Physician in charge, Ziv Dialysis Unit,
Initiator, attending in nephrogenetics Clinic
Nephrology and Hypertension Services
backenroth@hadassah.org.il
Education:
1962-1965 - Hebrew Teachers College High School, Brookline, MA, U.S.A.
1964-1968 - Brookline High School, with honor, Brookline, MA, U.S.A.
1968-1974 - Boston University Six-year Medical Program, Boston, MA: B.A. & M.D.
1978-1979 - Harvard School of Public Health, Boston, MA: M.P.H.
2008 - NIH web-based training course "Protecting Human Research Participants".
Training:
1974-1975 - Medical Internship, Baltimore City Hospitals, Johns Hopkins University, Baltimore, Maryland
1975-1976 - Medical Residency, Soroka Medical Center, Ben-Gurion University, Beer-Sheba, Israel
1976-1977 - Medical Residency, North Central Bronx and Montefiore Hospital and Medical Center, Bronx, New York
1977-1978 - Medical Residency, University of Massachusetts Medical Center, Worcester, MA
1979-1981 - Nephrology fellowship, Albert Einstein College of Medicine, Bronx, New York
Practice:
1982-1984 - Nephrology attending, Bellevue Hospital, and Clinical Instructor in Medicine, New York University, New York
1983-1984 - Research Associate in Nephrology, Booth Memorial Medical Center, Flushing, New York
1986-1987 - Nephrology research and Personnel Clinic, Hadassah University Hospital, Jerusalem, Israel
1987-1988 - Nephrologist in charge of hemodialysis, Shaaare Zedek Medical Center, Jerusalem
1989 - Nephrologist, New England Deaconess Hospital and St. Elizabeth’s Hospital, Boston, MA
1990-1993 - Internist, Personnel Clinic, Hadassah University Hospital, Jerusalem, Israel
1990-present - Nephrologist, Nephrology and Hypertension Service, Department of Medicine, Hadassah University Medical Center, Jerusalem.
1995-present - Initiator, in charge of ambulatory BP monitoring service, Hadassah university medical center, Ein Kerem.
2000-present - Attending physician, Internal medicine wards, Hadassah university medical center.
2003-present - Physician in charge, Ziv Dialysis Unit, Hadassah University Hospital, Jerusalem.
2003-present - Initiator, attending in nephrogenetics clinic, Hadassah university medical center, Ein Kerem.
2004-2006 - Medical director, Zor'a hemodialysis Unit, Kibbutz Zor'a, Israel.
Board Certification:
1978 - Internal Medicine, USA; Israel in 1990.
1982 - Nephrology, USA; Israel in 1990.
Licensure:
New York State #129217-1, current
Massachusetts #38772 - expired
Israel #018897
GCP course:
NIH certificate #125504 for completion of course: “Protecting human research participants”
Competetive Grants:
The Israeli Society of Nephrology and Hypertension, 15,000 IS, 2003.
PUBLICATIONS
Articles:
1. Galler M, Backenroth R, Folkert VW, Schlondorff D. Effect of converting enzyme inhibitors on prostaglandin synthesis by isolated glomeruli and aortic strips of rats. J Pharmacol & Exptl Therap 220: 23-28, 1982.
2. Maayan S, Backenroth R, G Wormser et al. Antibody to LAV/HTLV3 in various groups of illicit drug users in New York City. J Infect Dis 152: 843, 1985.
3. Backenroth R, BS Spinowitz, M Galler et al. Comparison of eosinophilia in patients undergoing peritoneal and hemo dialysis. Amer J Kidney Dis 8: 186-191, 1986.
4. Backenroth R, RE Longnecker, D Kambosus. Failure of the peritoneal membrane during chronic intermittent peritoneal dialysis. In: Gahl GM,M Kessel, K Nolph eds. Advances in Peritoneal Dialysis. Amsterdam: Exerpta Medica 1989, pp 208-213.
5. Backenroth R, LO Schuger, H Wald, MM Popovtzer. Glycerol-induced acute renal failure attenuates subsequent HgCl2-associated nephrotoxicity: Correlation of renal function and morphology. Renal Failure 20: 15-26, 1998.
6. Wald H, M Dranitzki-Elhalel, R Backenroth, MM Popovtzer. Evidence for interference of vitamin D with PTH/PTHrP receptor expression in opossum kidney cells. Pflügers Arch 436: 289-294, 1998.
