Research
DEPARTMENT OF OPHTHALMOLOGY
Research Activities
Professor:
Pe’er, J., MD1
(Head of Department)
Associate Professors:
Frucht-Pery, J., MD
Solomon, A., MD
Banin, E., MD, PhD
Blumenthal, E.Z., MD
Chowers, I., MD
Senior Lecturers:
Dr. Dror Sharon (Ph.D.)
Clinical Senior Lecturers:
Hemo, I., MD
Anteby, I., MD
Instructors:
Amer, R., MD
Yahalom, C., MD
Mechoulam, H., MD
Physicians participating in research:
Averbukh, E., MD
Deckel, Y., MD
Dotan, S., MD
Frenkel, S., MD, PhD
Greifner, G., MD
Halpert, M., MD
Hendler, K., MD
Ilsar, M., MD
Landau, D., MD
Miller, A., MD
1 Jonas Friedenwald Professor of Ophthalmic Research
INTRODUCTION
The members of the Department of Ophthalmology conduct both basic and clinical research. The research has been conducted mainly in the laboratories of the Department of Ophthalmology as well as in collaboration with other laboratories of the Faculty of Medicine, Hadassah University Hospital, departments in other hospitals in Israel, and with departments abroad.
With the establishment of the retinal and macular degeneration center, both basic and clinical research has been conducted in this field, on the molecular level, electrophysiology, and clinical studies such as experimental drugs. Cell proliferation in normal tissue and in ocular tumor tissue, with and without treatment, has been studied. In the field of ocular oncology, the goals of research are to find differences between primary uveal melanoma and its metastases, and developing new biomarkers for early detection of metastatic disease. In the field of cornea and ocular surface diseases, inflammatory and repair have been explored, as well as methods of drug delivery, the use of amniotic membranes and their preparation, and others. In glaucoma, investigation of visual fields methods and new instrumentation are the main fields of interest. Other areas of research carried out in the Department of Ophthalmology are in pediatric ophthalmology, neuro-ophthalmology, ocular inflammation, ocular microbiology, genetics of eye diseases, lasers in ophthalmology, and optic and refractive surgery.
The laboratories at our department are:
· The Visual Functions Laboratory, which provides diagnostic services (ERG, VEP, EOG, and psychophysical testing) as well as facilities for basic research.
· The Ophthalmic Pathology Laboratory, which provides, in addition to diagnostic services, also services for all the morphological studies that have been done in our department, including immunohistochemical studies.
· The Laboratory of Immuno-Ophthalmology provides research and diagnostic services in inflammatory eye disease.
· The Molecular Ophthalmology Laboratory has been established as a core for all studies involving molecular techniques, including molecular genetics, that are carried out by the researchers of our department.
· The Laboratory for Laser Research has been restructured and provides services in basic and applied research with femtosecond lasers.
Research areas
Macular & other retinal degenerations
(Banin, Chowers, Sharon, Hemo, Averbukh)
Angiogenesis and neovascularization
(Banin, Chowers, Hemo, Averbukh, Pe’er)
Other retinal diseases
(Hemo, Banin, Chowers, Averbukh)
Normal & pathological ocular cell proliferation
(Pe’er, Frenkel)
Ocular oncology and pathology
(Pe’er, Frenkel)
Visual functions & electrophysiology
(Banin, Chowers)
Cornea and Ocular surface
(Frucht-Pery, Solomon)
Molecular ophthalmology
(Sharon, Chowers, Solomon, Blumenfeld)
Molecular genetics of eye diseases
(Sharon, Chowers, Banin, Blumenthal, Blumenfeld)
Ocular immunology & inflammatory eye diseases
(Solomon, Amer)
Ocular pharmacology and drug delivery
(Frucht-Pery, Solomon, Blumenthal, Banin, Chowers,)
Albinism
(Blumenfeld, Banin)
Lasers in ophthalmology
(Hemo, Banin, Frucht-Pery, Solomon, Blumenthal, Lewis)
Glaucoma
(Blumenthal)
Pediatric ophthalmology and eye movements
(Anteby, Yahalom, Mechoulam)
Development of ophthalmic instrumentation
(Blumenthal)
Neuro-ophthalmology
(Dotan)
Ocular microbiology
(Frucht-Pery, Solomon)
Refractive surgery
(Frucht-Pery, Solomon, Landau)
Oculoplastics
(Ilsar, Deckel)
RECENT PUBLICATIONS
Macular and other retinal degenerations
Chowers I. and Banin, E. (2003) Experimental therapeutic modalities for Retinitis Pigmentosa. Harefuah 142:277-280. (in Hebrew)
Banin E. and Chowers I. (2004) Experimental therapeutic modalities for retinitis pigmentosa. Harefuah 143:368-371. (in Hebrew).
Abramov Y., Borik S., Yahalom C., Fatum M., Avgil G., Brzezinski A., and Banin E. (2004) The effect of hormone therapy on the risk for age-related maculopathy in postmenopausal women. Menopause 11:62-68.
Otani A,. Dorrell M.I., Kinder K., Moreno S.K., Nusinowitz S., Banin E., and Heckenlively J., Friedlander M. (2004) Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells. Journal of Clinical Investigations 114:765-774.
Banin E., Obolensky A., Idelson M., Hemo I., Reinhardtz E., Pikarsky E., Ben-Hur T., and Reubinoff B. (2006) Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells. Stem Cells 24:246-257. E-pub ahead of print: August 25, 2005.
