, in press, 2010
93. Gorodetsky, R., Iris Mironi-Harpaz, and Dror Seliktar. Fibrin based matrices to support stem cells based tissue regeneration. Chapter 8 in Stem Cell Based Tissue Repair, Royal Society of Chemistry, (RSC) Publishing, Thomas Graham House, Cambridge, United Kingdom, in press, 2010
Book Authorship
R. Gorodetsky & R. Schaefer, editors: Stem Cell Based Tissue Repair, Royal Society of Chemistry (RSC) Publishing, Thomas Graham House, Cambridge, United Kingdom, in press, 2010
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