Education:

1973-1979 M.D. Hebrew University - Hadassah Medical School, Jerusalem, Israel

Postgraduate training:

1980-1981 Rotating Internship, Hadassah University Hospital, Jerusalem 1984-1986 Resident in Medicine, Hadassah University Hospital, Jerusalem 1986-1990 Fellow in Cardiology, Hadassah University Hospital, Jerusalem 1991-1993 Research Fellow in Cardiology, Boston City Hospital, Boston 1992-1993 Research Fellow, Cardiac Muscle Research Laboratory, Boston University School of Medicine, Boston

Licensure and Certification:

1980 E.C.F.M.G. Examination and Certification 1981 Israeli Board of Registration in Medicine, License # 18209 1990 Israeli Board of Certification in Cardiology, License # 14535 1991-1992 Massachusetts Board of Registration in Medicine, Certificates of Limited Registration # 91-5209-91, 91-6274-92 1992 F.L.E.X. Examination 1993 Massachusetts Board of Registration in Medicine, License # 77552

Military service:

1981-1984 Field military physician, infantry division, Israel Defense Forces 1982-1983 Medical commander of the Jordan valley and the Jericho district

Clinical appointments:

1990-1991 Staff attending physician, Cardiology department, Hadassah University Hospital, Jerusalem 1993-1994 Staff attending physician, Cardiology department, Boston City Hospital, Boston, MA 1994-present Senior staff physician, Cardiology department, Hadassah University Hospital, Jerusalem 1/2001-present Director (interim), Intensive Coronary Care Unit, Hadassah University Hospital, Jerusalem

Academic appointments:

1986-1990 Instructor in Internal Medicine, Hebrew University - Hadassah Medical School, Jerusalem 1995-present Lecturer in Internal Medicine (Cardiology), Hebrew University - Hadassah Medical School, Jerusalem

Other appointments:

2001 Secretary of the Working Group on Myocardial and Pericardial Diseases, The Israel Heart Society

Awards, honors and grants:

1978 Elected class representative for medical student exchange program at Mount Sinai School of Medicine, New York. 1982 IDF Decoration of Honor for combat duty as military physician 1986 Hebrew University Medical Faculty Award for outstanding research on Pulmonary Function Tests in Israeli Children and Young Adults 1998 The frequency of the C677T mutation in the methylenetetrahydrofolate (MTHFR) gene and its relation to the extent of coronary disease in women undergoing cardiac catheterization. Hadassah Medical Organization Women's Health Research Grant ($6,000). 2001 Outstanding teacher of the year, Hebrew University - Hadassah Medical School, Jerusalem

Teaching experience:

1984-1987 Teaching bedside physical diagnosis to 3rd year medical students, Hebrew University - Hadassah Medical School, Jerusalem> 1987-1990 Teaching clinical cardiology to 4th and 6th year medical students, Hebrew University - Hadassah Medical School, Jerusalem 1991-1994 Teaching physical diagnosis, basic ECG, and learning objectives in cardiology to 4th (senior) year medical students, Boston University School of Medicine, Boston, MA 1991-1994 Teaching clinical cardiology to medical house-staff (residents in internal medicine and fellows in cardiology), Boston City Hospital, Boston, MA 1994-present Teaching clinical cardiology and echocardiography to 4th and 6th year medical students, Hebrew University - Hadassah Medical School, Jerusalem 1988-present Teaching ECG and intensive cardiac care to post-graduate nursing students, advanced intensive care courses, Hebrew University - Hadassah Nursing School, Jerusalem 1994-present Teaching Advanced Cardiac Life Support courses to medical students, nurses, junior and senior medical staff, Hadassah University Hospital, Jerusalem 2001 Teaching pathophysiology of acute myocardial infarction to 2nd year medical and dental students, course on medical physiology, Hebrew University - Hadassah Medical School, Jerusalem 2001 Mentor for MD thesis: Evaluation of cardiac function in thalassemic patients. Ms. Shibly Yasmin, 5th year medical student, Hebrew University - Hadassah Medical School 2001 Member of the Hebrew University - Hadassah Medical School committee for 4th year examinations in Internal Medicine

Invited lectures:

1998 The assessment of left ventricular diastolic function. Presented at the 2nd international meeting on non-invasive cardiology, Jerusalem, Israel 1999 Using transesophageal echocardiography to monitor heart function in the operating room. Presented at the joint meeting of the Israeli anesthesia and cardiac national societies, Haifa, Israel

Research interests and investigations currently in progress:

1. Echo-Doppler assessment of atrial function in health and disease and the influence of drugs. (see ref. 15 & 16).
2. Characterization of ventricular dysfunction and pericardial disease in cardiac amyloidosis and renal failure. (see ref. 25).
3. The effect of heat acclimation on cardiac function and cardiac protection during cardiopulmonary bypass. (see submitted ref. 2).
4. Utilizing tissue-Doppler imaging in the assessment of normal cardiac function and diastolic dysfunction (this project is part of an international multicenter study).
5. Utilizing tissue-Doppler imaging (strain and strain-rate) for the evaluation of cardiac function in thalassemic patients. (Mentor for MD thesis).
6. The methylenetetrahydrofolate reductase (MTHFR) genotype and the risk of ischemic heart disease. (see ref. 31). 7. Cardiac pathology in Familial Mediterranean Fever with and without renal failure.
8. Preconditioning and cardiac protection during off-pump coronary artery bypass grafting. (Collaborative research with the departments of anesthesiology and cardiothoracic surgery).
9. The EPHESUS international study: the use of eplerenone in patients with acute myocardial infarction and heart failure (participating as co-investigator).

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