CURRICULUM VITAE
DONNA R. ZFAT-ZWAS, M.D., F.A.C.C. F.A.S.E
PERSONAL
TITLE: Senior Cardiologist
Hadassah-Hebrew University Medical Center
Business Address: POB 12000
Jerusalem Israel
Business Telephone: 011-972-50-404-8274
BUSINESS FAX: 011-972-2-641-1028
BUSINESS E-MAIL: donnaz@hadassah.org.il
EDUCATION AND TRAINING
DATES DEGREE/YEAR/SUBJECT
UNDERGRADUATE SCHOOL
Barnard College 1985 A.B.
PROFESSIONAL SCHOOL
Harvard Medical School 1990 M.D.
GRADUATE MEDICAL EDUCATION
Fellowship, Echocardiography 1997-98 Columbia-Presbyterian
Medical Center, New York, NY
Fellowship, Cardiology 1994-97 Cornell University Medical Center
Fellowship, Circulatory Physiology 1993-94 Columbia-Presbyterian
And Heart Failure Medical Center, New York, NY
Medical Internship and Residency 1990-93 Columbia-Presbyterian
Medical Center, New York, NY
LICENSURE
Pennsylvania License Number MD-071926-L
New York License Number 190705-1
BOARD CERTIFICATION
American Board of Internal Medicine 1993 Internal Medicine Specialty
American Board of Internal Medicine 1997 Cardiovascular Sub-specialty
American Society of Echocardiography 2001 Echocardiography Sub-specialty
Academic Awards and Honors
Phi Beta Kappa
Summa cum Laude, AB
Lillian Niederman Pre-Medical Prize
GRANTS
Co-I “System for Excitation Enhanced Ultrasound Contrast Imaging”, NIH/HL62830 2001- 2003.
PI: “A Pilot Phase 3, International Multicenter Open-Label, Dual-Injection, Myocardial Imaging and Safety Study of AI-700 in Patients with Suspected Ischemic Heart Disease”. Supported by Acusphere, 2002-2004
Co-I: “Correlation of left ventricular dysfunction with small dense LDL in metabolic syndrome and its reversal by LDL lowering with Lipitor.” Supported by Pfizer 2004-2007
Co-I “Intra-Cardiac Pressure Measurements Using Subharmonic Microbubble Signals” American Heart Association Delaware Affiliate 0655441U 2006-2008
Co-I. Multicenter Automatic Defribrillator Implantation Trial with Cardiac Resynchronization Therapy. (MADIT-CRT). Multicenter study sponsored by Guidant. Deborah Heart and Lung Center. 2005 -
APPOINTMENTS
ACADEMIC
Clinical Assistant Professor, Thomas Jefferson University Hospital
2000-2007
Clinical Assistant Professor, Albert Einstein College of Medicine
1999-2000
Instructor in Medicine, New York University
1998-1999
HOSPITAL
Senior Cardiologist 2008-present
Hadassah-Hebrew University Medical Center
Director of Echocardiography Services
Thomas Jefferson University Hospital 2000-2007
Director of Adult Echocardiography
Long Island Jewish Medical Center 1999-2000
Cardiology Attending,
North Shore University Hospital 1998-1999
EDUCATIONAL/LEADERSHIP POSITIONS
Director of Echocardiography Training : Cardiology Fellowship Program at Thomas Jefferson University, 2000-present.
Course Director: “Echocardiography” Jefferson Ultrasound Research and Education Institute. February and August 2001,2002, 2003, 2004, 2005, 2006.
PROFESSIONAL MEMBERSHIPS
American Heart Association
American College of Cardiology, Fellow
American Society of Echocardiography, Fellow
Delaware Valley Echocardiography Society, Board of Directors
NATIONAL COMMITTEE MEMBERSHIPS
American Society of Echocardiography Best Practices Writing Committee
American Registry of Diagnostic and Medical Sonographers Adult Echocardiography
Educational Development Task Force
LOCAL COMMITTEE MEMBERSHIPS
Institutional Review Board 2001-2005
Committee on Clinical Informatics 2001-present
INVITED TALKS AND LECTURES
Talk entitled “New Dimensions in Echocardiography”, Medical Grand Rounds, August 1999,
Long Island Jewish Medical Center, New Hyde Park, NY
Talk entitled “The Evaluation of Cardiac Source of Embolus”, Cardiology Grand Rounds,
February 2001, Thomas Jefferson University Hospital, Philadelphia, PA
Talk entitled “The Echocardiographic Evaluation of Coronary Artery Disease and
Cardiomyopathy”, Philadelphia Board Review Course, October 2001, Philadelphia, PA
Talk entitled “Transesophageal Echocardiography in the Evaluation of Stroke”, Neurology
Grand Rounds, November 2001, Thomas Jefferson University Hospital
Talk entitled “Echocardiography Looking Forward: Contrast and 3D Echocardiography”,
Jefferson Ultrasound Research and Education Institute, given February and August, 2001
Philadelphia, PA
Talk entitled “3-Dimensional Echocardiography” Cardiology Grand Rounds, November 2002.
