(November 2007)
ZEEV PERLES, M.D.
Pediatric Cardiology Unit
Pediatric department
Hadassah-Hebrew University Medical Center
Kiriat Hadassah, Ein Karem
Jerusalem Israel
Phone: 972-2-6777111
Fax: 972-2-6434520
Cell Phone: 972-50-7874712
Email: zperles@hadassah.org.il
PERSONAL INFORMATION
Date of Birth: December 4, 1961
Place of Birth: Jerusalem, Israel
I.D. 05738704-5
Citizenship: Israeli
Marital Status: Married + 3 children
Wife- Sharon Perles, Dieticien, PhD student
Children: Michal (25.6.95)
Shlomo-Asher (7.8.97)
Itai (23.10.00)
Home Address and Phone:
4 Kimchi st., Jerusalem 92549, Israel
972-2-5635375
Army Service:
1979-1983: Parachuting Force, IDF.
1983-Present: Captain, Military Physician (reserve forces), IDF.
POSITIONS HELD AND EDUCATION
1984-1990 Faculty of Medicine, The Hebrew University – Hadassah Medical School
1991-1992 Rotating Internship, Hadassah University Hospital, Jerusalem, Israel
1992-1997 Residency in Department of Pediatrics, Hadassah University Hospital,Jerusalem, Israel, Department Head: Professor. S Yatsiv
1/1998-12/2000 Postdoctoral Fellow, Clinical. Texas Children’s Hospital. Pediatric Cardiology. Houston, TX USA. Section Chief: J. Timothy Bricker, MD
1/1/2001-6/30/2001 Postdoctoral Fellow, Research. Phoebe Willingham Muzzy, Pediatric Molecular Cardiology Laboratory, Baylor College of Medicine, One Baylor Plaza, Houston, TX USA. Laboratory Director: Jefferey A. Towbin, MD
08/10/2001-present Staff member, pediatric Cardiology Unit, Hadassah University Hospital, Jerusalem, Israel
LICENSURE/BOARD CERTIFICATION
1992 Israeli license to practice medicine (#22600 from 31/3/1992).
1995 Israeli Pediatric Board Examination Stage I and II.(License #16102 from 2/2/1998)
1995 United States Medical Licensing Examination (USMLE) Step I
1997 United States Medical Licensing Examination (USMLE) Step II
2001 Israeli Pediatric Cardiology Board Examination Stage I and II (License #54258 from 7/12/2001)
MEMBERSHIPS
American Academy of Pediatrics (1998-2001).
American College of Cardiology (1998-2001).
American Heart Association: (1998-2002).
Israel Medical Association (1992-present excluding 1998-2000)
Israel Pediatric Cardiology Society (2000-present)
PRE-MEDICAL WORK EXPERIENCE
Sleep lab technician, the laboratory for sleep disorders, Bikur Cholim hospital, Jerusalem, Israel, 1987-1989
OTHER ACADEMIC EXPERIENCE
Journal Peer Reviewer: Pediatric Cardiology
ACADEMIC RESPONSIBILITIES
Coordinator of pediatric residency weekly CME lecture program, Department of Pediatrics, Hadassah University Hospital, Jerusalem, Israel (1995-1996)
Coordinator, weekly fellow’s conference, Section of Pediatric Cardiology, Department of Pediatrics, Texas Children’s Hospital, Baylor College of Medicine. (March, 1999-June 2001).
Member, national committee for establishment of the Israeli pediatric syllabus 2007-2008
Supervision of Medical degree students:
Rosannah Blechter- 3rd year, Hebrew University: Obstructive Left Heart Syndromes- Hypoplastic left Heart Syndrome and Shone Complex. August 2005.
Courses Taught
Hebrew University Medical School: 4th year. Introduction to pediatrics (#96710)- Congenital Heart Lesions with Right to Left Shunts. 2 annual hours. (2002-present)
The Institute for Medical Equipment (Biotechnology): 2nd year, Introduction to Pediatric Cardiology. 60 annual hours. 2001-2006
Teaching Experience
Baylor College of Medicine Pediatric Residency Lecture Series: Total of 12 CME lectures
Texas Children’s Hospital Pediatric cardiology fellowship Lecture Series: Total of 6 semi-annual lectures.
Texas Children’s Hospital Critical Care Fellowship Lecture Series: Total of 3 annual lectures.
