Director, Mother and Child Anesthesia Center
Department of Anesthesiology and Critical Care Medicine
Hadassah Hebrew University Medical Center
Jerusalem, Israel
Tel: +972-2-6777111
Fax: +972-2-6434434
Email: yginosar@netvision.net.il
Undergraduate Education
1980-1982: Preclinical medical studies, King’s College, University of London.
1983: BSc (Neuroscience), King’s College and University College, University of London.
1983-1986: Clinical medical studies, King’s College Hospital, University of London.
Degrees, Licenses and Certification
1983: BSc (Hons) in Neuroscience, University of London
1986: MBBS University of London
1988: MD (Israel conversion examination)
1993: Board Certification in Anesthesiology, Scientific Council of Israel Medical Association
Postgraduate Training
1989 – 1993 Residency in Anesthesiology, Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
1992 - 1993: Chief Resident, Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
1993 to present: Senior Anesthesiologist, Staff Member, Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Sub-specialty Fellowship Training and Visiting Professorships
1999-2001: Research Fellow in Obstetric Anesthesia and Visiting Assistant Professor (with clinical work in Obstetric and Pediatric Anesthesia), Department of Anesthesiology, Lucille Packard Children's Hospital and Stanford University Medical Center, Stanford, California.
Dec 2000: Visiting Professor, Dept. of Anesthesiology, New York University Medical School, NY
April 2006: Visiting Professor, Dept of Anesthesia, University of Michigan School of Medicine, MI
July-Dec 2008: Honorary Consultant (Paediatric Anaesthesia), Departments of Anaesthetics, King's College Hospital NHS Trust & Evelina Children's Hospital, Guy's & St Thomas' Trust, London.
Dec 2008: Observer at Department of Anaesthetics, Great Ormond Street Hospital for Sick Children, NHS Trust, Institute of Child Health, London.
May 2009: Visiting Professor, Dept of Anesthesia, University of Michigan School of Medicine, MI
Clinical Appointments
1996 -2007:Acting Director, Obstetric Anesthesia Unit, Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
2008 - present: Director, Center for Mother and Child Anesthesia, Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Academic Appointments
1992 -1996:Instructor in Anesthesiology and Critical Care Medicine, Hebrew University-Hadassah School of Medicine
2002 - 2009: Lecturer in Anesthesiology and Critical Care Medicine, Hebrew University-Hadassah School of Medicine
Professional Affiliations and Other Major Administrative Responsibilities
1989: Israel Medical Association
1989: Israel Society of Anesthesiologists
1997: Scientific committee: 4th Annual meeting of European Society of Obstetric Anesthesia: Herzlia, Israel.
1998: Society of Obstetric Anesthesia and Perinatology
1999: 18th International Congress of the Israel Society of Anesthesiologists: Haifa, Israel: Coordinator of Obstetric Anesthesia Program
1999 - present: Examiner, Board Examinations in Anesthesia (Scientific Council, Israel Medical Association).
2002-2005; 2005-2008: Chairman, Israel Association of Obstetric Anesthesia.
2004: Conference Chairman, 1st Joint Israel Conference on Obstetric Anesthesia and Perinatology (3 day International meeting with Israel Society of Maternal Fetal Medicine and Israel Society of Anesthesiologists): Critical Care in Obstetrics.
2005: 20th International Congress of the Israel Society of Anesthesiologists: Tel Aviv, Israel: Coordinator of Obstetric Anesthesia Program.
2006: Israel Association of Pain, Annual Meeting: Jerusalem, Israel: Coordinator of Obstetric Anesthesia Program.
2007: Member, Ministry of Health Steering Committee for National Quality and Safety Assessment of Labor and Delivery Units .
2008: 21st International Congress of the Israel Society of Anesthesiologists: Tel Aviv, Israel: Coordinator of Obstetric Anesthesia Program.
Teaching Activities
1996 - 2008: Course organizer, 5th year Medical Student Teaching Program in Anesthesia, Hebrew University-Hadassah School of Medicine
1997 - 1999: Course organizer, Resident Teaching Program in Anesthesia, Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
2003 - current:: Chief author: National Curriculum for Medical Students: Anesthesiology, Critical Care and Pain.
2003 - 2005: Originator and course organizer: Biostatistics and Epidemiology for Clinical Researchers (course joint with the School of Public Health and the Computer Authority, later overtaken by course in Good Clinical Practice).