Thomas Jefferson University Hospital.
Talk entitled “Diseases of the Aorta: Cases” Echo Philly, September 2002 Philadelphia, PA
Talk entitled “Cases for the Ages” Echo Philly, September 2002, Philadelphia, PA
Talk entitled “Getting More Out of Your Visit: Doctor/Patient Communication”, American
Heart Association Pennsylvania Delaware Affiliate Woman’s Heart Health Day. February
21, 2003.
Talk entitled “Cases in Aortic Valve Disease”, Echo Philly, September 2003, Philadelphia, PA
Talk Entitled “Women and Heart Disease”, Thomas Jefferson University Hospital Women’s
Health Source, Sept 17, 2003.
Talk Entitled “Obesity and the Heart”, Cardiology Grand Rounds, Thomas Jefferson University
Hospital, April 20, 2004
Moderator, afternoon session: “Tenth Annual Contrast Agents Symposium” The Leading Edge
Conference, Atlantic City, May 11, 2004
Talk Entitled “Live Demonstration of Contrast: Endocardial Definition and Perfusion” The
Leading Edge Conference, Atlantic City, May 11, 2004
Talk Entitled “Cases in Contrast Echocardiography” The Leading Edge Conference, Atlantic
City, May 11, 2004
Moderator: “Cases, Cases: Test What You’ve Learned” Scientific Sessions of the American
Society of Echocardiography, June 2004
Talk entitled “Caring for your Heart: Cardiac Risk Factors for Women” Thomas Jefferson
University Hospital Women’s Health Source, January 25, 2005
Panelist National Women’s Heart Health Day Campaign, Philadelphia. Panel entitled
“Understanding Cholesterol”Feb 18, 2005
Talk Entitled “The Role of the Cardiologist in the Setting of a Terror Attack or Natural
Disaster.” Cardiology Grand Rounds, Thomas Jefferson University Hospital, April 7,
2006.
Talk Entitled “Advances in Contrast Echocardiography” Cardiology Grand Rounds, Hadassah
Hospital, Feb 5, 2007.
Talk Entitled “Women and Heart Disease” National Woman’s Heart Day. Philadelphia
Convention Center. Feb 16, 2007
PEER-REVIEWED ARTICLES
1. Baran D, Ogino K, Stennet R, Schnellbaecher M, Zwas DR, Morgan JP, Burkoff D. Interrelating of ventricular pressure and intracellular calcium in intact hearts. American Journal of Physiology. 1997;273(3pt2):M1509-22.
2. Altmann BD, Zwas DR, Spatz A, Bergman G, Spokojny A, Riva S, Sanborn TA. Use of contrast volume to estimated creatinine clearance ration to predict renal failure after angiography. Journal of Interventional Cardiology. 1997;10:1-7.
3. Yi GH, Burkhoff D, Zhang H, Zhu SM, Zwas DR, Wang J. Hemodynamic effects of a calcium channel promoter, BAY y 5959 are preserved after continuous administration in ischemic heart failure in conscious dogs. Journal of Pharmacology and Experimental Therapeutics. 1998;2862:760-6.
4. Takuma S, Zwas DR, Fard A, Wu H, Chaudhry H, Di Tullio MR, Ota T, Homma S. Real-time three-dimensional echocardiography acquires demonstration in 45 patients. Journal of the American Society of Echocardiography. 1999;12:1-6.
5. Zwas DR, Takuma S, Mullis-Jason S, Chaudhry H, Wu H, Di Tullio MR, Homma S. Feasibility of real-time three-dimensional treadmill stress echocardiography. Journal of the American Society of Echocardiography. 1999;12:285-289.