Hebrew University students:
4th year medical, 16 annual hours
6th year medical, 24 annual hours
Clin. Pharmacology. 9 annual hours
Hadassah University Hospital medical students and residents:
Outpatient clinics - 80 annual hours
Post cath rounds - 5 annual hours
echo lab -80 annual hours
Research Interests
Genetic basis of cardiomyopathies
Detection of fetal arrhythmias
Myocardial deformation analysis in different hemodynamic and pathologic conditions
Clinical Interests
Genetic congenital heart syndromes
Cardiomyopathies
Research Experience
Molecular Genetic Identification of Cardiac Disease-Causing Genes
Methods used include:
Mutation detection using linkage analysis, candidate gene approach and gene expression studies
Techniques used:
PCR, gel electrophoresis of DNA, SSCP and heteroduplex analysis, linkage analysis with STS and restriction enzyme markers for recombination mapping.
Expression studies: expression cloning in eukaryotic cells using plasmid vectors, western blotting, immunohistochemistry and immunoflorescence microscopy of transfected cell lines and of muscle tissue
AWARDS
Finalist and winner (first place) for the 2002 Young Investigators Awards Competition of the American College of Cardiology, section of Molecular & Cellular Cardiology (Familial Restrictive Cardiomyopathy Caused by a Missense Mutation in the Desmin Gene: Possible Role of Apoptosis in Disease Pathogenesis)
The 2002 outstanding teacher award, the Hebrew University Medical school, Jerusalem Israel
The 2006 outstanding teacher award, the Hebrew University Medical school, Jerusalem Israel
PRESENTATIONS AND PUBLICATIONS (Last updated January 2007)
Doctoral dissertation- MD thesis
Differential Flow Estimation in Pulmonary Arteries of Children with Congenital Heart Diseases. A Novel Modality using Digital Subtraction Angiography Technology
The work was done under the supervision of Dr. AJJT Rein at the Hadassah-Hebrew University Medical Center in 1998, and was not published in a journal.
Books: None published
Books Edited: None
Chapters in Collections: None published
Publications
Original Papers in Peer Reviewed Journals:
1) Rein AJ, O'Donnell C, Geva T, Nir A, Perles Z, Hashimoto I, Li XK, Sahn DJ. Use of tissue velocity imaging in the diagnosis of fetal cardiac arrhythmias. Circulation. 106:1827-1833, 2002. 16;16
2) Vatta M, Mohapatra B, Jimenez S, Sanchez X, Faulkner G, Perles Z, Sinagra G, Lin JH, Vu TM, Zhou Q, Bowles KR, Di Lenarda A, Schimmenti L, Fox M, Chrisco MA, Murphy RT, McKenna W, Elliott P, Bowles NE, Chen J, Valle G, Towbin JA.Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction. J Am Coll Cardiol.;42:2014-27, 2003. 54;54
3) Nir A, Bar-Oz B, Perles Z, Brooks R, Korach A, Rein AJJT. N-terminal pro-B-type natriuretic peptide. Normal plasma levels from birth to adolescence. Elevated levels at birth and in heart diseases. Acta Paediatr 93:603-7. 2004 17;14
4) Cohen S, Springer C, Avital A, Perles Z, Rein AJ, Argaman Z, Nir A. Amino-terminal pro-brain-type natriuretic peptide: heart or lung disease in pediatric respiratory distress? Pediatrics. 2005;115:1347-50. 3;3
5) Nasser N, Perles Z, Rein AJ, Nir A. NT-proBNP as a marker for persistent cardiac disease in children with a history of dilated cardiomyopathy and myocarditis. Pediatr Cardiol 27:87-90, 2006 0
6) Mott AR, Alomrani A, Tortoriello TA, Perles Z, East DL, Stayer SA. Changes in cerebral saturation profile in response to mechanical ventilation alterations in infants with bidirectional superior cavopulmonary connection. Pediatr Crit Care Med. 2006 Jul;7(4):346-50. 1;1
7) Fried I, Bar-Oz B, Perles Z, Rein AJJT, Zonis Z, Nir A. N-terminal-pro-B-type natriuretic peptide levels in acute versus chronic left ventricular J Pediatr 49:28-31, 2006. 0
8) Fried I, Bar-Oz B, Algur N, Fried E, Gavri S, Yatsiv I, Perles Z, Rein AJ, Zonis Z, Bass R, Nir A. Comparison of N-terminal pro-B-type natriuretic peptide levels in critically ill children with sepsis versus acute left ventricular dysfunction. Pediatrics. 2006 Oct;118(4):e1165-8. Epub 2006 Sep 11. 0
9) Perles Z, Gavri S, Rein AJJT. Assessment of fetal myocardial performance using myocardial deformation analysis. Am J Cardiol, 2007 Apr 1;99(7):993-6.
