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Molecular Laboratory

 

Head of Molecular Lab:

Dr. Israela (Issy) Lerer

Telephone 972-2-6776016

FAX 972-2-6777499

E-mail:  lereris@hadassah.org.il

 

Molecular tests for genetic diseases (see detailed list below):

Postnatal diagnosis

Prenatal diagnosis

Preimplantation diagnosis

Genetic screening

 

Lab team:

 

Liat Ben Avi

Gadjet Avital

Gruzman Gili

Havshush Yasmin

Metaviev Raisa

Nadel Avishag

Quint Adina

Silverstein Shira

Weinberg Naomi

 

 

List of Genetic Tests

Performed in the

Molecular Laboratory

 

Blood

Sample

(EDTA)

Exam.

population

 

Hadassah Code

M. Health

Code

 

 

Name of disease

Gene/Mutation examined

7ml

510364

J1040

 Achondroplasia

FGFR3/G380R

7ml

Iran

510169

J1051

Achromatopsia

CNGA3/V529M

7ml

North Africa

5100695

J0881

Adrenal Hyperplasia

11β Hydroxylase/ R448H

7 ml*

510326

J1070

 

Angelman Syndrome

15q11-1/Deletion;UPD;methylation

7ml

אירן

510885

J1081

APECED   

AIRE/Y85C

7ml

North Africa

Palestinians

510559

 J0671

Ataxia Telangiectasis

ATM1/R35X;2284del2;

497del17kb

7 ml*

510328

J1100

Beckwith Wiedemann Syndrome

11p/UPD;methylation 

7ml

Ashkenazim Jews

510245

J1111

 

Bloom Syndrome

RECQL3/

2281del6ins7

7ml

Oncogenetic Counselling

510318

J1311

 

510201

Breast Cancer

BRCA1/ 185delAG;5382insC;3053C>T

BRCA2/6174delT;8765delAG;

4093del4

7ml

Ashkenazim Jews

510382

J0031

 Canavan Disease

ASPA/G285A;Y231X

7 ml*

510324

J0681

 

 Charcot Marie Tooth

(CMT1A)

Chromosome 17p11.2/duplication

7ml

Abu Gosh

510885

Congenital Nephrotic Syndrome NPHS/2160insC;Q380X

7 ml**

Lybia

510108

J999

Creutzfeld-Jacob Disease (CJD)

PRNP/Exclusion test

 

7ml

North Africa

 

510322/

068510

J0211

CerebroTendinous

Xanthomatosis (CTX)

CYP27/720delT;IVS4-1G>A;T306M

 

7ml

 

510315

J1140

 Cystic Fibrosis CFTR/W1282X;∆F508;

G542X;

N1303K;3849+10kbC>T;17171G>A;405+1G>T;S549RT>G ;W1089X;

Y1092X;G85E; I1234V;2751+1insT;

3121-1G>A;Q359k; 4010del4;R75X;2183AA>G;

3120del8.6kb;C225X; Del2; 1677delTA

7ml

North Africa

510885

 

Cystinosis

CTNS/G339R

7ml 

510430

J0720

Torsion Dystonia (DYT1)    

TOR1/delGAG

7ml

Ashkenazim Jews

510162

J0991

Fanconi Anemia 

FANC/IVS4+4A>T

7ml

Ashkenazim Jews

510885

J0710

Familia Dysautonomia

IKBKAP/IVS20+6T>C; R696P

7ml

510316

J1271

 

Familial Mediterranean Fever (FMF)

MEFV/M694V;M694I;V726A;E148Q;M680I; K695R

7 ml***

510327

J9900

Fragile X Syndrome (FRAXA)   

FMR1/CGG repeats

7 ml

510435

J0830  or J0750

Friedrich Ataxia

FRATAXIN/GAA repeats

7ml

510975

J0061

Glycogen Storage Disease

(GSD1a) G6Pase/R83C

7ml

510317

J1151

 

Hearing Loss

GJB2;GJB6/167delT;35delG;

delCNX30

Mitochondrial1555A>G

7 ml

Onco

Genetic Counselling

510049

510492

510201

Hereditary Non-Polyposis Colorectal Cancer (HNPCC)

 MSH2/1906G>C MSI

(MSH6; MLH1)

7 ml*

510023

J0740

Hereditary Neuropathy with liability to Pressure Palsies (HNPP)

Chromosome 17p11.2/deletion

7ml

510329   510435or

J0750

Huntington disease

Huntingtin/CAG repeats

7ml

510885

J0221

Hypercholesterolemia

7ml

510329

Kennedy Disease (SBMA)

AR/CAG repeats

7 ml*

510652

J0790

Myotonic Dystrophy (MD1)

DM1/CTG repeats

7 ml

510323

Myotonic Dystrophy (MD2)

ZNF9/CCTG repeats

7ml

Palestinians

510885

 

Nephrotic Syndrome Steroid resistant

PODOCIN/R138X

7 ml**

510325

J9991

Neurofibromatosis NF1

NF1/Linkage; deletion

7ml

A-Tour

Village

510885

J0071

Non-Ketotic Hyperglycinemia

(NKH)  

GLDC/M1T

7 ml**

510069

J9991

 

Poly-Cystic Kidneys Disease

PKD1 (dominant); PKHD1

(recessive)/ linkage

7 ml*

510326

J1070

Prader-Will6y Syndrome (PWS)

15q11-13/Deletion;UPD;methylation

10 ml*

510819

J0860

Retinoblastoma

RB1/Deletion;sequencing

7 ml*

510331

Russel Silver Syndrome

Chromosome 7; 11/UPD; methylation

7ml

510329

J0830

 

Spino Cerebellar Ataxia (SCA)

SCA1;SCA2;SCA3;SCA6;SCA7;

DRPLA/

CAG repeats

7 ml*

510444

J0820

Spinal Muscular Atrophy (SMA)

SMN1 deletion

7 ml*

510331

Transient Neonatal Diabetes Chromosome 6/ duplication

7ml

Ashkenazim Jews

510040

 

Asher Syndrome

PCDH15/R245X

7ml**

510069

J9991

Waardenburg Syndrome

PAX 3/;linkage

7 ml

510331

 X Chromosome Inactivation

7 ml

510321

Deletion in Y Chromosome

 

510260

DNA Extraction

 

510322

510068

Molecular Test for a

Known Mutation

 

510885

J3011

A Familial Mutation

 

510331

Complex Molecular Test 

 

510163

QFPCR 

 

510069

510865

9991J

Linkage Analysis

 

* Blood samples from the patient and the parents.

** Blood samples from all family members.

*** Blood sample from the patient and his mother.

 

                           

 

 






            
     
 


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