Chowers I., Wong R., Dentchev T., Farkas R.H., Iacovelli J., Gunatilaka T.L., Medeiros N.E., Presley J.B., Campochiaro P.A., Curcio C.A., Dunaief J.L., and Zack D.J. (2006) The iron carrier transferrin is upregulated in retinas from patients with age-related macular degeneration. Investigative Ophthalmology and Visual Science 47:2135-40.
Averbukh E. and Banin E. (2006) Diabetic macular edema: towards therapy aimed at the underlying pathogenic mechanisms. Israel Medical Association Journal 8:127-128.
Ritter M.R., Banin E., Moreno S.K., Aguilar E., Dorrell M.I., and Friedlander M. (2006) Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy. Journal of Clinical Investigations 116:3266-3276.
Banin E., Mizrahi-Meissonnier L., Neis R., Silverstein S., Magyar I., Abeliovich D., Roepman R., Berger W., Rosenberg T., and Sharon D. (2007) A non-ancestral RPGR missence mutation in families with either recessive semi-dominant X-linked Retinitis Pigmentosa. American Journal of Medical Genetics 143:1150-1158.
Cervantes-Castaneda R.A., Banin E., Hemo I., Shpigel M., Averbukh E., and Chowers I. (2007) Lack of benefit of early awareness to age-related macular degeneration. EYE (in press).
Angiogenesis and neovascularization
Ritter M.R., Aguilar E., Banin E., Scheppke L., Uusitalo-Jarvinen H., and Friedlander M. (2005) Three-dimensional in vivo imaging of the mouse intraocular vasculature during development and disease. Investigative Ophthalmology and Visual Science 46:3021-3026.
Banin E., Dorrell M.I., Aguilar E., Ritter M.R., Aderman C.M., Smith A.C., Friedlander J., and Friedlander M. (2006) T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new methods of quantification. Investigative Ophthalmology and Visual Science 47:2125-2134.
Friedlander M., Dorrell M.I., Ritter M.R., Marchetti V., Moreno S.K., El-Kalay M., Bird A.C., Banin E., and Aguillar E. (2007) Progenitor cells and retinal angiogenesis. Angiogenesis 10:89-101.
Other retinal diseases
Banin E., Shalev R.S., Obolensky A., Neis R., Chowers I., and Gross-Tsur, V. (2003) Retinal function abnormalities in patients treated with vigabatrin. Archives of Ophthalmology 121:811-816.
Mechoulam H. and Pierce E.A. (2003) Retinopathy of prematurity: molecular pathology and therapeutic strategies. American Journal of Pharmacogenomics 3:261-277.
Gross M., Banin E., Eliashar R., and Ben-Hur T. (2004) Susac syndrome. Otology and Neurotology 25:470-473.
Sarrazin L., Averbukh E. Halpert M., Hemo I., and Rumelt S. (2004) Traumatic pediatric retinal detachment: A comparison between open and closed globe injuries. American Journal of Ophthalmology 137:1042-1049.
Sisak S., Banin E., and Blumenthal E.Z. (2004) A two-compartment model of the human retina. Medical Hypothesis 62:808-816.
Albini T.A., Wang R.C., Reiser B., Zamir E., Wu G.S., and Rao N.A. (2005) Microglial stability and repopulation in the retina. British Journal of Ophthalmology 89:901-903.
Averbukh E. (2005) The evidence supporting the early treatment for Type 1 Retinopathy of Prematurity needs further evaluation. Archives of Ophthalmology 123:406.
Lossos A., Khoury M., Rizzo W.B., Gomori J.M., Banin E., Zlotogorski A., Jaber S., Abramsky O., Argov Z., and Rosenmann H. (2006) Phenotypic variability among adult siblings with Sjogren-Larsson syndrome. Archives of Neurology 63:278-280.
Rumelt S., Sarrazin L., Averbukh E., Halpert M., and Hemo I. (2007) Paediatric vs adult retinal detachment. EYE (in press)
Ocular oncology and pathology
Cohen Y., Goldenberg-Cohen N., Parrella P., Chowers I., Merbs S.L., Pe'er J., and Sidransky D. (2003) Lack of BRAF mutation in primary uveal melanoma. Investigative Ophthalmology and Visual Science 44:2876-2878.
Amer R., Pe’er J., Chowers I., and Anteby I. (2004) Treatment options in the management of choroidal metastases. Ophthalmologica 218:372-377.
Kaiserman I., Amer R., and Pe’er J. (2004) Liver function tests in metastatic uveal melanoma. American Journal of Ophthalmology 137:236-243.
Kaiserman I., Anteby I., Chowers I., Blumenthal E.Z., Kliers I., and Pe'er J. (2004) Post-brachytherapy initial tumor regression rate correlates with metastatic spread in posterior uveal melanoma. British Journal of Ophthalmology 88:892-895.
Neudorfer M., Kessler A., Anteby I., Goldenberg D., and Barak A. (2004) Co-existence of intraocular and orbital lymphoma. Acta Ophthalmologica Scandinavia 218:372-377.
Amer R., Pe'er J., Pappo O., and Dotan S. (2005) Necrobiotic xanthogranuloma associated with choroidal infiltration and syncytial giant cell hepatitis. Journal of Neuro-Ophthalmology 25:189-192.
