Education and Professional Experience
1971-74 - B.Sc in Chemistry, Hebrew University, Jerusalem.
1974-76 - Israel Defence Forces.
1976-78 - M.Sc. from the Department of Biophysics; Weizmann Institute of Science (Rehovot, Israel), under the supervision of Prof. Meir Wilchek. Subject: Affinity columns with reactive azogroups for the binding of tyrosines in native proteins.
1979-84 - Ph.D. from the Department of Molecular Biology; Hebrew University Medical School, under the supervision of Prof. Shimon Schuldiner. Title: Identification and purification of the biogenic amine transporter in granules of the adrenal medulla.
1985-88 - Postdoctoral studies in the Department of Neurology, University of California at San Francisco, under the supervision of Prof. Stanley Prusiner.
From 1988 - Department of Neurology, Hadassah University Hospital.
1990 - Lecturer in the Hebrew University Medical School.
1994 (June-September)- Visiting Professor, Dept. of Neurology at the University of California at San Francisco.
1996-Senior lecturer in the Hebrew University medical School.
2002-Associate Professor in the Hebrew University Medical School.
Awards
1985. Weizman Scholarship for posdoctoral studies.
1992. Hebrew University Medical School Faculty award for excellence in research.
Journal Peer Reviewed Publications (since 1995)
20. Gabizon R., Halimi M., and Meiner Z.. Genetics and biochemistry
of Creutzfeldt-Jakob disease in Lybian Jews. Biomedicine &Pharmacotherapy , 48; 385-390, 1994.
21. Friedman G., Gabizon R., Shapira A., Castel., Wertman E., Matsa
D., Rosenmman H., Schurr D., Wirtheim E., Friedlander Y., Ben Yehuda A. Association of apolipoprotein E4 alleles with Alzeheimer's disease, but not with Down's syndrome or Creutzfeldt-Jakob disease among Israeli Jews. Alzheimer's Research 1; 45-48, 1995. ( NOT IN THE LISTS 6)
22. Spudich S., Mastrianni J.A., Wrensch M., Gabizon R., Kahana I.,Rosenmman H., Kahana E., Prusiner S.B. Complete penetrance of Creutzfeldt -Jakob disease in Libyan Jews carrying the E200K mutation in the prion protein. Molecular Medicine 6; 607-613, 1995. (5.032; 19/129;21)
23. Telling G.C., Scott M., Mastriani J., Gabizon R., Torchia M., Cohen F.E., DeArmond S.J., and Prusiner S.B. Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein. . Cell; 83, 79-90. 1995. (37.297; 1/129; 187)
24. Kaneko K., Peretz, D., Pan, Keh-Ming., Blochberger, T.C., Wille, H., Gabizon, R., Griffith, O.H., Cohen F.E., Baldwin, M.A., and Prusiner S.B. Prion protein (PrP) synthetic peptides induce cellular PrP to aquire properties of the scrapie isoform. Proc.Natl. Acad. Sci USA, 92; 11160-11164, 1995. (9.04; 3/56; 36)
25. Gabizon R., Telling G., Meiner Z., Halimi M., Kahana I., and Prusiner S.B. Insoluble wild type and protease resistant mutant PrP were found in the brains of patients who died of inherited prion disease. Nature Medicine, 2; 59-64, 1996. (28.114; 3/250; 25)
26. Ovadia H., Rosenmman H., Halimi M., Ofran I., Shezen E.,and Gabizon R.. Nitric oxide synthase is inhibited and abberantly processed in scrapie infected cells and brains. J. Biol. Chem, 271; 16856-61, 1996. (6.96; 23/ 250; 4)
