Updated February 2008
Laboratory Chief
Goldyne Savad Institute of Gene Therapy
Phone: 972-2-677-7998
Fax: 972-2-643-0982
Email: giladi@hadassah.org.il
Position
1998- Laboratory Chief, Goldyne Savad Institute of Gene Therapy
Affiliation
Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Education
1967 - B.Sc. - Hebrew University of Jerusalem Faculty of Life Science, Jerusalem, Israel.
1970 - M.Sc. - Hebrew University of Jerusalem, Institute of Microbiology. Research done in the laboratory of Prof. Y. Becker, Department of Virology. Thesis: "Protein synthesis of the trachoma agent."
1980 - Ph.D. - University of Chicago, Chicago, Ill., Department of Biology. Research done in the laboratory of Prof. Niza Frenkel. Thesis: "Biological and structural properties of defective interfering particles of herpes simplex virus."
Research interests
Development of adeno and lentiviral vectors for transduction of hepatocytes for treatment of liver diseases; induction of apoptosis in hepatitis C infected cells;
RNA interference of HBV gene expression; development of animal models of hepatitis C viral infection.
Selected recent publications
Khvalevsky E, Rivkin L, Rachmilewitz J, Galun E, Giladi H. 2007. TLR3 signaling in a hepatoma cell line is skewed towards apoptosis. J Cell Biochem Jan 22
Condiotti R, Curran MA, Nolan GP, Giladi H, Ketzinel-Gilad M, Gross E, Galun E. 2004. Prolonged liver-specific transgene expression by a non-primate lentiviral vector. Biochem Biophys Res Commun. Jul 30;320(3):998-1006.
Giladi H, Ketzinel-Gilad M, Rivkin L, Felig Y, Nussbaum O, Galun E. 2003. Small interfering RNA inhibits hepatitis B virus replication in mice. Mol Ther Nov;8(5):769-76.
Beider K, Nagler A, Wald O, Franitza S, Dagan-Berger M, Wald H, Giladi H, Brocke S. 2003. Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice. Blood, 102(6):1951-8.
Ohana P, Bibi O, Matouk I, Levy C, Birman T, Ariel I, Schneider T, Ayesh S, Giladi H., Laster M, de Groot N, Hochberg A. 2002. Use of H19 regulatory sequences for targeted gene therapy in cancer. Int J Cancer 98(5):645-50.
Abdul-Ghani, R, Ohana P, Matouk I, Ayesh S, Laster M, Bibi O, Giladi H, Molnar-Kimber K, Sughayer MA, de Groot N, Hochberg A. 2000. Use of transcriptional regulatory sequences of telomerase (hTER and hTERT) for selective killing of Cancer cells. Mol Therapy 2, 539-544.
Giladi H, Koby S, Prag G, Engelhorn M, Geiselmann J, Oppenheim AB. 1998. Participation of IHF and a distant UP element in the stimulation of the phage lambda PL promoter. Mol Microbiol 30:443-51.
Obuchowski M, Shotland Y, Koby S, Giladi H, Gabig M, Wegrzyn G, Oppenheim AB. 1997. Stability of CII is a key element in the cold stress response of bacteriophage lambda infection. J Bacteriol 179:5987-91.
Obuchowski M, Giladi H, Koby S, Szalewska-Palasz A, Wegrzyn A, Oppenheim AB, Thomas MS., Wegrzyn G. 1997. Impaired lysogenisation of the Escherichia coli rpoA341 mutant by bacteriophage lambda is due to the inability of CII to act as a transcriptional activator. Mol Gen Genet 254:304-11.
Research group
Condiotti, Reba, M.Sc. (investigator) Phone: 677-7927
Ketzinel-Gilad, Mali, Ph.D. Phone: 677-7944/7559
Rivkin, Mila, B.Sc. Phone: 677-7944
Elina Khvalevsky, M.Sc. Phone: 677-7944
RESEARCH SUMMARY
As Laboratory Chief, I direct and coordinate the operations of the activities taking place at the Gene Therapy Institute regarding liver-directed gene therapy including the development of delivery methods, animal models, novel vaccination approaches and specific therapeutics.