Goldenberg-Cohen N., Cohen Y., Rosenbaum E., Herscovici Z., Chowers I., Weinberger D., Pe'er J., and Sidransky D. (2005) T1799A BRAF mutations in conjunctival melanocytic lesions. Investigative Ophthalmology and Visual Science 46:3027-3030.
Kaiserman I., Amer R., Kaiserman N., and Pe'er J. (2005) Ultrasonographic tissue characteristics of mushroom-shaped uveal melanoma. Current Eye Research 30:171-177.
Kaiserman I., Rosner M., and Pe'er J. (2005) Forecasting the prognosis of choroidal melanoma with an artificial neural network. Ophthalmology 112:1608-1611.
Lin A.Y., Maniotis A.J., Valyi-Nagy K., Majumdar D., Setty S., Kadkol S., Leach L., Pe'er J., and Folberg R. (2005) Distinguishing fibrovascular septa from vasculogenic mimicry patterns. Archives of Pathology and Laboratory Medicine 129:884-892.
Pe'er J. (2005) Ocular surface squamous neoplasia. Ophthalmology Clinics of North America 18:1-13.
Pe'er J. and Barzel I. (2005) Multilobular choroidal melanoma following Ruthenium 106 brachytherapy. Archives of Ophthalmology 124:868-869.
Pe'er J. and Frucht-Pery J. (2005) The treatment of primary acquired melanosis (PAM) with atypia by topical Mitomycin C. American Journal of Ophthalmology 139:229-234.
Rumelt S., Pe'er J., and Rubin P.A. (2005) The clinicopathological spectrum of benign peripunctal tumours. Graefes Archives of Clinical and Experimental Ophthalmology 243:113-119.
Ben Simon G.J., Abulafia A., and Pe'er J. (2006) Apoptosis inhibitor, survivin, in posterior uveal melanoma: Comparison among primary tumors, tumors resistant to brachytherapy, tumors with liver metastases, and liver metastases. Current Eye Research 31:251-257.
Kadkol S.S., Lin A.Y., Barak V., Kalickman I., Leach L., Majumdar D., Setty S., Maniotis A.J., Folberg R., and Pe'er J (2006) Osteopontin expression and serum levels in metastatic uveal melanoma – a pilot study. Investigative Ophthalmology and Visual Science 47:802-806.
Millodot M., Hendler K., and Pe'er J. (2006) Iris melanoma: A case report. Ophthalmic and Physiological Optics 26:120-126.
Pe'er J. (2006) Current approach to treating pre-malignant and malignant conjunctival tumors. Ophthalmology International 1:17-21.
Pe'er J., Sancho C., Cantu J., Eilam S., Barzel I., Shulman M., and Blumenthal E.Z. (2006) Measurement of choroidal melanoma basal diameter by wide-angle digital fundus camera: A comparison with ultrasound measurement. Ophthalmologica 220:194-197.
Folberg R., Arbieva Z., Moses J., Hayee A., Sandal T., Kadkol S., Lin A.Y., Valyi-Nagi, K., Setty S., Leach L., Chevez-Barrios P., Larsen P., Majumdar D., Pe'er J., and Maniotis A.J. (2006) Tumor cell plasticity in uveal melanoma: Microenvironment directed dampening of the invasive and metastatic genotype and phenotype accompanies the generation of vasculogenic mimicry patterns. American Journal of Pathology 169:1376-1389.
Kaiserman I., Kaiserman N., and Pe'er J. (2006) Long-term ultrasonic follow-up of choroidal nevi and their transformation to melanoma. British Journal of Ophthalmology 90: 994-998.
Vicuna-Kojchen J., Banin E., Averbukh E., Barzel I., Shulman M., Hemo I., Pe'er J., and Chowers I. (2006) Application of the standard photodynamic treatment protocol for symptomatic circumscribed choroidal hemangioma. Ophthalmologica 220:351-355.
Frenkel S., Barzel I., Levy J., Lin A.Y., Bartsch D.U., Majumdar D., Folberg R., and Pe'er J. (2007) Demonstrating circulation in vasculogenic mimicry patterns of uveal melanoma by confocal indocyanine green angiography. EYE (in press).
Barak V., Frenkel S., Kalickman I., Maniotis A.J., Folberg R., and Pe'er J. (2007) Serum markers to detect metastatic uveal melanoma. Anticancer Research 27:1897-1900.
Goldberg S., Frenkel S., Blumenthal E.Z., Solomon A., and Pe'er J. (2007) Neovascular glaucoma in intraocular lymphoma. Ophthalmology 114:1236-1237.
Lin A.Y., Ai Z., Lee S.-C., Pajcsy P., Pe'er J., Leach L., Maniotis A.J., and Folberg R. (2007) Comparing vasculogenic mimicry and endothelial cell lined vessels: Techniques for 3D reconstruction and quantitative analysis of tissue components from archival paraffin blocks. Applied Immunohistochemistry and Molecular Morphology 15:113-119.
Pe'er J., Blumenthal E.Z., and Frenkel S. (2007) Punch biopsy of iris lesions: A novel technique for obtaining histology samples. British Journal of Ophthalmology 91:660-662.
Folberg R., Leach L., Valyi-Nagy K., Lin A.Y., Marsha A., Apushkin M.A., Ai Z., Barak V., Majumdar D., Pe'er J., and Maniotis A.J. (2007) Modeling the behavior of uveal melanoma in the liver. Investigative Ophthalmology and Visual Science 48:2967-2974.