27. Telling G.N , Parchi P. , DeArmond S.J. , Cortelli P. ,Montagna P., Gabizon R., Mastrianni J., Lugaresi E. , Gambetti B. , Prusiner SP. Evidence for the conformation of the phatologic isoform of the prion protein enciphering and propagating prion diversity. Science: 274; 2079-2082, 1996 (24.67; 2/56; 110)
28. Rosenmann H. , Meiner Z., Kahana E., Halimi H., Lenetsky E., Abramsky O.,Gabizon R. Detection of 14-3-3 protein in the cerebrospinal fluid of genetic CJD. Neurology 49(2); 593-595, 1997. (4.5; 5/107; 7)
29. Rosenmann H. , Halimi H. , Kahana I. , Biran I., and Gabizon R. Differential allelic expression of prp mrna in carriers of the E200K mutation. Neurology. 49(3); 851-6, 1997. (4.5; 5/107; 5)
30. Gabizon R and Taraboulos A. Of Mice and (mad) Cows. Trends Genet 13(7); 264-269, 1997. (9.9; 6/90; 5)
31. Meiner Z, Gabizon R and Prusiner S.B. 1977. Genetic Creutzfeldt-Jakob disease in Lybian Jews. Medicine (Baltimore) 76(4); 227-237, 1997. ( 4.48; 8/100;5)
32. Rosenmann H., Vardi J., Finkelstein Y., and Gabizon R.. Identification in Israel of 2 Jewish CJD patients with a 178 mutation at their PrP gene. Acta Neurol Scan ; 184-187, 1998. (0.902; 64/107;0)
33. Caspi S, Halimi M, Yanai A, Ben Sasson S, Taraboulos A and Gabizon R
The Anti Prion Activity Of Congo Red: Putative Mechanism. J. Biol. Chem 273; 3484-3489, 1998. .(6.96; 23/250/ 6)
34. Keshet G., Ovadia H and Gabizon R. Scrapie infected mice and PrP knockout mice share abnormal localization and activity of Neuronal Nitric Oxide Synthase. J. Nerochem, 72; 1224-1231, 1999. (4.23; 21/150/ 1)
35. Shaked GM, Fridlander G, Meiner Z, Taraboulos A and Gabizon R. Protease-Resistant And Detergent-Insoluble Prion Protein Is Not Necessarily Associated With Prion Infectivity, J.Biol. Chem 274; 17981-17986, 1999.(6.96; 23/250/ 1)
36. Rosenmann H, Kahana E, Korczyn, Kahana I, Chapman J, and Gabizon R. Preliminary Evidence For Anticipation In Genetic E200k Creutzfeld- Jakob - Disease. Neurology. 12; 53, 1328-9, 1999. (4.5; 5/107; 1)
37. Shaked Y, Rosenmann H, Talmor G and Gabizon R. A C-Terminal Truncated PrP Isoform Is Present In Mature Sperm. J. Biol. Chem , 274; 32153-8, 1999..(6.96; 23/250/ 0)
38. Yanai A, Meiner Z, Gahali I, Gabizon R and Taraboulos A. Subcellular trafficking abnormalities of a prion protein with a disrupted loop. Febs Lett, 22754; 11-16, 1999. (3.5; 53/250; 0)
39. Simon, E. S., Kahana, E., Chapman, J., Treves, T. A., Gabizon, R., Rosenmann, H., Zilber, N., Korczyn, A. D. Creutzfeldt-Jakob disease profile in patients homozygous for the PRNP E200K mutation. Ann Neurol, 47; 257-60, 2000. (9.5; 1/107; 0)
40. Keshet I, Bar-Peled O, Yaffe D, Nudel U, Gabizon R; The Cellular Prion Protein Is A Member Of The Dystroglycan Complex In The Brain. J Neurochem. 2000 Nov;75(5):1889-97.
41. Shaked GM, Meiner Z, Taraboulos Z and Gabizon R; Reconstitution of prion infectivity from solubilized protease resistant PrP and non-protein components of prion rods. J. Biol Chem. 2001 Jan 4
42. Rosenmann H, Talmor G, Halimi M, Yanai A, Gabizon R, Meiner Z. . Prion Protein With An E200k Mutation Displays Properties Similar To Those Of The Cellular Isoform, PrPc . Journal of Neurochemistry, 2001 Mar 15;76(6):1654-1662.
43. Shaked Y, Rosenmann H, Hijazi N, Halimi M and Gabizon R. Copper Binding To The PrP Isoforms: A Putative Marker Of Their Conformation And Function. Journal of Virology. 2001 Sep; 75(17):7872-4.