10) Ta-Shma A, Perles Z, Gavri S, Golender J, Tarshansky S, Shlichter C, Bar Tov H,
Rein AJ. Analysis of Segmental and Global Function of the Fetal Heart Using Novel Automatic Functional Imaging. J Am Soc Echocardiogr. 2007 Jul 10; [Epub ahead of print].
11) Ekstein S, Nir A, Rein AJ, Perles Z, Bar-Oz B, Salpeter L, Algur N, Weintraub M. N-terminal-proB-type natriuretic peptide as a marker for acute anthracycline
cardiotoxicity in children. J Pediatr Hematol Oncol. 2007 Jul;29(7):440-4.
Case Reports:
1) Perles Z, Bar-Ziv J, Granot E. Brain edema – An underdiagnosed complication of shigella infection. Pediatr Infec Dis J 14:1114-1115, 1995. 5;5
2) Nir A, Perles Z, Gomori JM, Rein AJ. Echocardiographic sign for cerebral ischemia. Pediatr Neurol 17:259-261, 1997. 0
3) Perles Z, Nir A, Cohen A, Bashary A, Engelhard D. Atrioventricular block in a toxic child: Do not forget diphtheria. Pediatr Cardiol 21:282-283, 2000. 3;3
4) Perles Z, Nir A, Nadjari M, Ergaz Z, Raas-Rothschild A, Rein AJ. Absent ductus venosus in the fetus: review of the literature and first report of direct umbilical venous drainage to the coronary sinus. Fetal Diagn Ther 18:247-251, 2003. 3;3
5) Gavri S, Nashashibi M, Perles Z, Milgarter E, Marzouka B, Rein AJJT. Tetralogy of Fallot with pulmonic atresia with cyclic occlusion of an associated aortic sinus of Valsalva-pulmonary artery communication. Pediatr Cardiol 27:131-3, 2006. 0
6) Daana M, Wexler, I, Milgalter E, Rein AJJT , Perles Z. Symptomatic myocardial bridging in a child without hypertrophic cardiomyopathy. Pediatrics 117:333-5, 2006 0
Letters:
Rein AJ, Mevorach D, Perles Z, Shovali A, Elchalal U. Fetal first-degree heart block, or where to set the confidence limit: comment on the article by Sonesson et al. Arthritis Rheum. 2005;52:366 3;3
Reviews:
Perles Z, Gavri S, Rein AJJT. Tachyarrhythmias in the Fetus: State of the Art Diagnosis and Treatment. Progress in Pediatric Cardiology 22:95-107, 2006 0
Abstracts Presented:
Braverman I, Perles Z, Elidan J, and Ramu N. Burkitt’s Lymphoma of the Head and Neck. Presented at the 3rd International Conference of Pediatric Otorhinolaryngology, Jerusalem, Israel, November 1993.
Rabinowitz R, Tadmor OP, Perles Z, Aboulafia Y, Diamant YZ: Comparison between fetal response to vibroacoustic stimulation in active and resting states. The Annual Symposium of Medical Physics In Memory of Edward W. Joseph. Jerusalem, Israel. April 1994.
Rabinowitz R, Tadmor O, Perles Z. et al. Comparison Between Fetal Response to Vibroacoustic Stimulation In Active and Resting States. Presented at the Medical Equipment and Technology Annual Conference, Jerusalem College of Technology, Jerusalem, Israel, March 1995.
Rein AJJTR, Perles Z., Nir A, Gozal D, Chisin R, Assessment of regional lung perfusion in children using digital subtraction angiography. Annual Meeting of the Israel Heart society, April 1998.
Perles Z, Fraser CC, Fraley K, Ayres NA., Vincent JA., Lewin MB. Echocardiographic Diagnosis Alone For the Complete Repair of Tetralogy of Fallot. Presented at the American Academy of Pediatrics Annual Meeting 2000,Chicago, Illinois, October 28-November 1, 2000, .
Perles Z, Fraser CC , Fraley K, Ayres NA, Vincent JA, Feltes TF, Pignatelli RH, Lewin MB. Do Unrecognized Diagnoses Affect Surgical Outcome in Tetralogy of Fallot Patients? Presented at the American Heart Association 73rd Annual Scientific Sessions, New Orleans, Louisiana, November 12-15, 2000.