Gall N., Leiba H., Handzel R., and Pe'er J. (2007) Severe radiation retinopathy and optic neuropathy after brachytherapy for choroidal melanoma, treated by hyperbaric oxygen. EYE 21:1010-1012.
Pe'er J., Maly A., Deckel Y., and Frenkel S. (2007) Solitary fibrous tumor of the conjunctiva. Archives of Ophthalmology 125:423-426.
Barak V., Frenkel S., Valyi-Nagy K., Leach L., Apushkin M.A., Lin A.Y., Kalickman I., Baumann N., Pe'er J., Maniotis A.J., and Folberg R. (2007) Using the direct-injection model of early uveal melanoma hepatic metastasis to identify TPS as a potentially useful serum biomarker. Investigative Ophthalmology and Visual Science (in press).
Meir T., Zeschnigk M., Masshofer L., Pe'er J., and Chowers I. (2007) The spatial distribution of monosomy 3 and network vasculogenic mimicry paterns in uveal melanoma. Investigative Ophthalmology and Visual Science 48:1918-1922.
Meir T., Dror R., Yu X., Qian J., Simon I. Pe'er J., and Chowers I. (2007) Molecular characteristics of liver metastases from uveal melanoma. Investigative Ophthalmology and Visual Science (in press).
Weintraub M., Revel-Vilk S., Charit M., Aker M., and Pe'er J. (2007) Secondary acute myeloid leukemia following etoposide therapy for retinoblastoma. Journal of Pediatric Hematology and Oncology (in press).
Cornea and ocular surface
Espana E.M., Solomon A., and Tseng S.C.G. (2003) Amniotic membrane transplantation for bullous keratopathy in eyes with poor visual potential. Journal of Cataract and Refractive Surgery 29:279-284.
Kaiserman, I. (2003) Large subconjunctival emphysema causing diplopia and lagophthalmos. European Journal of Ophthalmology 13:86-87.
Kaiserman I. (2003) Severe allergic blepharoconjunctivitis induced by a dye for eyelashes and eyebrows. Ocular Immunology and Inflammation 11:149-151.
Li de-Q., Shang T.Y., Kim H.S., Solomon A., Lokeshwar B.L., and Pflugfelder S.C. (2003) Regulated expression of collagenases MMP-1, -8, and -13 and stromelysins MMP-3, -10, and -11 by human corneal epithelial cells. Investigative Ophthalmology and Visual Science 44:2928-2936.
Solomon A., Chowers I., Raiskup F., Siganos C.S., and Frucht-Pery J. (2003) Inadvertent conjunctival trauma related to contact with drug container tips: a “masquerade syndrome". Ophthalmology 110:796-800.
Solomon A., Espana E.M., and Tseng S.C.G. (2003) Amniotic membrane transplantation for reconstruction of conjunctival fornices. Ophthalmology 110:93-100.
Solomon A., Grueterich M., Li D.Q., Lee S.B., Meller D., and Tseng S.C.G. (2003) Overexpression of insulin-like growth factor binding protein 2 (IGF-BP2) in pterygium body fibroblasts. IOVS 44:573-580.
Zamir E. and Solomon A. (2003) Interstomal corneal epithelial cyst following epikeratoplasty. Archives of Ophthalmology 121:1510.
Espana E.M., Di Pascuale M., Grueterich M., Solomon A., and Tseng S.C.G. (2004) Keratolimbal allograft in corneal reconstruction. Eye 18:406-417.
Solomon A., Kaiserman I., Raiskup F.D., Landau D., and Frucht-Pery J. (2004) Long-term effects of Mitomycin C in pterygium surgery on sceral thickness and the conjunctival epithelium. Ophthalmology 111:1522-1527.
Solomon A., Zamir E., Levartovsky S., and Frucht-Pery J (2004) Surgical management of corneal plaques in vernal keratoconjunctivitis: A clinico-pathologic study. Cornea 23:608-612.
Zamir E., Pe'er J., and Solomon A (2004) Cogan syndrome with disfiguring lipid keratopathy (photo essay). Archives of Ophthalmology 122:1242-1243.
Kaiserman I., Kaiserman N., Nakar S., and Vinker S (2005) Dry eye in diabetic patients. American Journal of Ophthalmology 139:498-503.
Kaiserman I. Kaiserman N., Nakar S., and Vinker S. (2005) Herpetic eye disease in diabetic patients. Ophthalmology 112:2184-2188.
Yahalom C., Mechoulam H., Raiskup F., Solomon A., Pe'er J., and Frucht-Pery J (2005) Forty years of changing indications of penetrating keratoplasty in Israel. Cornea 24:256-258.
Frucht-Pery J., Raiskup F.D., Ilsar M., Landau D., Orucov F., and Solomon A. (2006) Conjunctival autografting combined with low-dose mitomycin C for prevention of primary pterygium recurrence. American Journal of Ophthalmology 141:1044-1050.
Molecular ophthalmology
Banin E., Obolensky A., Piontek Y., Falk H., Pikarsky E., Pe'er J., Panet A., and Chowers I. (2003) Gene delivery by viral vectors in primary cultures of lacrimal gland tissues. Investigative Ophthalmology and Visual Science 44:1529-1533.