44. Shaked GM, Shaked Y, Kariv Z, Halimi M, Avraham Iand Gabizon R. A protease resistant PrP isoform is present in urine of animals and humans affected with prion diseases. J Biol Chem. 2001 Aug 24;276(34):31479-82.
45. Yuval Shaked , Roni Engelstein, Ruth Gabizon. The Binding Of Prion Proteins To Serum Components Is Affected By Detergent Extraction Conditions . 2002; J Neurochem. Jul;82(1):1-5.
46. Gideon Shaked, Roni Engelstein, Michele Halimi, Inbal Avraham
Hanna Rosenmann Ruth Gabizon. Valproic Acid, An Anti Epileptic Drug, Modulates The Accumulation of the Prion Proteins. 2002; Ann Neurol Oct;52(4):416-20.
47.Shaked Y, Hijazi N, Gabizon R. Doppel and PrP(C) do not share the same membrane microenvironment.2002; FEBS Lett Oct 23;530(1-3):85-8.
48. Tzaban S, Friedlander G, Schonberger O, Horonchik L, Yedidia Y, Shaked G, Gabizon R, Taraboulos A. Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes. 2002; Biochemistry 2002 Oct 22;41(42):12868-75
49. Shaked GM, Engelstein R, Avraham I, Kahana E, Gabizon R. Dimethyl sulfoxide delays PrP(sc) accumulation and disease symptoms in prion-infected hamsters. Brain Res. 2003 Sep 5;983(1-2):137-43.
50. Hijazi N, Shaked Y, Rosenmann H, Ben-Hur T, Gabizon R. Copper binding to PrPC may inhibit prion disease propagation.Brain Res. 2003 Dec 12; 993(1-2): 192-200.
51. Schonberger O, Horonchik L, Gabizon R, Papy-Garcia D, Barritault D, Taraboulos A.Novel heparan mimetics potently inhibit the scrapie prion protein and its endocytosis.
Biochem Biophys Res Commun. 2003 Dec 12; 312(2): 473-9.
52. Hijazi N, Kariv-Inbal Z, Gasset M, Gabizon R. PrPSc incorporation to cells requires endogenous GAGs expression. J Biol Chem. 2005 Jan 24
53. Engelstein R, Grigoriadis N, Greig NH, Ovadia H, Gabizon R. Inhibition of P53-related apoptosis had no effect on PrP(Sc) accumulation and prion disease incubation time. Neurobiol Dis. 2005 Mar;18(2):282-5.
Book Chapters
1. Garty H., Eisenbach M., Shuldman R*., Caplan S.R.: Effects of ionophores on light -induced pH changes in sub-bacterial particles of Halobacterium Halobium. In : Energetics and structure of halophilic Microorganisms, Caplan S.R., Ginzburg M (eds). Elsvier/North Holland and Biomed Res., pp. 261-267, 1978.
* Previous name of R Gabizon
2. Gabizon R., McKinley M.P., Prusiner S.B. Properties of scrapie prion liposomes and amyloid rods. In: Novel infectious agents and the central nervous system. Ciba Foundation Symposium 135, Bock, G, Marsh J., (eds). John Wiley and Sons, Chichester, UK pp 182-196, 1988.
3. Gabizon R., McKinley M.P., Prusiner S.B. Incorporation of scrapie prion protein and infectivity into Phospholipid vesicles. In: II International symposium on unconventional viruses of the central nervous system, Court L.A. Paris , 1989.
4. Gabizon R., McKinley M.P., Groth D.F., Prusiner S.B. Prions causing neurodegenerative diseases- Imunoaffinity purification and neutralization of scrapie infectivity. In: Biomedical advances in aging. Proceedings of the VIIIth International Washington spring symposium. Plenum Press, New York, 1990.
5. Gabizon R., McKinley M.P., Groth D.F., Westaway D., DeArmond S.J., Carlson G.A., Prusiner S.B. Imunoaffinity purification and neutralization of scrapie prions. In: Proceedings of the first International Conference on Alzheimer's Disease and Related Disorders, Las Vegas 1990.