6. Yi GH, Zwas D, Wang J. Chronic exercise training preserves prostaglandin-induced dilation of epicardial coronary artery during development of heart failure in awake dogs. Prostaglandins & Other Lipid Mediators. 2000;60:137-151.
7. Yamamoto N, Gu A, DeRosa CM, Shimuzu J, Zwas DR, Smith CR, Burkhoff D. Radiofrequency transmyocardial revascularization enhances angiogenesis and causes myocardial denervation in canine model. Lasers in Surgery and Medicine. 2000;27(1):18-28.
8. Leferovich JM, Bedelbaeva K, Samulewicz S, Zhang XM, Zwas D, Lankford EB, Heber-Katz E. Heart regeneration in adult MRL mice. Proceedings of the National Academy of Sciences of the United States of America. 2001;98(17):9830-9835.
9. Lu L, Mei DF, Gu AG, Wang S, Lentzner B, Gustein DE, Zwas D, Homma S, Yi GH, Wang J. Exercise training normalizes altered calcium-handling proteins during development of heart failure. Journal of Applied Physiology. 2002;92(4):1524-30.
10. Di Tullio MR, Zwas DR, Sacco RL, Sciacca RR, Homma S. Left ventricular mass and geometry and the risk of ischemic stroke. Stroke 2003;34(10):2380-4.
11. Weinberg NM, Zwas DR, Owen AO, Zangrilli JG, Van Tassell P. Left ventricular intracardiac metastatic germ cell tumor presenting with hemorrhagic cerebrovascular event. Journal of the American Society of Echocardiography 2004;17:1080-3.
12. Botta R. Gao E. Stassi G. Bonci D. Pelosi E. Zwas D. Patti M. Colonna L.
Baiocchi M. Coppola S. Ma X. Condorelli G. Peschle C. Heart infarct in NOD-
SCID mice: therapeutic vasculogenesis by transplantation of human CD34+ cells
and low dose CD34+KDR+ cells. FASEB Journal. 18(12):1392-4, 2004
13. Modified Inferior Vena Caval Anastomosis to Reduce Tricuspid Valve
Regurgitation After Heart Transplantation. Marelli D, Silvestry S, Zwas, D Mather P, Rubin S, Dempsey AF., Stein L, Rodriguez E, Diehl JT, Feldman AM. Texas Heart Institute Journal 34:30-5, 2007.
14. Clinical Outcome of Patients with Heart Failure and Preserved Left
Ventricular Function Gotsman, I., Zwas, D., Planer, D., Azaz-Livshits, T.,
Admon, D., Lotan, C., Keren, A.. 2008: American Journal of Medicine
121 (11), pp. 997-1001
15. Differences in Aortic Valve Area Measured with CT Planimetry and
Echocardiography (Continuity Equation) Are Related to Divergent Estimates of Left
Ventricular Outflow Tract Area. Halpern EJ., Mallya R, Sewell M, Shulman M,
Zwas, DR. Am. J. Roentgenol. 2009 192: 1668-1673
BOOKS, MONOGRAPHS, CHAPTERS
1. Burkhoff D, Schnellbaecher M, Stennet R, Zwas DR, Ogino K, Morgan JP. Explaining load – Dependent ventricular performance and energetic based on a model of E-C coupling. In: Lewiner M, Suga H, Watkins M, eds. Cardiac Energetics: From Emax to Pressure-Volume Area. Boston: Kluwer Academic Publishers; 1995:41-52.
2. Zwas DR, Devereux RB. Hypertensive left ventricular hypertrophy: pathophysiology, prognosis, and reversibility. Advances in Cardiovascular Medicine. 1997;4:1-7.
3. Berko BA, Owen AN, Zwas DR. Echocardiography: The role of this non-invasive test in the geriatric population. Geriatrics, 2003: 30-38
4. Halpern E, Zwas DR. Valve Disease. In Clinical Cardiac CT - Combining Anatomy & Function: A Text-Atlas. ( E Halpern, ed.) 2010 New York: Thieme Medical Publishers, Inc.
5. Owen AN. Berko BA, Zwas DR. Echocardiography. In Jefferson Heart Institute Handbook of Cardiology. P. Mather ed. In press