7. Ben-Chetrit E, R Backenroth, M Levy. Colchicine clearance by high-flux polysulfone dialyzers. Arthrit & Rheumat 48: 749-750, 1998.
8. Ben-Chetrit E, R Backenroth, R Haimov-Kochman, G Pizov. Azoospermia in familial Mediterranean fever patients: the role of colchicine and amyloidosis. Ann Rheum Dis 57: 259-260, 1998.
9. Multiple contributors, including Block C, Backenroth R, Shapiro M et al. Outbreaks of gram-negative bacterial bloodstream infections traced to probable contamination of hemodialysis machines- Canada 1995; United States 1997, and Israel 1997. Morbidity and Mortality Weekly Report, 47;3: 55-58, 1998.
10. Block C, Backenroth R, E Gershon, R Israeli, A Simhon, M Popovtzer, M Shapiro. Outbreak of bloodstream infections associated with dialysis machine waste ports in a hemodialysis facility. Eur J Clin Microbiol Infect Dis 18: 723-725, 1999.
11. Sarid R, Pizov G, Rubinger D, Backenroth R, Friedlaender MM, Schwartz F, Wolf DG. Detection of human herpesvirus-8 DNA in kidney allografts prior to the development of Kaposi’s sarcoma. Clin Infect Dis 15: 1502-1505, 2001.
12. Ben-Chetrit E, Backenroth R. Amyloidosis induced end stage renal disease in patients with Familial Mediterranean Fever is highly associated with point mutations in the MEFV gene. Ann Rheum Dis 60: 146-149, 2001.
13. Backenroth R, Popovtzer MM. Does type 2 diabetes mellitus delay renal failure in autosomal dominant polycystic kidney disease? Renal Failure 24;6: 803-813, 2002.
14. Araya K, Fukumoto S, Backenroth R, Takeuchi Y, Nakayama K, Ito N, Yoshii N, Yamazaki Y, Yamashita T, Silver J, Igashi T, Fujita T. A novel mutation in Fibroblast Growth Factor (FGF) 23 gene as a cause of Tumoral Calcinosis. J. Clin. Endocrinol. Metab.; 90(10):5523-7, 2005.
15. Rubinger D, Backenroth R, Pollak A, Sapoznikov D. Blood pressure and heart rate variability in patients on conventional or sodium-profiling hemodialysis. Renal Failure 30;3:277-86, 2008.
16. Rubinger D, Backenroth R, Sapoznikov D. Restoration of baroreflex function in patients with end-stage renal disease after renal transplantation. Nephrol Dial Transpl. 24(4): 1305-13, 2009.
17. Sapoznikiv D, Backenroth R, Rubinger D. Baroreflex sensitivity and sympatho-vagal balance during intradialytic hypotensive episodes. J. Hypertension 28(2): 314-24, 2010.
18. Backenroth R, Landau EH, Goren M, Raas-Rothschild A. Fabry disease and G6PD in three family members with Priapism: is the nitric oxide pathway to blame? Journal of Sexual Medicine Apr;7(4 Pt 1):1588-91, 2010.
Letters:
1. Rubinger D, Friedlaender MM, Backenroth R, Eid A, Tochner Z. Kaposi’s sarcoma after renal transplantation - withdrawal of immunosuppression or local irradiation? Letter to the Editor - Nephrol Dial Transplant 14: 1343, 1999.
2. Backenroth R. Dialysate calcium use in hemodialysis patients. Letter to the Editor-Kidney International 64(4): 1533, 2003.
3. Raas-Rothschild A, Friedlaender MM, Pizov G, Backenroth R. The kidney in Fabry disease. J Pediatr. Jan;146(1):148, 2005.
Selected abstracts, posters, presentation
1. Spinowitz BS, R Backenroth, HJ Rascoff et al. A comparison of CAPD and hemodialysis eosinophilia. ASIAO Journal 1984.
2. Backenroth R, MT Nejad, P Kurtin. Trarnsmission of non-A, non-B hepatitis in a hemodialysis unit. Kidney Intl 35: 181, 1984.