6. Prusiner, S.B., Carlson G.A., DeArmond S.J., Gabizon R., Hsiao K., Scott M., Stahl N., Westaway D. Transmissible and genetic prion diseases of humans and animals. In: The Molecular and Genetic Basis of Neurological Disease. 9R. Rosenberg, S. Prusiner, S. DiMauro, R. Bachi, L. Kunkel, eds) Butterworth Pub. Stoneham, Ma. 1992.
7. Gabizon R., Kahana R., Hsiao K., Prusiner S.B., Meiner Z. Inherited prion disease in Libyan Jews. In: Prion Diseases in Human and Animals. Prusiner S.B., Collingo J., Ponell J., Anderton B., (eds). Ellis Horwood, London, pp. 168-179. 1992.
8. Meiner Z., Halimi M., Polakiewics R.D., Prusiner S.B. and Gabizon R. Detection of the prion protein in peripheral tissues of Libyan Jews with Creutzfeldt-Jakob disease. In "Advances in the Biosciences". 87: 105-111. 1993.
9. Gabizon R, Telling G., Meiner Z., Halimi M., Kahana I., and Prusiner S.B. Altered properties of prion proteins in Creutzfeldt-Jakob disease patients heterozygous for the E200K mutation.In Transmissible subacute spongiform encephalopathies: Prion Diseases. Edited by Louis Court and Betty Dodet; Elsevier. 1996
10. Gabizon R , Glenn Telling, Zeev Meiner, Michele Halimi, Irit Kahana and Stanley B. Prusiner. Wild Type And Mutant Prion Protein Properties In Creutzfeldt Jakob Disease Patients Heterozygous For The E200k Mutation. Nato meeting on TSE diseases, Sicily, Italy. 1997.
11. Gambetti P, Petersen RS, Parchi P, Chen SG, Capellari S, Goldfarb L, Gabizon R, Montana P, Lugaresi E, Piccardo P, and Getti B. Inherited Prion Diseases; in Prion Biology and Disease, Cold Spring Harbor laboratory press. 1999.
Selected Abstracts
1. Schuldiner S., Gabizon R. The amine transporter from bovine chromaffin granules . J. Neurochem (Suppl.) 41: 953a, 1983.
2. Tamir H., Liu K.P., Hsuing S.H., Gabizon R., Gershon M.D. Photoaffinity labeling of 45 kd and 56 kd forms of the serotonin binding protein (SBP): Evidence that 45 kd SBP is stored in
synaptic vesicles. Society of Neuroscience, 1984.
3. Gabizon R., McKinley M.P., Prusiner S.B. Incorporation of scrapie prion protein and infectivity into Phospholipid vesicles. II Symposium International Sur Les Virus Non Conventionnels Du Systeme Nerveux Central. Paris, Dec 2-6, 1986.
4. Gabizon R., McKinley M.P., Prusiner S.B. reconstitution of the scrapie prion protein into liposomes. J. Cell Biol.103; 337a, 1986.
5. Gabizon R., Gilles K., McKinley M.P., Prusiner S.B. Reversible morphological changes of infectious scrapie prions. Clin. Res. 35: 614A, 1987.
6. Gabizon R., McKinley M.P., Groth D.F., Prusiner S.B. Properties of scrapie prion proteins in liposomes and amyloid rods. Ciba Foundation Symposium No. 135 Unconventional Viruses and the CNS, June 29-July 2, 1987.
7. Gabizon R., McKinley M.P., Groth D.F., Kenaga L., Prusiner S.B. Properties of scrapie prion proteins in detergent -lipid –protein complexes. Ann. Neurol. 22:157,1987.
8. Gabizon R., McKinley M.P., Groth D.F., Kenaga L., Prusiner S.B. Properties of scrapie prion proteins in detergent -lipid –protein complexes. VIIth Intl. Cong. Virol. Edmonton, Canada, pp 147, Aug
9-14, 1987.
9. Gabizon R., Prusiner S.B. Copurification of scrapie prion protein and infectivity by immunoaffinity chromatography. J. Cell Biochem. 35 (Suppl) : 10, 1987.