Chowers I., Gunatilaka T.L. , Farkas R.H., Qian J., Hackam S.H., Duh E., Kageyama M., Vora A., Campochiaro P.A., and Zack, D.J. (2003) Identification of novel retina-enriched genes using a custom human retina cDNA microarray. Investigative Ophthalmology and Visual Science 44:3732-3741.
Chowers I., Liu D., Farkas R.H., Gunatilaka T.L., Hackam A.S., Bernstein S.L., Campochiaro P.A., Parmigiani G., and Zack D.J. (2003) Gene expression variation in the adult human retina. Human Molecular Genetics 12:2881-2893.
Sharon D., Sandberg M.A., Caruso R.C., Berson E.L., and Dryja T.P. (2003) Shared mutations in NR2E3 in enhanced S-cone syndrome, Goldmann-Favre syndrome, and many cases of clumped pigmentary retinal degeneration. Archives of Ophthalmology 121:1316-1323.
Sharon D., Sandberg M.A., Rabe V.W., Stillberger M., Dryja T.P., and Berson E.L. (2003) RP2 and RPGR mutations and clinical correlations in patients with X-linked Retinitis Pigmentosa. American Journal of Human Genetics 73:1131-1146.
Chowers I., Esumi N., Campochiaro P., and Zack D.J. (2004) Studies on retinal and retinal pigment epithelial gene expression. Novartis Foundation Symposium 255:131-145, discussion 145-146, 177-178.
Chowers I., Kim Y., Farkas R.H., Gunatilaka T.S., Hackam A.S., Campochiaro P.A., Finnemann S.C., and Zack D.J. (2004) Changes in retinal pigment epithelial gene expression induced by rod outer segment uptake. Investigative Ophthalmology and Visual Science 45:2098-2106.
Farkas R.H., Chowers I., Hackam A.S., Kageyama M., Nickells R.W., Otteson D.C., Duh E.J., Wang C., Valenta D.F., Gunatilaka T.L., Pease M.E., Quigley H.A., and Zack D.J. (2004) Increased expression of iron-regulating genes in monkey and human glaucoma. Investigative Ophthalmology and Visual Science 45:1410-1417.
Fishman G.A., Roberts M.F., Derlacki D.J., Grimsby J.L., Yamamoto H,. Sharon D., Nishiguchi K.M., and Dryja T.P. (2004) Novel mutations in the cellular retinaldehyde-binding protein gene (RLBP1) associated with retinitis punctata albescens. Archives of Ophthalmology 122:70-75.
Hackam A.S., Strom R., Liu D., Qian J., Wang C., Otteson D., Gunatilaka T., Farkas R.H., Chowers ., Kageyama M., Leveillard T., Sahel J-A., Campochiaro P.A., Parmigiani G., and Zack D.J. (2004) Identification of gene expression changes associated with the progression of retinal degeneration in the rd1 mouse. Investigative Ophthalmology and Visual Science 45:2929-2942.
Hackam A.S., Qian J., Liu D., Gunatilaka T., Farkas R.H., Chowers I., Kageyama M., Parmigiani G., and Zack D.J. (2004) Comparative gene expression analysis of murine retina and brain. Molecular Vision 10:637-649.
Lossos A., Baala L., Soffer D., Averbuch-Heller L., Dotan S., Munnich A., Lyonnet S., Gomori J.M. Genem A., Neufeld M., Abramsky O., Zlotogora J., and Argov Z. (2005) A novel autosomal recessive myopathy with external ophthalmoplegia linked to chromosome 17p13.1-p12. Brain 128:42-51. E-pub ahead of print: November 17, 2004.
Qian J., Esumi N., Chen Y., Wang Q., Chowers I., and Zack D.J. (2005) Identification of regulatory targets of tissue-specific transcription factors: application to retina-specific gene regulation. Nucleic Acids Research 33:3479-3491.
Lossos A., Khoury M., Rizzo W.B., Gomori J.M., Banin E., Zlotogorski A., Jaber S., Abramsky O., Argoz Z., and Rosenmann H. (2006) Phenotypic variability among adult siblings with Sjogren-Larsson syndrome. Archives of Neurology 63:278-280.
Kaiserman N., Obolensky A., Banin E.*, and Sharon D.* (2007) Novel USH2A mutations in Israeli patients with Retinitis Pigmentosa and Usher Syndrome type 2. Archives of Ophthalmology 125:219-224. (* = equal contribution).
White D.R., Ganesh A., Nishimura D., Rattenberry E., Ahmed S., Smith U.M., Pasha S., Raeburn S., Trembath R.C., Rajab A., Macdonald F., Banin E., Stone E.M., Johnson C.A., Sheffield V.C., and Maher E.R. (2007) Autozygosity mapping of Bardet-Biedl syndrome to 12q21.2 and confirmation of FLJ23560 as BBS10. European Journal of Human Genetics 15:173-178.
Bandah D., Swissa T., Ben-Shlomo G., Banin E., Ofri R., and Sharon D. (2007) A complex expression pattern of Pax6 in the pigeon retina. Investigative Ophthalmology and Visual Science 48:2503-2509.
Beit-Ya'acov A., Mizrahi-Meissonnier L., Obolensky A., Landau C., Blumenfeld A., Rosenmann A., Banin E., and Sharon D. (2007) Homozygosity for a novel ABCA4 founder splicing mutation is associated with progressive severe Stargardt-like disease. Investigative Ophthalmology and Visual Science 48:4308-4314.