Perles Z, Bowles NE, Vatta M, Jimenez Shinawe, Szmuszkovicz J, Capetanaki Y, Towbin JA. Familial Restrictive Cardiomyopathy Caused by a Missense Mutation in the Desmin Gene: Possible Role of Apoptosis in Disease Pathogenesis. Presented at the 51st annual scientific session of the American College of Cardiology, Young Investigators Awards Competition, section of Molecular & Cellular Cardiology, Atlanta Georgia, march 17-20 2002
Rein AJJT, Nir A, Perles Z, Rothchild A, Ergaz Z. A Persistent Vena Cava is not a Normal Variant But a Marker for Congenital Heart Disease. The 49th annual conference of the Israel Heart Society, april 2002.
Nir A, Braun J, Perles Z, Rein AJJT. A Newly Described Functional Capacity Score May Predict Mortality in Infants and Children with Left Ventricular Dysfunction and Normal Cardiac Anatomy. The 49th annual conference of the Israel Heart Society, april 2002.
Perles Z, Nir A, Rein AJJT. Pre-operative echocardiographic diagnosis for tetralogy of fallot: the new gold standard. The 49th annual conference of the Israel Heart Society, April 2002.
Perles Z, Rein AJJT, Nir A, Hashimoto I, Li X, Sahn DJ. Strain Rate Imaging is Superior to Tissue Velocity Imaging for Measuring Atrioventricular Time Interval in the Fetus. 52nd Annual Scientific Session of the American College of Cardiology Chicago, Illinois, march 2003
Perles Z, Nir A, Rein AJJT, Cardiac Function in Fetuses with Echogenic Foci.
The 50th annual conference of the Israel Heart Society, April 2003
Perles Z, Nir A, Rein AJJT, Tissue Velocity And Strain Rate Imaging: Normal Values In Fetuses. The 50th annual conference of the Israel Heart Society, April 2003
Nir A, Bar Oz B, Perles Z, Brooks R, Rein AJJT. N-terminal pro-b-type natriuretic peptide. Normal plasma levels from birth to adolescence. Elevated levels at birth, and in patients with heart disease. A joint meeting of heart failure, the European society of cardiology and international society for heart research, Strasbourg, France June 2003.
Stephen A. Stayer, M.D., Ahmed Alomrani, M.D., Tia Tortoriello, M.D., Zeev Perles, M.D., Mott R. Antonio, M.D. The Effects of Alterations in Ventilation on Cerebral Oxygen Saturation among Infants after Bidirectional Superior Cavopulmonary Connection American Society of Anesthesiology annual meeting, San-Francisco, October 2003
Cohen S, Springer C, Argaman Z, Perles Z, Rein AJJT, Nir A. N-terminal pro-b-type natriuretic peptide differentiates lung from heart disease in infants with respiratory distress. Am College Cardiol, New Orleans, March 2004.
Ashraf M, Rein AJJT, Lysyansky P, De la Cruz JS, Perles Z, Jensen AJ, Nelson SL, Li X, Bhat AH Sahn DJ. Improved Delineation of Myocardial Twist by a New Two-Dimensional Strain Analysis Method: An in Vitro Study. The American Society of Echocardiography, San Diego, CA, 2004.
Pham P, Balaji S, Bhat AH, Rein AJJT, Pemberton J, Perles Z, Ashraf M, Reed R, Stuesse D, Li X, Lysyansky P, Shen I, Ungerleider RM, Sahn DJ. Tissue Doppler Echocardiography Combined with a New 2D Strain Analysis Method Aid Assessment of Ventricular Resynchronization Pacing in Children with Congenital Heart Disease. The American Society of Echocardiography, San Diego, CA, 2004
Eckstein S, Nir A, Perles Z, Rein AJJT, Weintraub M. NT-pro BNP as a sensitive marker for acute Anthracycline Cardiotoxicity in Children. The 52nd Annual Conference of the Israel heart Society. Tel Aviv, April 2005.
Elchalal U, Mevorach D, Perles Z, Gavri S, Nir A, Nadjari M, Yanai N, Rein AJJT. Early detection and treatment of first degree atrioventricular block in fetuses exposed to maternal autoantibodies – A fetal kinetocardiogram based prospective study. Society of Gynecological Investigation, Toronto, March 2006.