10. McKinley M.P., Stahl N., Gabizon R., Prusiner S.B., Isolated brain cells from scrapie infected hamsters. Faseb J. 2(4): A932, 1988.
11. Prusiner S.B., Gabizon R., McKinley M.P., Groth D.F., Imunoaffinity purification and neutralization of scrapie prions. First International Conference on Alzheimer's Disease and related Disorders, Las Vegas Nevada, Sep, 1988.
12. McKinley M.P., Meyer R., Kenaga L., Rabbahar F., Serban A., Gabizon R., Prusiner S.B. Scrapie rods formation requires both detergent extraction and limited proteolysis. Faseb J. 1989.
13. Gabizon R., Meiner Z., Kahana E., Cass C., Kahana I., Avrahami D., Scarlato G., Abramsky O., Prusiner S. B., and Hsioa K. Prion protein gene mutation in Libyan Jews with Creutzfeldt-Jakob
disease. Neurology 41: 160, 1991.
14. Gabizon R., Kahana R., Hsiao K., Prusiner S.B., Meiner Z. Inherited prion disease in Libyan Jews. Prion Diseases in Human and Animal Symposium, London Sept. 2-4, 1991.
15. Gabizon R., Meiner Z., Halimi M., Prusiner S.B. Prion proteins in fibroblasts and leukocytes of patients with familial Creutzfelt-Jakob disease carrying a mutation at codon 200 of the PrP gene.
Eight International Congress of Human Genetics, Washington D.C. Oct 6-11, 1991.
16. Meiner Z., Halimi M., Prusiner S.B., Gabizon R. Expression of PrP in peripheral tissues of Libyan Jews with Creutzfeldt-Jakob disease. Neurology 42: 351, 1992.
17. Meiner Z., Halimi M., Prusiner S.B., Gabizon R. Detection of the prion protein in peripheral tissues of patients with prion diseases. Neurobiology of aging 13;128 1992.
18. Gabizon R., Meiner Z., Halimi M., Prusiner S.B., Ben Sasson S. Biochemical Interaction of prion proteins with glycosaminoglycans. Neurobiology of aging. 13:365, 1992.
19. Gabizon R., Rosenman H., Meiner Z., Kahana I., and Kahana E. Mutation in codon 200 and polymorphism in codon 129 of the prion protein gene in Libyan Jews with Creutzfeldt -Jakob Disease. In "Hereditary diseases, molecular diagnosis and gene therapy" Israel-France Binational Symposium, Jerusalem 7-9/11 1994.
20. Meiner Z., Yanai A., Telling M., Halimi M., Taraboulos A., Prusiner S.B. and Gabizon R. Prion protein with the E200K mutation displays properties similar to those of the cellular isoform PrPC. 1997 Academy of Neurology.
21. Gabizon R, Shaked G. , Friglander G. , Meiner Z. and Taraboulos A. Anti Prion Agents As A Tool For The Investigation Of PrPsc Aggregation. First meeting on conformational diseases, Dead Sea Israel, November 1998.
21. Gabizon R. ,Rosenmann H, Halimi M, and Zeev Meiner. Wt And Mutant Prion Proteins In Heterozygoes Genetic CJD Patients: Friends Or Foes?. Meeting of the Royal Genetic Society, London November. 1998.
22. Shaked G. Fridlander G, Meiner Z., Taraboulos A. and Gabizon R. Protease-Resistant And Detergent-Insoluble Prion Protein Is Not Necessarily Associated With Prion Infectivity. IBRO meeting, July 1999. Jerusalem.
Invited Lectures
1. Incorporation of scrapie prion protein and infectivity into Phospholipid vesicles. II Symposium International Sur Les Virus Non Conventionnels Du Systeme Nerveux Central. Paris, Dec 2-6,
1986.
2. Properties of scrapie prion proteins in liposomes and amyloid rods. Ciba Foundation Symposium No. 135 Unconventional Viruses and the CNS, June 29-July 2, 1987.