Academic and Clinical Administrative Activity
1997 - 1999: Member, Residency Committee, Hadassah Hebrew University Medical Center, Jerusalem, Israel
1997 - 1998:Member, Clinical Skills Sub-committee, Curriculum Committee, Hebrew University - Hadassah School of Medicine
2005 - present: Member, Admissions Committee, Hebrew University-Hadassah School of Medicine
2005 - 2006: Member of Committee to Change the Criteria for Admission to Medical School, Hebrew University-Hadassah School of Medicine
Teaching Awards
1999, 2002, 2003, 2004, 2005, 2006, 2007, 2008 (nb: 2000-2001 abroad): Dean’s list of outstanding undergraduate teachers, Hebrew University-Hadassah School of Medicine
2007: Faculty Prize / Prof Lipman Halpern Award: Outstanding Teacher in the Faculty of Medicine, Hebrew University-Hadassah School of Medicine
Research awards
2001: 1st prize, Anesthesia Department Research Award, Stanford University Medical School.
2003: Clinical Scholar Research Award for 2003, International Anesthesia Research Society
2004: 1st Prize, Best Research Award, Society of Obstetric Anesthesia and Perinatology.
2008: 1st Prize, Best Research Award, Israel Society of Anesthesiologists,
Research grants
1999-2000: Departmental Grant, Department of Anesthesia, Stanford University. Analgesic potency and sympathectomy: a dose ranging study comparing intrathecal clonidine and bupivacaine in healthy volunteers. (PI: Angst MS)
2000-2001: Departmental Grant, Department of Anesthesia, Stanford University. Pharmacodynamics of epidural fentanyl in healthy volunteers: a predominantly spinal or supraspinal mechanism of action is dependent upon the mode of drug administration. (PI: Angst MS)
2002:-2003: European Society of Anesthesiologists Research Grants Program. Spinal cord protection from aortic occlusion-related ischemia in the rabbit in a new model of subarachnoid cannulation. (PI: Drenger B)
2002-2003: “Sal Klita” bridging grant for clinical investigators, Hadassah-Hebrew University Medical Center. Acute opioid tolerance and withdrawal in human subjects: the effect of gender and mode of drug administration. (PI: Ginosar Y)
2002-2003: Womens Health Research Fund, Hadassah Womens Organization. Antepartum chronic epidural therapy (ACET) versus nifedipine versus placebo for pre-eclampsia and intrauterine growth retardation: a randomized controlled trial. (PI: Ginosar Y).
2003-2005: Clinical Scholar Research Award for 2003: International Anesthesia Research Society. Antepartum chronic epidural therapy (ACET) for pre-eclampsia and intrauterine growth retardation: dose-finding study and randomized clinical trial.. (PI: Ginosar Y).
2006-2007: Industry grant, Bioline Rx.. A randomized, double blind, single center, 5-way cross-over study to assess the effect of adding oral phenylephrine and oral sorbitol to low dose (1.5mg) plain oral morphine in human volunteers: analgesia and side effect assessment. (co-PI: Ginosar Y, Davidson E).
2008-2009: Departmental Grant, Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University Medical Center. Investigating the novel observation of right-left difference in uterine artery vascular resistance in pre-eclampsia: A double-blinded, randomized, placebo-controlled study to assess the dose-dependent effect of epidural lidocaine on right-left uterine artery blood flow differences in pre-eclampsia, with healthy term pregnant and non-pregnant controls. (PI: Ginosar Y).
Supervision of Medical Students MD thesis:
2006: Aron Brody, Hebrew University-Hadassah Medical School: "A randomized, double-blinded, single-center, 5-way cross-over study to assess the effect of adding oral phenylephrine and sorbitol to low dose (1mg) plain oral morphine in human volunteers."
2007: rene Hoogeveen, University of Utrecht Medical School, The Netherlands: "A prospective randomized comparison of fentanyl, methadone and morphine for post-operative epidural analgesia".
2007: Oshrit Bart:, Hebrew University-Hadassah Medical School: "GASER: General anesthesia for Cesarean section in Emergencies. A Prospective study of factors determining choice of anesthesia."
2008: Alejandro Levin, Hebrew University-Hadassah Medical School: "Investigating the novel observation of right-left difference in uterine artery vascular resistance in pre-eclampsia: A double-blinded, randomized, placebo-controlled study to assess the dose-dependent effect of epidural lidocaine on right-left uterine artery blood flow differences in pre-eclampsia, with healthy term pregnant and non-pregnant controls."
Supervision of Anesthesia Resident thesis
1998: Dr. Weineger, Department of Anesthesiology, Hadassah: “Patient controlled epidural analgesia for nulliparous labor: the effects of bupivacaine concentration on analgesic requirements and labor outcome.” This study won 3rd Prize in the Gertie Marx Research Competition at the Society of Obstetric Anesthesia and Perinatology, Denver, USA, 1999, and 1st prize in the Israel Society of Anesthesiologists resident research competition, 1999.