Ocular immunology and inflammatory eye diseases
Rao N.A., Kimoto T., Zamir E., Giri R., Wang R., Ito S., Pararajasegaram G., Read R.W., and Wu G.-S. (2003) Pathogenic role of retinal microglia in experimental uveoretinitis. Investigative Ophthalmology and Visual Sciences 44:22-31.
Solomon A., Puxeddu I., and Levi-Schaffer F. (2003) Fibrosis in ocular allergic inflammation: recent concepts in the pathogenesis of ocular allergy. Current Opinions in Allergy and Clinical Immunology 3:389-393.
Zamir E., Bodaghi B., Tugal-Tutkun I., See R.F., Charlotte F., Wang R.C., Wechsler B., LeHoang P., Anteby I., and Rao N.A. (2003) Conjunctival ulcers in Behcet's disease. Ophthalmology 110:1137-1141.
Planer D., Cukierman T., Liebster D., Ilsar M., and Chajek-Shaul T. (2004) Anterior uveitis as a complication of treatment with high dose cytosine-arabinoside. American Journal of Hematology 76:304-306.
Albini T.A., Zamir E., Read R.W., Smith R.E., See F.R., and Rao, N.A. (2005) Evaluation of subconjunctival triamcinolone for nonnecrotizing anterior scleritis. Ophthalmology 112:1814-1820.
BenEzra D., Cohen E., and Maftzir G. (2005) Uveitis in children and adolescents. British Journal of Ophthalmology 89:444-448.
Micera A., Puxeddu I., Lambiase A., Antonelli A., Bonini S., Bonini S., Aloe L., Pe'er J., and Levi-Schaffer F. (2005) The pro-fibrogenic effect of nerve growth factor on conjunctival fibroblasts is mediated by transforming growth factor-beta. Clinical and Experimental Allergy 35:650-656.
Shoshani Y., Pe'er J., Doviner V., Frucht-Pery J., and Solomon A. (2005) Increased expression of inflammatory cytokines and matrix metalloproteinases in pseudophakic corneal edema. Investigative Ophthalmology and Visual Science 46:1940-1947.
Solomon A., Wajngarten M., Alviano F., Anteby I., Elchalal U., Pe'er J., and Levi-Schaffer F. (2005) Suppression of inflammatory and fibrotic responses in allergic inflammation by the amniotic membrane stromal matrix. Clinical and Experimental Allergy 35:941-948.
Ocular pharmacology and drug delivery
Banin E., Morad Y., Berenshtein E., Obolensky A., Yahalom C., Goldich J., Adibelli F., Zuniga G., DeAnda M., Pe'er J., and Chevion M. (2003) Injury induced by chemical warfare agents: Characterization and treatment of ocular tissues exposed to nitrogen mustard. Investigative Ophthalmology and Visual Science 44:2966-2972.
Eljarrat-Binstock E., Raiskup F., Frucht-Pery J., and Domb A.J. (2004) Hydrogel probe for iontophoresis drug delivery to the eye. Journal of Biomaterial Science: Polymer Edition 15:397-413.
Eljarrat-Binstock E., Raiskup F., Stepensky D., Domb A.J., and Frucht-Pery J. (2004) Delivery of gentamicin to the rabbit eye by drug-loaded hydrogel iontophoresis. Investigative Ophthalmology and Visual Sciences 45:2543-2548.
Frucht-Pery J., Mechoulam H., Siganos CS., Ever-Hadani P., Shapiro M., and Domb A. (2004) Iontophoresis-gentamicin delivery into the rabbit cornea, using a hydrogel delivery probe. Experimental Eye Research (David Maurice Festschrift issue) 78:745-749.
Eljarrat-Binstock E., Raiskup F., Frucht-Pery J., and Domb A.J. (2005) Transcorneal and transscleral iontophoresis of dexamethasone phosphate using drug loaded hydrogel. Journal of Control Release 106:386-390.
Morad Y., Banin E., Averbukh E., Berenshtein E., Obolensky A., and Chevion M. (2005) Treatment of ocular tissues exposed to nitrogen mustard: beneficial effect of zinc desferrioxamine combined with steroids. Investigative Ophthalmology and Visual Science 46:1640-1646.
Frucht-Pery J., Raiskup F., Mechoulam H., Shapiro M., Eljarrat-Binstock E., and Domb A. (2006) Iontophoretic treatment of experimental pseudomonas keratitis in rabbit eyes using gentamicin-loaded hydrogels. Cornea 25:1182-1186.
Raiskup-Wolf F., Eljarrat-Binstock E., Rehak M., Domb A., and Frucht-Pery J. (2006) Delivery of the gentamicin to the eye via iontophoresis. (In Czech). Ceska a Slovenska Oftalmolmologie 62:175-182.
Eljarrat-Binstock E., Domb A.J., Orukov F., Frucht-Pery J., and Pe'er J. (2007) Methotrexate delivery to the eye using transscleral hydrogel iontophoresis. Current Eye Research 32:639-646.
Albinism
Schreyer-Shafir N., Huizing M., Anikster Y., Nusinker Z., Bejarano-Achache I., Maftzir G., Resnik L., Helip-Wooley A., Westbroek W., Gradstein L., Rosenmann A., and Blumenfeld, A. (2006) A new genetic isolate with a unique phenotype of syndromic oculocutaneous albinism: Clinical, molecular and cellular characteristics. Human Mutation 27:1158.