3. Inherited prion disease in Libyan Jews. Prion Diseases in Human and Animal Symposium, London Sept. 2-4, 1991.
4. Genetics and Biochemisty of CJD in Libyan Jews. Israel-France Binational Symposium; Paster Institute January 7-10, 1993
5. Genetics and Biochemistry of CJD in Libyan Jews; In Genetic Disorders of the Mediterranian See. Toledo, Spain May 5-7, 1993
6. Mutation in codon 200 and polymorphism in codon 129 of the prion protein gene in Libyan Jews with CJD. In The Royal Society Discussion meeting on "Molecular Biology of Prion diseases". London, September 22-23, 1993.
7. Genetic and Biochemistry of CJD in Libyan Jews. Lecture of the month Hadassah Medical School, May 1992.
8. Mutation in codon 200 and polymorphism in codon 129 of the prion protein gene in Libyan Jews with Creutzfeldt -Jakob Disease. In "Hereditary diseases, molecular diagnosis and gene therapy" Israel- France Binational Symposium, Jerusalem 7-9/11 1994.
9. Biochemistry of genetic CJD, Cold Spring Harbor Workshop on prions. November 5-7, 1995.
10. Genetic and Biochemistry of CJD in Libyan Jews 3nd International Symposium on prion diseases. France, Val De Grace, March 25-28, 1996
11. Chairmen of prion session. International Congress of Virology, Jerusalem; August 1996.
12. Differential expresion of prion proteins in heterozygous individuals. Nato seminar on prion diseases. Erice Siccily, August 27-30 1996.
12. Differential expresion of prion proteins in heterozygous CJD mutation carriers Seminar in the Brain research institute, University of Zurich. May 1996
13. International Society of Zoonotics. May 1996, Jerusalem. Biochemistry and Genetic of Prion diseases.
14. GIF neuroscience meeting. August 1998, Jerusalem.Biochemistry and Genetic of Prion diseases.
15. Anti Prion Agents As A Tool For The Investigation Of PrPsc Aggregation, first meeting on conformational diseases, Dead Sea Israel, November 1998.
16. Wt And Mutant Prion Proteins In Heterozygoes Genetic CJD Patients: Friends Or Foes? Prion meeting of the Royal Genetical Society, London ; November 1998.
17. Biochemistry and Genetic of Prion diseases. Marine institute of Biology, napoly, Italy. May 1999.
18. Anti Prion Agents As A Tool For The Investigation Of PrPSc Aggregation, first meeting on conformational diseases. Prion Disease Symposium, Tubingem, September 1999.
19. International Society of Blood Transfusion, Jerusalem; Israel, 2000.
20. Transmissible Spongiform Encephalopathies (TSE) Research Meeting. Center Borschette, Brussels. February 2001.
21. Unfolded proteins and mad cow disease. Domus Museum, La Coruna Spain. March 2001
22. In-vivo diagnosis of animals and humans affected with prion diseases. III Balkan Microbiology meeting. Thesaloniky. Nov 2001.
23. Ilanit Congress, Eilat February 2002.
24. The Pittsburgh Conference, PITTCON 2002. A Global Technical Conference & Exposition. New Orleans, LA, March 2002.
25. Euro’sat, Paris France October 2002.
26. In-vivo diagnosis of prion diseases , American Association of Blood Bank (AABB) Annual Meeting.Orlando, USA, October 2002.
27. New Perspectives for Prion Therapeutics. Paris France December 2002.
28. WHO Consultation on Transmissible Spongiform Encephalopathies (TSE’s) in relation to Biological and Pharmaceutical Products. Geneva, February 2003.
29. XVTH International Congress of Neuropathology. Torino September 2003.
30. Diagnosis and treatment of prion diseases South – East Europan Society for Neurology and Psychiatry. Thessaloniki, Greece. October 2003.
31. Annual Meeting of the Israel Society for Neuroscience.
Eilat, Israel, December 2003.
32. Conference on “The Biosafety of Urinary Derived Medicinal Products”. Buenos Aires - Argentina, April 2004.
33. First International Conference of the European Network of Excellence NeuroPrion. Paris May 2004.