3. Spinowitz BS, R Backenroth, M White et al. Zinc, T-cells and skin anergy in azotemia, CAPD and hemodialysis. Presented at the 1984 International Congress of Nephrology, California, USA
4. Maayan S, R Backenroth, D Hewlett et al. Lymphocyte markers in drug addicts. Clin Res 31: 618A, 1983.
5. Backenroth R, H Wald, L Schuger, E Rosenman, MM Popovtzer. Glycerol-induced acute renal failure protects against mercuric chloride nephrotoxicity: functional and pathological correlations. Kidney Intl 33: 352, 1988.
6. Backenroth R, S Sprague, H Wald, MM Popovtzer. New mutant strain of OKC with spontaneously elevated basal cAMP levels: Evidence for key role of cAMP in modulating Na-coupled uptake. J Am Soc Nephrol 5: 859, 1994 (presented as poster).
7. Rubinger D, R Backenroth, H Wald, E Shiloni, MM Popovtzer. Cytokines suppress activation of adenylate cyclase (AC) in renal tubule cells in vitro. J Am Soc Nephrol 5: 729, 1994.
8. Backenroth R, M Parnas, S. Sprague, H Wald, MM Popovtzer. New mutant strain of opposum kidney cells with spontaneously elevated basal cAMP levels: evidence for key role of cAMP in modulating Na-coupled phosphate uptake. Congr Isrrael Soc Nephrology and Hypertension, Zichron Yaakov, June 1995 (oral presentation).
9. Popovtzer MM, R Backenroth, M Elhalel-Dranitzki, D. Rubinger, MM Friedlaender, J Silver, A Moscovici. Recurrence of tumoral calcinosis after kidney transplantation: evidence against an intrinsic defect of tubular phosphate (Pi) reabsorption. J Am Soc Nephrol 6: 954, 1995 (presented as poster).
10. Backenroth R, M Parnas, SM Sprague, H Wald, MM Popovtzer. Strain of opposum kidney cells with spontaneously elevated basal cAMP levels. Evidence for a key role of cAMP in modulating Na-coupled phosphate uptake. J Am Soc Nephrol 6: 942, 1995 (presented as poster).
11. Backenroth R, M Parnas, SM Sprague, H Wald, MM Popovtzer. Strain of Opposum kidney cells with spontaneously elevated basal cAMP levels: Evidence for a key role of cAMP in modulating Na-coupled phosphate uptake. J Am Soc Nephrol 7: 1798, 1996 (presented as poster).
12. Elhalel-Dranitzki M, D Rubinber, A Moscovici, R Backenroth, Y Haviv, M Friedlaender, J Silver, MM Popovtzer. Improved functional capacity in patients with intractable cardiac insufficiency (CHF) with CAPD therapy. J Am Soc Nephrol 7: 1445, 1996 (presented as poster).
13. Rubinger D, R Backenroth, H Wald, I Gottesman, E Shiloni, MM Popovtzer. Tumor necrosis factor (TNF) modulates phosphate (Pi) transport in renal epithelial cells. J Am Soc Nephrol 7: 1806, 1996 (presented as poster).
14. Backenroth R, D Rubinger, J Silver, MM Friedlaender, M Elhalel-Dranitzki, A Moscovici, E Galun, R. Barsuk, MM Popovtzer. Coinfection with hepatitis B (HBV) and hepatitis C (HCV) virus in kidney transplant patients (KTx). J Am Soc Nephrol 8: 673A, 1997 (presented as poster).
15. Backenroth R, C Block, R Yisraeli, M Elhalel-Dranitzki, A Moscovici, M Friedlaender, A Simhon, M Shapira, D Rubinber, MM Popovtzer. An outbreak of blood stream infections related to use of a waste handling device in a hemodialysis unit. Congress Israel Soc Nephrol 1998 (accepted as poster).
16. Wald H, M Elhnalel-Dranitzki, R Backenroth, MM Popovtzer. Modulation of PTH action on kidney by 1,25(OH)2Vit D3: Evidence for downregulation of PTH/PTHrP receptor mRNA by vit D. J Am Soc Nephrol 8: 581A, 1997 (presented as poster).
17. Backenroth R, M Elhalel-Dranitzki, SM Sprague, H Wald, GV Segre, MM Popovtzer. Strain of opossum kidney cells with spontaneously elevated basal cAMP levels: Evidence for decreased PTH/PTHrP receptor RNA expression and a key role of cAMP in modulating Na-coupled phosphate uptake. J Am Soc Nephrol 8: 557A, 1997 (presented as poster).
