Clinical Research
· Development of hardware and computer techniques for the measurement of lung function in infants
· Acoustic analysis of breath sounds for the detection and quantification of wheezing in infants and young children
· Studies of bronchial reactivity in infants, children and adults with asthma and other types of chronic lung disease
· Studies of nitric oxide levels in normal adults and children and in patients with lung disease
· Screening and early detection of lung cancer
· Pulmonary hypertension, including genetic screening
· Lung function methodology
International, Multi-Institutional Clinical Trials, Conducted in Cooperation with Commercial Entities
· Drug therapy in moderate-to-severe asthma, outpatient and emergency room settings
· Drug therapy in stable and moderate-to severe COPD, and in acute exacerbation of COPD
· Drug therapy in pulmonary hypertension
· Drug therapy in idiopathic pulmonary fibrosis
· Drug therapy in outpatient pneumonia
Basic Research
· Cellular and molecular mechanisms of lung fibrosis
· Cellular and molecular remodeling in asthma
· Chemokines and asthma
· Murine model of post-transplant bronchiolitis obliterans
· Genetic predisposition for lung cancer
· Development of diagnostic techniques for detecting gastro-esophageal reflux and aspiration in animal models and in young children