Lasers in ophthalmology
Zeira E., Manevitch A., Manevitch Z., Kedar E., Gropp M., Daudi N., Barsuk R., Harati M., Yotvat H., Troilo P.J., Griffiths T.G., Pacchione S.J., Roden D.F., Niu Z., Nussbaum O., Zamir G., Papo O., Hemo I., Lewis A., and Galun E. (2007) Femtosecond laser: a new intradermal DNA delivery method for efficient, long-term gene expression and genetic immunization. FASEB J. (in press). E-pub ahead of print: June 15, 2007.
Glaucoma
Blumenthal E.Z. and Morales A. (2003) Resolution of hypotony maculopathy. Archives of Ophthalmology 121:1502-1503.
Blumenthal E.Z., Sample P.A., Berry C.C., Lee A.C., Girkin C.A., Zangwill L., Caprioli J., and Weinreb R.N. (2003) Evaluating several sources of variability for standard and SWAP visual fields in glaucoma patients, suspects, and normals. Ophthalmology 110:1895-1902.
Blumenthal E.Z. and Sapir-Pichhadze R. (2003) Misleading statistical calculations in far-advanced glaucomatous visual field loss. Ophthalmology 110:196-200.
Guedes V., Schuman J.S., Hertzmark E., Wollstein G., Correnti A., Mancini R., Lederer D., Voskanian S., Velazquez L., Pakter H.M., Pedut-Kloizma T., Fujimono J.G., and Mattox C. (2003) Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes. Ophthalmology 110:177-189.
Nesher, R. and Ticho, U. (2003) Switching from systemic to the topical carbonic anhydrase inhibitor dorzolamide: effect on the quality of life of glaucoma patients wth drug-related side effects. Israel Medical Association Journal 5:260-263.
Sapir-Pichhadze R. and Blumenthal E.Z. (2003) The medical treatment of glaucoma. Harefuah 142:66-69. (in Hebrew)
Sapir-Pichhadze R. and Blumenthal E.Z. (2003) Steroid-induced glaucoma. Harefuah 142:137-140. (in Hebrew)
Blumenthal E.Z. (2004) Quantifying retinal nerve fiber layer thickness histologically: a novel approach to sectioning of the retina. Investigative Ophthalmology and Visual Science 45:1404-1409.
Blumenthal E.Z., Haddad A., Horani A., and Anteby I. (2004) The reliability of frequency- doubling perimetry in young children. Ophthalmology 111:435-439.
Boden C., Blumenthal E.Z., Pascual J., McEwan G., Weinreb R.N., Medeiros F., and Sample P.A. (2004) Patterns of glaucomatous visual field progression identified by three progression criteria. American Journal of Ophthalmology 138:1029-1036.
Frenkel S. Morgan J.E., and Blumenthal .EZ. (2005) Histological measurement of retinal nerve fibre layer thickness. Eye 19:491-498. Epub ahead of print: August 27, 2004.
Goldberg S., Gallily R., Bishara S., and Blumenthal E.Z. (2004) Dorzolamide-induced choroidal detachment in a surgically untreated eye. American Journal of Ophthalmology 138:285-286.
Sample P.A., Chan K., Boden C., Lee T-W., Blumenthal E.Z., Weinreb R.N., Bernd A., Pascual J., Hao J., Sejnowski T., and Goldbaum M.H. (2004) Using unsupervised learning with variational Bayesian mixture of factor analysis to identify patterns of glaucomatous visual field defects. Investigative Ophthalmology and Visual Science 45:2596-2605.
Abramov Y., Borik S., Yahalom C., Fatum M., Avgil G., Brzezinski A. and Banin E. (2005) Does postmenopausal hormone replacement therapy affect intraocular pressure? Journal of Glaucoma 14:271-275.
Frenkel S., Katz S., Horani A., Kaiserman I., Abu Asleh S., and Blumenthal E.Z. (2006) Estimating intraocular pressure using a glass rod. Annals of Ophthalmology 38:195-199.
Blumenthal E.Z., Horani A., Sasikumar R., Garudadri C., Udaykumar A., and Thomas R. (2006) Correlating structure with function in end-stage glaucoma. Ophthalmic Surgery, Lasers and Imaging 37:218-223.
Pediatric ophthalmology and eye movements
Anteby I., Isaac M., and BenEzra D. (2003) Hereditary subluxated lenses: visual performances and long-term follow-up after surgery. Ophthalmology 110:1344-1348.
BenEzra, D. (2003) In-vitro fertilization and retinoblastoma. Lancet 361:273-4.
Amer R. and Anteby I. (2004) Familial intraocular cysts in association with anisometropia. British Journal of Ophthalmology 88:1349-1350.
BenEzra D. (2005) In vitro fertilization and childhood retinoblastoma. British Journal of Clinical Pharmacology 59:724.
BenEzra D (2005) IVF and retinoblastoma. British Journal of Ophthalmology 89:393.
Habil I., Cohen E., Karshai I., BenEzra D., and Behar-Cohen F. (2005) Spontaneous involution of autologous lenses and phacoanaphylaxis reaction in Stickler syndrome. British Journal of Ophthalmology 89:1532-1533.
Kowal L., Yahalom C., and Shuey N.H. (2006) Chiari 1 malformation presenting as strabismus. Binocular Vision and Strabismus Quarterly 21:18-26.