1999: Dr Kurtz, Department of Anesthesiology, Hadassah: “Epidural bupivacaine and sympathectomy: the effect of drug volume and concentration on photoplethysmographic waveform analysis.”
2005: Dr Chirov, Department of Anesthesiology, Hadassah: "A118G genetic polymorphism for the spinal cord mu-opioid receptor: variable response to intrathecal fentanyl in labor."
2007: Dr Yagmour, Department of Anesthesiology, Hadassah: "A prospective randomized comparison of fentanyl, methadone and morphine for post-operative epidural analgesia."
Courses taught
1990 - present: Anesthesia and Critical Care: 5th year medical students
2003 - present: Obstetrics and Gynecology: 5th year medical students
Course organizer
1996 - 2008: Anesthesia and Critical Care: 5th year medical students
For Full List of Publications please see PubMed
Selected recent publications (past five years)
Ginosar Y, Riley ET, Angst MS . The site of action of epidural fentanyl in humans: the difference between infusion and bolus administration. Anesth Analg; 2003; 97:1428-38.
Ginosar Y, Columb MO, Cohen SE, Mirikatani E, Tingle MS, Ratner EF, Angst MS, Riley ET. The site of action of epidural fentanyl infusions in the presence of local anesthetics: a minimum local analgesic concentration infusion study in nulliparous labor. Anesth Analg; 2003; 97:1439-45
Ginosar Y, Mirikatani E, Drover DR, Cohen SE, Riley ET. ED50 and ED95 of intrathecal hyperbaric bupivacaine coadministered with opioids for cesarean delivery. Anesthesiology; 2004; 100: 76-82.
Carvalho B, Durbin M, Drover DR, Cohen SE, Ginosar Y, Riley ET. The ED50 and ED95 of intrathecal isobaric bupivacaine with opioids for cesarean delivery. Anesthesiology; 2005; 103: 606-612.
Weiniger CF, Elram T, Ginosar Y, Mankuta D, Weissman C, Ezra Y. Anaesthetic management of placenta accreta: use of a pre-operative high and low suspicion classification. Anaesthesia; 2005; 60: 1079-84
Eid L, Ginosar Y, Elchalal U, Pollak A, Weiniger CF. Caesarean section following the Fontan procedure: two different deliveries and different anaesthetic choices in the same patient. Anaesthesia 2005; 60: 1137-40.
Ginosar Y, Halpern SH, Russell IF: Is general anesthesia more risky for Cesarean section?
In: Evidence Based Medicine in Obstetric Anesthesia. Edited by Halpern S and Douglas J, Blackwell Publication. 2005
Weiniger CF, Wand S, Nadjari M, Elchalal U, Mankuta D, Ginosar Y, Matot I. Post-void residual volume in labor: a prospective study comparing parturients with and without epidural analgesia. Acta Anaesthesiol Scand; 2006; 50(10):1297-303.
Weiniger CF, Ginosar Y, Elchalal U, Sharon E, Nokrian M, Ezra Y. External cephalic version for breech presentation with or without spinal analgesia in nulliparous women at term: a randomized controlled trial. Obstet Gynecol. 2007;110(6):1343-50.
Davidson EM, Sklar EM, Ginosar Y, Abdi S, Bhatia RG, Garcia L, Hulen RB, Arheart KL, Birnbach DJ. Evaluation of magnetic resonance imaging following neuraxial steroid administration: does epidural injection produce pathologic findings? Reg Anesth Pain Med. 2008; 33(4):326-31.
Ginosar Y, Weiniger CF, Elchalal U, Davidson EM. Emergency Cesarean delivery for umbilical cord prolapse: the head-down, knee-chest prone position for spinal anesthesia.. Canadian Journal of Anesthesia. 2008; 55: 612-615
Davidson E, Sklar E, Bahatia R, Garcia L, Ginosar Y, Arheart K, Birnbach D. MRI findings following uneventful continuous infusion neuraxial analgesia. A prospective study to determine whether epidural infusion produces pathologic MRI findings. Anesth Analg 2008; In press.
Tutenhauer A, Schapira S, Ginosar Y: Obstetric Anesthesia. In: "Pregnancy, Birth and the Parturient
Edited by Elchalal U and Shenker J: 2009; In press
Y Ginosar, EM Davidson, N Firman, HJ Lemmens, CF Weiniger. Analgesia requirement and maternal satisfaction following epidural PCA in nulliparous labor: the effect of a four-fold change in local anesthetic concentration. Int J Obstet Anesth. 2009; In press.