18. Backenroth R, C Block, R Yisraeli, N Revis, M Elhalel-Dranitzki, A Moscovici, M Friedlaender, M Shapira, D Rubinger, MM Popovtzer. Outbreak of blood stream infections in hemodialysis unit related to use of a dialysis machine waste port. J Am Soc Nephrol 9: 242A, 1998 (poster presention).
19. Haviv YS, R Backenroth, N Revis, MM Popovtzer. Anticardiolipin antibodies and vascular access occlusion. Congress Israel Soc Nephrology and Hypertension, Eilat 1999.
20. Backenroth R, MM Popovtzer. Diabetes mellitus delays renal failure in autosomal dominant polycystic kidney disease. J Am Soc Nephrol 10: 414A, 1999.
21. Backenroth R, Z Haklai, D Rubinger, MM Friedlaender, MM Popovtzer. Under representation of women in a kidney transplant clinic. Women and Renal Disease conference, Sept. 14-17, 1999. Natl Inst Diab & Digest & Kidney Dis (Bethesda, MD) USA (accepted for presentation).
22. Backenroth R, YS Haviv, E Polak, Y Shtoyer, P Stein, MM Popovtzer. Use of sevelamer hydrochloride in conjunction with calcium carbonate lowers hyperphosphatemia and improves the cholesterol profile but lowers 25(OH)D3 in hemodialysis patients. J Am Soc Nephrol 11: 249A, 2000.
23. Haviv YS, D Rubinber, J Silver, MM Friedlaender, A Gal-Moscovici, R Backenroth, M Elhalel-Dranitzki, MM Popovtzer. Rapidly progressive aortic valve disease in five hemodialysis patients with severe secondary hyperparathyroidism. Congress Israel Soc Nephrology and Hypertension year Eilat 2000.
24. Backenroth R, YS Haviv, E Polak, Y Shtoyer, P Stein, MM Popovtzer. Use of sevelamer hydrochloride in conjunction with calcium carbonate lowers hyperphosphatemia, and improves the cholesterol profile in hemodialysis patients. Congress Israel Soc Nephrol and Hypertension March 2000, Eilat, Israel (oral presentation).
25. Backenroth R, Parnas M, Wald H, Popovtzer MM, Lederer ED, Levi M. Mutant opossum kidney cells (OK) with spontaneously elevated cAMP levels. Evidence for a key role of cAMP in modulating Na coupled phosphate transport, and spontaneous activation of PTH transduction pathway. J Am Soc Nephrol 12: 749A, 2001 (poster presentation).
26. Backenroth R, Sarid R, Rubinger D, Friedlaender MM, Saleh N, Wolf D. Kaposi’s sarcoma and human herpes virus 8 serology in Jerusalem nephrology patients. Congress Israel Soc Nephrol and Hypertension March 2003, Eilat, Israel (oral presentation).
27. Backenroth R, Rein AJJT, Zeigler J, Rapoport J, Bach G, Raas-Rothschild A, Fabry disease, the Jerusalem experience. Congress Israel Soc Nephrol and Hypertension, March 2005, Eilat, Israel, ( poster presentation).
28. Backenroth R, Revis N, Parnas M, Yisraeli R, Rubinger D. Spontaneously Elevated Hemoglobin Levels in Chronic Hemodialysis Patients are Associated with High Serum Cobalt Levels. Israel Soc Nephrol and Hypertension, March 2005, Eilat, Israel,(oral presentation).
29. Backenroth R, Segal I, Rubinger D. Cobalt May Be an Important Modulator of Hematopoiesis in Hemodialysis Patients. (oral presentation at the annual American Society of Nephrology convention Nov. 15, 2006).
30. Backenroth R, Landau E, Raas-Rothschild A. Priapism and Fabry disease in two generations. International workshop on lysosomal storage disorders, Brussels Nov. 16-17, 2007, (poster, oral presentation, 3rd prize in Fabry Disease).
31. Backenroth R, Bergman M, Stein P, Rubinger D. Cobalt Levels in Hemodialysis and Transplant Patients: Evidence Suggesting That Elevated Levels Are Important Modulators of Erythropoeisis in Hemodialysis. Accepted for poster presentation at the annual American Society of Nephrology convention Oct. 2009.