Development of ophthalmic instrumentation
Miron H. and Blumenthal E.Z. (2003) Bridging analog and digital video in the surgical setting. Journal of Cataract and Refractive Surgery 29:1874-1877.
Blumenthal E.Z. and Frenkel S. (2005) Inter-device reproducibility of the scanning laser polarimeter with variable corneal compensation. Eye 19:308-311. Epub ahead of print: July 30, 2004.
Frenkel S., Slonim E., Horani A., Molcho M., Barzel I., and Blumenthal E.Z. (2005) Operator learning effect and inter-operator reproducibility of the scanning laser polarimeter with variable corneal compensation. Ophthalmology 112:257-261.
Horani A., Frenkel S., and Blumenthal E.Z. (2006) The effect on pupil dilation on scanning laser polarimetry with variable corneal complensation. Ophthalmic Surgery, Lasers and Imaging 37:212-216.
Horani A., Frenkel S., and Blumenthal E.Z. (2007) Test-retest variability in visual field testing using frequency doubling technology. European Journal of Ophthalmology 17:203-207.
Orlev A., Horani A., Rapson Y., Cohen M.J., and Blumenthal E.Z. (2007) Clinical characteristics of eyes demonstrating atypical patterns in scanning laser polarimetry. EYE (in press). E-pub ahead of print: July 13, 2007.
Blumenthal E.Z., Parikh R.S., Pe'er J., Naik M., Kaliner E., Cohen M.J., Prabakaran S., Kogan M., and Thomas R. (2007) Retinal nerve fiber layer imaging compared with histological measurements in a human eye. EYE (in press). E-pub ahead of print: August 24, 2007.
Neuro-ophthalmology
Levin N., Orlov T., Dotan S., Zohary E. (2006) Normal and abnormal fMRI ativation patterns in the visual cortex after recovery from optic neuritis. Neuroimage 33:1161-1168.
Ocular microbiology
Enk C.D., Anteby I., Abramson N., Amer R., Amit Y., Bergshtein-Kronhaus T., Cohen E., Greenberg Z., Jonas F., Maayan S., Marva E., Strauss U., and BenEzra D. (2003) Onchocerciasis among Ethiopian immigrants in Israel. Israel Medical Association Journal 5:485-488.
Enk C.D., Gardlo K., Ruzicka T., and BenEzra D. (2003) Onchocerciasis. Hautarzt 4:513-517. (in German)
Refractive surgery
Rubinfeld R.S., Hardten D.R., Donnenfeld E.D., Stein R.M., Koch D.D., Speaker M.G., Frucht-Pery J., Kameen A.J., and Negvesky G.J. (2003) To lift or recut: changing trends in LASIK enhancement. Journal of Cataract and Refractive Surgery 29:2306-2317.
Zadok D., Raiskup F., Landau D., and Frucht-Pery J. (2003) Long-term evaluation of hyperopic LASIK. Journal of Cataract and Refractive Surgery 29:2181-2188.
Kaiserman I., Hazarbassanov R., Varssano D., and Grinbaum A. (2004) Contrast sensitivity after wave front-guided LASIK. Ophthalmology 111:454-457.
Varssano D., Kaiserman I., Hazarbassanov R. (2004) Topographic patterns in refractive surgery candidates. Cornea 23:602-607.
Lifshitz T., Levy J., Raiskup F., Klemperer I., and Frucht-Pery J. (2005) Two cases of pneumococcal keratitis following myopic LASIK. Journal of Refractive Surgery 21:498-501.
Landau D., Levy J., Solomon A., Lifshitz T., Orucov F., Strassman E., and Frucht-Pery J. (2006) Traumatic corneal flap dislocation one to six years after LASIK in nine eyes with a favorable outcome. Journal of Refractive Surgery 22:884-889.
Landau D., Siganos C.S., Mechoulam H., Solomon A., and Frucht-Pery J. (2006) Astigmatism following mersilene and nylon suture use for penetrating keratoplasty. Cornea 25:691-694.
Frucht-Pery J., Landau D., Raiskup F.D., Strassman E., Blumenthal E.Z., and Solomon A. (2007) Early transient post-LASIK visual acuity loss due to steroid-induced elevation of the intraocular pressure. Journal of Refractive Surgery 23:244-251.
Oculoplastics
Nemet A.Y., Deckel Y., and Kourt G. (2006) Orbital invasion of frontal sinus lymphoma. Oribt 25:149-51.
Nemet A.Y., Deckel Y., Martin P.A., Kourt G., Chilov M., Sharma V., and Benger R. (2006) Management of periocular basal and squamous cell carcinoma: a series of 485 cases. American Journal of Ophthalmology 142:293-297.
Other
Farber M.D. (2003) National registry for the blind in Israel: Estimation of prevalence and incidence rates and causes of blindness. Ophthalmic Epidemiology 10:267-277.
Rodriguez P. and Blumenthal E.Z. (2003) Photo quiz. Abnormal ocular findings. American Family Physician 68:933-934.
Morales A.J. and Blumenthal E.Z. (2004) Painful red eye after surgery. American Family Physician 70:155-156.
Mimran S. and Rotem R. (2005) Ocular trauma under the shadow of terror. Insight (journal of the American Society of Ophthalmic Registered Nurses, Inc.) 30:9-11.
Vicuna-Kojchen J., Amer R., and Chowers I. (2007) Reversible structural disruption of the outer retina in acute welding maculopathy. EYE 21:127-129.
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