Nir A., Fried I., Bar-Oz B., Algur N., Fried E., Gavri S., Yatsiv I., Perles Z., Rein A.J.J.T., Zonis Z., Bass R N-terminal-pro-B-type Natriuretic Peptide Differentiates Sepsis from Acute Left Ventricular Dysfunction in Critically Ill Children41st Annual Meeting Association for European Paediatric Cardiology. Basel, Switzerland, May 2006
Abstracts Published:
Rein AJJT, Perles Z, Nir A, Gozal D, Chisin R. Assessment of regional lung perfusion in children using digital subtraction angiography. J Isr Heart Soc, 18,1998.
Perles Z, Fraser CC , Fraley K, Ayres NA, Vincent JA, Feltes TF, Pignatelli RH, Lewin MB. Do Unrecognized Diagnoses Affect Surgical Outcome in Tetralogy of Fallot patients? Circulation 102(18) #4004, Oct 2000.
Perles Z, Fraser CC, Fraley K, Ayres NA., Vincent JA., Lewin MB. Echocardiographic Diagnosis Alone For the Complete Repair of Tetralogy of Fallot. Pediatr Cardiol 21(6):598 #30, Nov-Dec 2000
Perles Z, Bowles NE, Vatta M, Jimenez Shinawe, Szmuszkovicz J, Capetanaki Y, Towbin JA. Familial Restrictive Cardiomyopathy Caused by a Missense Mutation in the Desmin Gene: Possible Role of Apoptosis in Disease Pathogenesis. J Am Coll Card 39(5) supp A 445A #410-5, March 2002.
J J T Rein A,Perles Z, Nir A, Hashimoto I, Li X, Sahn DJ. Strain rate imaging is superior to tissue velocity imaging for measuring atrioventricular time interval in the fetus. J Am Coll Cardiol 2003 Mar 19 41: 6 Suppl B 494
Stephen A. Stayer, M.D., Ahmed Alomrani, M.D., Tia Tortoriello, M.D., Zeev Perles, M.D., Mott R. Antonio, M.D. The Effects of Alterations in Ventilation on Cerebral Oxygen Saturation among Infants after Bidirectional Superior Cavopulmonary Connection
Anesthesiology 2003; 99: A1447
Nir A, Bar Oz B, Perles Z, Brooks R, Korach A, Rein AJJT. N-terminal pro-b-type natriuretic peptide. Normal plasma levels from birth to adolescence. Elevated levels at birth, and with heart disease. Cardiology in the young 13 suppl 1: 40 2003
Cohen S, Springer C, Perles Z, Rein AJJT, Avital A, Argaman Z, Nir A. N-Terminal Pro-B-Type Natriuretic Peptide Differentiates Lung From Heart Disease in Infants With Respiratory
Distress. J American Coll Cardiol 3: 391A , 2004
Nir A, Bar-Oz B, Perles Z, Korach A, Rein AJJT. N-terminal pro-B-type natriuretic peptide: reference plasma levels from birth to adolescence. Elevated levels at birth and in children with heart diseases. Acta Paediatr 2004:93:603-607.
National Scientific Meetings Attended:
04/02 The 49th annual conference of the Israel Heart Society, Tel Aviv (Presenter)
04/03 The 50th annual conference of the Israel Heart Society, Tel Aviv (Presenter)
04/04 The 51st annual conference of the Israel Heart Society, Tel Aviv
04/05 The 52nd Annual Conference of the Israel heart Society, Tel Aviv
04/06 The 53rd Annual Conference of the Israel heart Society, Tel Aviv
International Scientific Meetings Attended:
11/98 71st Annual Scientific Sessions of the American Heart Association. Dallas, Texas
11/99 72nd Annual Scientific Sessions of the American Heart Association, Atlanta, GA
10/00 American Academy of Pediatrics Annual Meeting 2000,Chicago, Illinois (Presenter)
11/00 73rd Annual Scientific Sessions of the American Heart Association, New Orleans, LA (Presenter)
03/01 ACC 50th Annual Scientific Session of the American College of Cardiology
03/02 ACC 51st Annual Scientific Session of the American College of Cardiology Atlanta, GA (Presenter, finalist and first place winner for the 2002 Young Investigators Awards Competition)
02/04 5th Symposium on Myocardial Velocity and Deformation Imaging, University Hospital Gastuisberg, Leuven, Belgium
12/06 Euroecho 10, Annual Meeting of the European Association of Echocardiography, Prague, Czech Republic.