Includes the conservative therapy of adhesion ileus; septic and metabolic complications during short-term and long-term total parenteral nutrition; surgical interventions in crohn's disease for quality of life; role of cholecystostomy for acute cholecystitis; the role of ERCP in the laparoscopic era.

Diagnosis of thyroid cancer by electrical impedance.   

The role of laparoscopic band,  gastric  bypass and sleeve gastrectomy  in Bariatric Surgery.

FNA diagnosis of thyroid lesions.

Role of  FDP-PET in the diagnosis of thyroid cancer.

Role and efficacy of laparoscopic groin hernia repair

Electrical Impedance Scanning for the detection of neoplastic diseases

Electrical Impedance Scanning (EIS) is a novel imaging modality utilizing the lower impedance of neoplastic tissue as compared to normal tissues.

1.  Electrical impedance scanning of the breast as an adjunct to mammography.

Single institution prospective clinical trial was conducted at Hadassah University Hospital Mount Scopus between 1996-2000. In collaboration with Dr. Fields from the Department of Radiology we studied the added value of EIS to screening mammography in the detection of breast cancer using the TS-2000 (TransScan Medical Inc, Migdal Haemek, Israel). . The study was completed showing increase in the sensitivity of mammography from 90% to 89% in 300 women. Interim analysis was presented at the ESSO meeting and a manuscript will be submitted soon to Radiology.

2. Electrical impedance scanning of the breast for the detection of breast cancer in young women.

A multicenter trial conducted by TransScan Medical Inc. including medical centers in the US and Israel. Preliminary results were presented at the ASBS San Antonio December 2004 (Principal Investigators: Dr Alexander Stojadinovic and Dr. Aviram Nissan) and a manuscript was submitted to J. Clin Oncol.

3. Electrical Impedance Scanning of thyroid nodules prior to thyroid surgery: A prospective study.

A multicenter trial conducted by TransScan Medical Inc. including medical centers in the US and Israel. Preliminary results were presented at the SSO meeting in New York 2004. (Principal Investigators: Dr Alexander Stojadinovic and Dr. Aviram Nissan) and a manuscript was accepted for publication by the Ann Surg Oncol.

Needle guided Vs isotope guided breast lumpectomies.

Prospective Randomized trial of wire versus radioactive isotope localization for occult breast lesions

Localization of clinically occult breast abnormalities is currently performed using a needle or wire placed under mammgraphic or sonographic guidance. We hypothesize that localization of occult breast lesions can be achieved with equal or better success than wire-guided approaches using ultrasound or stereotactically guided intra-tumoral injection of radiopharmaceutical with intra-operative localization of the abnormality using a hand-held gamma probe.

(P.I Aviram Nissan, Co- investigators: Tanir M. Alweiss, Scott I. Fields, Miriam Skaler-Levy.)

Biological Relevance of Sentinel Lymph Node (SLN) Micrometastasis in Patients with Colon Carcinoma, a multicenter trial

The objective of this study is to determine the prognostic significance of molecular staging of colon carcinoma on the basis of sentinel lymph node mapping and analysis

Inclusion criteria:

1. Males or females over 18 years of age capable of providing informed consent

2. Primary, non-metastatic [localized, node negative, or node positive] colon carcinoma confirmed by tissue biopsy or colon mass clinically consistent with cancer and eventually confirmed by pathology, palpable at time of surgery

(P.I. Dr Alexander Stojadinovic, Walter Reed Army Medical Center, Washington, D.C, USA, Co-investigator (Isarel) Dr. Aviram Nissan).