Y Ginosar, M Nadjari, A Hoffman, N Firman, EM Davidson, CF Weiniger, C Weissman, U Elchalal and the ACET study group. Antepartum continuous epidural ropivacaine therapy reduces uterine artery vascular resistance in preeclampsia: a randomised controlled trial. British Journal of Anaesthesia 2009; 102: 369-78
Y Ginosar, CF Weiniger, V Kurz, A Babchenko, M Nitzan, EM Davidson: (2009) Sympathectomy-mediated vasodilatation and differential sensory block after epidural bupivacaine: a randomized concentration ranging study. Canadian Journal of Anesthesia 2009; In press.
Y Ginosar, CF Weiniger, Y Meroz, V Kurz, T Bdolach-Abram, A Babchenko, M Nitzan, EM Davidson: (2009) Sympathectomy-mediated vasodilatation and differential sensory block after epidural bupivacaine: a randomized concentration ranging study. Acta Anaesthesiologica Scandinavica 2009; In press.
Invited Lectures
Cardiac and respiratory physiology: Annual National Refresher Course for Anesthesiology Residents; Israel. May 1996 and May 1997
Routines of epidural analgesia in labor: 4th Annual meeting of the European Society of Obstetric Anesthesia, Herzlia, Israel. November 1997
Tailoring the epidural technique to the different stages of labor. 18th International Congress of the Israel Society of Anesthesiologists: Haifa, Israel. June 1999
Trauma in Pregnancy. 12th World Congress of Anesthesiology, Montreal, Canada. May 2000
Triage in a field hospital in the Rwandan cholera epidemic: 12th World Congress of Anesthesiology, Montreal, Canada. May 2000
Trauma in Pregnancy: Visiting Professor, Department of Anesthesiology, New York University Medical School, December 2000
General anesthesia versus regional anesthesia for Cesarean section in the high risk parturient:: 19th International Congress, Israel Society of Anesthesiologists: Tel Aviv, November 2002.
Research hour: Does epidural fentanyl really work by a spinal mechanism? Society of Obstetric Anesthesia and Perinatology, Hilton Head, USA. 2002
Doctor, why can't I move my leg after yesterday's epidural? Israel Association of Obstetric Anesthesia, January 2003
Do lipophilic opioids really work by a spinal mechanism? Israel Association of Obstetric Anesthesia, May 2003
Fetal bradycardia after epidural analgesia for labor. Israel Society of Maternal-Fetal Medicine, Tel Aviv, June 2003.
Antepartum Chronic Epidural Therapy (ACET) for Pre-Eclampsia and Intrauterine Growth Retardation: Dose Finding Study and Randomized Clinical Trial. IARS 78th Congress, April 2004, Tampa, Florida.
Minidose spinal local anesthetics for Cesarean section anesthesia. Israel Association of Obstetric Anesthesia, May 2005
Does epidural fentanyl really work by a spinal mechanism? 20th International Congress of the Israel Society of Anesthesiologists: Tel Aviv, Israel. November 2005.
Antepartum Chronic Epidural Therapy (ACET) for Pre-Eclampsia and Intrauterine Growth Retardation. 20th International Congress of the Israel Society of Anesthesiologists: Tel Aviv, Israel. November 2005.
Anesthesia for pre-eclampsia. Visiting Professor, Department of Anesthesia, University of Michigam School of Medicine, April 2006
Quality and safety in obstetric anesthesia and analgesia. Israel Association of Obstetric Anesthesia, May 2006.
Labor pain as a clinical model for research into acute pain. Annual Meeting of the Israel Association of Pain, Jerusalem, Israel, November 2006.
Penylephrine and co-hydration: what's new in the prevention of hypotension following spinal anesthesia for Cesarean section. Annual Meeting of the Israel Society of Anesthesiologists, Tel Aviv, Israel, 2006.
Cardiorespiratory arrest after labor epidural analgesia: safety first. Israel Association of Obstetric Anesthesia, May 2007
Regional anesthesia and analgesia in parturients with previous spine surgery. Israel Society of Maternal-Fetal Medicine, Tel Aviv, June 2007.
Maternal mortality: Israel Association of Obstetric Anesthesia, February 2008
Regional Analgesia for Labor: 1st Joint Conference on Obstetric Anesthesia for Israeli and Palestinian Physicians, Israel Association of Obstetric Anesthesia and the Peres Center for Peace, Tel Aviv, February 2009
Anesthesia and the Fetus as a Patient: Joint Romanian-Israel Symposium on Anesthesia and Intensive Care, Bucharest, April 2009
Anesthesia and Pre-eclampsia: Updates: Joint Romanian-Israel Symposium on Anesthesia and Intensive Care, Bucharest, April 2009
Breakfast with the Experts: Society of Obstetric Anesthesiology and Perinatology, Washington, May 2009
Anesthesia and the Fetus as a Patient: Visiting Professor, University of Michigan Health Systems, Ann Arbor, May 2009
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